Herb & supplement monograph

Trendione Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated June 2026
What is this page for?

First and foremost: how Trendione interacts with medications. The heart of this page is the interaction list — every drug Trendione is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Trendione is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Interaction report

Drugs that interact with Trendione

0 medications have a known interaction with Trendione, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Trendione. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Trendione combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Trendione: Uses, Safety & Side Effects

Medically reviewed by · Reviewed June 2026 ·
The bottom line

Trendione (also marketed as estra-4,9,11-trien-3,17-dione) is a synthetic anabolic steroid sold as a so-called "prohormone" or "designer steroid," not a natural herb or vitamin. It is not a legitimate dietary supplement, has not been proven safe in humans, and is linked to potentially serious side effects, including liver harm. We strongly advise against using it and recommend talking with your doctor or pharmacist.

Part used
Not applicable; Trendione is a synthetic steroid compound, not a plant part
Common forms
Capsules, tablets, oral powders (sold as a bodybuilding supplement)
People commonly use it for
  • Muscle building
  • Strength gains
  • Body recomposition
  • Athletic performance

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

This is a synthetic anabolic steroid with serious safety concerns and no established safe use.

PregnancyPossibly Unsafe

When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility,...

Read the full pregnancy detail
BreastfeedingPossibly Unsafe

When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility,...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Trendione is the common name for a synthetic steroid compound often listed on labels as estra-4,9,11-trien-3,17-dione or "tren-dione." Despite being sold in bottles that look like ordinary supplements, it is not an herb, vitamin, or food. It is a lab-made chemical that is closely related to anabolic steroids.

It has been marketed mainly to bodybuilders and athletes as a "prohormone" or "designer steroid," meaning it is meant to convert into or act like a powerful anabolic steroid once it is in the body. Products like this have appeared in muscle-building and "hardcore" sports supplements.

Because Trendione is a synthetic steroid rather than a true dietary ingredient, it sits in a gray legal and safety area. In many places, steroid-like prohormones have been restricted or pulled from the market.

How it works

Trendione is thought to act as a "prohormone" that the body may convert into an active anabolic steroid, or it may directly stimulate androgen (male hormone) receptors. Anabolic steroids work by telling muscle cells to build more protein, which can increase muscle size and strength.

These proposed mechanisms are based on the chemistry of related steroids and on laboratory reasoning, not on solid human studies of Trendione itself. Activating androgen pathways can also disrupt the body's own hormone balance and stress the liver, which is part of why these compounds are risky.

Effectiveness

Does Trendione work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 4 uses evaluated
4 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Trendione, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 4 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Athletic performance
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using trendione for athletic performance, there is insufficient reliable information about the clinical effects of trendione for this purpose.

Insufficient Reliable Evidence To Rate Exercise-induced muscle damage
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using trendione for muscle recovery after exercise, there is insufficient reliable information about the clinical effects of trendione for this purpose.

Insufficient Reliable Evidence To Rate Muscle strength
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using trendione to increase muscle strength, there is insufficient reliable information about the clinical effects of trendione for this purpose.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

Although there is interest in using trendione for weight loss, there is insufficient reliable information about the clinical effects of trendione for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

We consider Trendione unsafe for general use. Like other anabolic steroids and prohormones, it has been linked to liver injury, unhealthy changes in cholesterol, and disruption of natural hormone production.

People who should absolutely avoid it include anyone who is pregnant or breastfeeding, teenagers and young adults whose bodies are still developing, and anyone with liver problems, heart disease, high cholesterol, hormone-sensitive conditions, or a history of mood disorders.

Products containing Trendione may also be mislabeled or contain unlisted ingredients, since they are often sold outside normal regulatory oversight. Pregnancy and breastfeeding: avoid completely. If you are using or considering anything like this, please talk with your doctor or pharmacist first.

Side effects

Reported and expected side effects of steroid-like prohormones include liver damage (sometimes serious), acne, oily skin, hair loss, and unhealthy cholesterol changes.

Hormone-related effects can include shrinking of the testicles, reduced sperm count, breast tissue growth in men, and menstrual changes, deepening of the voice, or unwanted hair growth in women. Some users report mood swings, irritability, or aggression.

Rare but serious problems can include liver failure and cardiovascular complications. Any sign of jaundice (yellow skin or eyes), dark urine, severe abdominal pain, chest pain, or unusual swelling should prompt immediate medical attention.

Dosing

There is no established safe or effective dose for Trendione. Because it is a synthetic steroid rather than a studied medicine, no health authority has set a recommended amount.

We do not provide dosing for this product because we do not recommend using it. If you see a product containing Trendione or "estra-4,9,11-trien-3,17-dione," the safest step is to not take it and to speak with a pharmacist or doctor about safer, evidence-based ways to reach your fitness goals.

Pregnancy & Breastfeeding

Trendione & Pregnancy

Possibly Unsafe

When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss, and acne. Prohormones have also been associated with hepatotoxicity and increased risk of cardiovascular disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing prohormones are dangerous. Avoid using.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100.

Trendione & Breastfeeding

Possibly Unsafe

When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss, and acne. Prohormones have also been associated with hepatotoxicity and increased risk of cardiovascular disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing prohormones are dangerous. Avoid using.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Trendione monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Pharmacist Counseling Corner

Trendione: Common Questions

What is Trendione used for, and does it work?
People use Trendione for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Trendione interact with prescription medications?
We do not currently list any known drug interactions for Trendione. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Trendione interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Trendione with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Trendione interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Trendione a natural supplement or herb?
No. Despite being sold in supplement-style bottles, Trendione is a synthetic steroid compound, not a plant, vitamin, or food.
Is Trendione safe to take?
We do not consider it safe. It is a steroid-like prohormone linked to liver damage, hormone disruption, and other serious risks, with no good human safety data.
Can I take Trendione if I'm pregnant or breastfeeding?
No. Anabolic steroids can harm a developing baby or nursing infant, so it should be avoided completely during pregnancy and breastfeeding.
Will Trendione really build muscle?
There are no quality human studies proving it works. Any potential muscle effects come with real risks, and we recommend safer, proven approaches instead.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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