Medication interaction hub

What Supplements Interact with Acetazolamide?

Acetazolamide brand names: Diamox, Ak-Zol. Every interaction below applies to the brands too.

284 Interactions 15 Major 242 Moderate 27 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetazolamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetazolamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Acetazolamide, taken for glaucoma, altitude sickness, and certain seizure types, works partly as a diuretic and can make people drowsy, and most of the supplements that interact with it press on one of those two points. The biggest group adds to its blood-pressure and fluid effects, a second deepens sedation (alcohol and kava sit at the serious end of that one), and a third compounds the potassium loss its diuretic action can cause. This list deserves real vigilance, not a passing glance.

A smaller cluster can strain the kidneys, which do the work of clearing acetazolamide, and activated charcoal can soak up the drug before it absorbs, so keep oral doses spaced well apart. The full page runs to 284 ingredients, and while 242 are moderate and 27 minor, the 15 rated major are where I would spend my reading time.

— , Clinical Pharmacist · July 18, 2026

Major 15 Moderate 242 Minor 27 No known interaction 1,168

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetazolamide: Top Interactions at a Glance

The Acetazolamide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 284 interacting ingredients — plus 1,168 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetazolamide Combinations Today

The Acetazolamide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Agmatine + Acetazolamidei

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Sodium + Acetazolamidei

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Fish Oil + Acetazolamidei

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Probable Apple + Acetazolamidei

Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.

Read the full interaction Minor Likelihood Possible Coenzyme Q10 + Acetazolamidei

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Flaxseed + Acetazolamidei

Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Read the full interaction
The complete list

Every Supplement Checked Against Acetazolamide

All 1,452 ingredients in our database, ranked by severity — 284 with a Acetazolamide interaction on file and 1,168 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetazolamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Agmatine with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Full Agmatine + Acetazolamide answer

Can you take Sodium with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.

Full Sodium + Acetazolamide answer

Can you take Fish Oil with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Acetazolamide answer

Can you take Apple with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.

Full Apple + Acetazolamide answer

Can you take Coenzyme Q10 with Acetazolamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Acetazolamide answer

Can you take Aristolochia with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aristolochia is nephrotoxic.

Full Aristolochia + Acetazolamide answer

Can you take Arrach with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of arrach can increase risk of adverse effects, as unspecified Chenopodium species are associated with photos...

Full Arrach + Acetazolamide answer

Can you take Artichoke with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.

Full Artichoke + Acetazolamide answer

Can you take Asafoetida with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that asafoetida has hypotensive effects.

Full Asafoetida + Acetazolamide answer

Can you take Ash with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ash seed with antihypertensive drugs might have additive blood pressure lowering effects.

Full Ash + Acetazolamide answer

Can you take Ashwagandha with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Acetazolamide answer

Can you take Asparagus with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Full Asparagus + Acetazolamide answer

Can you take Asparagus Racemosus with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, asparagus racemosus root might increase diuresis and electrolyte loss when used with diuretic drugs.

Full Asparagus Racemosus + Acetazolamide answer

Can you take Baikal Skullcap with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotensi...

Full Baikal Skullcap + Acetazolamide answer

Can you take Basil with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.

Full Basil + Acetazolamide answer

Can you take Bay Leaf with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Full Bay Leaf + Acetazolamide answer

Can you take Berberine with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase the sedative effects of CNS depressants.

Full Berberine + Acetazolamide answer

Can you take Beta-glucans with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.

Full Beta-glucans + Acetazolamide answer

Can you take Betony with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, betony might have additive effects with blood pressure lowering drugs due to hypotensive activity of the glycosides found in...

Full Betony + Acetazolamide answer

Can you take Bishop's Weed with Acetazolamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bishop's weed constituents seem to cause photosensitivity.

Full Bishop's Weed + Acetazolamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetazolamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetazolamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetazolamide sits in 8 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Acetazolamide through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Acetazolamide through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Acetazolamide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Acetazolamide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetazolamide through this category.

Anticonvulsants 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Acetazolamide through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetazolamide through this category.

Acetazolamide 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Acetazolamide through this category.

About Acetazolamide

Acetazolamide is a diuretic medication used to treat glaucoma, altitude sickness, fluid retention, and certain types of epilepsy.

Generic name: Acetazolamide  ·  Brand names: Diamox, Ak-Zol.

See the full Acetazolamide drug information

Related: does Acetazolamide deplete any nutrients?

Acetazolamide has 8 reported nutrient associations in the research literature — see the Acetazolamide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetazolamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetazolamide.

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Pharmacist Counseling Corner

Acetazolamide & Supplements: Common Questions

What supplements interact with Acetazolamide?
In our interaction database, 284 supplement and herbal ingredients have an interaction with Acetazolamide on file — 15 rated major, 242 moderate, and 27 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Beer, Siberian Cocklebur.
Which Acetazolamide supplement interactions are the most serious?
Focus on the major group: American Hellebore, Beer, Siberian Cocklebur, Tyramine and Wine, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Acetazolamide?
That depends entirely on which supplement. The honest answer for Acetazolamide is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Diamox have the same supplement interactions as Acetazolamide?
Yes — Diamox, Ak-Zol all contain Acetazolamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetazolamide deplete any vitamins or nutrients?
It might — Acetazolamide has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetazolamide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetazolamide and my other medications?
This page covers Acetazolamide against supplements and herbal ingredients. Checking Acetazolamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Acetazolamide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.