Drug & supplement interaction

Guarumo + Acetazolamide

Acetazolamide brand names: Diamox, Ak-Zol.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Acetazolamide falls into 2 drug categories that Guarumo can interact with; the most serious is rated moderate. In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle relaxant activity.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Guarumo and Acetazolamide

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Guarumo interacts with whole categories of medication. Acetazolamide falls into 2 of those categories, so it can interact with Guarumo in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CNS DEPRESSANTS

1 of 2

Why this applies to Acetazolamide

Acetazolamide falls under CNS DEPRESSANTS — the group Guarumo interacts with.

In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle relaxant activity. Theoretically, guarumo might potentiate the sedative effects of drugs.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the honest picture: this concern comes from a single animal study where a water extract of guarumo seemed to calm the nervous system, causing some clumsiness and muscle relaxation. The worry is that, in theory, guarumo could add to the drowsy or sedating effects of other medicines.

With acetazolamide, that overlap is loose. Acetazolamide isn't a heavy sedative, but it can already cause tiredness, dizziness, and drowsiness, especially when you start it or use it for altitude sickness. If guarumo nudges things in the same direction, you might feel a little more sluggish or foggy. This is a low-strength, theoretical interaction, so I wouldn't panic, but I'd mention it to your pharmacist or doctor before combining them, particularly if you'll be driving or hiking.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Perez-Guerrero, C., Herrera, M. D., Ortiz, R., Alvarez, de Sotomayor, and Fernandez, M. A. A pharmacological study of Cecropia obtusifolia Bertol aqueous extract. J Ethnopharmacol 2001;76(3):279-84. PubMed
Moderate

ANTIHYPERTENSIVE DRUGS

2 of 2

Acetazolamide also falls under ANTIHYPERTENSIVE DRUGS.

Evidence from animal research suggests that aqueous and ethanolic extracts of guarumo leaf can lower blood pressure when administered intravenously to rats. Theoretically, concomitant use of antihypertensive drugs with guarumo might enhance therapeutic effects and increase the risk of hypotension. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: guarumo may gently nudge your blood pressure down. We know acetazolamide (Diamox) mostly for glaucoma, altitude sickness, and fluid buildup, but because it makes you lose fluid like a mild water pill, it can also lower blood pressure a bit. Stack guarumo on top, and the two could add up. You might notice lightheadedness, dizziness when you stand, or feeling more tired than usual.

That said, this caution rests only on animal lab studies, so it's more theoretical than proven. A casual cup of leaf tea is unlikely to cause trouble for most folks, while concentrated supplement doses are a bigger question mark. Before combining them, check with your pharmacist or doctor, especially if you already run on the low side.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Vidrio, H., Garcia-Marquez, F., Reyes, J., and Soto, R. M. Hypotensive activity of Cecropia obtusifolia. J Pharm Sci 1982;71:475-76. PubMed
  2. Salas, I., Brenes, J. R., and Morales, O. M. Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats. Rev Biol Trop 1987;35(1):127-30.
  3. Salas, I. G., Morales, O. M., and Brenes, J. R. Effect of chronic administration of Cecropia obtusifolia (Moraceae) on mean arterial pressure in rats. Rev Biol Trop 1987;35(2):359-62.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Guarumo Also Interacts With Other Medications

Guarumo has 504 moderate known drug interactions in our database — the Acetazolamide one above is among them. If you take anything else, check it against the full list below.

Moderate 504 No known interaction 2,326 (incl. Acetazolamide)
Taking anything else?

Check Another of Your Medications Against Guarumo

Covers the 2,830 medications we’ve checked against Guarumo. Pick one to open its full report.

From our Q&A

Questions About Guarumo or Acetazolamide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Guarumo or Acetazolamide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Acetazolamide

This page covers Guarumo only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetazolamide page lists 284 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Hellebore (major), American Mistletoe (major) and Asarabacca (major).

By severity: 15 major · 242 moderate · 27 minor.

From our pharmacist’s overview on the Acetazolamide page

“Acetazolamide, taken for glaucoma, altitude sickness, and certain seizure types, works partly as a diuretic and can make people drowsy, and most of the supplements that interact with it press on one of those two points. The biggest group adds to its blood-pressure and fluid effects, a second deepens sedation (alcohol and kava sit at th…”

Reviewed by 2 · Jul 18, 2026

Open the Acetazolamide interaction page

How much people look this up

Where Guarumo and Acetazolamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Guarumo
Steady interest

#846 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetazolamide
Top 25%

#448 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Guarumo

What is Guarumo?

Guarumo
  • Type 2 diabetes / blood sugar support
  • High blood pressure
  • Cough, asthma, and bronchitis
  • Heart failure symptoms
  • Liver and rheumatic complaints

Guarumo (Cecropia obtusifolia) is a tropical tree used in Latin American traditional medicine, most often as a leaf tea for diabetes and high blood pressure. Some early laboratory and small human studies suggest it may modestly affect blood sugar, but the evidence is limited and not strong enough to recommend it as a treatment. Talk with your pharmacist or doctor before using it, especially if you have a chronic condition or take medication.

Read the full Guarumo monograph & all interactions
Medication

About Acetazolamide

What Is Acetazolamide Used For?

Brand names: Diamox, Ak-Zol

Acetazolamide is used as an add-on (adjunctive) treatment. Across products, it is used for glaucoma, which is high pressure inside the eye.

Some products have more uses. Acetazolamide tablets and Acetazolamide injection are also used for swelling (edema) from congestive heart failure, drug-induced edema, and certain epilepsies (petit mal and unlocalized seizures). Acute mountain sickness prevention is listed for the tablets, the extended-release capsules, and one of the injection labels, but not every injection product.

See full Acetazolamide drug information
Keep checking

Other Drugs & Guarumo

Browse every other medication we’ve checked against Guarumo — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
504Moderate
0Minor
2,325No known interaction
504 Moderate 2,325 No interaction
Moderate

504 interactions

Showing 60 of 504 moderate interactions — see all 504 on the Guarumo page.

No interaction 2,325 drugs checked — show the list

We also checked Guarumo against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,325 medications checked with no known interaction — see the full Guarumo list.

See the full Guarumo interactions page
See every supplement checked against Acetazolamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Guarumo monograph › Uses, safety, and every drug interaction in one place Acetazolamide supplement interactions › Every supplement checked against Acetazolamide, ranked by severity Acetazolamide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Guarumo and Acetazolamide Together: Common Questions

Can you take Guarumo with Acetazolamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Guarumo and Acetazolamide?
Acetazolamide belongs to more than one drug category, and Guarumo interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Guarumo and Acetazolamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetazolamide and Guarumo?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.