Globemallow Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Globemallow interacts with medications. The heart of this page is the interaction list — every drug Globemallow is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Globemallow is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Globemallow against your medication
Add one medicationDrugs that interact with Globemallow
0 medications have a known interaction with Globemallow, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Globemallow. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Globemallow combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Globemallow: Uses, Safety & Side Effects
Globemallow refers to plants in the genus Sphaeralcea, which have a long history of traditional use among Indigenous peoples of the Americas, mainly as a soothing remedy for skin, throat, and digestive complaints. There is very little modern scientific research on its safety or effectiveness, so its benefits remain unproven. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.
- Scientific name
- Sphaeralcea
- Family
- Malvaceae
- Part used
- Leaves, flowers, roots, and whole aerial parts
- Common forms
- Tea, poultice, dried herb, infusion
- Soothing skin irritation
- Cough and sore throat
- Digestive upset
- Minor wounds and inflammation
- Mouth and throat soothing
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Little modern safety data exists, so use cautiously and under professional guidance.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Globemallow is a common name for flowering plants in the genus Sphaeralcea, part of the mallow family (Malvaceae). These plants are best known for their cup-shaped orange, red, or pink flowers and are found across dry, sunny regions of western North America, Mexico, and parts of South America.
Like other plants in the mallow family, globemallow contains slippery, gel-like compounds called mucilage. This is why it has traditionally been used to soothe irritated tissues. Indigenous peoples of the American Southwest and Mexico have used various globemallow species for skin problems, coughs, sore throats, and stomach upset.
Today globemallow is mostly of interest as a traditional folk remedy. It is not a widely studied or commonly sold commercial supplement, and you will most often find it as a dried herb, tea, or topical preparation rather than a standardized capsule.
How it works
The main proposed active ingredient in globemallow is mucilage, a soluble fiber-like substance that becomes slippery and gel-like when mixed with water. This mucilage may form a soothing coating over irritated skin, throat, or digestive lining, which could explain its traditional use for sore throats, coughs, and stomach upset.
Plants in the mallow family may also contain flavonoids and other plant compounds with possible antioxidant or anti-inflammatory activity. These mechanisms are based mostly on knowledge of related plants and laboratory observations, not on detailed studies of globemallow itself.
Because globemallow has not been well studied, the exact compounds responsible for any effects and how they act in the human body are not clearly understood.
Does Globemallow work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Globemallow, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Osteoarthritis
It is unclear if topical globemallow is beneficial in patients with osteoarthritis.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
There is very little modern safety information about globemallow. It has a history of traditional use, which suggests it may be reasonably well tolerated when used in modest amounts, but this is not a substitute for proper safety studies.
Some species in the mallow family, including globemallow, have fine hairs on their leaves and stems that can irritate the skin, eyes, or throat in some people. Use care when handling the raw plant.
Pregnancy and breastfeeding: Because there is no reliable safety data, globemallow should be avoided during pregnancy and breastfeeding. People with chronic medical conditions, children, and older adults should also be cautious and check with a healthcare provider first.
Since plant identification can be tricky and quality control of wild or homemade preparations is limited, only use products from a trusted source and talk to your pharmacist or doctor before trying globemallow.
Side effects
Reported side effects of globemallow are not well documented. Based on its plant family and mucilage content, possible effects could include mild stomach upset or, rarely, an allergic reaction in people sensitive to mallow-family plants.
Handling the raw plant may cause skin, eye, or throat irritation due to its tiny leaf hairs. As with any herbal product, stop using it and seek medical care if you notice signs of an allergic reaction such as rash, swelling, or trouble breathing.
Dosing
There is no established or standardized dose for globemallow. It has not been studied enough to set safe, effective amounts for any use.
If you choose to use a globemallow product, follow the directions on the product label and do not exceed them. Because formulations and plant strength vary widely, it is best to start low and check with a pharmacist or doctor before use, especially if you take other medicines or have health conditions.
Globemallow & Pregnancy
Globemallow & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 sources that drive our Globemallow monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.
- Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
- Herbal Supplements — MedlinePlus Source
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Globemallow: Common Questions
What is Globemallow used for, and does it work?
Does Globemallow interact with prescription medications?
How are Globemallow interactions rated?
Is it safe to take Globemallow with my medications?
Where does this Globemallow interaction information come from?
What is Globemallow used for?
Is Globemallow safe to take?
Can I use Globemallow during pregnancy or breastfeeding?
How is Globemallow usually taken?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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