Herb & supplement monograph

Globemallow Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines
Interaction report

Drugs that interact with Globemallow

0 medications have a known interaction with Globemallow, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Globemallow. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Globemallow combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Globemallow: Uses, Safety & Side Effects

The bottom line

Globemallow refers to plants in the genus Sphaeralcea, which have a long history of traditional use among Indigenous peoples of the Americas, mainly as a soothing remedy for skin, throat, and digestive complaints. There is very little modern scientific research on its safety or effectiveness, so its benefits remain unproven. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Scientific name
Sphaeralcea
Family
Malvaceae
Part used
Leaves, flowers, roots, and whole aerial parts
Common forms
Tea, poultice, dried herb, infusion
People commonly use it for
  • Soothing skin irritation
  • Cough and sore throat
  • Digestive upset
  • Minor wounds and inflammation
  • Mouth and throat soothing

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallLimited data

Little modern safety data exists, so use cautiously and under professional guidance.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Globemallow is a common name for flowering plants in the genus Sphaeralcea, part of the mallow family (Malvaceae). These plants are best known for their cup-shaped orange, red, or pink flowers and are found across dry, sunny regions of western North America, Mexico, and parts of South America.

Like other plants in the mallow family, globemallow contains slippery, gel-like compounds called mucilage. This is why it has traditionally been used to soothe irritated tissues. Indigenous peoples of the American Southwest and Mexico have used various globemallow species for skin problems, coughs, sore throats, and stomach upset.

Today globemallow is mostly of interest as a traditional folk remedy. It is not a widely studied or commonly sold commercial supplement, and you will most often find it as a dried herb, tea, or topical preparation rather than a standardized capsule.

How it works

The main proposed active ingredient in globemallow is mucilage, a soluble fiber-like substance that becomes slippery and gel-like when mixed with water. This mucilage may form a soothing coating over irritated skin, throat, or digestive lining, which could explain its traditional use for sore throats, coughs, and stomach upset.

Plants in the mallow family may also contain flavonoids and other plant compounds with possible antioxidant or anti-inflammatory activity. These mechanisms are based mostly on knowledge of related plants and laboratory observations, not on detailed studies of globemallow itself.

Because globemallow has not been well studied, the exact compounds responsible for any effects and how they act in the human body are not clearly understood.

Effectiveness

Does Globemallow work?

Evidence overview · 1 use evaluated
1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Globemallow, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Osteoarthritis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical globemallow is beneficial in patients with osteoarthritis.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

There is very little modern safety information about globemallow. It has a history of traditional use, which suggests it may be reasonably well tolerated when used in modest amounts, but this is not a substitute for proper safety studies.

Some species in the mallow family, including globemallow, have fine hairs on their leaves and stems that can irritate the skin, eyes, or throat in some people. Use care when handling the raw plant.

Pregnancy and breastfeeding: Because there is no reliable safety data, globemallow should be avoided during pregnancy and breastfeeding. People with chronic medical conditions, children, and older adults should also be cautious and check with a healthcare provider first.

Since plant identification can be tricky and quality control of wild or homemade preparations is limited, only use products from a trusted source and talk to your pharmacist or doctor before trying globemallow.

Side effects

Reported side effects of globemallow are not well documented. Based on its plant family and mucilage content, possible effects could include mild stomach upset or, rarely, an allergic reaction in people sensitive to mallow-family plants.

Handling the raw plant may cause skin, eye, or throat irritation due to its tiny leaf hairs. As with any herbal product, stop using it and seek medical care if you notice signs of an allergic reaction such as rash, swelling, or trouble breathing.

Dosing

There is no established or standardized dose for globemallow. It has not been studied enough to set safe, effective amounts for any use.

If you choose to use a globemallow product, follow the directions on the product label and do not exceed them. Because formulations and plant strength vary widely, it is best to start low and check with a pharmacist or doctor before use, especially if you take other medicines or have health conditions.

Pregnancy & Breastfeeding

Globemallow & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Globemallow & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 sources that drive our Globemallow monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
  2. Herbal Supplements — MedlinePlus Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Pharmacist Counseling Corner

Globemallow: Common Questions

What is Globemallow used for, and does it work?
People use Globemallow for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Globemallow interact with prescription medications?
We do not currently list any known drug interactions for Globemallow. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Globemallow interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Globemallow with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Globemallow interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Globemallow used for?
It is a traditional folk remedy used mainly to soothe irritated skin, calm coughs and sore throats, and ease minor digestive upset. These uses come from history and tradition, not from strong scientific proof.
Is Globemallow safe to take?
There is very little modern safety research, so its safety is largely unknown. It appears to have been used traditionally without major reported problems, but you should still check with a pharmacist or doctor before using it.
Can I use Globemallow during pregnancy or breastfeeding?
No reliable safety information is available, so it is best to avoid Globemallow if you are pregnant or breastfeeding.
How is Globemallow usually taken?
It is most often used as a tea or infusion made from the dried leaves and flowers, or applied to the skin as a poultice. There is no standardized dose, so follow product directions and ask a healthcare professional.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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