Greater Burnet Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Greater Burnet interacts with medications. The heart of this page is the interaction list — every drug Greater Burnet is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Greater Burnet is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Greater Burnet against your medication
Add one medicationDrugs that interact with Greater Burnet
0 medications have a known interaction with Greater Burnet, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Greater Burnet. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Greater Burnet combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Greater Burnet: Uses, Safety & Side Effects
Greater Burnet (Sanguisorba officinalis) is a traditional herb whose tannin-rich root has long been used for diarrhea, minor bleeding, and skin problems. Modern human evidence for these uses is very limited, so it should not replace proven treatments. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.
- Scientific name
- Sanguisorba officinalis
- Family
- Rosaceae
- Part used
- Root and rhizome (sometimes the leaves and aerial parts)
- Common forms
- Dried root, tea/decoction, tincture, powder, topical preparations
- Diarrhea and digestive upset
- Minor bleeding and wounds
- Burns and skin irritation (topical)
- Sore throat and mouth inflammation
- Hemorrhoids
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Generally used traditionally, but human safety data are limited and its high tannin content can cause stomach upset.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Greater Burnet is a flowering perennial plant known botanically as Sanguisorba officinalis, part of the rose family (Rosaceae). It grows in damp meadows and grasslands across Europe and Asia and has small, dark-red, button-like flower heads.
The part used most often in herbal medicine is the root and rhizome, which is rich in tannins. The Latin name Sanguisorba comes from words meaning "to soak up blood," reflecting its long folk use for stopping bleeding and treating wounds.
People have traditionally used Greater Burnet as a tea, tincture, powder, or topical preparation for digestive complaints, minor bleeding, burns, and skin problems. It has a history in both European and traditional East Asian herbal practice.
How it works
The most studied compounds in Greater Burnet are tannins and related polyphenols. Tannins are astringent, meaning they can bind to proteins and tighten tissues. This is the proposed reason behind its traditional use for diarrhea, minor bleeding, and skin irritation.
The plant also contains triterpenoid saponins (such as ziyuglycosides), flavonoids, and other antioxidant compounds. In laboratory tests, extracts have shown anti-inflammatory, antioxidant, and germ-fighting effects.
It is important to know that most of this information comes from test-tube and animal research. How well these mechanisms translate into real benefits for people is not well established.
Does Greater Burnet work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Greater Burnet, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Aging skin
It is unclear if topical greater burnet is beneficial for improving the appearance of aging skin.
Insufficient Reliable Evidence To Rate Varicose veins
Although there has been interest in using oral greater burnet for varicose veins, there is insufficient reliable information about the clinical effects of greater burnet for this purpose.
Insufficient Reliable Evidence To Rate Wound healing
Although there has been interest in using topical greater burnet for wound healing, there is insufficient reliable information about the clinical effects of greater burnet for this purpose.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
Greater Burnet has been used traditionally for a long time, but modern safety information is limited. Because the root is high in tannins, large amounts or long-term use may irritate the stomach and could affect how well your body absorbs some nutrients like iron.
People with stomach or bowel sensitivity, kidney problems, or those who are prone to constipation should be cautious. Always choose products from reputable manufacturers, since herbal products can vary in quality and strength.
Pregnancy: There is not enough reliable safety information, so Greater Burnet is best avoided during pregnancy.
Breastfeeding: Safety data are lacking, so avoid using it while breastfeeding.
Children, older adults, and people with chronic health conditions should speak with a pharmacist or doctor before use.
Side effects
When used in usual amounts, Greater Burnet is generally well tolerated, but it has not been carefully studied for safety. Possible side effects are mostly related to its tannin content.
- Stomach upset, nausea, or constipation, especially with strong preparations or long-term use.
- Mouth or throat irritation with concentrated rinses or gargles.
- Allergic reactions such as skin rash are possible, particularly with topical use.
If you notice a rash, trouble breathing, swelling, or any severe reaction, stop using it and seek medical care.
Dosing
There is no well-established standardized dose for Greater Burnet. Traditional use varies widely depending on the form (tea, tincture, powder, or topical) and the part of the plant.
Because reliable dosing studies are lacking, the safest approach is to follow the directions on the product label and not exceed the recommended amount. Avoid using it long-term without guidance.
Talk with your pharmacist or doctor before starting Greater Burnet, especially if you take other medicines or have a health condition. They can help you decide whether it is appropriate and what amount, if any, is reasonable.
Greater Burnet & Pregnancy
Greater Burnet & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 sources that drive our Greater Burnet monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.
- Herbs and Supplements — MedlinePlus Source
- About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Greater Burnet: Common Questions
What is Greater Burnet used for, and does it work?
Does Greater Burnet interact with prescription medications?
How are Greater Burnet interactions rated?
Is it safe to take Greater Burnet with my medications?
Where does this Greater Burnet interaction information come from?
What is Greater Burnet used for?
Is Greater Burnet safe to take?
Can I use Greater Burnet during pregnancy or while breastfeeding?
How is Greater Burnet usually taken?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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