Herb & supplement monograph

Greater Burnet Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Greater Burnet

0 medications have a known interaction with Greater Burnet, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Greater Burnet. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Greater Burnet combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Greater Burnet: Uses, Safety & Side Effects

The bottom line

Greater Burnet (Sanguisorba officinalis) is a traditional herb whose tannin-rich root has long been used for diarrhea, minor bleeding, and skin problems. Modern human evidence for these uses is very limited, so it should not replace proven treatments. Talk with your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Scientific name
Sanguisorba officinalis
Family
Rosaceae
Part used
Root and rhizome (sometimes the leaves and aerial parts)
Common forms
Dried root, tea/decoction, tincture, powder, topical preparations
People commonly use it for
  • Diarrhea and digestive upset
  • Minor bleeding and wounds
  • Burns and skin irritation (topical)
  • Sore throat and mouth inflammation
  • Hemorrhoids

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally used traditionally, but human safety data are limited and its high tannin content can cause stomach upset.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Greater Burnet is a flowering perennial plant known botanically as Sanguisorba officinalis, part of the rose family (Rosaceae). It grows in damp meadows and grasslands across Europe and Asia and has small, dark-red, button-like flower heads.

The part used most often in herbal medicine is the root and rhizome, which is rich in tannins. The Latin name Sanguisorba comes from words meaning "to soak up blood," reflecting its long folk use for stopping bleeding and treating wounds.

People have traditionally used Greater Burnet as a tea, tincture, powder, or topical preparation for digestive complaints, minor bleeding, burns, and skin problems. It has a history in both European and traditional East Asian herbal practice.

How it works

The most studied compounds in Greater Burnet are tannins and related polyphenols. Tannins are astringent, meaning they can bind to proteins and tighten tissues. This is the proposed reason behind its traditional use for diarrhea, minor bleeding, and skin irritation.

The plant also contains triterpenoid saponins (such as ziyuglycosides), flavonoids, and other antioxidant compounds. In laboratory tests, extracts have shown anti-inflammatory, antioxidant, and germ-fighting effects.

It is important to know that most of this information comes from test-tube and animal research. How well these mechanisms translate into real benefits for people is not well established.

Effectiveness

Does Greater Burnet work?

Evidence overview · 3 uses evaluated
3 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Greater Burnet, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Aging skin
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical greater burnet is beneficial for improving the appearance of aging skin.

Insufficient Reliable Evidence To Rate Varicose veins
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral greater burnet for varicose veins, there is insufficient reliable information about the clinical effects of greater burnet for this purpose.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical greater burnet for wound healing, there is insufficient reliable information about the clinical effects of greater burnet for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Greater Burnet has been used traditionally for a long time, but modern safety information is limited. Because the root is high in tannins, large amounts or long-term use may irritate the stomach and could affect how well your body absorbs some nutrients like iron.

People with stomach or bowel sensitivity, kidney problems, or those who are prone to constipation should be cautious. Always choose products from reputable manufacturers, since herbal products can vary in quality and strength.

Pregnancy: There is not enough reliable safety information, so Greater Burnet is best avoided during pregnancy.

Breastfeeding: Safety data are lacking, so avoid using it while breastfeeding.

Children, older adults, and people with chronic health conditions should speak with a pharmacist or doctor before use.

Side effects

When used in usual amounts, Greater Burnet is generally well tolerated, but it has not been carefully studied for safety. Possible side effects are mostly related to its tannin content.

  • Stomach upset, nausea, or constipation, especially with strong preparations or long-term use.
  • Mouth or throat irritation with concentrated rinses or gargles.
  • Allergic reactions such as skin rash are possible, particularly with topical use.

If you notice a rash, trouble breathing, swelling, or any severe reaction, stop using it and seek medical care.

Dosing

There is no well-established standardized dose for Greater Burnet. Traditional use varies widely depending on the form (tea, tincture, powder, or topical) and the part of the plant.

Because reliable dosing studies are lacking, the safest approach is to follow the directions on the product label and not exceed the recommended amount. Avoid using it long-term without guidance.

Talk with your pharmacist or doctor before starting Greater Burnet, especially if you take other medicines or have a health condition. They can help you decide whether it is appropriate and what amount, if any, is reasonable.

Pregnancy & Breastfeeding

Greater Burnet & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Greater Burnet & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 sources that drive our Greater Burnet monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Herbs and Supplements — MedlinePlus Source
  2. About Herbs, Botanicals & Other Products — Memorial Sloan Kettering Cancer Center Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Pharmacist Counseling Corner

Greater Burnet: Common Questions

What is Greater Burnet used for, and does it work?
People use Greater Burnet for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Greater Burnet interact with prescription medications?
We do not currently list any known drug interactions for Greater Burnet. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Greater Burnet interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Greater Burnet with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Greater Burnet interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Greater Burnet used for?
It is traditionally used for diarrhea and digestive upset, minor bleeding and wounds, burns, and skin or mouth irritation. Strong human evidence for these uses is limited.
Is Greater Burnet safe to take?
It has a long history of traditional use and is generally tolerated in usual amounts, but modern safety data are limited. Its high tannin content can cause stomach upset, so use it cautiously and check with a healthcare professional.
Can I use Greater Burnet during pregnancy or while breastfeeding?
No reliable safety information is available, so it is best to avoid it during pregnancy and breastfeeding.
How is Greater Burnet usually taken?
It is commonly used as a tea or decoction of the root, a tincture, a powder, or in topical preparations for the skin. Because there is no standard dose, follow the product label and ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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