Major interaction on record — check this product against your medications before combining. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Digestive Bitters Citrus Ingredients & Drug Interactions

by Urban Moonshine

Digestive Bitters Citrus label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Bitters Citrus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Digestive Bitters Citrus is a dietary supplement by Urban Moonshine with 8 active ingredients. Its ingredients are commonly taken for nausea and vomiting, motion sickness, morning sickness in pregnancy.Based on those ingredients, 1,184 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are organic Ginger, organic Fennel, organic Dandelion. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digestive Bitters Citrus by Urban Moonshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Bitters Citrus by Urban Moonshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digestive Bitters Citrus by Urban Moonshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Herbal Extract Blend (Herb/Botanical)” is a proprietary blend — the label gives one combined amount (1.20 mL) without saying how much of each component you get.

This product contains 8 ingredients total, including 6 herbal actives: organic ginger, organic burdock, organic fennel, organic dandelion, organic yellow dock, and organic gentian. It also includes a proprietary herbal extract blend (the other components are listed separately).

The inactive ingredients are water, organic alcohol, gum arabic, and essential oils.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“digestive support and digestion”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Dysmenorrhea — rated "Possibly Effective" (Fennel) (Natural Medicines).
  • On file: Osteoarthritis — rated "Possibly Effective" (Ginger) (Natural Medicines).
  • On file: Pregnancy-induced nausea and vomiting — rated "Possibly Effective" (Ginger) (Natural Medicines).

The evidence for this product's active ingredients is mixed. Ginger is possibly effective for pregnancy-related nausea, period pain (dysmenorrhea), and osteoarthritis, but possibly ineffective for muscle soreness after exercise and chemotherapy-induced nausea.

For the other herbs—burdock, fennel, dandelion, yellow dock, and gentian—we hold insufficient reliable evidence to establish their effectiveness for the conditions they're traditionally used for.

The evidence, ingredient by ingredient Ginger Burdock Fennel Dandelion Yellow Dock Gentian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ginger is generally well tolerated in typical food and supplement amounts for most healthy adults. However, doses of 5 grams or more per day raise the risk of side effects.

Common mild effects include abdominal discomfort, burping, diarrhea, heartburn, and a peppery irritation in the mouth and throat. Yellow dock acts as a laxative and contains oxalates; use it short-term and with care—raw leaves or rhizomes can cause serious effects including kidney stones and low calcium.

Burdock is generally well tolerated as food, though serious allergic reactions (including anaphylaxis) are rare. Fennel, dandelion, and gentian are generally well tolerated in small amounts but are less well studied at higher doses.

For pregnancy and breastfeeding: ginger is rated likely or possibly safe, but check with your doctor first and keep amounts moderate. Fennel, burdock, yellow dock, and dandelion carry cautions or avoidance recommendations in pregnancy or lactation due to limited safety data.

Side effects, ingredient by ingredient Ginger Burdock Fennel Dandelion Yellow Dock Gentian

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Burdock, Fennel, Yellow Dock, Dandelion, Gentian, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,185 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your own doctor or pharmacist if you take: diuretics (water pills) or digoxin for your heart, any blood thinners or blood-thinning drugs, diabetes medications, antihypertensive drugs (blood pressure medicine), birth control pills or hormone replacement therapy, ciprofloxacin or other quinolone antibiotics, potassium-sparing diuretics, lithium, or certain cancer drugs (CYP3A4 substrates). Yellow dock poses Major-severity risks with diuretics and digoxin; all others are Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This is a traditional bitters blend with some evidence supporting ginger for nausea and period pain, but several of its herbs interact with common medications—especially blood thinners, diabetes drugs, heart medications, and birth control. If you take any prescription medications, blood pressure drugs, or a diuretic, check your exact drugs against the search tool before starting.

Talk it over with your own doctor or pharmacist, especially if you're pregnant, nursing, or take digoxin or a diuretic.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Bitters Citrus, straight from the product label.

Brand Urban Moonshine
Barcode (UPC) 851588002043
Net contents 8.4 fl. Oz.; 250 mL
Market status On market
Date entered into DSLD Sep 25, 2015
DSLD ID 50594
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Bitters Citrus by Urban Moonshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 tsp
Maximum serving Sizes:
0.25 tsp
Servings per container
200
UPC/BARCODE
851588002043
IngredientAmount% DV
Calories0 {Calories}--
organic Ginger0 NP--
Proprietary Herbal Extract Blend (Herb/Botanical)1.2 mL--
organic Orange0 NP--
organic Burdock0 NP--
organic Fennel0 NP--
organic Dandelion0 NP--
organic Yellow Dock0 NP--
organic Angelica0 NP--
organic Gentian0 NP--

Other ingredients: Water, organic Alcohol, org. Gum Arabic, Essential Oils

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten Free.

Vermont Organic Farmers Certified

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

30%-35% Alcohol

General Statements

Urban Moonshine is a Vermont herbal company specializing in organic bitters and herbal tonics. We created Urban Moonshine Digestive Bitters because we believe the root of good health is great digestion. Urban Moonshine Bitters are used to optimize digestive function and relieve gas, bloating, and upset stomach; occasional nausea and heartburn; as well as to support liver function and healthy skin. Our Bitters are formulated from exceptional blends of Vermont herbs and roots, complemented by a few worldly exotics- a delicious, quality medicinal. To your health and well-being! -Jovial King

Herbal Apothecary

Handcrafted Digestif

Natural sediment occurs in this product. For recipes, herbal blog and press, visit: www.urbanmoonshine.com

Seals/Symbols

USDA ORGANIC

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Shake well before using.

Suggested Use: To optimize digestive function, enjoy 1/4 tsp (a few dashes) of our Bitters before or after meals, up to 6 times a day, and salute your health.

Brand IP Statement(s)

Not a significant source of calories from fat, carbohydrates, or protein.

Precautions

Not to be used during pregnancy.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Bitters Citrus by Urban Moonshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Bitters Citrus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Bitters Citrus by Urban Moonshine

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.25 tsp Dosage formLiquid Servings per container200 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Herbal Extract Blend (Herb/Botanical)

1.2 mL per serving

Other (inactive) ingredients: Water, Organic Alcohol, Org. Gum Arabic, Essential Oils. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Bitters Citrus by Urban Moonshine Drug Interactions

Want to check YOUR meds against Digestive Bitters Citrus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,184Drugs
76 Major 1,054 Moderate 54 Minor

Ingredients driving the most interactions

organic Ginger 1,007
organic Fennel 740
organic Dandelion 457
organic Gentian 172
organic Burdock 122

Individual Drug Interactions

The ingredients in Digestive Bitters Citrus interact with 1,184 drugs. Click any drug to see the details.

6 of the 8 ingredients in Digestive Bitters Citrus interact with drugs. Each result below shows which ingredient is responsible. organic Ginger organic Fennel organic Dandelion organic Gentian organic Burdock organic Yellow Dock

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Bitters Citrus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Ginger14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
organic Ginger full monograph & interactions

organic Fennel6 drug types · 740 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fennel might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Animal research suggests that fennel oil has antithrombotic and antiplatelet effects.

Likelihood Possible Evidence D
Ciprofloxacin (Cipro)

Theoretically, fennel might decrease the levels and clinical effects of ciprofloxacin.

Animal research shows that fennel reduces ciprofloxacin bioavailability by nearly 50%, possibly due to the metal cations such as calcium, iron, and magnesium contained in fennel. This study also found that fennel increased tissue distribution and slowed elimination of ciprofloxacin.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking large amounts of fennel might decrease the effects of contraceptive drugs due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, fennel might increase levels of drugs metabolized by CYP3A4.

In vitro research suggests that fennel inhibits CYP3A4 enzyme activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking large amounts of fennel might interfere with hormone replacement therapy due to competition for estrogen receptors.

Some constituents of fennel have estrogenic activity.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, taking large amounts of fennel might decrease the antiestrogenic effect of tamoxifen.

Some constituents of fennel have estrogenic activity, which may interfere with the antiestrogenic activity of tamoxifen.

Likelihood Possible Evidence D
organic Fennel full monograph & interactions

organic Dandelion7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
organic Dandelion full monograph & interactions

organic Gentian1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
organic Gentian full monograph & interactions

organic Burdock1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
organic Burdock full monograph & interactions

organic Yellow Dock3 drug types · 78 drugs

Digoxin (Lanoxin)

Theoretically, yellow dock might increase the risk of digoxin toxicity when used long-term or in large amount.
When yellow dock is used chronically or in large amounts, hypokalemia may occur. This might increase the toxic effects of digoxin.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
When yellow dock is used chronically or in large amounts, hypokalemia may occur, and overuse of yellow dock might compound diuretic-induced potassium loss.

Likelihood Probable Evidence D
Warfarin (Coumadin)

Theoretically, the laxative effects of yellow dock might increase the effects of warfarin, including the risk of bleeding.
The anthraquinones in yellow dock have a mild stimulant laxative effect. Consuming excessive amounts can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
organic Yellow Dock full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Bitters Citrus, from the product label.

Urban Moonshine

See all Urban Moonshine products
Name
Urban Moonshine
Street Address
255 S. Champlain St.
City
Burlington
State
VT
ZipCode
05401
Phone Number
802-428-4707
Web Address
urbanmoonshine.com
Pharmacist Counseling Corner

Digestive Bitters Citrus by Urban Moonshine: Common Questions

Does Digestive Bitters Citrus by Urban Moonshine interact with any medications?
Yes. Based on its ingredients, Digestive Bitters Citrus has a known interaction with 1,184 medications, including 76 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Bitters Citrus contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is ginger in this product safe for morning sickness?
Ginger is rated likely or possibly safe in pregnancy, and it's possibly effective for pregnancy-related nausea. However, the safety data we hold advise checking with your doctor first and keeping amounts moderate—this product is concentrated, not a food amount. Talk it over with your own doctor or pharmacist before starting.
Will this help my digestion?
The product contains herbs traditionally used as bitters to support digestion, but we hold insufficient reliable evidence to establish whether burdock, fennel, dandelion, yellow dock, or gentian actually work for digestion specifically. Ginger may help with nausea, which is listed as possibly effective in our data.
What are the most common side effects of ginger in this blend?
Mild effects include abdominal discomfort, burping, diarrhea, heartburn, and a peppery irritation in the mouth and throat. These are generally more common at doses of 5 grams or more per day. Serious side effects are rare.
Can I use this while breastfeeding?
Ginger is rated likely safe while breastfeeding. However, fennel, burdock, yellow dock, and dandelion carry cautions or avoidance recommendations due to limited safety data—laxative compounds from yellow dock may pass into breast milk. Talk with your own doctor or pharmacist about whether this product is right for you.
Does this product contain any fillers?
The product contains inactive ingredients: water, organic alcohol, gum arabic, and essential oils. These are excipients (binders and carriers), not active herbal ingredients.
Why does the product interact with so many medications?
This blend contains six different herbs, each with its own interactions. Ginger and fennel affect liver enzymes that break down many drugs; ginger, burdock, fennel, and dandelion all interact with blood thinners; and yellow dock's potassium loss can compound diuretic effects. Multiple ingredients mean a wider interaction footprint.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Bitters Citrus label
Go deeper

The Full Monographs Behind Digestive Bitters Citrus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Burdock

Interacts with 122 drugs

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...

Read the full Burdock monograph → Herb & supplement monograph

Fennel

Interacts with 740 drugs

Fennel is a Mediterranean herb widely used as a food and spice, and traditionally taken for digestive complaints, colic, and menstrual cramps. Some small studies suggest possible benefit for...

Read the full Fennel monograph → Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Yellow Dock

Interacts with 78 drugs

Yellow dock is a traditional herb used mostly as a mild laxative and a digestive and skin tonic. Good-quality human studies are lacking, so its benefits are largely unproven, and its natural...

Read the full Yellow Dock monograph → Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph →
Sources

Sources & How We Checked

Digestive Bitters Citrus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 132 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ginger 64 references
  1. Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1991;38:19-24. PubMed
  2. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2000;(2):CD000145. PubMed
  3. Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial. Obstet Gynecol 2001;97:577-82. DOI
  4. Backon J. Ginger in preventing nausea and vomiting of pregnancy; a caveat due to its thromboxane synthetase activity and effect on testosterone binding. Eur J Obstet Gynecol Reprod Biol 1991;42:163-4. PubMed
  5. Srivastava KC. Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostaglandins Leukot Essent Fatty Acids 1989;35:183-5. PubMed
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Fennel 17 references
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Dandelion 27 references
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Yellow Dock 8 references
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See these in context on the Yellow Dock monograph →

Gentian 5 references
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See these in context on the Gentian monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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