Drug & supplement interaction

Bay Leaf + Acetazolamide

Acetazolamide brand names: Diamox, Ak-Zol.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Bay Leaf has a moderate interaction with Acetazolamide. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Bay Leaf and Acetazolamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Acetazolamide

Acetazolamide falls under CNS DEPRESSANTS — the group Bay Leaf interacts with.

Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.
Bay leaf contains methyl eugenol. Animal research shows that methyl eugenol has sedative properties. Avoid concomitant use.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the honest picture: this concern is mostly theoretical. Bay leaf contains a compound called methyl eugenol, and in animal studies it showed mild sedative (sleepy) effects. The worry is that concentrated bay leaf supplements could add to the drowsiness side of medications that calm the nervous system.

Now, acetazolamide (Diamox) isn't a classic sedative, but it can cause drowsiness, fatigue, dizziness, and tiredness on its own. So in theory, large supplement-level doses of bay leaf might make those effects feel stronger. The good news is that the small amounts you use to flavor soup or stew are very unlikely to cause any problem. If you're thinking about a concentrated extract or bay leaf essential oil, check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Bay Leaf Also Interacts With Other Medications

Bay Leaf has 334 moderate known drug interactions in our database — the Acetazolamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 334 No known interaction 2,496 (incl. Acetazolamide)
Taking anything else?

Check Another of Your Medications Against Bay Leaf

Covers the 2,830 medications we’ve checked against Bay Leaf. Pick one to open its full report.

From our Q&A

Questions About Bay Leaf or Acetazolamide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Bay Leaf or Acetazolamide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Acetazolamide

This page covers Bay Leaf only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetazolamide page lists 284 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), American Mistletoe (major) and Asarabacca (major).

By severity: 15 major · 242 moderate · 27 minor.

From our pharmacist’s overview on the Acetazolamide page

“Acetazolamide, taken for glaucoma, altitude sickness, and certain seizure types, works partly as a diuretic and can make people drowsy, and most of the supplements that interact with it press on one of those two points. The biggest group adds to its blood-pressure and fluid effects, a second deepens sedation (alcohol and kava sit at th…”

Reviewed by 2 · Jul 18, 2026

Open the Acetazolamide interaction page

How much people look this up

Where Bay Leaf and Acetazolamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bay Leaf
Top 25%

#360 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetazolamide
Top half

#1,054 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Bay Leaf

What is Bay Leaf?

Bay Leaf
  • Cooking and flavoring
  • Digestive upset
  • Blood sugar support
  • Colds and congestion
  • Joint and muscle discomfort

Bay leaf is a common culinary herb that is safe in the small amounts used in cooking. Some people take it for digestion, blood sugar, or colds, but strong human evidence for these uses is lacking. Talk to your pharmacist or doctor before using concentrated supplements or essential oils.

Read the full Bay Leaf monograph & all interactions
Medication

About Acetazolamide

What Is Acetazolamide Used For?

Brand names: Diamox, Ak-Zol

Acetazolamide is used as an add-on treatment for several conditions. Across tablets and the intravenous injection, it treats glaucoma (including open-angle and secondary glaucoma, and before surgery for acute angle-closure glaucoma), certain types of epilepsy (centrencephalic seizures, including petit mal), edema (fluid buildup) due to congestive heart failure, and drug-induced edema.

Acetazolamide extended-release capsules are specifically indicated for the prevention or reduction of acute mountain sickness symptoms — such as headache, nausea, and dizziness — in climbers attempting rapid ascent. Acetazolamide tablets and the intravenous injection are also indicated for acute mountain sickness.

See full Acetazolamide drug information
Keep checking

Other Drugs & Bay Leaf

Browse every other medication we’ve checked against Bay Leaf — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
334Moderate
0Minor
2,495No known interaction
334 Moderate 2,495 No interaction
Moderate

334 interactions

Showing 60 of 334 moderate interactions — see all 334 on the Bay Leaf page.

No interaction 2,495 drugs checked — show the list

We also checked Bay Leaf against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,495 medications checked with no known interaction — see the full Bay Leaf list.

See the full Bay Leaf interactions page
See every supplement checked against Acetazolamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Bay Leaf monograph › Uses, safety, and every drug interaction in one place Acetazolamide supplement interactions › Every supplement checked against Acetazolamide, ranked by severity Acetazolamide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Bay Leaf and Acetazolamide Together: Common Questions

Can you take Bay Leaf with Acetazolamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Bay Leaf and Acetazolamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetazolamide and Bay Leaf?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.