Herb & supplement monograph

Laurelwood Drug Interactions, Uses, Safety & More

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Interaction report

Drugs that interact with Laurelwood

0 medications have a known interaction with Laurelwood, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Laurelwood. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Laurelwood combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Laurelwood: Uses, Safety & Side Effects

The bottom line

Laurelwood, the source of tamanu oil, is a tropical tree whose seed oil is used mainly on the skin for moisturizing, soothing irritation, and supporting wound healing. Most evidence is preliminary or based on laboratory studies, and it is meant for external use only. Talk to a pharmacist or doctor before using it, and avoid swallowing the oil.

Scientific name
Calophyllum inophyllum
Family
Calophyllaceae
Part used
Seeds (pressed into oil), and at times the bark and leaves
Common forms
Tamanu oil (cold-pressed seed oil), creams, balms, and topical skincare products
People commonly use it for
  • Skin care and moisturizing
  • Minor wounds and scars
  • Acne-prone skin
  • Dry or irritated skin
  • Soothing minor burns or insect bites

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally used on the skin only; it can cause allergic reactions and should not be swallowed.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Laurelwood is a tropical evergreen tree (Calophyllum inophyllum) that grows along coastlines and in islands across the Pacific, Southeast Asia, parts of Africa, and other warm regions. It is best known as the source of tamanu oil, which is pressed from the tree's seeds.

The seeds are dried and then cold-pressed to make a thick, greenish oil with a distinctive nutty smell. People have used this oil in traditional island medicine for many generations, mostly applied directly to the skin.

Today, laurelwood (tamanu) oil is most often found in skincare products such as creams, balms, and facial oils. It is marketed for moisturizing, soothing irritated skin, and supporting the healing of minor wounds and scars.

Uses & effectiveness

People mainly use laurelwood (tamanu) oil on the skin. Traditional and popular uses include moisturizing dry skin, calming irritation, helping minor cuts and scrapes heal, reducing the look of scars, and managing acne-prone skin.

The scientific evidence is limited and mostly preliminary. Laboratory and a few small studies suggest the oil may have antioxidant, anti-inflammatory, and wound-supporting properties. However, there are very few high-quality human trials, so we cannot say with confidence how well it works for any specific condition.

In short, laurelwood oil is a popular folk remedy with some promising lab findings, but strong human evidence is lacking. It should not replace proven treatments for skin conditions, infections, or wounds.

How it works

Laurelwood seed oil contains a mix of fatty acids, plant compounds called coumarins and xanthones, and antioxidants. Researchers believe these compounds may help calm inflammation, fight certain microbes, and protect skin cells from damage.

The oil's fatty acids may also help support the skin's natural moisture barrier, which could explain why it feels soothing and moisturizing.

It is important to know that most of this information comes from laboratory and animal research, not large human studies. So while the proposed mechanisms are reasonable, they have not been firmly proven in people.

Safety & precautions

Laurelwood (tamanu) oil is intended for external (skin) use only. It should not be swallowed. The seeds and oil are not considered a food.

People with nut allergies or sensitive skin should be especially careful, since allergic reactions are possible. It is wise to do a small patch test on the inner forearm before applying it more widely, and to stop using it if redness, itching, or a rash develops.

Because reliable safety data are limited, pregnant and breastfeeding people should use caution and check with a doctor or pharmacist first. If you are nursing, keep the oil away from the nipple and any area the baby may contact. Keep all products out of reach of children.

If you have a skin condition, infection, or a wound that is not healing, see a healthcare professional rather than relying on the oil alone.

Side effects

When applied to the skin, laurelwood oil is usually well tolerated. The most common problems are skin irritation, redness, itching, or an allergic rash (contact dermatitis), especially in people with sensitive skin or nut allergies.

Serious allergic reactions are rare but possible. Stop using the product and seek medical help if you notice swelling, trouble breathing, or a widespread rash.

Swallowing the oil is not recommended and could cause stomach upset or other harm, since it is not meant to be eaten.

Laurelwood: Reported Adverse Effects

Documented safety reports on Laurelwood from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

There is currently a limited amount of information available about the adverse effects of laurelwood. Orally, calanolide A, a constituent of laurelwood, has been reported to cause an oily aftertaste, nausea, dizziness, and headache. Topically, tamanu oil from the laurelwood nut has been reported to cause allergic contact dermatitis.

  1. Reuters Health. Anti-HIV herbal product shows therapeutic potential in phase I trial. November 1, 1999.
  2. Oku, H., Ueda, Y., Iinuma, M., and Ishiguro, K. Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice. Planta Med 2005;71(1):90-92.
Reports by condition
Cluster headache Neurologic/CNS

Orally, the use of calanolide A, a laurelwood constituent, can cause dizziness and headache.

  1. Reuters Health. Anti-HIV herbal product shows therapeutic potential in phase I trial. November 1, 1999.
Dermatitis Immunologic

Topically, there is one case report of allergic contact dermatitis related to the use of tamanu oil from the nut of laurelwood.

  1. Le Coz, C. J. Allergic contact dermatitis from tamanu oil (Calophyllum inophyllum, Calophyllum tacamahaca). Contact Dermatitis 2004;51(4):216-217.
Nausea and vomiting Gastrointestinal

Orally, the use of calanolide A, a laurelwood constituent, can cause an oily aftertaste and nausea.

  1. Reuters Health. Anti-HIV herbal product shows therapeutic potential in phase I trial. November 1, 1999.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official or standardized dose for laurelwood (tamanu) oil. It is used topically, and the amount depends on the product and the area being treated.

The safest approach is to follow the directions on the product label and to start with a small amount on a small area. A patch test first can help you check for irritation.

Because formulations and quality vary widely, ask your pharmacist or doctor before starting, especially if you have allergies, sensitive skin, or a skin condition.

Pregnancy & Breastfeeding

Laurelwood & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Laurelwood & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 3 references that drive our Laurelwood monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Reuters Health. Anti-HIV herbal product shows therapeutic potential in phase I trial. November 1, 1999.
  2. Le Coz, C. J. Allergic contact dermatitis from tamanu oil (Calophyllum inophyllum, Calophyllum tacamahaca). Contact Dermatitis 2004;51(4):216-217. PubMed
  3. Oku, H., Ueda, Y., Iinuma, M., and Ishiguro, K. Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice. Planta Med 2005;71(1):90-92. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Laurelwood: Common Questions

Does Laurelwood interact with prescription medications?
We do not currently list any known drug interactions for Laurelwood. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Laurelwood interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Laurelwood with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Laurelwood interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Laurelwood oil used for?
It is used mainly on the skin to moisturize, soothe irritation, support healing of minor wounds and scars, and help with acne-prone or dry skin. Most of these uses come from tradition and early research rather than strong human studies.
Is Laurelwood (tamanu) oil safe to use?
For most people it is reasonably safe when applied to the skin, but it can cause irritation or allergic reactions, especially in those with nut allergies. It should never be swallowed, and a small patch test is a good idea before regular use.
Can I use Laurelwood oil while pregnant or breastfeeding?
There is not enough reliable safety information, so it is best to use caution and talk to your doctor first. If you are nursing, keep the oil away from the nipple and any area your baby might touch.
Can Laurelwood oil be taken by mouth?
No. Tamanu oil from Laurelwood is meant for external use only and should not be swallowed, as it is not a food and could cause harm.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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