Drug & supplement interaction

Solomon's Seal + Rosuvastatin

Rosuvastatin brand names: Crestor, Ezallor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Solomon's Seal and Rosuvastatin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Solomon's Seal and Rosuvastatin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Rosuvastatin and Solomon's Seal in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Solomon's Seal safety at a glance

Solomon's Seal overall Use caution Limited safety data exists in people, so use carefully and choose reputable products.
Pregnancy Avoid Safety has not been established, so it is best to avoid use during pregnancy.
Breastfeeding Avoid There is not enough information to consider it safe while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Rosuvastatin and Solomon's Seal? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Rosuvastatin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Rosuvastatin is filed under 4 classifications — including hmg-coa reductase inhibitors ("statins"), hepatotoxic drugs, oral drugs. Solomon's Seal has documented interactions with 3 drug classes — the most serious being antidiabetes drugs (moderate), chlorpropamide (diabinese) (moderate) and insulin (moderate) — and none of Rosuvastatin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Solomon's Seal Does Interact With Other Medications

Solomon's Seal has 86 moderate known drug interactions in our database — Rosuvastatin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Rosuvastatin)
Taking anything else?

Check Another of Your Medications Against Solomon's Seal

Covers the 2,830 medications we’ve checked against Solomon's Seal. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Solomon's Seal and Rosuvastatin May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea reported in 5.4% of FDA reports for Rosuvastatin Additional detail

    Solomon's Seal

    “A thorough evaluation of safety outcomes has not been conducted. Orally, long-term use of Solomon's seal has been reported to cause gastrointestinal irritation. Use of large doses or overdoses may cause nausea, diarrhea, and other gastrointestinal complaints (18).”

    Solomon's Seal · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, Solomon's seal may cause gastrointestinal irritation when used long-term. Use of large doses or overdoses may cause nausea, diarrhea, and other gastrointestinal complaints (18).”

    Solomon's Seal · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Rosuvastatin

    Listed in the ADVERSE REACTIONS section of the FDA label for Rosuvastatin, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Solomon's Seal but not commonly for Rosuvastatin: diarrhea.

Effects for Rosuvastatin come from the ADVERSE REACTIONS section of its FDA label; effects for Solomon's Seal come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 223,851 voluntary FDA FAERS reports for Rosuvastatin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Solomon's Seal or Rosuvastatin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Solomon's Seal or Rosuvastatin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Rosuvastatin

This page covers Solomon's Seal only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Rosuvastatin page lists 63 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 48 moderate · 10 minor.

From our pharmacist’s overview on the Rosuvastatin page

“Rosuvastatin (Crestor, Ezallor) is a statin taken daily for years to lower cholesterol, and its supplement list deserves real scrutiny, not a quick skim. Five of the 63 ingredients on file carry a major rating, headed by grapefruit, which can raise statin blood levels, and by heavy drinking, since beer and wine compound the strain this…”

Reviewed by 2 · Jul 18, 2026

Open the Rosuvastatin interaction page

One more smart check

Taking Solomon's Seal as Part of a Dietary Supplement Product? Check It for Interactions

We hold 113 real supplement products containing Solomon's Seal, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Solomon's Seal. Even though Solomon's Seal itself has no known interaction with Rosuvastatin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Solomon's Seal and Rosuvastatin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Solomon's Seal
Top half

#498 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Rosuvastatin
Top 10

#9 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Solomon's Seal reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Solomon's Seal and Rosuvastatin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Solomon's Seal

What is Solomon's Seal?

Solomon's Seal
  • Joint and muscle discomfort
  • Tendon and ligament injuries
  • Inflammation
  • Digestive complaints
  • Skin and wound care
  • Dry cough and throat irritation

Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies are largely lacking. There is not enough reliable evidence to confirm it works for any specific condition, so use it cautiously and talk with your pharmacist or doctor first.

Polygonatum multiflorum · Asparagaceae · Rhizome (root) and sometimes the whole plant · Capsules, dried root, teas, tinctures, powders, and topical salves

An interaction check asks whether these two react with each other — it does not ask whether Solomon's Seal is a good idea for someone in your situation. Here is what our Solomon's Seal record says about it on its own.

Solomon's Seal: dosing

There is no standardized, scientifically established dose for Solomon's Seal. Products vary widely in strength and form, so amounts on labels are not based on strong clinical research.If you choose to use it, follow the directions on the product label and do not exceed the suggested amount. Because doses are not well studied, it is wise to start low.

From our Solomon's Seal monograph — the full record covers uses, side effects and every documented interaction.

Read the full Solomon's Seal monograph & all interactions
Medication

About Rosuvastatin

What Is Rosuvastatin Used For?

Brand names: Crestor, Ezallor

Rosuvastatin tablets are used alongside diet changes to lower LDL-C ("bad" cholesterol), total cholesterol, and triglycerides (blood fats), and to raise HDL-C ("good" cholesterol) in adults with high cholesterol or mixed cholesterol problems. They are also used in adults with very high triglycerides, a condition called primary dysbetalipoproteinemia (Type III, a genetic fat-metabolism disorder), and to slow the buildup of plaque in arteries (atherosclerosis).

In people without established heart disease but with multiple risk factors, rosuvastatin tablets can reduce the risk of heart attack, stroke, and procedures to open blocked arteries. For children and teens aged 8 and older with heterozygous familial hypercholesterolemia (HeFH, an inherited high-cholesterol condition), the tablet form is used to lower LDL-C after diet alone has not worked. Crestor tablets are also approved to treat homozygous familial hypercholesterolemia (HoFH, a more severe inherited form) in adults and in children aged 7 and older.

Most-Reported Side Effects for Rosuvastatin

From FAERS, the FDA’s public side-effect reporting system (229,715 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 14,778 reports
Nausea 12,432 reports
Dyspnea 11,981 reports
Diarrhea 11,370 reports
Headache 10,154 reports
See full Rosuvastatin drug information
Keep checking

Other Drugs & Solomon's Seal

Browse every other medication we’ve checked against Solomon's Seal — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Solomon's Seal page.

No interaction 2,743 drugs checked — show the list

We also checked Solomon's Seal against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Solomon's Seal list.

See the full Solomon's Seal interactions page
See every supplement checked against Rosuvastatin, ranked by severity
Evidence & sources

Solomon's Seal References

The 2 references that drive our Solomon's Seal monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Solomon's Seal and Rosuvastatin Together: Common Questions

Is it safe to take Solomon's Seal with Rosuvastatin?
We do not list a known interaction between Solomon's Seal and Rosuvastatin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Solomon's Seal and Rosuvastatin have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Solomon's Seal and Rosuvastatin combination checked?
Interactions in our licensed database are recorded against drug classes. Rosuvastatin is filed under 4 classifications, and Solomon's Seal has documented interactions with 3 drug classes — none of Rosuvastatin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Solomon's Seal interact with any other medications?
Yes. Solomon's Seal has 86 documented drug interactions in our database — Rosuvastatin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Rosuvastatin interact with any supplements?
Yes. Rosuvastatin has documented interactions with 63 supplements in our database — Solomon's Seal is not one of them. The Rosuvastatin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Solomon's Seal monograph Uses, safety profile, and every drug interaction in one place Rosuvastatin drug information The full plain-English guide to this medication Rosuvastatin supplement interactions Every supplement checked against Rosuvastatin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Rosuvastatin and Solomon's Seal?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.