Drug & supplement interaction

Jojoba + Hydrochlorothiazide

Hydrochlorothiazide brand names: Esidrix, Hydro, Microzide, HydroDiuril, Hydro-D, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Jojoba and Hydrochlorothiazide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Jojoba and Hydrochlorothiazide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydrochlorothiazide and Jojoba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Jojoba at all — not against Hydrochlorothiazide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jojoba safety at a glance

Jojoba overall Use caution Generally safe applied to the skin, but jojoba should not be taken by mouth.
Pregnancy Use caution Topical use is likely low risk, but avoid swallowing it and check with your doctor first.
Breastfeeding Likely Safe When used topically for hygienic uses. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydrochlorothiazide and Jojoba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Jojoba and Hydrochlorothiazide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Jojoba

    “Side effects of jojoba are mainly limited to contact dermatitis and gastrointestinal concerns in animals fed large amounts of jojoba meal.”

    Jojoba · Natural Medicines adverse-effect record, reported in dermatitis.

    “Contact dermatitis to jojoba oil has been described in case reports.”

    Jojoba · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 57197. Wantke, F., Hemmer, W., Gotz, M., and Jarisch, R. Contact dermatitis from jojoba oil and myristyl lactate/maleated soybean oil. Contact Dermatitis 1996;34(1):71-72. PubMed
    2. 57186. Di Berardino, L., Di Berardino, F., Castelli, A., and Della, Torre F. A case of contact dermatitis from jojoba. Contact Dermatitis 2006;55(1):57-58. PubMed

    Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide. Read the label on DailyMed ›

Effects for Hydrochlorothiazide come from the ADVERSE REACTIONS section of its FDA label; effects for Jojoba come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 209,395 voluntary FDA FAERS reports for Hydrochlorothiazide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Jojoba in Pregnancy & Breastfeeding

Lactation Likely Safe

When used topically for hygienic uses.

Lactation Likely Unsafe

When used orally.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Jojoba or Hydrochlorothiazide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Jojoba or Hydrochlorothiazide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide

This page covers Jojoba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide page lists 230 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 195 moderate · 25 minor.

From our pharmacist’s overview on the Hydrochlorothiazide page

“Hydrochlorothiazide sits at the strong end of the caution scale for supplement interactions, and the small group of major-rated entries deserves a careful read before everything else on the page. Most of what appears here either adds to the pill's blood-pressure-lowering effect or piles onto its diuretic action, pushing fluid and potas…”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide interaction page

One more smart check

Taking Jojoba as Part of a Dietary Supplement Product? Check It for Interactions

We hold 7 real supplement products containing Jojoba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Jojoba. Even though Jojoba itself has no known interaction with Hydrochlorothiazide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Jojoba and Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jojoba
Steady interest

#1,128 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide
Top 25%

#522 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jojoba reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Jojoba and Hydrochlorothiazide records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jojoba

What is Jojoba?

  • Skin moisturizer
  • Hair and scalp care
  • Acne-prone skin
  • Soothing dry or irritated skin
  • Carrier oil for essential oils

Jojoba is an oil-like wax pressed from the seeds of a desert shrub, used mainly on the skin and hair as a moisturizer and carrier oil. It is generally well tolerated when applied to the skin, but it should not be swallowed. Talk with your pharmacist or doctor before using it for any specific skin condition.

Simmondsia chinensis · Simmondsiaceae · Seeds (pressed into oil/wax) · Oil (liquid wax), creams, lotions, hair products, soaps

An interaction check asks whether these two react with each other — it does not ask whether Jojoba is a good idea for someone in your situation. Here is what our Jojoba record says about it on its own.

Jojoba: dosing

There is no established medical dose for jojoba because it is used on the skin and hair, not taken by mouth. The right amount depends on the product and how you are using it.Follow the directions on the product label, and use only enough to lightly cover the area you are treating. If you are using it as a carrier oil, mix it with essential oils as directed.

From our Jojoba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jojoba monograph & all interactions
Medication

About Hydrochlorothiazide

What Is Hydrochlorothiazide Used For?

Brand names: Esidrix, Hydro, Microzide, HydroDiuril, Hydro-D, Oretic, Aquazide H, Aquazide, HCTZ

Hydrochlorothiazide treats high blood pressure (hypertension) in adults and children, either alone or combined with other blood pressure medicines. Lowering blood pressure reduces the risk of strokes and heart attacks. The capsule form is indicated specifically for hypertension management.

It also treats edema (fluid buildup) associated with congestive heart failure, liver cirrhosis, and kidney diseases including nephrotic syndrome. The tablet form is additionally indicated for edema caused by corticosteroid and estrogen therapy, as well as conditions such as acute glomerulonephritis and chronic renal failure. Inzirqo (the oral suspension) is indicated for both hypertension and edema in adult and pediatric patients.

Most-Reported Side Effects for Hydrochlorothiazide

From FAERS, the FDA’s public side-effect reporting system (209,395 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 13,772 reports
Nausea 13,724 reports
Diarrhea 11,763 reports
Dizziness 11,243 reports
Headache 10,766 reports
See full Hydrochlorothiazide drug information
Keep checking

Other Drugs & Jojoba

Browse every other medication we’ve checked against Jojoba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Jojoba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Jojoba list.

See the full Jojoba interactions page
See every supplement checked against Hydrochlorothiazide, ranked by severity
Evidence & sources

Jojoba References

The 6 references that drive our Jojoba monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Govere J, Durrheim DN, Baker L, et al. Efficacy of three insect repellents against the malaria vector Anopheles arabiensis. Med Vet Entomol 2000;14:441-4.
  3. Lee, S. Y. [The effect of lavender aromatherapy on cognitive function, emotion, and aggressive behavior of elderly with dementia]. Taehan Kanho Hakhoe Chi 2005;35(2):303-312.
  4. Di Berardino, L., Di Berardino, F., Castelli, A., and Della, Torre F. A case of contact dermatitis from jojoba. Contact Dermatitis 2006;55(1):57-58. PubMed
  5. Wantke, F., Hemmer, W., Gotz, M., and Jarisch, R. Contact dermatitis from jojoba oil and myristyl lactate/maleated soybean oil. Contact Dermatitis 1996;34(1):71-72. PubMed
  6. Meier L, Stange R, Michalsen A, Uehleke B. Clay jojoba oil facial mask for lesioned skin and mild acne - results of a prospective observational pilot study. Forsch Komplementmed 2012;19(2):75-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jojoba and Hydrochlorothiazide Together: Common Questions

Is it safe to take Jojoba with Hydrochlorothiazide?
We do not list a known interaction between Jojoba and Hydrochlorothiazide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Jojoba and Hydrochlorothiazide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Hydrochlorothiazide interact with any supplements?
Yes. Hydrochlorothiazide has documented interactions with 230 supplements in our database — Jojoba is not one of them. The Hydrochlorothiazide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jojoba monograph Uses, safety profile, and every drug interaction in one place Hydrochlorothiazide drug information The full plain-English guide to this medication Hydrochlorothiazide supplement interactions Every supplement checked against Hydrochlorothiazide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hydrochlorothiazide and Jojoba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.