Drug & supplement interaction

Beta-glucans + Acetazolamide

Acetazolamide brand names: Diamox, Ak-Zol.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Beta-glucans has a moderate interaction with Acetazolamide. Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Beta-glucans and Acetazolamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Acetazolamide

Acetazolamide falls under ANTIHYPERTENSIVE DRUGS — the group Beta-glucans interacts with.

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: oat and barley beta-glucans can gently nudge your blood pressure down on their own. Acetazolamide (Diamox) isn't a classic blood pressure pill, but it is a diuretic-type medicine that makes you lose extra fluid and sodium, which can also lower blood pressure a bit. So in theory, stacking the two could add up and leave you feeling lightheaded, dizzy, or extra tired, especially when you stand up quickly.

That said, this is mostly a theoretical concern backed by weak, anecdotal evidence. Food amounts of oats or barley are very unlikely to cause trouble. If you take a concentrated beta-glucan supplement, just mention it to your pharmacist or doctor so they can keep an eye on how you're feeling. Don't change anything on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Beta-glucans Also Interacts With Other Medications

Beta-glucans has 292 moderate known drug interactions in our database — the Acetazolamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 292 No known interaction 2,538 (incl. Acetazolamide)
Taking anything else?

Check Another of Your Medications Against Beta-glucans

Covers the 2,830 medications we’ve checked against Beta-glucans. Pick one to open its full report.

From our Q&A

Questions About Beta-glucans or Acetazolamide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Beta-glucans or Acetazolamide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Acetazolamide

This page covers Beta-glucans only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetazolamide page lists 284 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), American Mistletoe (major) and Asarabacca (major).

By severity: 15 major · 242 moderate · 27 minor.

From our pharmacist’s overview on the Acetazolamide page

“Acetazolamide, taken for glaucoma, altitude sickness, and certain seizure types, works partly as a diuretic and can make people drowsy, and most of the supplements that interact with it press on one of those two points. The biggest group adds to its blood-pressure and fluid effects, a second deepens sedation (alcohol and kava sit at th…”

Reviewed by 2 · Jul 18, 2026

Open the Acetazolamide interaction page

One more smart check

Taking Beta-glucans as Part of a Dietary Supplement Product? Check It for Interactions

We hold 809 real supplement products containing Beta-glucans, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Beta-glucans. Your product may carry other ingredients that interact with Acetazolamide too, on top of Beta-glucans — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Beta-glucans and Acetazolamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beta-glucans
Top 25%

#255 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetazolamide
Top half

#1,054 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Beta-glucans

What is Beta-glucans?

  • High cholesterol
  • Heart health
  • Immune support
  • Blood sugar control
  • Wound care (topical)

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while immune-related claims from yeast and mushroom sources are far less proven. They are generally well tolerated, but check with your pharmacist before starting any supplement.

Read the full Beta-glucans monograph & all interactions
Medication

About Acetazolamide

What Is Acetazolamide Used For?

Brand names: Diamox, Ak-Zol

Acetazolamide is used as an add-on treatment for several conditions. Across tablets and the intravenous injection, it treats glaucoma (including open-angle and secondary glaucoma, and before surgery for acute angle-closure glaucoma), certain types of epilepsy (centrencephalic seizures, including petit mal), edema (fluid buildup) due to congestive heart failure, and drug-induced edema.

Acetazolamide extended-release capsules are specifically indicated for the prevention or reduction of acute mountain sickness symptoms — such as headache, nausea, and dizziness — in climbers attempting rapid ascent. Acetazolamide tablets and the intravenous injection are also indicated for acute mountain sickness.

See full Acetazolamide drug information
Keep checking

Other Drugs & Beta-glucans

Browse every other medication we’ve checked against Beta-glucans — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
292Moderate
0Minor
2,537No known interaction
292 Moderate 2,537 No interaction
Moderate

292 interactions

Showing 60 of 292 moderate interactions — see all 292 on the Beta-glucans page.

No interaction 2,537 drugs checked — show the list

We also checked Beta-glucans against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,537 medications checked with no known interaction — see the full Beta-glucans list.

See the full Beta-glucans interactions page
See every supplement checked against Acetazolamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Beta-glucans monograph › Uses, safety, and every drug interaction in one place Acetazolamide supplement interactions › Every supplement checked against Acetazolamide, ranked by severity Acetazolamide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Beta-glucans and Acetazolamide Together: Common Questions

Can you take Beta-glucans with Acetazolamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Beta-glucans and Acetazolamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetazolamide and Beta-glucans?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.