What Supplements Interact with Captopril, Hydrochlorothiazide?
Captopril, Hydrochlorothiazide brand names: Capozide, Acezide. Every interaction below applies to the brands too.
Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy
What is this page for?
One answer, for one medication: what supplements and herbal products interact with Captopril, Hydrochlorothiazide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.
This page covers supplement interactions only — to check Captopril, Hydrochlorothiazide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy
What is this?
The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.Someone taking Capozide (captopril with hydrochlorothiazide) for blood pressure is often the same person browsing the supplement aisle for heart health, and that is exactly where this list bites. Of the 236 ingredients on file, 10 are rated major, enough to make this a genuine safety review, not trivia. Most of the 199 moderate entries add to the blood-pressure drop or push against it, but the majors go further, into kidney damage and dangerous mineral swings.
Calcium is the everyday standout, since the thiazide half keeps calcium in the body, and adding calcium or dolomite supplements can raise blood calcium enough to harm the kidneys. Potassium cuts both ways, captopril holding it in while the diuretic sheds it. Twenty more ingredients add sun sensitivity, activated charcoal can soak up the dose itself, and the 27 minor entries echo these themes faintly. Start with the ten major-rated names below and work down from there.
This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓
Captopril, Hydrochlorothiazide: Top Interactions at a Glance
The Captopril, Hydrochlorothiazide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.
Showing the 12 highest-ranked of 236 interacting ingredients — plus 1,216 more checked with no known interaction. See the complete ranked list.
The Most-Checked Captopril, Hydrochlorothiazide Combinations Today
The Captopril, Hydrochlorothiazide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full interaction Moderate Likelihood Possible Cola Nut + Captopril, HydrochlorothiazideiTheoretically, using cola nut with diuretic drugs might increase the risk of hypokalemia.
Read the full interaction Moderate Likelihood Possible Rue + Captopril, HydrochlorothiazideiTheoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.
Read the full interaction Major Likelihood Probable Oleander + Captopril, HydrochlorothiazideiTheoretically, diuretic drugs may increase the risk of oleander toxicity.
Read the full interaction Moderate Likelihood Probable Calcium + Captopril, HydrochlorothiazideiTaking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Read the full interaction Major Likelihood Likely American Hellebore + Captopril, HydrochlorothiazideiAmerican hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.
Read the full interactionEvery Supplement Checked Against Captopril, Hydrochlorothiazide
All 1,452 ingredients in our database, ranked by severity — 236 with a Captopril, Hydrochlorothiazide interaction on file and 1,216 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.
Looking for an interaction with a specific supplement product? Search products instead ↓
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American HelleboreVeratrum Viride, american Veratrum, american White Hellebore, +11 more Likely
What it is: American Hellebore (Veratrum viride) is a highly poisonous plant whose root contains toxic alkaloids that can cause dangerous drops in heart...
American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.
Read the full American Hellebore + Captopril, Hydrochlorothiazide interactionSiberian Cocklebur Likely
What it is: Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and al...
Siberian cocklebur can adversely affect the kidney.
Read the full Siberian Cocklebur + Captopril, Hydrochlorothiazide interactionTyramine Likely
What it is: Tyramine is a natural compound formed when certain proteins break down, and it is found in aged cheeses, cured meats, fermented foods, and s...
Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.
Read the full Tyramine + Captopril, Hydrochlorothiazide interactionActivated CharcoalActivated Carbon, animal Charcoal, carbo Vegetabilis, +13 more Probable
What it is: Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some...
Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Read the full Activated Charcoal + Captopril, Hydrochlorothiazide interactionAmerican MistletoePhoradendron Leucarpum, eastern Mistletoe Probable
What it is: American mistletoe is a parasitic plant that is best known as a holiday decoration, not a proven medicine.
American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pressure and heart rate.
Read the full American Mistletoe + Captopril, Hydrochlorothiazide interactionDolomiteCalcium Magnesium Carbonate, calcaire Dolomitique, dolomita, +2 more Probable
What it is: Dolomite is a natural mineral that provides both calcium and magnesium.
Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.
Read the full Dolomite + Captopril, Hydrochlorothiazide interactionLithiumCarbonate De Lithium, citrate De Lithium, lithium Aspartate, +8 more Probable
What it is: Lithium is a naturally occurring metal that, in prescription form (lithium carbonate or citrate), is an FDA-approved, well-proven treatment...
Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.
Read the full Lithium + Captopril, Hydrochlorothiazide interactionOleander Probable
What it is: Oleander is a highly poisonous ornamental plant, and every part of it can cause life-threatening heart and nervous system effects, even in s...
Theoretically, diuretic drugs may increase the risk of oleander toxicity.
Read the full Oleander + Captopril, Hydrochlorothiazide interactionYellow Dock Probable
What it is: Yellow dock is a traditional herb used mostly as a mild laxative and a digestive and skin tonic.
Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
Read the full Yellow Dock + Captopril, Hydrochlorothiazide interactionAsarabaccaAsarum Europaeum, asara, asari Herba, +12 more Possible
What it is: Asarabacca is a European woodland plant traditionally used to clear the nose, cause sweating, or trigger vomiting, but it is rarely used tod...
Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.
Read the full Asarabacca + Captopril, Hydrochlorothiazide interactionPotassium Likely
What it is: Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough fro...
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
Read the full Potassium + Captopril, Hydrochlorothiazide interactionAppleMalus Domestica, abilde, almindelig Aeble, +25 more Probable
What it is: Apples are a nutritious whole food that provides fiber, vitamins, and antioxidant plant compounds, and eating them regularly fits well into...
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple + Captopril, Hydrochlorothiazide interactionBanabaLagerstroemia Speciosa, banaba Extract, banabalean, +8 more Probable
What it is: Banaba is a leaf extract most often used to help support healthy blood sugar, and small early studies suggest its active compound corosolic...
Theoretically, concomitant use of banaba and antihypertensive drugs might cause additive effects.
Read the full Banaba + Captopril, Hydrochlorothiazide interactionBeer Probable
What it is: Beer is an alcoholic beverage that contains some minerals, B vitamins, and plant compounds from hops and grain, but it is not a health suppl...
Theoretically, concomitant use may interfere with blood pressure control.
Read the full Beer + Captopril, Hydrochlorothiazide interactionBergamotCitrus Bergamia, aceite De Bergamota, bergamot, +8 more Probable
What it is: Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some...
Theoretically, topical bergamot essential oil might increase the risk of side effects when used along with photosensitizing drugs.
Read the full Bergamot + Captopril, Hydrochlorothiazide interactionCalcium Probable
What it is: Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps w...
Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Read the full Calcium + Captopril, Hydrochlorothiazide interactionCasein Peptides Probable
What it is: Casein peptides are small protein fragments made from milk casein, often studied for mild blood pressure support and relaxation.
Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.
Read the full Casein Peptides + Captopril, Hydrochlorothiazide interactionCat's ClawGriffe Du Chat, hawk's Claw, liane Du Pérou, +4 more Probable
What it is: Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support.
Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Read the full Cat's Claw + Captopril, Hydrochlorothiazide interactionCeleryApium Graveolens, ache Des Marais, ajamoda, +13 more Probable
What it is: Celery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint d...
Theoretically, celery seed extract might have additive effects with antihypertensive drugs.
Read the full Celery + Captopril, Hydrochlorothiazide interactionChenopodium OilAceite De Paico, aceite De Quenopodio, american Wormseed, +15 more Probable
What it is: Chenopodium oil is a strong-smelling essential oil from the epazote plant that was historically used to treat intestinal worms.
Theoretically, concomitant use of chenopodium oil with other photosensitizing drugs can increase the risk of adverse effects.
Read the full Chenopodium Oil + Captopril, Hydrochlorothiazide interactionChlorophyllChlorophylle, chlorophylle A, chlorophylle B, +3 more Probable
What it is: Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin.
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Captopril, Hydrochlorothiazide interactionChlorophyllinChloresium, chlorophylline, chlorophylline De Cuivre Sodique, +6 more Probable
What it is: Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support woun...
Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Read the full Chlorophyllin + Captopril, Hydrochlorothiazide interactionCocaErythroxylum Coca, bolivian Coca, coca De Java, +11 more Probable
What it is: Coca is a South American plant best known as the natural source of cocaine.
Theoretically, coca might reduce the effects of antihypertensive drugs.
Read the full Coca + Captopril, Hydrochlorothiazide interactionCod Liver Oil Probable
What it is: Cod liver oil supplies omega-3 fatty acids (EPA and DHA) along with vitamins A and D, and is popular for heart, joint, and general health su...
Theoretically, taking cod liver oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Cod Liver Oil + Captopril, Hydrochlorothiazide interactionCoffee CharcoalCafé Arabica, café Carbonisé, café Robusta, +5 more Probable
What it is: Coffee charcoal is made by roasting green coffee beans until they turn black, creating a charcoal-like material used traditionally for diarr...
Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two hours.
Read the full Coffee Charcoal + Captopril, Hydrochlorothiazide interactionDocosahexaenoic Acid (dha)Adh, dha, fish Oil Fatty Acid, +7 more Probable
What it is: DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes.
Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Read the full Docosahexaenoic Acid (dha) + Captopril, Hydrochlorothiazide interactionEicosapentaenoic Acid (epa) Probable
What it is: EPA is an omega-3 fatty acid found mostly in fatty fish and fish oil, and it is best known for lowering high triglycerides.
Theoretically, taking EPA with antihypertensive drugs might increase the risk of hypotension.
Read the full Eicosapentaenoic Acid (epa) + Captopril, Hydrochlorothiazide interactionEuropean MandrakeMandragora Officinarum, alraunwurzel, mandragora, +7 more Probable
What it is: European mandrake is a highly toxic plant from the nightshade family that was used in ancient and medieval times as a sedative and pain reli...
Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European mandrake.
Read the full European Mandrake + Captopril, Hydrochlorothiazide interactionFever BarkAlstonia Constricta, alstonia Bark, australian Febrifuge, +10 more Probable
What it is: Fever bark is the bark of the Australian tree Alstonia constricta, used in traditional medicine for fever, diarrhea, and infections.
Theoretically, fever bark might alter the effects of antihypertensive drugs.
Read the full Fever Bark + Captopril, Hydrochlorothiazide interactionFish Oil Probable
What it is: Fish oil provides omega-3 fatty acids (EPA and DHA) that are best known for lowering high triglyceride levels.
Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Fish Oil + Captopril, Hydrochlorothiazide interactionGlucomannanGlucomanano, glucomannane, konjac, +1 more Probable
What it is: Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipati...
Theoretically, glucomannan may decrease absorption of drugs taken orally.
Read the full Glucomannan + Captopril, Hydrochlorothiazide interactionJapanese Persimmon Probable
What it is: Japanese persimmon is a nutritious fruit rich in fiber, vitamins, and antioxidant plant compounds, and its leaves and calyx are used in trad...
Japanese persimmon is thought to have hypotensive effects.
Read the full Japanese Persimmon + Captopril, Hydrochlorothiazide interactionJava Tea Probable
What it is: Java Tea is a Southeast Asian herb traditionally used as a gentle diuretic and for urinary tract and kidney support.
Some preliminary clinical evidence suggests that Java tea has antihypertensive effects.
Read the full Java Tea + Captopril, Hydrochlorothiazide interactionL-arginine2-amino-5-guanidinopentanoic Acid Probable
What it is: L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen.
Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
Read the full L-arginine + Captopril, Hydrochlorothiazide interactionMasterwortHeracleum Sphondylium, berce Commune, berce Laineuse, +9 more Probable
What it is: Masterwort (Heracleum sphondylium), a plant in the carrot family, has a long folk-medicine history for digestion, nerves, and skin.
The use of masterwort in conjunction with photosensitizing drugs is contraindicated due to the potential for additive photosensitizing effects.
Read the full Masterwort + Captopril, Hydrochlorothiazide interactionOlive Oil Probable
What it is: Olive oil, especially extra virgin olive oil, is a healthy fat that forms a cornerstone of the Mediterranean diet and is linked with better...
Theoretically, taking olive oil with antihypertensive drugs might have additive effects on blood pressure.
Read the full Olive Oil + Captopril, Hydrochlorothiazide interactionPeriwinkle Probable
What it is: Periwinkle (Vinca minor) is a flowering plant whose alkaloids are the source of vinpocetine, a compound marketed for memory and brain circul...
Theoretically, taking periwinkle may increase the effects of antihypertensive drugs due to the hypotensive activity of vincamine, a constituent of periwinkle.
Read the full Periwinkle + Captopril, Hydrochlorothiazide interactionSesame Probable
What it is: Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant co...
Taking sesame oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Sesame + Captopril, Hydrochlorothiazide interactionSodium Probable
What it is: Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work.
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Captopril, Hydrochlorothiazide interactionTaurine Probable
What it is: Taurine is an amino acid your body makes naturally and that you also get from animal foods.
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Taurine + Captopril, Hydrochlorothiazide interactionVitamin DErgocalciferol, cholecalciferol Probable
What it is: Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function.
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Captopril, Hydrochlorothiazide interactionWild CarrotDaucus Carota, beesnest Plant, bird's Nest Root, +10 more Probable
What it is: Wild carrot is a traditional herb (the wild ancestor of the garden carrot) used mostly for urinary, digestive, and menstrual complaints.
Theoretically, excessive doses of wild carrot seed oil might interfere with antihypertensive therapy due to cardiotonic effects.
Read the full Wild Carrot + Captopril, Hydrochlorothiazide interactionWine Probable
What it is: Wine is an alcoholic beverage made from fermented grapes and is not a true dietary supplement or medicine.
Theoretically, concomitant use may interfere with blood pressure control.
Read the full Wine + Captopril, Hydrochlorothiazide interactionYohimbePausinystalia Yohimbe, 11-hydroxy Yohimbine, coryanthe Yohimbe, +7 more Probable
What it is: Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac.
Theoretically, yohimbe might reduce the effects of antihypertensive drugs.
Read the full Yohimbe + Captopril, Hydrochlorothiazide interactionAbutaAaknadi, bejunco De Cerca, bhatindupat, +20 more Possible
What it is: Abuta (Cissampelos pareira) is a tropical climbing plant used in traditional medicine, especially for menstrual and urinary complaints.
Theoretically, taking abuta with diuretic drugs might cause additive effects and increase the risk of adverse effects.
Read the full Abuta + Captopril, Hydrochlorothiazide interactionAdrafinilAdrafinilum, benzhydryl Sulfinyl Acetyl Hydroxamic Acid, crl-40028, +1 more Possible
What it is: Adrafinil is a synthetic compound that the body converts into modafinil, a prescription wakefulness-promoting drug.
Theoretically, adrafinil might reduce the effects of antihypertensive drugs.
Read the full Adrafinil + Captopril, Hydrochlorothiazide interactionAfrican Wild Potato Possible
What it is: African Wild Potato (Hypoxis hemerocallidea) is a southern African plant traditionally used as a tonic and for immune, prostate, and inflamm...
In vitro evidence shows that African wild potato extract inhibits OAT3.
Read the full African Wild Potato + Captopril, Hydrochlorothiazide interactionAgmatineAgmatin, agmatine Sulfate, decarboxylated Arginine Possible
What it is: Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement.
Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Agmatine + Captopril, Hydrochlorothiazide interactionAlder BuckthornFrangula Alnus, rhamnus Frangula, alder Dogwood, +14 more Possible
What it is: Alder buckthorn bark is a stimulant laxative traditionally used for short-term relief of constipation.
Alder buckthorn has stimulant laxative effects.
Read the full Alder Buckthorn + Captopril, Hydrochlorothiazide interactionAlfalfaMedicago Sativa, feuille De Luzerne, grand Trèfle, +9 more Possible
What it is: Alfalfa is a nutrient-rich legume that people use for high cholesterol, menopause symptoms, and general wellness, but solid human evidence f...
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa + Captopril, Hydrochlorothiazide interactionAlgal OilDha-s Oil, dha-t Oil, dhasco Oil, +7 more Possible
What it is: Algal oil is a plant-based source of the omega-3 fats DHA and (in some products) EPA, making it a popular alternative to fish oil for vegeta...
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Algal Oil + Captopril, Hydrochlorothiazide interactionAloeAloe Vera, aloe Capensis, aloe Gel, +18 more Possible
What it is: Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help.
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe + Captopril, Hydrochlorothiazide interactionAndrographisAndrographis Paniculata, bhunimba, bidara, +19 more Possible
What it is: Andrographis is a bitter Asian herb traditionally used for colds, flu, and infections, and some studies suggest it may ease cold symptoms an...
Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Andrographis + Captopril, Hydrochlorothiazide interactionAngelica ArchangelicaAmerican Angelica, angelicae Fructus, angelicae Herba, +12 more Possible
What it is: Angelica archangelica is a tall aromatic herb used traditionally for digestive complaints, poor appetite, and to flavor foods and liqueurs.
Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.
Read the full Angelica Archangelica + Captopril, Hydrochlorothiazide interactionApple Cider VinegarAcv, cider Vinegar, vinagre De Manzana, +2 more Possible
What it is: Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion.
Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
Read the full Apple Cider Vinegar + Captopril, Hydrochlorothiazide interactionAristolochiaAristolochia Auricularia, birthwort, guan Mu Tong, +15 more Possible
What it is: Aristolochia contains aristolochic acid, a potent toxin linked to severe kidney damage and cancer, and it is not safe to take.
Aristolochia is nephrotoxic.
Read the full Aristolochia + Captopril, Hydrochlorothiazide interactionArrachChenopodium Vulvaria, arroche Puante, chénopode Fétide, +11 more Possible
What it is: Arrach (Chenopodium vulvaria) is a strong-smelling European herb that has been used in traditional folk medicine, mainly for menstrual and n...
Theoretically, concomitant use of arrach can increase risk of adverse effects, as unspecified Chenopodium species are associated with photosensitivity.
Read the full Arrach + Captopril, Hydrochlorothiazide interactionArtichokeCynara Cardunculus, alcachofa, alcaucil, +17 more Possible
What it is: Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indig...
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke + Captopril, Hydrochlorothiazide interactionAsafoetidaFerula Assa-foetida, a Wei, asafétida, +13 more Possible
What it is: Asafoetida is a strong-smelling plant resin used widely as a spice and in traditional medicine, mainly for digestive complaints.
Evidence from animal research suggests that asafoetida has hypotensive effects.
Read the full Asafoetida + Captopril, Hydrochlorothiazide interactionAshFraxinus Americana, fraxinus Excelsior, bird's Tongue, +15 more Possible
What it is: Ash (Fraxinus excelsior and related species) is a tree whose leaves, bark, and seeds have a long history in folk medicine for arthritis, fev...
Theoretically, concomitant use of ash seed with antihypertensive drugs might have additive blood pressure lowering effects.
Read the full Ash + Captopril, Hydrochlorothiazide interactionAshwagandhaWithania Somnifera, ajagandha, amangura, +17 more Possible
What it is: Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, thoug...
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Ashwagandha + Captopril, Hydrochlorothiazide interactionAsparagusAsparagus Officinalis, asparagi Rhizoma Root, asperge, +9 more Possible
What it is: Asparagus is a nutritious vegetable that is safe and healthy to eat as part of a normal diet.
Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.
Read the full Asparagus + Captopril, Hydrochlorothiazide interactionAsparagus Racemosus Possible
What it is: Asparagus racemosus, often called shatavari, is an Ayurvedic herb traditionally used to support women's health, digestion, and overall vital...
Theoretically, asparagus racemosus root might increase diuresis and electrolyte loss when used with diuretic drugs.
Read the full Asparagus Racemosus + Captopril, Hydrochlorothiazide interactionBaikal SkullcapScutellaria Baicalensis, baikal Scullcap, baikal Skullcap Root, +16 more Possible
What it is: Baikal skullcap is a traditional Chinese herb (Huang Qin) used for inflammation, allergies, and infections, with active compounds like baica...
Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Baikal Skullcap + Captopril, Hydrochlorothiazide interactionBanderolOtoba Parvifolia Possible
What it is: Banderol is a Nutramedix-branded herbal extract made from the bark of the Amazonian tree Otoba parvifolia, most often promoted as part of al...
Small lab studies have found that Banderol may also inhibit OATP1B3 (Organic Anion Transporting Polypeptide 1B3), in addition to OATP1B1.
Read the full Banderol + Captopril, Hydrochlorothiazide interactionBasilOcimum Basilicum, albahaca, basilic, +15 more Possible
What it is: Basil is a popular cooking herb that is generally safe in the amounts used in food.
Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Basil + Captopril, Hydrochlorothiazide interactionBerberineAlcaloïde De Berbérine, berberina, berbérine, +5 more Possible
What it is: Berberine is a yellow plant compound that has shown promise for lowering blood sugar and cholesterol in some studies, but the quality of res...
Theoretically, berberine might have additive effects with antihypertensive drugs.
Read the full Berberine + Captopril, Hydrochlorothiazide interactionBeta-glucans Possible
What it is: Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast.
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Read the full Beta-glucans + Captopril, Hydrochlorothiazide interactionBetony Possible
What it is: Betony (Stachys officinalis) is a traditional European herb long used for headaches, nervous tension, and digestive complaints.
Theoretically, betony might have additive effects with blood pressure lowering drugs due to hypotensive activity of the glycosides found in betony.
Read the full Betony + Captopril, Hydrochlorothiazide interactionBishop's WeedAmmi Majus, Élevé, ammi Inodore, +12 more Possible
What it is: Bishop's Weed (Ammi majus) is a flowering plant whose seeds contain natural light-sensitizing compounds called psoralens, which have been st...
Bishop's weed constituents seem to cause photosensitivity.
Read the full Bishop's Weed + Captopril, Hydrochlorothiazide interactionBlack HelleboreHelleborus Niger, christe Herbe, christmas Rose, +9 more Possible
What it is: Black Hellebore is a highly toxic plant that was used in old folk medicine but has no proven, safe modern use.
Theoretically, concomitant use of potassium depleting diuretics and black hellebore can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Black Hellebore + Captopril, Hydrochlorothiazide interactionBlack Root Possible
What it is: Black Root is a traditional North American herb that was historically used as a strong laxative and to support digestion and liver function.
Overuse of black root might compound diuretic-induced potassium loss.There is some concern that people taking black root along with potassium depleting diuretics might have an increased risk for hypokalemia.
Read the full Black Root + Captopril, Hydrochlorothiazide interactionBlack SeedNigella Sativa, black Caraway, black Cumin, +18 more Possible
What it is: Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure...
Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.
Read the full Black Seed + Captopril, Hydrochlorothiazide interactionBlack Tea Possible
What it is: Black tea is a popular caffeinated drink made from the fully oxidized leaves of the Camellia sinensis plant, and it contains caffeine and an...
Theoretically, using black tea with diuretic drugs might increase the risk of hypokalemia.
Read the full Black Tea + Captopril, Hydrochlorothiazide interactionBlue Cohosh Possible
What it is: Blue cohosh is a traditional herb historically used by Native Americans and midwives to bring on labor or menstruation, but it carries serio...
Constituents in blue cohosh might increase blood pressure by causing coronary vasoconstriction.
Read the full Blue Cohosh + Captopril, Hydrochlorothiazide interactionBlue Flag Possible
What it is: Blue Flag is a flowering plant whose root has been used in traditional and herbal medicine for skin and digestive complaints, but there is v...
Overuse of blue flag might compound diuretic-induced potassium loss.
Read the full Blue Flag + Captopril, Hydrochlorothiazide interactionBreadfruit Possible
What it is: Breadfruit is a starchy tropical fruit eaten as a staple food, and its leaves are used in traditional medicine for conditions like high bloo...
Theoretically, concomitant use with antihypertensive drugs might increase the risk of hypotension.
Read the full Breadfruit + Captopril, Hydrochlorothiazide interactionBridelia Possible
What it is: Bridelia is a group of tropical plants, with Bridelia ferruginea widely used in traditional African medicine for diabetes, infections, and d...
Animal research suggests that Bridelia extracts decrease arterial pressure.
Read the full Bridelia + Captopril, Hydrochlorothiazide interactionButternut Possible
What it is: Butternut (Juglans cinerea) is a North American tree whose inner bark was traditionally used as a mild laxative and folk remedy.
Butternut has stimulant laxative effects.
Read the full Butternut + Captopril, Hydrochlorothiazide interactionCaffeic Acid Possible
What it is: Caffeic acid is a natural plant compound found in coffee, many fruits, vegetables, and herbs, and it is studied mainly for its antioxidant a...
Theoretically, caffeic acid might increase the levels and clinical effects of OAT3 substrates.
Read the full Caffeic Acid + Captopril, Hydrochlorothiazide interactionCaffeine Possible
What it is: Caffeine is a natural stimulant found in coffee, tea, and many other plants and products.
Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.
Read the full Caffeine + Captopril, Hydrochlorothiazide interactionCalamusAcorus Calamus, acore Calame, acore Odorant, +20 more Possible
What it is: Calamus is a swamp plant with a long history in Ayurvedic and traditional Chinese medicine, mostly for digestive and nervous-system complain...
Theoretically, taking calamus with other antihypertensive medications might increase the risk of hypotension.
Read the full Calamus + Captopril, Hydrochlorothiazide interactionCalotropis Possible
What it is: Calotropis is a milkweed-family plant long used in traditional medicine, but its milky latex and other parts are potentially toxic and can h...
Theoretically, concomitant use of calotropis and potassium depleting diuretics can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Calotropis + Captopril, Hydrochlorothiazide interactionCanadian Hemp Possible
What it is: Canadian Hemp (Apocynum cannabinum) is a toxic North American plant historically used as a heart stimulant and diuretic, but it contains pot...
Canadian hemp contains cardiac glycosides.
Read the full Canadian Hemp + Captopril, Hydrochlorothiazide interactionCannabigerol (cbg) Possible
What it is: Cannabigerol (CBG) is a minor cannabinoid from the cannabis (hemp) plant that is marketed for anxiety, pain, and inflammation, but human res...
Theoretically, taking cannabigerol with antihypertensive drugs might increase the risk of hypotension.
Read the full Cannabigerol (cbg) + Captopril, Hydrochlorothiazide interactionCaprylic AcidOctanoic Acid Possible
What it is: Caprylic acid is a medium-chain fatty acid found in coconut oil and palm kernel oil that is popularly used for yeast overgrowth and gut heal...
Theoretically, caprylic acid might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Caprylic Acid + Captopril, Hydrochlorothiazide interactionCarawayCarum Carvi, alcaravea, anis Canadien, +20 more Possible
What it is: Caraway is a common cooking spice that has long been used to ease gas, bloating, and indigestion.
Theoretically, caraway might increase the risk of hypokalemia when used with diuretics that deplete potassium.
Read the full Caraway + Captopril, Hydrochlorothiazide interactionCascara SagradaFrangula Purshiana, rhamnus Purshiana, bitter Bark, +13 more Possible
What it is: Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipati...
Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Cascara Sagrada + Captopril, Hydrochlorothiazide interactionCastor Bean Possible
What it is: Castor bean is the source of castor oil, a well-known stimulant laxative, but the raw seeds contain ricin, a potent and potentially deadly p...
Theoretically, castor oil might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Castor Bean + Captopril, Hydrochlorothiazide interactionCatechuBlack Catechu, acacia Catechu: Acacia à Cachou, acacia Catechu Heartwood Extract, +17 more Possible
What it is: Catechu is an astringent extract made from the heartwood of the Acacia (Senegalia) catechu tree, used traditionally for mouth sores, sore th...
Theoretically, concomitant use with antihypertensive drugs might increase the risk of hypotension.
Read the full Catechu + Captopril, Hydrochlorothiazide interactionCesium Possible
What it is: Cesium chloride is a mineral salt sold as an alternative cancer therapy ('high pH therapy'), but there is no reliable scientific evidence th...
Theoretically, taking cesium concomitantly with other drugs that deplete potassium, such as diuretics, may increase the risk of hypokalemia.
Read the full Cesium + Captopril, Hydrochlorothiazide interactionCeylon CinnamonCinnamomum Verum, batavia Cassia, batavia Cinnamon, +13 more Possible
What it is: Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and diges...
Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Ceylon Cinnamon + Captopril, Hydrochlorothiazide interactionChanca PiedraPhyllanthus Niruri, amli, arranca-pedras, +16 more Possible
What it is: Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health.
Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Read the full Chanca Piedra + Captopril, Hydrochlorothiazide interactionChelation Therapy Products Possible
What it is: Chelation therapy uses binding agents (like EDTA, DMSA, or DMPS) that latch onto certain metals so the body can remove them.
Concomitant use of ethylenediamine tetraacetic acid (EDTA) and potassium-depleting diuretics might increase the risk for hypokalemia.
Read the full Chelation Therapy Products + Captopril, Hydrochlorothiazide interactionChlorellaChlorella Pyrenoidosa, algue Verte D'eau Douce, bulgarian Chlorella, +12 more Possible
What it is: Chlorella is a nutrient-rich freshwater green algae taken as a supplement for general wellness, immune support, and 'detox.' Some small stud...
Theoretically, chlorella might have additive effects with photosensitizing drugs.
Read the full Chlorella + Captopril, Hydrochlorothiazide interactionCilantro Possible
What it is: Cilantro is the leafy part of the Coriandrum sativum plant and is widely eaten as a food, where it is considered safe for most people.
Evidence from in vitro research suggests that coriandrin, a constituent of cilantro, has photosensitizing effects.
Read the full Cilantro + Captopril, Hydrochlorothiazide interactionCocoaTheobroma Cacao, chocolat, chocolat Noir, +14 more Possible
What it is: Cocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate pro...
Theoretically, taking cocoa with antihypertensive drugs might increase the risk of hypotension.
Read the full Cocoa + Captopril, Hydrochlorothiazide interactionCoconut WaterCocos Nucifera Possible
What it is: Coconut water is a natural drink rich in potassium and other electrolytes that many people use for hydration, especially around exercise.
Theoretically, taking coconut water with antihypertensive drugs might increase the risk of hypotension.
Read the full Coconut Water + Captopril, Hydrochlorothiazide interactionCoffee Possible
What it is: Coffee is a widely consumed beverage made from roasted coffee beans, valued mainly for its caffeine, which boosts alertness and energy.
Theoretically, concomitant use might increase the risk of hypokalemia.
Read the full Coffee + Captopril, Hydrochlorothiazide interactionCola NutCola Acuminata, bissey Nut, bissy Nut, +10 more Possible
What it is: Cola nut is a caffeine-containing seed from West Africa used mainly as a natural stimulant for energy and alertness.
Theoretically, using cola nut with diuretic drugs might increase the risk of hypokalemia.
Read the full Cola Nut + Captopril, Hydrochlorothiazide interactionColeus6beta, 17beta-acetoxy-8, 13-epoxy-1alpha, +15 more Possible
What it is: Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart he...
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Coleus + Captopril, Hydrochlorothiazide interactionColocynth Possible
What it is: Colocynth is a bitter desert gourd used in traditional medicine mainly as a powerful laxative, but it is highly toxic and can cause severe,...
Theoretically, colocynth might increase the risk of hypokalemia when taken with potassium-depleting diuretic drugs.
Read the full Colocynth + Captopril, Hydrochlorothiazide interactionColtsfootTussilago Farfara, ass's Foot, brandlattich, +17 more Possible
What it is: Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking.
Theoretically, excessive doses of coltsfoot may interfere with antihypertensive or cardiovascular therapy.
Read the full Coltsfoot + Captopril, Hydrochlorothiazide interactionCombretum MicranthumAntidote à L'opium, antidote D'opium, antídoto De Opio, +8 more Possible
What it is: Combretum micranthum (kinkeliba) is a West African shrub whose leaves are brewed into a traditional tea for digestion, liver complaints, and...
Theoretically, taking Combretum micranthum leaf with antihypertensive drugs might increase the risk of hypotension.
Read the full Combretum Micranthum + Captopril, Hydrochlorothiazide interactionConjugated Linoleic Acid (cla) Possible
What it is: CLA is a fatty acid found naturally in meat and dairy, and supplements are usually made from safflower oil.
Theoretically, taking CLA with antihypertensive drugs might increase the risk of hypotension.
Read the full Conjugated Linoleic Acid (cla) + Captopril, Hydrochlorothiazide interactionCorianderCoriandrum Sativum, coriander Essential Oil, coriandre, +5 more Possible
What it is: Coriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints...
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Coriander + Captopril, Hydrochlorothiazide interactionCorn SilkZea Mays, barbe De Maïs, blé D'inde, +13 more Possible
What it is: Corn silk is a traditional herbal remedy taken as a tea or extract, mostly for urinary and mild fluid-related complaints.
Taking corn silk extract with antihypertensive drugs might increase the risk of hypotension.
Read the full Corn Silk + Captopril, Hydrochlorothiazide interactionCorydalis Yanhusuo Possible
What it is: Corydalis yanhusuo is a traditional Chinese herb used mainly for pain.
Theoretically, Corydalis yanhusuo might have additive effects with antihypertensive drugs.
Read the full Corydalis Yanhusuo + Captopril, Hydrochlorothiazide interactionDanshenSalvia Bowleyana, ch'ih Shen, chinese Red Sage, +15 more Possible
What it is: Danshen is a root used in traditional Chinese medicine, mainly for heart and circulation problems.
Theoretically, taking danshen with antihypertensive drugs might increase the risk of hypotension.
Read the full Danshen + Captopril, Hydrochlorothiazide interactionDiindolylmethaneDim Possible
What it is: Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone b...
Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Read the full Diindolylmethane + Captopril, Hydrochlorothiazide interactionEuropean BarberryBerberis Vulgaris, agracejo, barberry, +15 more Possible
What it is: European barberry is a shrub whose root, bark, and berries contain berberine, a bitter plant alkaloid that has been studied mostly in isolat...
Theoretically, taking European barberry with antihypertensive drugs might increase the risk of hypotension.
Read the full European Barberry + Captopril, Hydrochlorothiazide interactionEuropean Buckthorn Possible
What it is: European Buckthorn is a shrub whose bark and berries contain compounds that act as a strong, irritant-type laxative.
European buckthorn has stimulant laxative effects.
Read the full European Buckthorn + Captopril, Hydrochlorothiazide interactionEuropean MistletoeViscum Album, all-heal, banda, +23 more Possible
What it is: European mistletoe is a parasitic plant most studied as an injectable extract used alongside conventional cancer care in some European count...
Theoretically, European mistletoe might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full European Mistletoe + Captopril, Hydrochlorothiazide interactionFermented Milk Possible
What it is: Fermented milk is a food made by culturing milk with helpful bacteria or yeast, and it provides protein, calcium, and probiotics.
Theoretically, fermented milk might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Fermented Milk + Captopril, Hydrochlorothiazide interactionFig Possible
What it is: Fig (Ficus carica) is a common fruit that has long been used as a gentle food remedy for constipation, and its leaves are used traditionally...
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Captopril, Hydrochlorothiazide interactionFigwort Possible
What it is: Figwort is a traditional herb used mainly for skin problems and minor swelling, but solid human studies are lacking, so its benefits remain...
Theoretically, overuse of figwort might compound diuretic-induced potassium loss.
Read the full Figwort + Captopril, Hydrochlorothiazide interactionFlaxseedLinum Usitatissimum, alasi, aliviraaii, +20 more Possible
What it is: Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans.
Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Read the full Flaxseed + Captopril, Hydrochlorothiazide interactionFlaxseed Oil Possible
What it is: Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil.
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Flaxseed Oil + Captopril, Hydrochlorothiazide interactionFo-ti Possible
What it is: Fo-ti (He Shou Wu) is a root used in traditional Chinese medicine, often promoted for healthy aging and hair.
Theoretically, fo-ti, particularly raw fo-ti root, might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Fo-ti + Captopril, Hydrochlorothiazide interactionFoxglove Possible
What it is: Foxglove is a beautiful but highly poisonous plant that contains powerful heart-affecting compounds called cardiac glycosides.
Theoretically, concomitant use of potassium depleting diuretics increases the risk of cardiac glycoside toxicity.
Read the full Foxglove + Captopril, Hydrochlorothiazide interactionGamboge Possible
What it is: Gamboge is a bright yellow tree resin used historically as a strong laxative and as an artists' pigment, but it is toxic in even modest amou...
Overuse of gamboge might compound diuretic-induced potassium loss.
Read the full Gamboge + Captopril, Hydrochlorothiazide interactionGamma-aminobutyric Acid (gaba)Acide Bêta-phényl-gamma-amino-butyrique, acide Gamma-aminobutyrique, Ácido Gama-aminobutríco, +3 more Possible
What it is: GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety,...
Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Read the full Gamma-aminobutyric Acid (gaba) + Captopril, Hydrochlorothiazide interactionGarden CressLepidium Sativum, berro Hortelano, cresson Alénois, +3 more Possible
What it is: Garden cress is a nutritious leafy herb and seed used widely in cooking and traditional medicine, providing vitamins, minerals, and fiber.
Theoretically, taking garden cress with antihypertensive drugs might increase the risk of hypotension.
Read the full Garden Cress + Captopril, Hydrochlorothiazide interactionGarlicAllium Sativum, aged Black Garlic Extract, aged Garlic Extract, +16 more Possible
What it is: Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects...
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Garlic + Captopril, Hydrochlorothiazide interactionGentian Possible
What it is: Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before...
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian + Captopril, Hydrochlorothiazide interactionGojiLycium Chinense, lycium Barbarum, barberry Matrimony Vine, +15 more Possible
What it is: Goji berries are a nutritious fruit rich in antioxidants, vitamins, and plant polysaccharides, and they are safe for most people as a food.
Theoretically, concomitant use of goji root bark, but not goji fruit, with antihypertensive drugs might have additive effects.
Read the full Goji + Captopril, Hydrochlorothiazide interactionGoldenrod Possible
What it is: Goldenrod is a flowering plant traditionally used as an herbal diuretic and for urinary tract health.
Theoretically, goldenrod might increase the effects and adverse effects of diuretic drugs.
Read the full Goldenrod + Captopril, Hydrochlorothiazide interactionGoldensealHydrastis Canadensis, chinese Goldenseal, eye Balm, +14 more Possible
What it is: Goldenseal is a popular North American herb that contains berberine, a compound studied for antimicrobial effects.
Theoretically, goldenseal might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Goldenseal + Captopril, Hydrochlorothiazide interactionGossypolCoton Velu, cotonnier Herbacé, cottonseed Oil Extract, +3 more Possible
What it is: Gossypol is a toxic yellow pigment from cotton plants that has been studied mainly as an experimental male contraceptive because it can lowe...
Theoretically, gossypol might increase the risk of hypokalemia when taken with potassium-depleting diuretic drugs.
Read the full Gossypol + Captopril, Hydrochlorothiazide interactionGreen CoffeeCoffea Arabica, coffea Canephora, coffea Bukobensis, +2 more Possible
What it is: Green coffee is the unroasted bean of the coffee plant, prized for its high chlorogenic acid content.
Theoretically, concomitant use might increase the risk of hypokalemia.
Read the full Green Coffee + Captopril, Hydrochlorothiazide interactionGreen TeaCamellia Sinensis, green Sencha Tea, green Tea Extract, +17 more Possible
What it is: Green tea is a popular beverage rich in antioxidants called catechins, and drinking it in normal amounts is considered safe for most people.
Theoretically, using green tea with diuretic drugs might increase the risk of hypokalemia.
Read the full Green Tea + Captopril, Hydrochlorothiazide interactionGuar GumDietary Fiber, farine De Guar, fibre Alimentaire, +10 more Possible
What it is: Guar gum is a soluble, gel-forming fiber from the guar bean that may modestly help with cholesterol, blood sugar, and bowel regularity.
Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.
Read the full Guar Gum + Captopril, Hydrochlorothiazide interactionGuaranaPaullinia Cupana, brazilian Cocoa, cacao Brésilien, +3 more Possible
What it is: Guarana is an Amazonian seed that is naturally high in caffeine, which explains most of its stimulant and energy effects.
Theoretically, using guarana with diuretic drugs might increase the risk of hypokalemia.
Read the full Guarana + Captopril, Hydrochlorothiazide interactionGuarumoCecropia Obtusifolia, chancarro, grayumbo, +9 more Possible
What it is: Guarumo (Cecropia obtusifolia) is a tropical tree used in Latin American traditional medicine, most often as a leaf tea for diabetes and hig...
Evidence from animal research suggests that aqueous and ethanolic extracts of guarumo leaf can lower blood pressure when administered intravenously to rats.
Read the full Guarumo + Captopril, Hydrochlorothiazide interactionGum ArabicAcacia, acacia Gum, arabic Gum, +16 more Possible
What it is: Gum arabic is a soluble dietary fiber from the acacia tree that is widely used as a safe food additive and is sometimes taken as a supplemen...
Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.
Read the full Gum Arabic + Captopril, Hydrochlorothiazide interactionHedge Mustard Possible
What it is: Hedge mustard is a traditional European herb long nicknamed the 'singer's plant' because it was used to soothe hoarseness and sore throats.
Theoretically, taking hedge mustard with diuretic drugs might increase the risk of cardiac glycoside toxicity.
Read the full Hedge Mustard + Captopril, Hydrochlorothiazide interactionHesperidinAlpha-glucosyl Hesperidin, alpha-glucosylhesperidin, bioflavonoid, +8 more Possible
What it is: Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrh...
Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Read the full Hesperidin + Captopril, Hydrochlorothiazide interactionHibiscus SabdariffaHibiscus Sabdariffa, agua De Jamaica, ambashthaki, +16 more Possible
What it is: Hibiscus sabdariffa is a tart, cranberry-flavored plant most often consumed as a tea, and its best-studied use is for mildly lowering blood...
Theoretically, taking Hibiscus sabdariffa with antihypertensive drugs might increase the risk of hypotension.
Read the full Hibiscus Sabdariffa + Captopril, Hydrochlorothiazide interactionHoodiaHoodia Gordonii, cactus, cactus Hoodia, +6 more Possible
What it is: Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that...
Clinical research shows that hoodia can increase blood pressure.
Read the full Hoodia + Captopril, Hydrochlorothiazide interactionHorny Goat WeedEpimedium Grandiflorum, barrenwort, Épimède, +10 more Possible
What it is: Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence...
Theoretically, horny goat weed might increase the risk of hypotension.
Read the full Horny Goat Weed + Captopril, Hydrochlorothiazide interactionHorsetailEquisetum Arvense, alligator Cane, asprêle, +15 more Possible
What it is: Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is...
Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Read the full Horsetail + Captopril, Hydrochlorothiazide interactionIlex Guayusa Possible
What it is: Ilex guayusa is a caffeine-containing holly leaf from the Amazon, traditionally brewed as a tea for energy and alertness, much like yerba ma...
Theoretically, concomitant use might increase the risk of hypokalemia.
Read the full Ilex Guayusa + Captopril, Hydrochlorothiazide interactionIndian Cassia Possible
What it is: Indian Cassia (Cinnamomum tamala), also known as Indian bay leaf or tejpat, is an aromatic leaf used widely as a cooking spice and in tradit...
Theoretically, Indian cassia might increase the risk of potassium depletion in patients taking diuretic drugs.
Read the full Indian Cassia + Captopril, Hydrochlorothiazide interactionIndian SnakerootRauvolfia Serpentina, ajmaline, alseroxylon, +16 more Possible
What it is: Indian snakeroot is a traditional Ayurvedic plant that contains reserpine, a compound with real blood-pressure-lowering and sedative effects...
Theoretically, concomitant use of Indian snakeroot and antihypertensive drugs might increase the risk of hypotension.
Read the full Indian Snakeroot + Captopril, Hydrochlorothiazide interactionIsopropylnorsynephrine Possible
What it is: Isopropylnorsynephrine is a synthetic stimulant chemically related to synephrine, marketed mainly in weight-loss and pre-workout supplements...
Theoretically, isopropylnorsynephrine might decrease the effects of antihypertensive drugs.
Read the full Isopropylnorsynephrine + Captopril, Hydrochlorothiazide interactionJalap Possible
What it is: Jalap is a powerful traditional laxative made from the root of a Mexican morning-glory plant.
Jalap has diuretic effects.
Read the full Jalap + Captopril, Hydrochlorothiazide interactionKhatCatha Edulis, abessinischer Tea, abyssinian Tea, +23 more Possible
What it is: Khat is a plant chewed for its amphetamine-like stimulant effects, but it carries serious risks including high blood pressure, heart problem...
Human research shows that khat and its constituent, cathinone, can increase blood pressure.
Read the full Khat + Captopril, Hydrochlorothiazide interactionKhellaAmmi Visnaga, ammi Daucoides, daucus Visnaga, +13 more Possible
What it is: Khella is a Mediterranean herb whose seeds contain compounds like khellin that may relax smooth muscle in the airways and blood vessels.
Theoretically, concomitant use might result in increased photosensitivity.
Read the full Khella + Captopril, Hydrochlorothiazide interactionKiwi Possible
What it is: Kiwi is a nutritious fruit that is rich in vitamin C, fiber, and antioxidants, and it is generally safe to eat as a food.
Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals.
Read the full Kiwi + Captopril, Hydrochlorothiazide interactionKorean Pine Possible
What it is: Korean Pine is best known as the source of edible pine nuts and pine nut oil, which are nutritious foods rich in healthy fats.
Animal research shows that Korean pine nut oil reduces blood pressure in spontaneously hypertensive rats.
Read the full Korean Pine + Captopril, Hydrochlorothiazide interactionL-citrulline Possible
What it is: L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blo...
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Captopril, Hydrochlorothiazide interactionLaminaria Possible
What it is: Laminaria is a type of brown seaweed (kelp) that is very rich in iodine and is also used in medical settings as a natural cervical dilator.
Theoretically, laminaria might increase the risk of hyperkalemia when taken with ACEIs.
Read the full Laminaria + Captopril, Hydrochlorothiazide interactionLicoriceGlycyrrhiza Echinate, alcacuz, bois Doux, +17 more Possible
What it is: Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most...
Theoretically, licorice might reduce the effects of antihypertensive drugs.
Read the full Licorice + Captopril, Hydrochlorothiazide interactionLight Therapy Possible
What it is: Light therapy uses controlled exposure to bright artificial light and is best supported for seasonal affective disorder, where it is a recog...
Light therapy may increase the risk for photosensitization.
Read the full Light Therapy + Captopril, Hydrochlorothiazide interactionLily-of-the-valleyConvallaria Majalis, clochette Des Bois, constancy, +14 more Possible
What it is: Lily-of-the-valley is a poisonous plant that contains powerful heart-affecting compounds called cardiac glycosides, similar to the drug digo...
Theoretically, using lily-of-the-valley with diuretics can increase the risk of cardiac glycoside toxicity.
Read the full Lily-of-the-valley + Captopril, Hydrochlorothiazide interactionLimeCitrus Aurantifolia, adam's Apple, bara Nimbu, +11 more Possible
What it is: Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants.
Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.
Read the full Lime + Captopril, Hydrochlorothiazide interactionLovage Possible
What it is: Lovage is a celery-like herb traditionally used for digestion, bloating, and as a mild diuretic to flush the urinary tract.
Theoretically, lovage root might interfere with diuretic therapy due to its aquaretic effects.
Read the full Lovage + Captopril, Hydrochlorothiazide interactionMaitake MushroomGrifola Frondosa, champignon Dansant, champignon Des Fous Dansants, +13 more Possible
What it is: Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sug...
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Mushroom + Captopril, Hydrochlorothiazide interactionMalic Acid Possible
What it is: Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and mu...
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Malic Acid + Captopril, Hydrochlorothiazide interactionMannaFraxinus Ornus Possible
What it is: Manna is the dried, sweet sap of the flowering ash tree (Fraxinus ornus) and is best known as a gentle, mild laxative because it contains a...
Theoretically, manna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Manna + Captopril, Hydrochlorothiazide interactionMelatoninN-acetyl-5-methoxytryptamine Possible
What it is: Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with...
Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Read the full Melatonin + Captopril, Hydrochlorothiazide interactionMountain AshSorbus Aucuparia, arbre Aux Grives, corbier D'europe, +12 more Possible
What it is: Mountain ash (rowan) is a northern-hemisphere tree whose bright red berries are traditionally cooked into jams, syrups, and teas.
Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.
Read the full Mountain Ash + Captopril, Hydrochlorothiazide interactionN-acetyl Cysteine (nac)Acetyl Cysteine, mucomyst Possible
What it is: N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione.
Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full N-acetyl Cysteine (nac) + Captopril, Hydrochlorothiazide interactionNattokinaseBsp, extrait De Natto, fermented Soybeans, +7 more Possible
What it is: Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects.
Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Read the full Nattokinase + Captopril, Hydrochlorothiazide interactionNiacin3-pyridinecarboxylic Acid, vitamin B3 Possible
What it is: Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countri...
Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
Read the full Niacin + Captopril, Hydrochlorothiazide interactionNoniMorinda Citrifolia, ba Ji Tian, bois Douleur, +17 more Possible
What it is: Noni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claime...
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Read the full Noni + Captopril, Hydrochlorothiazide interactionOctopamine Possible
What it is: Octopamine is a stimulant-like compound found in small amounts in some plants (such as bitter orange) and made naturally in the body.
In humans, octopamine 450-600 mg daily increases blood pressure in hypotensive patients.
Read the full Octopamine + Captopril, Hydrochlorothiazide interactionOolong Tea Possible
What it is: Oolong tea is a traditional partially oxidized tea made from the same plant as green and black tea, and it provides caffeine and plant antio...
Theoretically, using oolong tea with diuretic drugs might increase the risk of hypokalemia.
Read the full Oolong Tea + Captopril, Hydrochlorothiazide interactionOregon GrapeMahonia Aquifolium, barberry, berberis, +13 more Possible
What it is: Oregon grape is a shrub whose root contains berberine and related compounds.
Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Oregon Grape + Captopril, Hydrochlorothiazide interactionParsleyPetroselinum Crispum, common Parsley, garden Parsley, +16 more Possible
What it is: Parsley is a popular culinary herb that is safe to eat in normal food amounts and is a good source of vitamins K and C.
Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Read the full Parsley + Captopril, Hydrochlorothiazide interactionPheasant's EyeAdonis Vernalis, adonide, adonide Annuelle, +14 more Possible
What it is: Pheasant's Eye (Adonis vernalis) is a toxic plant that contains heart-acting compounds similar to those in foxglove.
Theoretically, taking pheasant's eye with diuretic drugs might increase the risk of cardiac glycoside toxicity.
Read the full Pheasant's Eye + Captopril, Hydrochlorothiazide interactionPhellodendronPhellodendron Amurense, amur Cork Bark, amur Cork Tree, +7 more Possible
What it is: Phellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and an...
Theoretically, phellodendron might have additive effects with antihypertensive drugs.
Read the full Phellodendron + Captopril, Hydrochlorothiazide interactionPleurisy Root Possible
What it is: Pleurisy root is the dried root of Asclepias tuberosa (butterfly weed), a plant used in traditional North American and herbal medicine mainl...
Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Pleurisy Root + Captopril, Hydrochlorothiazide interactionPomegranatePunica Granatum, anardana, dadim, +14 more Possible
What it is: Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice.
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate + Captopril, Hydrochlorothiazide interactionQuassia Possible
What it is: Quassia is a tropical wood known for its very bitter taste, traditionally used as a digestive bitter and as a folk remedy for parasites and...
Overuse of quassia might compound diuretic-induced potassium loss.
Read the full Quassia + Captopril, Hydrochlorothiazide interactionQuercetin7-pentahydroxyflavone, bioflavonoid, bioflavonoid Complex, +9 more Possible
What it is: Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties found in many common foods and sold as a supplement.
Theoretically, taking quercetin with antihypertensive drugs might increase the risk of hypotension.
Read the full Quercetin + Captopril, Hydrochlorothiazide interactionRauvolfia Vomitoria Possible
What it is: Rauvolfia vomitoria is an African shrub whose root contains powerful alkaloids, including reserpine, that have historically been used for hi...
Theoretically, Rauvolfia vomitoria might increase the risk of hypotension.
Read the full Rauvolfia Vomitoria + Captopril, Hydrochlorothiazide interactionRehmannia Possible
What it is: Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health.
Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Rehmannia + Captopril, Hydrochlorothiazide interactionReishi MushroomGanoderma Lucidum, basidiomycetes Mushroom, champignon Reishi, +15 more Possible
What it is: Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness.
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi Mushroom + Captopril, Hydrochlorothiazide interactionRhodiolaRhodiola Rosea, arctic Root, golden Root, +12 more Possible
What it is: Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress.
Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
Read the full Rhodiola + Captopril, Hydrochlorothiazide interactionRhubarbRheum Officinale, chinese Rhubarb, da Huang, +13 more Possible
What it is: Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food.
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Rhubarb + Captopril, Hydrochlorothiazide interactionRice Protein Possible
What it is: Rice protein is a plant-based protein powder made from rice that offers an easy way to add protein to your diet, especially if you avoid dai...
In laboratory research, hydrolyzed rice protein inhibits angiotensin-converting enzyme (ACE).
Read the full Rice Protein + Captopril, Hydrochlorothiazide interactionRooibosAspalathus Linearis, green Red Bush, infusion Rooibos, +9 more Possible
What it is: Rooibos is a caffeine-free herbal tea from South Africa that is rich in antioxidants and generally considered safe as a beverage.
Theoretically, taking rooibos with ACEIs may increase the therapeutic and adverse effects of ACEIs.
Read the full Rooibos + Captopril, Hydrochlorothiazide interactionRoyal JellyBee Saliva, bee Spit, gelée Royale, +4 more Possible
What it is: Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee.
Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Royal Jelly + Captopril, Hydrochlorothiazide interactionRueRuta Graveolens, aruta, arvada, +17 more Possible
What it is: Rue is a strong-smelling herb from southern Europe with a long history in folk medicine, but there is very little reliable human research to...
Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.
Read the full Rue + Captopril, Hydrochlorothiazide interactionSaffronCrocus Sativus, autumn Crocus, azafrán, +16 more Possible
What it is: Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most r...
Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Read the full Saffron + Captopril, Hydrochlorothiazide interactionSageSalvia Officinalis, broadleaf Sage, common Sage, +14 more Possible
What it is: Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and me...
Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Read the full Sage + Captopril, Hydrochlorothiazide interactionSea BuckthornAnanas De Sibérie, argasse, argousier, +17 more Possible
What it is: Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart he...
Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.
Read the full Sea Buckthorn + Captopril, Hydrochlorothiazide interactionSennaSenna Alexandrina, alexandrian Senna, alexandrinische Senna, +13 more Possible
What it is: Senna is a plant-based stimulant laxative that is widely used and generally effective for short-term relief of constipation.
Theoretically, senna might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Senna + Captopril, Hydrochlorothiazide interactionSlippery ElmIndian Elm, moose Elm, olmo Americano, +7 more Possible
What it is: Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and ir...
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm + Captopril, Hydrochlorothiazide interactionSodium Bicarbonate Possible
What it is: Sodium bicarbonate (baking soda) is a simple compound most often used as a fast-acting antacid and, in sports, as a buffer that may help wit...
Theoretically, sodium bicarbonate may increase the risk of hypokalemia in patients taking thiazide diuretics.
Read the full Sodium Bicarbonate + Captopril, Hydrochlorothiazide interactionSoy Possible
What it is: Soy is a nutritious bean that is a staple food and a popular source of plant protein and isoflavones.
Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Read the full Soy + Captopril, Hydrochlorothiazide interactionSquillUrginea Indica, cebolla Albarrana, charpentaire, +17 more Possible
What it is: Squill is a bulb plant that contains potent cardiac glycosides, which can affect the heart much like the drug digoxin.
Squill contains cardiac glycosides.
Read the full Squill + Captopril, Hydrochlorothiazide interactionSt. John's WortHypericum Perforatum, amber Touch-and-heal, barbe De Saint-jean, +13 more Possible
What it is: St.
Theoretically, St.
Read the full St. John's Wort + Captopril, Hydrochlorothiazide interactionStar Of Bethlehem Possible
What it is: Star of Bethlehem is a small flowering plant best known as one of the ingredients in Bach flower remedies, where it is used for emotional sh...
Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.
Read the full Star Of Bethlehem + Captopril, Hydrochlorothiazide interactionStinging NettleUrtica Dioica, urtica Urens, bichu, +12 more Possible
What it is: Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain.
Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Read the full Stinging Nettle + Captopril, Hydrochlorothiazide interactionStrophanthus Possible
What it is: Strophanthus is a plant that contains powerful heart-affecting compounds called cardiac glycosides (the best known is ouabain/g-strophanthin...
Theoretically, concomitant use of potassium-depleting diuretics and strophanthus can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Strophanthus + Captopril, Hydrochlorothiazide interactionSwamp Milkweed Possible
What it is: Swamp Milkweed is a native North American wetland plant best known today as a butterfly and pollinator garden plant, not a proven medicine.
Theoretically, potassium depleting diuretics might increase the risk of toxicity with swamp milkweed.
Read the full Swamp Milkweed + Captopril, Hydrochlorothiazide interactionTheanine Possible
What it is: Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without...
Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Read the full Theanine + Captopril, Hydrochlorothiazide interactionTragacanthAdragante, astragale Adragant, astragale De Marseille, +14 more Possible
What it is: Tragacanth is a plant gum used mainly as a thickener and emulsifier in foods, cosmetics, and medicines, and traditionally to soothe the thro...
Theoretically, tragacanth might alter absorption of oral drugs.
Read the full Tragacanth + Captopril, Hydrochlorothiazide interactionTree Turmeric Possible
What it is: Tree turmeric (Berberis aristata) is a shrub used in traditional Indian (Ayurvedic) medicine, valued mainly for its berberine content.
Theoretically, taking tree turmeric along with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Tree Turmeric + Captopril, Hydrochlorothiazide interactionTribulusTribulus Terrestris, abrojo, abrojos, +17 more Possible
What it is: Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind th...
Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Read the full Tribulus + Captopril, Hydrochlorothiazide interactionUzaraXysmalobium Undulatum Possible
What it is: Uzara is a traditional African root remedy used mainly for diarrhea and stomach cramps.
Theoretically, concomitant use of potassium-depleting diuretics and uzara can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Uzara + Captopril, Hydrochlorothiazide interactionVitamin B6 Possible
What it is: Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cell...
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Captopril, Hydrochlorothiazide interactionWahooEuonymus Atropurpureus, arrowwood, bitter Ash, +17 more Possible
What it is: Wahoo is a North American shrub historically used as a laxative and 'liver tonic,' but it is a poisonous plant with no proven benefit and a...
Theoretically, concomitant use of potassium-depleting diuretics with wahoo can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Wahoo + Captopril, Hydrochlorothiazide interactionWallflower Possible
What it is: Wallflower (Erysimum cheiri) is a fragrant garden plant with a long history in traditional medicine, but there is very little modern human r...
Theoretically, concomitant use of potassium-depleting diuretics and wallflower can increase the risk of cardiac glycoside toxicity due to potassium depletion.
Read the full Wallflower + Captopril, Hydrochlorothiazide interactionWhite HorehoundMarrubium Vulgare, bonhomme, grand Bonhomme, +8 more Possible
What it is: White horehound is a traditional bitter herb used mainly for coughs, sore throats, and mild digestive complaints, and it is a common flavori...
Evidence from animal research suggests that taking white horehound extract lowers blood pressure.
Read the full White Horehound + Captopril, Hydrochlorothiazide interactionYerba MateIlex Paraguariensis, chimarrao, green Mate, +14 more Possible
What it is: Yerba mate is a caffeine-containing herbal beverage from South America that is widely enjoyed for its stimulating, coffee-like effects.
Theoretically, the caffeine in yerba mate might increase the risk of hypokalemia when used concomitantly with other diuretics.
Read the full Yerba Mate + Captopril, Hydrochlorothiazide interactionAmerican IvyParthenocissus Quinquefolia, american Woodbine, creeper, +9 more Unlikely
What it is: American Ivy (Virginia creeper) is mainly an ornamental climbing vine with a long history of folk use for digestion and sweating, but there...
The berries of American ivy contain up to 2% oxalic acid, which can be toxic because it has the potential to cause kidney failure by precipitating solid calcium oxalate.
Read the full American Ivy + Captopril, Hydrochlorothiazide interactionThyroid Extract Likely
What it is: Thyroid extract supplements are made from dried animal thyroid gland and may contain real thyroid hormones (T3 and T4), but the amounts in o...
Food and medications can interfere with thyroid hormone absorption.
Read the full Thyroid Extract + Captopril, Hydrochlorothiazide interactionAgarAgar-agar, agarose, agarose Gel, +17 more Possible
What it is: Agar is a plant-based gel made from red seaweed that is widely used as a vegetarian alternative to gelatin and as a source of dietary fiber.
Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.
Read the full Agar + Captopril, Hydrochlorothiazide interactionAlginAlginate, alginate De Calcium, alginate De Magnésium, +12 more Possible
What it is: Algin (alginate) is a fiber-like substance from brown seaweed that is widely used as a thickener, gel, and binder in foods and medicines.
Theoretically, algin can alter the absorption of oral drugs.
Read the full Algin + Captopril, Hydrochlorothiazide interactionAmerican SpikenardAralia Racemosa, anis Sauvage, grande Salsepareille, +8 more Possible
What it is: American spikenard is a traditional North American herb used mainly as an expectorant and to ease coughs and colds, but there is no reliable...
American spikenard is purported to have diaphoretic properties.
Read the full American Spikenard + Captopril, Hydrochlorothiazide interactionBeetBeta Vulgaris, beet Greens, beet Juice, +19 more Possible
What it is: Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in...
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.
Read the full Beet + Captopril, Hydrochlorothiazide interactionBirch Possible
What it is: Birch is a tree whose leaves, bark, and sap are used in traditional remedies, most often as a mild diuretic or for joint and urinary complai...
Theoretically, birch might interfere with diuretic therapy.
Read the full Birch + Captopril, Hydrochlorothiazide interactionBlack PsylliumAfrican Plantain, brown Psyllium, dietary Fiber, +16 more Possible
What it is: Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive...
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Black Psyllium + Captopril, Hydrochlorothiazide interactionBlond PsylliumPlantago Ovata, balle De Psyllium, blond Plantago, +14 more Possible
What it is: Blond psyllium is a soluble fiber from the seed husks of Plantago ovata, and it is one of the better-studied fiber supplements.
Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Read the full Blond Psyllium + Captopril, Hydrochlorothiazide interactionCarobCeratonia Siliqua, algarrobo, carob Flour, +16 more Possible
What it is: Carob is a Mediterranean tree whose pods are widely used as a caffeine-free, naturally sweet cocoa alternative and as a thickener (carob gum...
Theoretically, carob might also impair the absorption of oral drugs.
Read the full Carob + Captopril, Hydrochlorothiazide interactionCoenzyme Q10Coq10 Possible
What it is: CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant.
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10 + Captopril, Hydrochlorothiazide interactionDendrobium Possible
What it is: Dendrobium is a group of orchids long used in traditional Chinese medicine, often to moisten the body and as a general tonic.
The dendrobium constituent dendrobine is reported to have hypotensive effects.
Read the full Dendrobium + Captopril, Hydrochlorothiazide interactionDulsePalmaria Palmata, rhodymenia Palmata Possible
What it is: Dulse is a red seaweed eaten as a food in many coastal cultures and is a natural source of iodine, potassium, protein, and antioxidant compo...
Theoretically, dulse might increase the risk of hyperkalemia when taken with ACEIs.
Read the full Dulse + Captopril, Hydrochlorothiazide interactionFenugreekTrigonella Foenum-graecum, alholva, bird's Foot, +14 more Possible
What it is: Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk prod...
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Fenugreek + Captopril, Hydrochlorothiazide interactionHumann Superbeets Heart Chews Possible
What it is: SuperBeets Heart Chews are a beetroot- and grape-seed-based supplement marketed to support healthy blood flow, blood pressure, and nitric ox...
Each serving of HumanN SuperBeets includes 500mg of beetroot powder (2 chews).
Read the full Humann Superbeets Heart Chews + Captopril, Hydrochlorothiazide interactionJuniper Possible
What it is: Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid.
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Read the full Juniper + Captopril, Hydrochlorothiazide interactionKaraya GumBassora Tragacanth, goma Karaya, gomme Karaya, +14 more Possible
What it is: Karaya gum is a natural plant gum from the Sterculia tree that is mostly used as a bulk-forming laxative and as a thickener or adhesive in f...
Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption of drugs.
Read the full Karaya Gum + Captopril, Hydrochlorothiazide interactionMarshmallowAlthaea Officinalis, altea, alteia, +16 more Possible
What it is: Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sor...
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow + Captopril, Hydrochlorothiazide interactionN-methyltyramine Possible
What it is: N-methyltyramine is a natural compound related to tyramine that is found in bitter orange, barley, and other plants, and it is often added t...
In animal research, N-methyltyramine increased blood pressure.
Read the full N-methyltyramine + Captopril, Hydrochlorothiazide interactionNicotinamide Riboside Possible
What it is: Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair.
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside + Captopril, Hydrochlorothiazide interactionPu-erh Tea Possible
What it is: Pu-erh tea is a fermented, aged form of tea made from the same plant as green and black tea.
Theoretically, using pu-erh tea with diuretic drugs might increase the risk of hypokalemia.
Read the full Pu-erh Tea + Captopril, Hydrochlorothiazide interactionPuravive Possible
What it is: Puravive is a branded, multi-ingredient capsule marketed mainly for weight loss by claiming to boost brown fat activity, but there is no pub...
Puravive contains quercetin, which has been found to slightly reduce blood pressure in individuals with mild hypertension (https://pubmed.ncbi.nlm.nih.gov/17951477/).
Read the full Puravive + Captopril, Hydrochlorothiazide interactionStevia Possible
What it is: Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by...
Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Read the full Stevia + Captopril, Hydrochlorothiazide interactionXanthan GumBacterial Polysaccharide, corn Sugar Gum, goma Xantana, +7 more Possible
What it is: Xanthan gum is a fermentation-made fiber widely used to thicken and stabilize foods and to thicken liquids for people with swallowing diffic...
Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.
Read the full Xanthan Gum + Captopril, Hydrochlorothiazide interactionAsian Water PlantainAlisma Plantago-aquatica, dong Fang Ze Xie, jilgyeongitaegsa, +6 more Unlikely
What it is: Asian water plantain (Ze Xie) is a rhizome long used in traditional Chinese medicine, mainly as a diuretic and for fluid retention.
Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg orally daily and does not cause harm to the body.
Read the full Asian Water Plantain + Captopril, Hydrochlorothiazide interactionCapsicum Unlikely
What it is: Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain.
Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
Read the full Capsicum + Captopril, Hydrochlorothiazide interactionEquol Unlikely
What it is: Equol is a compound made in the gut when some people break down soy isoflavones, and it is also sold as a supplement.
Theoretically, equol might cause additive diuretic effects when used with diuretic drugs.
Read the full Equol + Captopril, Hydrochlorothiazide interactionHempCannabis Sativa, cheungsam, fiber Hemp, +14 more Unlikely
What it is: Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generall...
Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
Read the full Hemp + Captopril, Hydrochlorothiazide interactionCan You Take It With Captopril, Hydrochlorothiazide?
One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.
Can you take Ashwagandha with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Full Ashwagandha + Captopril, Hydrochlorothiazide answerCan you take Cola Nut with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using cola nut with diuretic drugs might increase the risk of hypokalemia.
Full Cola Nut + Captopril, Hydrochlorothiazide answerCan you take Rue with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.
Full Rue + Captopril, Hydrochlorothiazide answerCan you take Oleander with Captopril, Hydrochlorothiazide?
Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, diuretic drugs may increase the risk of oleander toxicity.
Full Oleander + Captopril, Hydrochlorothiazide answerCan you take Calcium with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Full Calcium + Captopril, Hydrochlorothiazide answerCan you take Nattokinase with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Full Nattokinase + Captopril, Hydrochlorothiazide answerCan you take Niacin with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
Full Niacin + Captopril, Hydrochlorothiazide answerCan you take Noni with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Full Noni + Captopril, Hydrochlorothiazide answerCan you take Octopamine with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In humans, octopamine 450-600 mg daily increases blood pressure in hypotensive patients.
Full Octopamine + Captopril, Hydrochlorothiazide answerCan you take Oolong Tea with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using oolong tea with diuretic drugs might increase the risk of hypokalemia.
Full Oolong Tea + Captopril, Hydrochlorothiazide answerCan you take Oregon Grape with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the risk of hypotension when taken with antihypertensive drugs.
Full Oregon Grape + Captopril, Hydrochlorothiazide answerCan you take Parsley with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might enhance or interfere with the effects of diuretic drugs.
Full Parsley + Captopril, Hydrochlorothiazide answerCan you take Pheasant's Eye with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pheasant's eye with diuretic drugs might increase the risk of cardiac glycoside toxicity.
Full Pheasant's Eye + Captopril, Hydrochlorothiazide answerCan you take Phellodendron with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might have additive effects with antihypertensive drugs.
Full Phellodendron + Captopril, Hydrochlorothiazide answerCan you take Pleurisy Root with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of potassium-depleting diuretics and pleurisy root can increase the risk of cardiac glycoside toxicity due to...
Full Pleurisy Root + Captopril, Hydrochlorothiazide answerCan you take Pomegranate with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Full Pomegranate + Captopril, Hydrochlorothiazide answerCan you take Quassia with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Overuse of quassia might compound diuretic-induced potassium loss.
Full Quassia + Captopril, Hydrochlorothiazide answerCan you take Quercetin with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking quercetin with antihypertensive drugs might increase the risk of hypotension.
Full Quercetin + Captopril, Hydrochlorothiazide answerCan you take Rauvolfia Vomitoria with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Rauvolfia vomitoria might increase the risk of hypotension.
Full Rauvolfia Vomitoria + Captopril, Hydrochlorothiazide answerCan you take Rehmannia with Captopril, Hydrochlorothiazide?
Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Full Rehmannia + Captopril, Hydrochlorothiazide answerWhat Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
How Does Our Interaction Checker Work?
Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).
So the check works in three steps: (1) Captopril, Hydrochlorothiazide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Captopril, Hydrochlorothiazide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.
Captopril, Hydrochlorothiazide sits in 9 interaction categories. Open any one to see what the group means:
Antihypertensive Drugs 119 ingredients
Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.
119 of the supplement ingredients on this page reach Captopril, Hydrochlorothiazide through this category.
Diuretic Drugs 73 ingredients
Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.
73 of the supplement ingredients on this page reach Captopril, Hydrochlorothiazide through this category.
Photosensitizing Drugs 20 ingredients
Medications that make skin more sun-sensitive. Supplements with the same property can compound it.
20 of the supplement ingredients on this page reach Captopril, Hydrochlorothiazide through this category.
Oral Drugs 17 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
17 of the supplement ingredients on this page reach Captopril, Hydrochlorothiazide through this category.
Ace Inhibitors (Aceis) 12 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
12 of the supplement ingredients on this page reach Captopril, Hydrochlorothiazide through this category.
Nephrotoxic Drugs 6 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
6 of the supplement ingredients on this page reach Captopril, Hydrochlorothiazide through this category.
Thiazide Diuretics 5 ingredients
Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.
5 of the supplement ingredients on this page reach Captopril, Hydrochlorothiazide through this category.
Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
4 of the supplement ingredients on this page reach Captopril, Hydrochlorothiazide through this category.
Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients
A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.
4 of the supplement ingredients on this page reach Captopril, Hydrochlorothiazide through this category.
About Captopril, Hydrochlorothiazide
Captopril and hydrochlorothiazide is a combination of an ACE inhibitor and a thiazide diuretic used to treat high blood pressure (hypertension).
Generic name: Captopril, Hydrochlorothiazide · Brand names: Capozide, Acezide.
See the full Captopril and Hydrochlorothiazide drug informationRelated: does Captopril, Hydrochlorothiazide deplete any nutrients?
Captopril, Hydrochlorothiazide has 16 reported nutrient associations in the research literature — see the Captopril, Hydrochlorothiazide nutrient depletion report.
Take a Supplement Product? Check the Whole Bottle Against Captopril, Hydrochlorothiazide
Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Captopril, Hydrochlorothiazide.
Search a supplement product
Type a product name, brand, or UPC — smart search across our full catalog.
Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI
Or scan the bottle
Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.
Prefer typing? The interaction checker looks up products by name too.
Products that contain Captopril, Hydrochlorothiazide-interacting ingredients
Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Captopril, Hydrochlorothiazide.
Captopril, Hydrochlorothiazide & Supplements: Common Questions
What supplements interact with Captopril, Hydrochlorothiazide?
Which Captopril, Hydrochlorothiazide supplement interactions are the most serious?
Can I take vitamins or supplements while on Captopril, Hydrochlorothiazide?
Do brands like Capozide have the same supplement interactions as Captopril, Hydrochlorothiazide?
Where do these interaction ratings come from?
Does Captopril, Hydrochlorothiazide deplete any vitamins or nutrients?
What about Captopril, Hydrochlorothiazide and my other medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Where This Data Comes From — and Why You Can Trust It
🧪 Licensed clinical database
Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.
🧑⚕️ Pharmacist review
This page is curated and coded by Dr. Brian Staiger, PharmD, BCPS, Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.
🔄 Kept current
Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.
🔍 Full transparency
How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.
Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.