Drug & supplement interaction

Alpha-alanine + Hydrochlorothiazide

Hydrochlorothiazide brand names: Esidrix, Hydro, Microzide, HydroDiuril, Hydro-D, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Alpha-alanine and Hydrochlorothiazide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Alpha-alanine and Hydrochlorothiazide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydrochlorothiazide and Alpha-alanine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Alpha-alanine at all — not against Hydrochlorothiazide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Alpha-alanine safety at a glance

Alpha-alanine overall Use caution Likely fine in food amounts, but supplement safety and benefits are not well studied.
Pregnancy Likely Safe When used in amounts commonly found in foods. There is insufficient reliable information available about the safety of using larger amounts as medicine during p... Read the full pregnancy detail
Breastfeeding Likely Safe When used in amounts commonly found in foods. There is insufficient reliable information available about the safety of using larger amounts as medicine during p... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydrochlorothiazide and Alpha-alanine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Hydrochlorothiazide’s Own FDA Label Lists

This is not an interaction — none of it involves Alpha-alanine. These are the most notable effects listed in the ADVERSE REACTIONS section of Hydrochlorothiazide’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • An electrolyte imbalance Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • High blood sugar Worth acting on
  • A severe skin reaction Worth acting on
  • Shortness of breath Worth acting on mentioned in 5.0% of FDA reports for Hydrochlorothiazide
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Hives Worth acting on

Showing the 10 most notable of 30 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide. Read the label on DailyMed › Where a percentage is shown, it is the share of 209,395 voluntary FDA FAERS reports for Hydrochlorothiazide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Alpha-alanine’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Alpha-alanine side to compare — that is a limit of the record, not a statement that Alpha-alanine has no side effects.

Special populations

Alpha-alanine in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used in amounts commonly found in foods. There is insufficient reliable information available about the safety of using larger amounts as medicine during pregnancy or lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Alpha-alanine or Hydrochlorothiazide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Alpha-alanine or Hydrochlorothiazide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide

This page covers Alpha-alanine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide page lists 230 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 195 moderate · 25 minor.

From our pharmacist’s overview on the Hydrochlorothiazide page

“Hydrochlorothiazide sits at the strong end of the caution scale for supplement interactions, and the small group of major-rated entries deserves a careful read before everything else on the page. Most of what appears here either adds to the pill's blood-pressure-lowering effect or piles onto its diuretic action, pushing fluid and potas…”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide interaction page

How much people look this up

Where Alpha-alanine and Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alpha-alanine
Steady interest

#1,038 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide
Top 25%

#522 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Alpha-alanine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpha-alanine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Alpha-alanine and Hydrochlorothiazide records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Alpha-alanine

What is Alpha-alanine?

Alpha-alanine
  • Sports and exercise support
  • Blood sugar balance
  • General amino acid supplementation
  • Energy and metabolism support

Alpha-alanine (usually called alanine) is a non-essential amino acid your body can make on its own and that you also get from protein foods. Most people do not need a supplement, and strong human evidence for any specific health benefit is limited. If you are considering it, talk with your pharmacist or doctor first.

Amino acid (made by the body and found in protein-rich foods) · Capsules, tablets, powders, and as part of amino acid blends and protein supplements

An interaction check asks whether these two react with each other — it does not ask whether Alpha-alanine is a good idea for someone in your situation. Here is what our Alpha-alanine record says about it on its own.

Alpha-alanine: dosing

There is no well-established standard supplement dose of alanine for any specific health goal. The amount people get from a normal diet varies and is usually enough.If you choose to use an alanine supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Alpha-alanine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Alpha-alanine monograph & all interactions
Medication

About Hydrochlorothiazide

What Is Hydrochlorothiazide Used For?

Brand names: Esidrix, Hydro, Microzide, HydroDiuril, Hydro-D, Oretic, Aquazide H, Aquazide, HCTZ

Hydrochlorothiazide treats high blood pressure (hypertension) in adults and children, either alone or combined with other blood pressure medicines. Lowering blood pressure reduces the risk of strokes and heart attacks. The capsule form is indicated specifically for hypertension management.

It also treats edema (fluid buildup) associated with congestive heart failure, liver cirrhosis, and kidney diseases including nephrotic syndrome. The tablet form is additionally indicated for edema caused by corticosteroid and estrogen therapy, as well as conditions such as acute glomerulonephritis and chronic renal failure. Inzirqo (the oral suspension) is indicated for both hypertension and edema in adult and pediatric patients.

Most-Reported Side Effects for Hydrochlorothiazide

From FAERS, the FDA’s public side-effect reporting system (209,395 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 13,772 reports
Nausea 13,724 reports
Diarrhea 11,763 reports
Dizziness 11,243 reports
Headache 10,766 reports
See full Hydrochlorothiazide drug information
Keep checking

Other Drugs & Alpha-alanine

Browse every other medication we’ve checked against Alpha-alanine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Alpha-alanine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Alpha-alanine list.

See the full Alpha-alanine interactions page
See every supplement checked against Hydrochlorothiazide, ranked by severity
Evidence & sources

Alpha-alanine References

The 2 sources that drive our Alpha-alanine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Alpha-alanine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Amino acids — MedlinePlus (NIH) Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Alpha-alanine and Hydrochlorothiazide Together: Common Questions

Is it safe to take Alpha-alanine with Hydrochlorothiazide?
We do not list a known interaction between Alpha-alanine and Hydrochlorothiazide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Hydrochlorothiazide interact with any supplements?
Yes. Hydrochlorothiazide has documented interactions with 230 supplements in our database — Alpha-alanine is not one of them. The Hydrochlorothiazide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Alpha-alanine monograph Uses, safety profile, and every drug interaction in one place Hydrochlorothiazide drug information The full plain-English guide to this medication Hydrochlorothiazide supplement interactions Every supplement checked against Hydrochlorothiazide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hydrochlorothiazide and Alpha-alanine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.