Drug & supplement interaction

Tree Tobacco + Hydrochlorothiazide

Hydrochlorothiazide brand names: Esidrix, Hydro, Microzide, HydroDiuril, Hydro-D, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Tree Tobacco and Hydrochlorothiazide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Tree Tobacco and Hydrochlorothiazide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Hydrochlorothiazide and Tree Tobacco in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Tree Tobacco at all — not against Hydrochlorothiazide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tree Tobacco safety at a glance

Tree Tobacco overall Avoid Tree tobacco is toxic and has caused serious poisonings and deaths when eaten.
Pregnancy Likely Unsafe When tree tobacco is used orally. Tree tobacco contains anabasine, which is poisonous and teratogenic. Read the full pregnancy detail
Breastfeeding Likely Unsafe When tree tobacco is used orally. Tree tobacco contains anabasine, which is poisonous and teratogenic. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Hydrochlorothiazide and Tree Tobacco? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Tree Tobacco and Hydrochlorothiazide May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on reported in 5.0% of FDA reports for Hydrochlorothiazide Additional detail

    Tree Tobacco

    “Orally, tree tobacco is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Tree tobacco can cause nausea, vomiting, diarrhea, abdominal pain, changes in blood pressure and heart rate, muscle weakness and paralysis, respiratory distress, and neurological symptoms including vertigo, confusion, fatigue, headache, hallucinations, spasms, weakness, and coma.”

    Tree Tobacco · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    6 sources cited
    1. 28735. Mizrachi, N., Levy, S., and Goren, Z. Q. Fatal poisoning from Nicotiana glauca leaves: identification of anabasine by gas-chromatography/mass spectrometry. J Forensic Sci 2000;45(3):736-741. DOI
    2. 28736. Mellick, L. B., Makowski, T., Mellick, G. A., and Borger, R. Neuromuscular blockade after ingestion of tree tobacco (Nicotiana glauca). Ann Emerg Med 1999;34(1):101-104. PubMed
    3. 28737. Sims, D. N., James, R., and Christensen, T. Another death due to ingestion of Nicotiana glauca. J Forensic Sci 1999;44(2):447-449.
    4. 28738. Castorena, J. L., Garriott, J. C., Barnhardt, F. E., and Shaw, R. F. A fatal poisoning from Nicotiana glauca. J Toxicol Clin Toxicol 1987;25(5):429-435.
    5. 28739. Manoguerra, A. S. and Freeman, D. Acute poisoning from the ingestion of Nicotiana glauca. J Toxicol Clin Toxicol 1982;19(8):861-864.
    6. 98622. Bardas SL. Short-term intubation after ingestion of Nicotiana glauca. Am J Health Syst Pharm. 2011;68(18):1678-9.

    “Orally, the mistaken and intentional intake of tree tobacco has been reported to cause acute respiratory distress requiring short-term intubation in elderly females. It has also been reported to cause rapid or slowed breathing.”

    Tree Tobacco · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    4 sources cited
    1. 98622. Bardas SL. Short-term intubation after ingestion of Nicotiana glauca. Am J Health Syst Pharm. 2011;68(18):1678-9.
    2. 98623. Sercan Y, Selahattin KG. Respiratory failure due to plant poisoning: Nicotiana glauca Graham. J Emerg Med. 2018;55(3):e61-e63. PubMed
    3. 106641. Kear BM, Lee RW, Church SB, Youssef FA, Arguija A. Ingestion of a common plant's leaves leads to acute respiratory arrest and paralysis: a case report. Clin Pract Cases Emerg Med 2020;4(3):371-4. PubMed
    4. 28734. Steenkamp, P. A., van Heerden, F. R., and van Wyk, B. E. Accidental fatal poisoning by Nicotiana glauca: identification of anabasine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci Int 2002;127(3):208-217. PubMed

    Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    Tree Tobacco

    “Orally, tree tobacco has been reported to cause hypertension, hypotension, bradycardia, tachycardia, and asystole. Hypertension tends to occur early, within 4 hours of consumption.”

    Tree Tobacco · Natural Medicines adverse-effect record, reported in hypertension.

    3 sources cited
    1. 28735. Mizrachi, N., Levy, S., and Goren, Z. Q. Fatal poisoning from Nicotiana glauca leaves: identification of anabasine by gas-chromatography/mass spectrometry. J Forensic Sci 2000;45(3):736-741. DOI
    2. 98623. Sercan Y, Selahattin KG. Respiratory failure due to plant poisoning: Nicotiana glauca Graham. J Emerg Med. 2018;55(3):e61-e63. PubMed
    3. 106641. Kear BM, Lee RW, Church SB, Youssef FA, Arguija A. Ingestion of a common plant's leaves leads to acute respiratory arrest and paralysis: a case report. Clin Pract Cases Emerg Med 2020;4(3):371-4. PubMed

    Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide. Read the label on DailyMed ›

  • Dizziness / Headache reported in 5.4% of FDA reports for Hydrochlorothiazide Additional detail

    Tree Tobacco

    “Orally, tree tobacco has been reported to cause vertigo, confusion, fatigue, headache, photophobia, spasms, tingling, severe sweating, progressively worsening aphasia, neuromuscular blockage, seizures, coma, and bulbar palsy. Dizziness and confusion tend to occur early, within 4 hours of consumption. Weakness, coma, and paralysis occur later.”

    Tree Tobacco · Natural Medicines adverse-effect record, reported in cluster headache.

    4 sources cited
    1. 28734. Steenkamp, P. A., van Heerden, F. R., and van Wyk, B. E. Accidental fatal poisoning by Nicotiana glauca: identification of anabasine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci Int 2002;127(3):208-217. PubMed
    2. 98622. Bardas SL. Short-term intubation after ingestion of Nicotiana glauca. Am J Health Syst Pharm. 2011;68(18):1678-9.
    3. 98623. Sercan Y, Selahattin KG. Respiratory failure due to plant poisoning: Nicotiana glauca Graham. J Emerg Med. 2018;55(3):e61-e63. PubMed
    4. 106641. Kear BM, Lee RW, Church SB, Youssef FA, Arguija A. Ingestion of a common plant's leaves leads to acute respiratory arrest and paralysis: a case report. Clin Pract Cases Emerg Med 2020;4(3):371-4. PubMed

    Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Diarrhea / Nausea / Vomiting reported in 6.6% of FDA reports for Hydrochlorothiazide Additional detail

    Tree Tobacco

    “Orally, tree tobacco has been reported to cause nausea, vomiting, diarrhea, dry mouth, salivation, and abdominal pain. Nausea and vomiting tend to occur early, within 4 hours of consumption.”

    Tree Tobacco · Natural Medicines adverse-effect record, reported in diarrhea.

    5 sources cited
    1. 28734. Steenkamp, P. A., van Heerden, F. R., and van Wyk, B. E. Accidental fatal poisoning by Nicotiana glauca: identification of anabasine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci Int 2002;127(3):208-217. PubMed
    2. 28736. Mellick, L. B., Makowski, T., Mellick, G. A., and Borger, R. Neuromuscular blockade after ingestion of tree tobacco (Nicotiana glauca). Ann Emerg Med 1999;34(1):101-104. PubMed
    3. 98622. Bardas SL. Short-term intubation after ingestion of Nicotiana glauca. Am J Health Syst Pharm. 2011;68(18):1678-9.
    4. 98623. Sercan Y, Selahattin KG. Respiratory failure due to plant poisoning: Nicotiana glauca Graham. J Emerg Med. 2018;55(3):e61-e63. PubMed
    5. 106641. Kear BM, Lee RW, Church SB, Youssef FA, Arguija A. Ingestion of a common plant's leaves leads to acute respiratory arrest and paralysis: a case report. Clin Pract Cases Emerg Med 2020;4(3):371-4. PubMed

    Hydrochlorothiazide

    Listed in the ADVERSE REACTIONS section of the FDA label for Hydrochlorothiazide, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Tree Tobacco but not commonly for Hydrochlorothiazide: muscle weakness, stomach pain, hallucinations and raised blood pressure.

Effects for Hydrochlorothiazide come from the ADVERSE REACTIONS section of its FDA label; effects for Tree Tobacco come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 209,395 voluntary FDA FAERS reports for Hydrochlorothiazide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Tree Tobacco in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When tree tobacco is used orally. Tree tobacco contains anabasine, which is poisonous and teratogenic.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Tree Tobacco or Hydrochlorothiazide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Tree Tobacco or Hydrochlorothiazide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Hydrochlorothiazide

This page covers Tree Tobacco only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrochlorothiazide page lists 230 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 195 moderate · 25 minor.

From our pharmacist’s overview on the Hydrochlorothiazide page

“Hydrochlorothiazide sits at the strong end of the caution scale for supplement interactions, and the small group of major-rated entries deserves a careful read before everything else on the page. Most of what appears here either adds to the pill's blood-pressure-lowering effect or piles onto its diuretic action, pushing fluid and potas…”

Reviewed by 2 · Jul 18, 2026

Open the Hydrochlorothiazide interaction page

How much people look this up

Where Tree Tobacco and Hydrochlorothiazide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tree Tobacco
Steady interest

#1,405 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrochlorothiazide
Top 10%

#263 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tree Tobacco reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Tree Tobacco and Hydrochlorothiazide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Tree Tobacco

What is Tree Tobacco?

  • Topical use on wounds or sores (folk use)
  • Joint and muscle pain (folk use)
  • Headache relief (traditional poultice)
  • Insect or pest control

Tree tobacco is a poisonous shrub that contains the toxic alkaloid anabasine, and it is not a safe dietary supplement. There is no reliable evidence that it treats any condition, and swallowing it can cause severe poisoning or death. We strongly recommend avoiding internal use entirely.

Nicotiana glauca · Solanaceae · Leaves · Crushed leaves, poultices, traditional topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Tree Tobacco is a good idea for someone in your situation. Here is what our Tree Tobacco record says about it on its own.

Tree Tobacco: dosing

There is no safe or established dose for tree tobacco. It is not sold or recommended as a standardized dietary supplement, and no amount is known to be safe to swallow.Because of its toxicity, we recommend avoiding it entirely.

From our Tree Tobacco monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tree Tobacco monograph & all interactions
Medication

About Hydrochlorothiazide

What Is Hydrochlorothiazide Used For?

Brand names: Esidrix, Hydro, Microzide, HydroDiuril, Hydro-D, Oretic, Aquazide H, Aquazide, HCTZ

Hydrochlorothiazide treats high blood pressure (hypertension) in adults and children, either alone or combined with other blood pressure medicines. Lowering blood pressure reduces the risk of strokes and heart attacks. The capsule form is indicated specifically for hypertension management.

It also treats edema (fluid buildup) associated with congestive heart failure, liver cirrhosis, and kidney diseases including nephrotic syndrome. The tablet form is additionally indicated for edema caused by corticosteroid and estrogen therapy, as well as conditions such as acute glomerulonephritis and chronic renal failure. Inzirqo (the oral suspension) is indicated for both hypertension and edema in adult and pediatric patients.

Most-Reported Side Effects for Hydrochlorothiazide

From FAERS, the FDA’s public side-effect reporting system (209,395 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 13,772 reports
Nausea 13,724 reports
Diarrhea 11,763 reports
Dizziness 11,243 reports
Headache 10,766 reports
See full Hydrochlorothiazide drug information
Keep checking

Other Drugs & Tree Tobacco

Browse every other medication we’ve checked against Tree Tobacco — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Tree Tobacco against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Tree Tobacco list.

See the full Tree Tobacco interactions page
See every supplement checked against Hydrochlorothiazide, ranked by severity
Evidence & sources

Tree Tobacco References

The 9 references that drive our Tree Tobacco monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Steenkamp, P. A., van Heerden, F. R., and van Wyk, B. E. Accidental fatal poisoning by Nicotiana glauca: identification of anabasine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci Int 2002;127(3):208-217. PubMed
  2. Mizrachi, N., Levy, S., and Goren, Z. Q. Fatal poisoning from Nicotiana glauca leaves: identification of anabasine by gas-chromatography/mass spectrometry. J Forensic Sci 2000;45(3):736-741. DOI
  3. Mellick, L. B., Makowski, T., Mellick, G. A., and Borger, R. Neuromuscular blockade after ingestion of tree tobacco (Nicotiana glauca). Ann Emerg Med 1999;34(1):101-104. PubMed
  4. Sims, D. N., James, R., and Christensen, T. Another death due to ingestion of Nicotiana glauca. J Forensic Sci 1999;44(2):447-449.
  5. Castorena, J. L., Garriott, J. C., Barnhardt, F. E., and Shaw, R. F. A fatal poisoning from Nicotiana glauca. J Toxicol Clin Toxicol 1987;25(5):429-435.
  6. Manoguerra, A. S. and Freeman, D. Acute poisoning from the ingestion of Nicotiana glauca. J Toxicol Clin Toxicol 1982;19(8):861-864.
  7. Bardas SL. Short-term intubation after ingestion of Nicotiana glauca. Am J Health Syst Pharm. 2011;68(18):1678-9.
  8. Sercan Y, Selahattin KG. Respiratory failure due to plant poisoning: Nicotiana glauca Graham. J Emerg Med. 2018;55(3):e61-e63. PubMed
  9. Kear BM, Lee RW, Church SB, Youssef FA, Arguija A. Ingestion of a common plant's leaves leads to acute respiratory arrest and paralysis: a case report. Clin Pract Cases Emerg Med 2020;4(3):371-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tree Tobacco and Hydrochlorothiazide Together: Common Questions

Is it safe to take Tree Tobacco with Hydrochlorothiazide?
We do not list a known interaction between Tree Tobacco and Hydrochlorothiazide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Tree Tobacco and Hydrochlorothiazide have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Hydrochlorothiazide interact with any supplements?
Yes. Hydrochlorothiazide has documented interactions with 230 supplements in our database — Tree Tobacco is not one of them. The Hydrochlorothiazide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tree Tobacco monograph Uses, safety profile, and every drug interaction in one place Hydrochlorothiazide drug information The full plain-English guide to this medication Hydrochlorothiazide supplement interactions Every supplement checked against Hydrochlorothiazide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Hydrochlorothiazide and Tree Tobacco?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.