Captopril and Hydrochlorothiazide
Captopril and hydrochlorothiazide is a combination ACE inhibitor and thiazide diuretic used to treat high blood pressure (hypertension).
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 1 clinical label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Captopril and hydrochlorothiazide, an older standby available as a generic, treats high blood pressure by pairing an ACE inhibitor that relaxes blood vessels with a thiazide water pill that flushes out extra salt and water, and together they lower pressure more than either alone. Most people tolerate it reasonably well, and the side effects they notice most are a dry, nagging cough and lightheadedness when standing up. Its boxed warning covers pregnancy, since in the second and third trimesters it can injure or even kill a developing baby, so stop it as soon as pregnancy is detected and plan a switch before trying to conceive.
Clinical pearls
- Take it one hour before meals, because food noticeably cuts how much captopril your body absorbs.
- Skip potassium salt substitutes and potassium supplements unless your prescriber approves, since together they can push potassium dangerously high.
- Report a sore throat or fever promptly, since captopril can rarely drop white blood cells, especially with kidney disease or lupus.
- Sudden swelling of the lips, tongue or throat can appear at any point during treatment and needs emergency care.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾
Do not take this medication if you are pregnant, and stop it immediately if you become pregnant. When ACE inhibitors like captopril are taken during the second or third trimester of pregnancy, they can cause serious injury or death to the developing baby — including kidney failure, skull defects, dangerously low blood pressure, and in some cases, death. If you discover you are pregnant while taking this medication, contact your doctor right away so it can be discontinued as soon as possible.
Patient information guide A plain-language walkthrough of Captopril and Hydrochlorothiazide, written from its FDA label.
What Captopril and Hydrochlorothiazide is used for
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Captopril and hydrochlorothiazide is a fixed-dose combination medication approved to treat high blood pressure (hypertension).
- CAPTOPRIL AND HYDROCHLOROTHIAZIDE tablets treat high blood pressure (hypertension) in adults with normal kidney function
- The combination may be used as a first-line treatment or when a patient has already been stabilized on captopril and hydrochlorothiazide taken separately
- In patients with impaired kidney function or collagen vascular diseases (such as lupus), it is reserved for those who have failed or cannot tolerate other drug combinations
How Captopril and Hydrochlorothiazide works
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Captopril blocks an enzyme called ACE (angiotensin-converting enzyme), which the body uses to produce angiotensin II — a substance that tightens blood vessels and causes the body to retain sodium and fluid. By blocking ACE, captopril allows blood vessels to relax, reduces fluid retention, and lowers blood pressure. Hydrochlorothiazide is a thiazide diuretic that acts on the kidneys to increase the excretion of sodium and water, further reducing blood volume and pressure. Together, their blood pressure-lowering effects are approximately additive.
Captopril and Hydrochlorothiazide dosage
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CAPTOPRIL AND HYDROCHLOROTHIAZIDE tablets are taken by mouth, one hour before meals — food can reduce captopril absorption by 30 to 40%. Treatment is typically started once daily, with dose adjustments made at roughly 6-week intervals since the full effect may take 6 to 8 weeks to appear. Patients with kidney impairment may need lower doses or less frequent dosing.
- Take one hour before meals
- Usually taken once daily
- Allow up to 6–8 weeks for full effect before assuming a dose change is needed
- Follow your prescriber's instructions exactly — do not adjust your dose on your own
Dosing details from the FDA-approved label
From the Captopril and Hydrochlorothiazide prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Hypertension - initial therapy or substitution (general dosing)
- Dosage must be individualized according to patient's response
- May be substituted for the previously titrated individual components
- Alternatively, therapy may be instituted with a single tablet of captopril and hydrochlorothiazide 25 mg/15 mg taken once daily
- For patients insufficiently responsive, additional captopril or hydrochlorothiazide may be added a
- Maximum: Daily doses of captopril should not exceed 150 mg and of hydrochlorothiazide should not exceed 50 mg.
- Take one hour before meals; adjust dosage generally at 6 week intervals, as full effect may not be attained for 6 to 8 weeks
- Renal impairment
- These patients may respond to smaller or less frequent doses
- After the desired therapeutic effect has been achieved, the dose intervals should be increased or the total daily dose reduced until the minimal effective dose is achieved
- For severe renal dysfunction the combination tablet is not usually recommended; a loop diuretic (e.g., furosemide) rather than a thiazide is preferred with captopril
Read the label’s full dosing text
DOSAGE & ADMINISTRATION DOSAGE MUST BE INDIVIDUALIZED ACCORDING TO PATIENT'S RESPONSE. Captopril and hydrochlorothiazide tablets may be substituted for the previously titrated individual components. Alternatively, therapy may be instituted with a single tablet of captopril and hydrochlorothiazide 25 mg/15 mg taken once daily. For patients insufficiently responsive to the initial dose, additional captopril or hydrochlorothiazide may be added as individual components or by using captopril and hydrochlorothiazide tablets 50 mg/15 mg, 25 mg/25 mg or 50 mg/25 mg, or divided doses may be used. Because the full effect of a given dose may not be attained for 6 to 8 weeks, dosage adjustments should generally be made at 6 week intervals, unless the clinical situation demands more rapid adjustment. In general, daily doses of captopril should not exceed 150 mg and of hydrochlorothiazide should not exceed 50 mg. Captopril and hydrochlorothiazide tablets should be taken one hour before meals. Dosage Adjustment in Renal Impairment: Because captopril and hydrochlorothiazide are excreted primarily by the kidneys, excretion rates are reduced in patients with impaired renal function. These patients will take longer to reach steady-state captopril levels and will reach higher steady-state levels for a given daily dose than patients with normal renal function. Therefore, these patients may respond to smaller or less frequent doses of captopril and hydrochlorothiazide. After the desired therapeutic effect has been achieved, the dose intervals should be increased or the total daily dose reduced until the minimal effective dose is achieved. When concomitant diuretic therapy is required in patients with severe renal impairment, a loop diuretic (e.g., furosemide), rather than a thiazide diuretic is preferred for use with captopril; therefore, for patients with severe renal dysfunction the captopril-hydrochlorothiazide combination tablet is not usually recommended. (See WARNINGS: Captopril: Anaphylactoid Reactions During Membrane Exposure and PRECAUTIONS: Hemodialysis ).
Read the full Dosage and Administration section on DailyMed →
Captopril and Hydrochlorothiazide side effects
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Like all medications, this combination can cause side effects — most are manageable, but some require prompt medical attention.
Common side effects
- Skin rash, sometimes with itching or mild fever
- Dry, persistent cough
- Altered or diminished sense of taste
- Dizziness or lightheadedness
- Low blood pressure (feeling faint, especially when standing up)
- Nausea, vomiting, or stomach upset
- Fatigue or weakness
- Skin rash, sometimes with itching, mild fever, or joint aches — common in the first few weeks
- Dry, persistent cough — a known effect of ACE inhibitors
- Diminished or altered taste — usually temporary and reversible
- Low blood pressure (hypotension), particularly in people who are dehydrated or on other diuretics
- Nausea, vomiting, stomach upset, or diarrhea
- Increased urination (from the diuretic component)
When to get medical help
- Get emergency help immediately if you have sudden swelling of the face, lips, tongue, throat, or difficulty breathing — this is angioedema and can be life-threatening
- Call your doctor right away if you have signs of infection such as sore throat or fever — this medication can rarely cause a dangerous drop in white blood cells
- Stop this medication and call your doctor if you become pregnant — this drug can cause serious harm or death to an unborn baby in the second or third trimester
- Contact your doctor if you notice yellowing of the skin or eyes (jaundice) or marked stomach pain — rare but serious liver reactions have been reported
- Call your doctor if you develop severe or unusual stomach pain with or without nausea — this can be a sign of intestinal angioedema
- Seek care for signs of high potassium: muscle weakness, irregular heartbeat
- Report unusual bruising, bleeding, or signs of anemia — blood cell changes can occur
Serious reactions requiring immediate attention include sudden swelling of the face, lips, tongue, or throat (angioedema); signs of infection like sore throat or fever (possible low white blood cells); yellowing of the skin or eyes (jaundice); and any symptoms of a severe allergic reaction.
Captopril and Hydrochlorothiazide warnings and precautions
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- Pregnancy (Boxed Warning): This medication can cause serious injury or death to an unborn baby if taken during the second or third trimester. Stop it immediately if you become pregnant and contact your doctor.
- Angioedema: Sudden swelling of the face, throat, or tongue can occur and may block the airway — this is a medical emergency. Black patients face a higher risk than non-black patients.
- Low white blood cell count (neutropenia/agranulocytosis): Captopril can rarely cause a dangerous drop in white blood cells, increasing infection risk. This is more likely in patients with kidney disease, lupus, or scleroderma. Report any fever or sore throat immediately.
- Low blood pressure (hypotension): Can occur, especially in patients who are dehydrated, on a low-salt diet, or on dialysis.
- Liver toxicity: Rare cases of serious liver damage (including fulminant hepatic necrosis) have been reported with ACE inhibitors. Report jaundice or marked elevation in liver tests immediately.
- Skin cancer risk: Long-term use of hydrochlorothiazide has been linked to a higher risk of squamous cell carcinoma (a type of skin cancer), particularly in white patients with high cumulative doses. Use sun protection.
- Kidney function: This combination is not usually recommended in patients with severe kidney impairment.
Captopril and Hydrochlorothiazide interactions
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This combination interacts with several common medications and substances — always share your full medication list with your prescriber and pharmacist.
- Potassium-sparing diuretics and potassium supplements — can raise potassium to dangerously high levels when combined with captopril
- Potassium-containing salt substitutes — same risk as potassium supplements; use with caution
- Lithium — both captopril and hydrochlorothiazide can raise lithium blood levels, increasing the risk of lithium toxicity; frequent monitoring is needed
- NSAIDs (ibuprofen, aspirin, indomethacin) — can reduce the blood pressure-lowering effect of this combination
- Diabetes medications (insulin and oral agents) — hydrochlorothiazide can raise blood sugar, possibly requiring dose adjustments
- Alcohol, barbiturates, and opioids — can worsen dizziness and low blood pressure
- Injectable gold (sodium aurothiomalate) — can cause facial flushing, nausea, vomiting, and low blood pressure
- Cholestyramine and colestipol — these cholesterol-lowering resins can reduce absorption of hydrochlorothiazide by up to 85%; take hydrochlorothiazide at a different time if possible
- Vasodilators (nitroglycerin, nitrates) — additive blood pressure-lowering effect; use with caution
Interactions listed in the FDA-approved label
From the Captopril and Hydrochlorothiazide prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Captopril: Diuretics (patients on diuretic therapy, severe dietary salt restriction or dialysis): May occasionally experience a precipitous reduction of blood pressure, usually within the first hour after the initial dose of captopril. Discontinue the diuretic or increase salt intake approximately one week prior to starting captopril, or start with small doses (6.25 or 12.5 mg), or provide medical supervision for at least one hour after the initial dose.
- Captopril: Agents having vasodilator activity (nitroglycerin, other nitrates): Data on concomitant use of other vasodilators in patients receiving captopril for heart failure are not available. If possible, discontinue before starting captopril; if resumed, administer cautiously and perhaps at lower dosage.
- Captopril: Agents causing renin release (e.g., thiazide diuretics): Captopril's effect is augmented by antihypertensive agents that cause renin release.
- Captopril: Agents affecting sympathetic activity (ganglionic or adrenergic neuron blocking agents); beta-blockers: The sympathetic nervous system may be important in supporting blood pressure; beta-blockers add some further antihypertensive effect but the overall response is less than additive. Use agents affecting sympathetic activity with caution.
- Captopril: Agents increasing serum potassium (potassium-sparing diuretics, potassium supplements, potassium-containing salt substitutes): Since captopril decreases aldosterone production, elevation of serum potassium may occur and may be significant. Give potassium-sparing diuretics or potassium supplements only for documented hypokalemia, and with caution; use potassium-containing salt substitutes with caution.
- Injectable gold (sodium aurothiomalate): Nitritoid reactions (facial flushing, nausea, vomiting and hypotension) have been reported rarely with concomitant ACE inhibitor therapy.
- Inhibitors of endogenous prostaglandin synthesis (indomethacin, other NSAIDs e.g., aspirin): Indomethacin may reduce the antihypertensive effect of captopril, especially in low renin hypertension; other NSAIDs may also have this effect. When used with hydrochlorothiazide, observe closely to determine if the desired diuretic effect is obtained.
- Lithium: Increased serum lithium levels and symptoms of lithium toxicity reported with ACE inhibitors; diuretics reduce renal clearance of lithium and increase the risk of toxicity. Coadminister with caution and monitor serum lithium levels frequently.
- Hydrochlorothiazide: Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur.
- Hydrochlorothiazide: Cholestyramine and colestipol resins: Absorption of hydrochlorothiazide is impaired; single doses reduce its absorption by up to 85 and 43 percent, respectively.
Read the label’s full interactions text
Drug Interactions: Captopril : Hypotension—Patients On Diuretic Therapy : Patients on diuretics and especially those in whom diuretic therapy was recently instituted, as well as those on severe dietary salt restrictions or dialysis, may occasionally experience a precipitous reduction of blood pressure usually within the first hour after receiving the initial dose of captopril. The possibility of hypotensive effects with captopril can be minimized by either discontinuing the diuretic or increasing the salt intake approximately one week prior to initiation of treatment with captopril or initiating therapy with small doses (6.25 or 12.5 mg). Alternatively, provide medical supervision for at least one hour after the initial dose. If hypotension occurs, the patient should be placed in a supine position and, if necessary, receive an intravenous infusion of normal saline. This transient hypotensive response is not a contraindication to further doses which can be given without difficulty once the blood pressure has increased after volume expansion. Agents Having Vasodilator Activity : Data on the effect of concomitant use of other vasodilators in patients receiving captopril for heart failure are not available; therefore, nitroglycerin or other nitrates (as used for management of angina) or other drugs having vasodilator activity should, if possible, be discontinued before starting captopril. If resumed during captopril therapy, such agents should be administered cautiously, and perhaps at lower dosage. Agents Causing Renin Release : Captopril’s effect will be augmented by antihypertensive agents that cause renin release. For example, diuretics (e.g., thiazides) may activate the renin-angiotensin-aldosterone system. Agents Affecting Sympathetic Activity : The sympathetic nervous system may be especially important in supporting blood pressure in patients receiving captopril alone or with diuretics.
Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Captopril and Hydrochlorothiazide
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- You are pregnant or may become pregnant — this medication must be stopped immediately upon detection of pregnancy due to serious fetal risk
- You have had angioedema (severe swelling) with any ACE inhibitor in the past — this is a contraindication
- You are allergic to captopril, any other ACE inhibitor, hydrochlorothiazide, or any sulfonamide-derived drug
- You have kidney disease — dose adjustments are needed; the combination is not recommended in severe kidney impairment
- You have liver disease — hydrochlorothiazide should be used with caution in liver disease or progressive liver conditions
- You have collagen vascular diseases such as lupus (systemic lupus erythematosus) or scleroderma — risk of dangerous low white blood cell counts is significantly higher
- You are Black — ACE inhibitors carry a higher rate of angioedema in Black patients compared to non-Black patients
- You have no urine production (anuria) — hydrochlorothiazide is contraindicated in this condition
- You take lithium, potassium supplements, or potassium-sparing diuretics — important drug interactions apply
- You are scheduled for surgery — discuss with your doctor, as this medication can interact with anesthetics and muscle relaxants
Captopril and Hydrochlorothiazide overdose
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Taking too much captopril can cause a significant drop in blood pressure (hypotension), which is the primary concern with overdose. Too much hydrochlorothiazide can cause increased urination, electrolyte imbalances, and — in larger overdoses — varying degrees of drowsiness that can progress to unconsciousness, along with stomach irritation. If an overdose is suspected, seek emergency medical care immediately. Treatment focuses on restoring blood pressure (often with IV fluids), maintaining electrolyte balance, and supporting breathing and kidney function.
What Captopril and Hydrochlorothiazide does in the body
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Captopril reduces the narrowing of blood vessels by blocking the production of angiotensin II, resulting in lower peripheral arterial resistance (less resistance to blood flow) without reducing — and sometimes increasing — cardiac output (the heart's pumping ability). Blood pressure reduction is usually greatest 60 to 90 minutes after a dose, with the duration of effect being extended when a thiazide diuretic is used alongside it. Hydrochlorothiazide works by reducing the amount of sodium and water reabsorbed by the kidneys, lowering the volume of fluid in the circulation and thereby reducing blood pressure.
How your body processes Captopril and Hydrochlorothiazide
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Captopril is rapidly absorbed after oral dosing, with blood levels peaking at about one hour — but food in the stomach reduces absorption by 30 to 40%, which is why it should be taken one hour before meals. More than 95% of the absorbed captopril dose is eliminated in the urine within 24 hours, and its half-life (the time for half the drug to leave the body) is likely less than two hours in patients with normal kidney function. In patients with kidney impairment, captopril is cleared more slowly and accumulates to higher levels, requiring dose adjustments. Hydrochlorothiazide is also primarily eliminated by the kidneys, so impaired kidney function affects its clearance as well.
How to store Captopril and Hydrochlorothiazide
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Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure. Store at 20° to 25°C (68° to 77°F). Protect from moisture.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Captopril and Hydrochlorothiazide
236 supplements and herbal products have documented interactions with Captopril and Hydrochlorothiazide in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 10
- Moderate · 199
- Minor · 27
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Nutrient depletion considerations
Captopril and Hydrochlorothiazide has been associated with lower levels of 8 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.
- Higher significance · 3
- Moderate · 2
- Unrated · 3
Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.
Captopril and Hydrochlorothiazide: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Captopril and Hydrochlorothiazide — the kind of thing our pharmacy team would talk through with you at the counter.
Why do I need to take this pill one hour before eating?
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I've developed a dry, nagging cough since starting this — is that normal?
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Is this medication safe to take during pregnancy?
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What warning signs should I call my doctor about right away?
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Can I use a salt substitute or take potassium vitamins while on this?
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How long will it take before my blood pressure actually improves?
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Is Captopril and Hydrochlorothiazide available over the counter?
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When was Captopril and Hydrochlorothiazide first available?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Captopril and Hydrochlorothiazide on HelloPharmacist
Captopril and Hydrochlorothiazide forms and strengths (how it comes)
Captopril and Hydrochlorothiazide is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- CAPTOPRIL AND HYDROCHLOROTHIAZIDE tablets are used to treat high blood pressure (hypertension)
- CAPTOPRIL AND HYDROCHLOROTHIAZIDE tablets may be used as initial therapy or as a substitute when a patient has already been stabilized on the individual ingredients
- CAPTOPRIL AND HYDROCHLOROTHIAZIDE tablets should be taken one hour before meals to ensure proper absorption
- CAPTOPRIL AND HYDROCHLOROTHIAZIDE tablets are typically taken once daily, but your doctor may adjust the frequency based on your response
- The full blood pressure-lowering effect may take 6 to 8 weeks — do not adjust your dose without consulting your prescriber
- In patients with impaired kidney function, CAPTOPRIL AND HYDROCHLOROTHIAZIDE tablets may need less frequent dosing or dose reduction as directed by your doctor
Captopril and Hydrochlorothiazide on the U.S. market: products, makers and brands
How Captopril and Hydrochlorothiazide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
1 company lists 4 Captopril and Hydrochlorothiazide product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 2023. Brand names on the directory include Capozide; the rest are generics.
Compare Captopril and Hydrochlorothiazide products
A representative set of FDA-listed product records for Captopril and Hydrochlorothiazide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Tablet | ||||
| CAPTOPRIL 25 mg/1; HYDROCHLOROTHIAZIDE 15 mg | Oral | Rising Pharma Holdings, Inc. | ANDA | View NDC → |
| CAPTOPRIL 25 mg/1; HYDROCHLOROTHIAZIDE 25 mg | Oral | Rising Pharma Holdings, Inc. | ANDA | View NDC → |
| CAPTOPRIL 50 mg/1; HYDROCHLOROTHIAZIDE 15 mg | Oral | Rising Pharma Holdings, Inc. | ANDA | View NDC → |
| CAPTOPRIL 50 mg/1; HYDROCHLOROTHIAZIDE 25 mg | Oral | Rising Pharma Holdings, Inc. | ANDA | View NDC → |
Showing 4 of 4 products — FDA National Drug Code Directory. See every product, package size and price: browse all 4 Captopril and Hydrochlorothiazide NDCs →
Captopril and Hydrochlorothiazide side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Captopril and Hydrochlorothiazide — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Captopril and Hydrochlorothiazide in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Captopril and Hydrochlorothiazide FDA approval history
How Captopril and Hydrochlorothiazide went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Captopril and Hydrochlorothiazide recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Captopril and Hydrochlorothiazide recalls since July 2021.
✅No Captopril and Hydrochlorothiazide recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
Captopril and Hydrochlorothiazide supply and shortage status
Whether Captopril and Hydrochlorothiazide is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
Captopril and Hydrochlorothiazide brand names
Captopril and Hydrochlorothiazide is sold under one brand name in the FDA directory — Capozide. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Captopril and Hydrochlorothiazide: manufacturers and labelers
One company lists Captopril and Hydrochlorothiazide products with the FDA. By number of product records, the largest are Rising Pharma Holdings, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Captopril and Hydrochlorothiazide drug class (RxNorm)
Captopril and Hydrochlorothiazide belongs to the Angiotensin Converting Enzyme Inhibitor class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Captopril and Hydrochlorothiazide page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Rising Pharma Holdings, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →