Herb & supplement monograph

Androsterone Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Androsterone interacts with medications. The heart of this page is the interaction list — every drug Androsterone is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Androsterone is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Androsterone Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated August 2026

Based on the available evidence, the overall risk of a clinically significant Androsterone drug interaction appears low for most people. None of the recorded interactions are rated major or even moderate, and every one of them is classed as minor.

Interactions deserving the most attention

The pairing that deserves the most attention is with androgens, such as testosterone. Because androsterone is itself a steroid hormone that acts on the same receptors, combining it with these medicines could add to their hormonal effects. Even so, this concern is graded as only possible, meaning it rests on how the hormones work rather than on strong human studies, and it is still rated minor. Nothing in the profile points to bleeding, blood sugar, blood pressure, or other narrow-margin medicines.

What the rest of the list means

A handful of medications appear on the interaction list, but that does not mean each combination is harmful. The concerns here are largely theoretical, predicted from androsterone's hormone activity rather than from documented problems in people. For most medicines, no meaningful effect has been shown.

Check your medications against Androsterone

Based on HelloPharmacist’s Androsterone interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Androsterone

9 medications have a known interaction with Androsterone, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Androsterone using our pharmacist-reviewed interaction data.

AI summaries are generated from our Androsterone interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Androsterone combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Androsterone affects

Every type of medication (drug category) Androsterone is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Androsterone interacts with

Androgens

Androsterone, as an androgenic hormone, may interact with other androgenic drugs, such as testosterone, due to their similar mechanisms of action. Both androsterone and testosterone bind to androgen receptors in various tissues throughout the body, leading to similar physiological effects related to the development and maintenance of male secondary sexual characteristics. When taken together, these compounds can potentially amplify these effects, leading to an increased risk of androgenic side effects, such as acne, hair loss, and changes in libido. Additionally, combining androsterone with testosterone or other androgenic drugs may also affect hormone levels and balance in the body, potentially leading to hormonal imbalances or disruptions in the endocrine system.

Likelihood Possible Evidence C

Monograph

Androsterone: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are banned from U.S. dietary supplements under the DASCA law. There is no good evidence that taking it is safe or effective, and it carries the same hormone-related risks as other anabolic steroids. Avoid products that contain it, and talk to a pharmacist or doctor about safer, legal options.

Part used: Not applicable (a steroid hormone, not a plant)
Common forms: Historically sold as oral capsules, tablets, and sublingual products in 'prohormone' supplements (now banned in the U.S.)

People commonly use it for

Muscle building and athletic performance
Boosting testosterone or androgen levels
Supporting libido
Bodybuilding 'prohormone' stacks

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallBest avoided

It is a controlled anabolic-androgenic steroid that is illegal to sell as a dietary supplement in the U.S.

PregnancyPossibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including red...

Read the full pregnancy detail

BreastfeedingPossibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including red...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Androsterone is a natural steroid hormone, not a plant or herb. Your body makes it in the adrenal glands, testes, and ovaries. It is a breakdown product (metabolite) of testosterone and androstenedione, and it has mild androgenic (male hormone-like) activity. Small amounts show up in the urine and sweat of both men and women.

In the past, androsterone was sold in so-called "prohormone" or "testosterone-boosting" supplements aimed at bodybuilders and athletes. Because of how it behaves in the body, U.S. law now treats it as an anabolic-androgenic steroid. Under the Designer Anabolic Steroid Control Act (DASCA), it is illegal to include androsterone in dietary supplements sold in the United States.

This means any product claiming to contain androsterone is not a legal or quality-controlled dietary supplement. It should be approached with great caution.

How it works

Androsterone is a weak androgen, meaning it can mildly stimulate the same receptors that testosterone acts on. It is part of the normal chain of hormones the body makes and breaks down as it processes testosterone and related compounds.

The theory behind supplement use was that taking androsterone could push the body toward higher androgen activity, supporting muscle growth and male traits. However, much of this is based on its chemical relationship to other steroids rather than on careful human research. How much an oral dose actually converts to active hormones in the body is not well established.

Like other anabolic-androgenic steroids, it may also affect the body's own hormone production through feedback loops, potentially lowering natural testosterone over time.

Effectiveness

Does Androsterone work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 10 uses evaluated

10 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Androsterone, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 10 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Age-related testosterone deficiency