Medication interaction hub

What Supplements Interact with Hydrochlorothiazide?

Hydrochlorothiazide brand names: Esidrix, Hydro, Microzide, HydroDiuril, Hydro-D, and others. Every interaction below applies to the brands too.

230 Interactions 10 Major 195 Moderate 25 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Hydrochlorothiazide sits at the strong end of the caution scale for supplement interactions, and the small group of major-rated entries deserves a careful read before everything else on the page. Most of what appears here either adds to the pill's blood-pressure-lowering effect or piles onto its diuretic action, pushing fluid and potassium balance further than intended. A smaller cluster raises sensitivity to sunlight, and a handful can stress the kidneys. Even plain calcium matters, since thiazides make the body hold onto calcium and large supplemental doses can drive levels dangerously high.

Activated charcoal works the opposite way, soaking up the medication in the gut so less of it reaches the bloodstream. All told, 230 ingredients are on file, and though 195 rate moderate and 25 minor, the ten majors are what set the tone here.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 195 Minor 25 No known interaction 1,222

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrochlorothiazide: Top Interactions at a Glance

The Hydrochlorothiazide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 230 interacting ingredients — plus 1,222 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrochlorothiazide Combinations Today

The Hydrochlorothiazide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Berberine + Hydrochlorothiazidei

Theoretically, berberine might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Flaxseed Oil + Hydrochlorothiazidei

Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Theanine + Hydrochlorothiazidei

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.

Read the full interaction Moderate Likelihood Probable Fish Oil + Hydrochlorothiazidei

Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Reishi Mushroom + Hydrochlorothiazidei

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Hydrochlorothiazidei

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide

All 1,452 ingredients in our database, ranked by severity — 230 with a Hydrochlorothiazide interaction on file and 1,222 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Berberine with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might have additive effects with antihypertensive drugs.

Full Berberine + Hydrochlorothiazide answer

Can you take Flaxseed Oil with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.

Full Flaxseed Oil + Hydrochlorothiazide answer

Can you take Theanine with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.

Full Theanine + Hydrochlorothiazide answer

Can you take Fish Oil with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fish oil with antihypertensive drugs might increase the risk of hypotension.

Full Fish Oil + Hydrochlorothiazide answer

Can you take Reishi Mushroom with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Full Reishi Mushroom + Hydrochlorothiazide answer

Can you take Horny Goat Weed with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the risk of hypotension.

Full Horny Goat Weed + Hydrochlorothiazide answer

Can you take Horsetail with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.

Full Horsetail + Hydrochlorothiazide answer

Can you take Ilex Guayusa with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk of hypokalemia.

Full Ilex Guayusa + Hydrochlorothiazide answer

Can you take Indian Cassia with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian cassia might increase the risk of potassium depletion in patients taking diuretic drugs.

Full Indian Cassia + Hydrochlorothiazide answer

Can you take Indian Snakeroot with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Indian snakeroot and antihypertensive drugs might increase the risk of hypotension.

Full Indian Snakeroot + Hydrochlorothiazide answer

Can you take Isopropylnorsynephrine with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, isopropylnorsynephrine might decrease the effects of antihypertensive drugs.

Full Isopropylnorsynephrine + Hydrochlorothiazide answer

Can you take Jalap with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Jalap has diuretic effects.

Full Jalap + Hydrochlorothiazide answer

Can you take Khat with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Human research shows that khat and its constituent, cathinone, can increase blood pressure.

Full Khat + Hydrochlorothiazide answer

Can you take Khella with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Khella + Hydrochlorothiazide answer

Can you take Kiwi with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals.

Full Kiwi + Hydrochlorothiazide answer

Can you take Korean Pine with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that Korean pine nut oil reduces blood pressure in spontaneously hypertensive rats.

Full Korean Pine + Hydrochlorothiazide answer

Can you take L-citrulline with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotensio...

Full L-citrulline + Hydrochlorothiazide answer

Can you take Licorice with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might reduce the effects of antihypertensive drugs.

Full Licorice + Hydrochlorothiazide answer

Can you take Light Therapy with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Light therapy may increase the risk for photosensitization.

Full Light Therapy + Hydrochlorothiazide answer

Can you take Lily-of-the-valley with Hydrochlorothiazide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using lily-of-the-valley with diuretics can increase the risk of cardiac glycoside toxicity.

Full Lily-of-the-valley + Hydrochlorothiazide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide sits in 8 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide through this category.

About Hydrochlorothiazide

Hydrochlorothiazide is a diuretic ('water pill') used to treat high blood pressure and fluid retention.

Generic name: Hydrochlorothiazide  ·  Brand names: Esidrix, Hydro, Microzide, HydroDiuril, Hydro-D, Oretic, Aquazide H, Aquazide, HCTZ.

See the full Hydrochlorothiazide drug information

Related: does Hydrochlorothiazide deplete any nutrients?

Hydrochlorothiazide has 81 reported nutrient associations in the research literature — see the Hydrochlorothiazide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide.

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Pharmacist Counseling Corner

Hydrochlorothiazide & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide?
Our database currently documents 230 ingredients with a known Hydrochlorothiazide interaction (10 major, 195 moderate, 25 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 230. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydrochlorothiazide supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide?
Plenty of supplements coexist fine with Hydrochlorothiazide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Esidrix have the same supplement interactions as Hydrochlorothiazide?
Yes — Esidrix, Hydro, Microzide, HydroDiuril, Hydro-D and other brands all contain Hydrochlorothiazide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide deplete any vitamins or nutrients?
It might — Hydrochlorothiazide has 81 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide and my other medications?
This page covers Hydrochlorothiazide against supplements and herbal ingredients. Checking Hydrochlorothiazide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Hydrochlorothiazide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.