Solomon's Seal - Acetazolamide Interaction
Herbal: Solomon's Seal
Also Known As: Polygonatum multiflorum
Drug: Acetazolamide
Brand names:
Diamox, Ak-Zol
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
There were no interactions found between Acetazolamide and Solomon's Seal. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Solomon's Seal Overview
Solomon's Seal (Polygonatum) is a genus of flowering plants encompassing around 60 species, belonging to the family Asparagaceae. These plants are characterized by their distinctive arching stems, dangling pairs of bell-shaped flowers, and simple, lance-shaped leaves. They are primarily found in temperate regions of the Northern Hemisphere and are often cultivated for their ornamental value in gardens due to their elegant and graceful appearance. Additionally, Solomon's Seal has been used in traditional herbal medicine for its purported anti-inflammatory and healing properties.
Acetazolamide Overview
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Acetazolamide is used to treat glaucoma, a condition in which increased pressure in the eye can lead to gradual loss of vision. Acetazolamide decreases the pressure in the eye. Acetazolamide is also used to reduce the severity and duration of symptoms (upset stomach, headache, shortness of breath, dizziness, drowsiness, and fatigue) of altitude (mountain) sickness. Acetazolamide is used with other medicines to reduce edema (excess fluid retention) and to help control seizures in certain types of epilepsy.
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This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Solomon's Seal - More Interactions
Solomon's Seal interacts with 84 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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