Laurelwood Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Laurelwood interacts with medications. The heart of this page is the interaction list — every drug Laurelwood is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Laurelwood is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Laurelwood against your medication
Add one medicationDrugs that interact with Laurelwood
0 medications have a known interaction with Laurelwood, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Laurelwood. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Laurelwood combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Laurelwood: Uses, Safety & Side Effects
Laurelwood, the source of tamanu oil, is a tropical tree whose seed oil is used mainly on the skin for moisturizing, soothing irritation, and supporting wound healing. Most evidence is preliminary or based on laboratory studies, and it is meant for external use only. Talk to a pharmacist or doctor before using it, and avoid swallowing the oil.
- Scientific name
- Calophyllum inophyllum
- Family
- Calophyllaceae
- Part used
- Seeds (pressed into oil), and at times the bark and leaves
- Common forms
- Tamanu oil (cold-pressed seed oil), creams, balms, and topical skincare products
- Skin care and moisturizing
- Minor wounds and scars
- Acne-prone skin
- Dry or irritated skin
- Soothing minor burns or insect bites
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally used on the skin only; it can cause allergic reactions and should not be swallowed.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Laurelwood is a tropical evergreen tree (Calophyllum inophyllum) that grows along coastlines and in islands across the Pacific, Southeast Asia, parts of Africa, and other warm regions. It is best known as the source of tamanu oil, which is pressed from the tree's seeds.
The seeds are dried and then cold-pressed to make a thick, greenish oil with a distinctive nutty smell. People have used this oil in traditional island medicine for many generations, mostly applied directly to the skin.
Today, laurelwood (tamanu) oil is most often found in skincare products such as creams, balms, and facial oils. It is marketed for moisturizing, soothing irritated skin, and supporting the healing of minor wounds and scars.
Uses & effectiveness
People mainly use laurelwood (tamanu) oil on the skin. Traditional and popular uses include moisturizing dry skin, calming irritation, helping minor cuts and scrapes heal, reducing the look of scars, and managing acne-prone skin.
The scientific evidence is limited and mostly preliminary. Laboratory and a few small studies suggest the oil may have antioxidant, anti-inflammatory, and wound-supporting properties. However, there are very few high-quality human trials, so we cannot say with confidence how well it works for any specific condition.
In short, laurelwood oil is a popular folk remedy with some promising lab findings, but strong human evidence is lacking. It should not replace proven treatments for skin conditions, infections, or wounds.
How it works
Laurelwood seed oil contains a mix of fatty acids, plant compounds called coumarins and xanthones, and antioxidants. Researchers believe these compounds may help calm inflammation, fight certain microbes, and protect skin cells from damage.
The oil's fatty acids may also help support the skin's natural moisture barrier, which could explain why it feels soothing and moisturizing.
It is important to know that most of this information comes from laboratory and animal research, not large human studies. So while the proposed mechanisms are reasonable, they have not been firmly proven in people.
Safety & precautions
Laurelwood (tamanu) oil is intended for external (skin) use only. It should not be swallowed. The seeds and oil are not considered a food.
People with nut allergies or sensitive skin should be especially careful, since allergic reactions are possible. It is wise to do a small patch test on the inner forearm before applying it more widely, and to stop using it if redness, itching, or a rash develops.
Because reliable safety data are limited, pregnant and breastfeeding people should use caution and check with a doctor or pharmacist first. If you are nursing, keep the oil away from the nipple and any area the baby may contact. Keep all products out of reach of children.
If you have a skin condition, infection, or a wound that is not healing, see a healthcare professional rather than relying on the oil alone.
Side effects
When applied to the skin, laurelwood oil is usually well tolerated. The most common problems are skin irritation, redness, itching, or an allergic rash (contact dermatitis), especially in people with sensitive skin or nut allergies.
Serious allergic reactions are rare but possible. Stop using the product and seek medical help if you notice swelling, trouble breathing, or a widespread rash.
Swallowing the oil is not recommended and could cause stomach upset or other harm, since it is not meant to be eaten.
Laurelwood: Reported Adverse Effects
Documented safety reports on Laurelwood from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
There is currently a limited amount of information available about the adverse effects of laurelwood. Orally, calanolide A, a constituent of laurelwood, has been reported to cause an oily aftertaste, nausea, dizziness, and headache. Topically, tamanu oil from the laurelwood nut has been reported to cause allergic contact dermatitis.
- Reuters Health. Anti-HIV herbal product shows therapeutic potential in phase I trial. November 1, 1999.
- Oku, H., Ueda, Y., Iinuma, M., and Ishiguro, K. Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice. Planta Med 2005;71(1):90-92.
Cluster headache Neurologic/CNS
Orally, the use of calanolide A, a laurelwood constituent, can cause dizziness and headache.
- Reuters Health. Anti-HIV herbal product shows therapeutic potential in phase I trial. November 1, 1999.
Dermatitis Immunologic
Topically, there is one case report of allergic contact dermatitis related to the use of tamanu oil from the nut of laurelwood.
Nausea and vomiting Gastrointestinal
Orally, the use of calanolide A, a laurelwood constituent, can cause an oily aftertaste and nausea.
- Reuters Health. Anti-HIV herbal product shows therapeutic potential in phase I trial. November 1, 1999.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no official or standardized dose for laurelwood (tamanu) oil. It is used topically, and the amount depends on the product and the area being treated.
The safest approach is to follow the directions on the product label and to start with a small amount on a small area. A patch test first can help you check for irritation.
Because formulations and quality vary widely, ask your pharmacist or doctor before starting, especially if you have allergies, sensitive skin, or a skin condition.
Laurelwood & Pregnancy
Laurelwood & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 3 references that drive our Laurelwood monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Reuters Health. Anti-HIV herbal product shows therapeutic potential in phase I trial. November 1, 1999.
- Le Coz, C. J. Allergic contact dermatitis from tamanu oil (Calophyllum inophyllum, Calophyllum tacamahaca). Contact Dermatitis 2004;51(4):216-217. PubMed
- Oku, H., Ueda, Y., Iinuma, M., and Ishiguro, K. Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice. Planta Med 2005;71(1):90-92. PubMed
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Laurelwood: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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