Drug & supplement interaction

Androsterone + Pyrazinamide

Pyrazinamide brand name: Tebrazid.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Androsterone and Pyrazinamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Androsterone and Pyrazinamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pyrazinamide and Androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Androsterone safety at a glance

Androsterone overall Avoid It is a controlled anabolic-androgenic steroid that is illegal to sell as a dietary supplement in the U.S.
Pregnancy Possibly Unsafe When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced ferti... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced ferti... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pyrazinamide and Androsterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pyrazinamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pyrazinamide is filed under 5 classifications — including antibiotic drugs, photosensitizing drugs, hepatotoxic drugs. Androsterone has documented interactions with 1 drug class — the most serious being androgens (minor) — and none of Pyrazinamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Androsterone Does Interact With Other Medications

Androsterone has 9 minor known drug interactions in our database — Pyrazinamide isn’t one of them. If you take anything else, check it against the full list below.

Minor 9 No known interaction 2,821 (incl. Pyrazinamide)
Taking anything else?

Check Another of Your Medications Against Androsterone

Covers the 2,830 medications we’ve checked against Androsterone. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Androsterone and Pyrazinamide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on reported in 7.0% of FDA reports for Pyrazinamide Additional detail

    Androsterone

    “Orally, androsterone is possibly unsafe. As an anabolic androgenic steroid, there is concern that it might cause serious side effects including heart disease and liver injury.”

    Androsterone · Natural Medicines adverse-effect record, reported in cardiovascular disease (cvd).

    Pyrazinamide

    Listed in the ADVERSE REACTIONS section of the FDA label for Pyrazinamide, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Pyrazinamide come from the ADVERSE REACTIONS section of its FDA label; effects for Androsterone come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 9,209 voluntary FDA FAERS reports for Pyrazinamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Androsterone in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Pyrazinamide

This page covers Androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pyrazinamide page lists 102 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Alfalfa (moderate).

By severity: 4 major · 86 moderate · 12 minor.

From our pharmacist’s overview on the Pyrazinamide page

“Pyrazinamide is one of the core tuberculosis drugs, and because treatment runs for months while the liver already carries the drug's own strain, the 102 supplements and herbs on file here warrant real caution. Thirty-eight of them add their own liver stress, and three of the four major-rated entries sit in that group, including somethi…”

Reviewed by 2 · Jul 18, 2026

Open the Pyrazinamide interaction page

One more smart check

Taking Androsterone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing Androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Androsterone. Even though Androsterone itself has no known interaction with Pyrazinamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Androsterone and Pyrazinamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Androsterone
Steady interest

#1,008 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pyrazinamide
Steady interest

#1,968 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Androsterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Androsterone and Pyrazinamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Androsterone

What is Androsterone?

Androsterone
  • Muscle building and athletic performance
  • Boosting testosterone or androgen levels
  • Supporting libido
  • Bodybuilding 'prohormone' stacks

Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are banned from U.S. dietary supplements under the DASCA law. There is no good evidence that taking it is safe or effective, and it carries the same hormone-related risks as other anabolic steroids. Avoid products that contain it, and talk to a pharmacist or doctor about safer, legal options.

Not applicable (a steroid hormone, not a plant) · Historically sold as oral capsules, tablets, and sublingual products in 'prohormone' supplements (now banned in the U.S.)

An interaction check asks whether these two react with each other — it does not ask whether Androsterone is a good idea for someone in your situation. Here is what our Androsterone record says about it on its own.

Androsterone: dosing

There is no established or recommended safe dose of androsterone as a supplement, and it is illegal to sell in U.S. dietary supplements. We do not provide dosing for it.If you see a product that lists androsterone or one of its alternate names on the label, treat it as a banned anabolic steroid rather than a normal supplement.

From our Androsterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Androsterone monograph & all interactions
Medication

About Pyrazinamide

What Is Pyrazinamide Used For?

Brand name: Tebrazid

Pyrazinamide tablets are used to treat active tuberculosis (TB) in adults and children. It is always used in combination with other anti-TB medicines — never alone. The standard CDC-recommended approach uses pyrazinamide as part of a 6-month regimen, typically for the first 2 months.

It is also used when initial TB treatment with other drugs has failed. People with drug-resistant TB or with HIV infection may need a treatment plan specifically tailored to their situation, which can include pyrazinamide as a key part of the regimen.

See full Pyrazinamide drug information
Keep checking

Other Drugs & Androsterone

Browse every other medication we’ve checked against Androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
9Minor
2,820No known interaction
9 Minor 2,820 No interaction
Minor

9 interactions

No interaction 2,820 drugs checked — show the list

We also checked Androsterone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,820 medications checked with no known interaction — see the full Androsterone list.

See the full Androsterone interactions page
See every supplement checked against Pyrazinamide, ranked by severity
Evidence & sources

Androsterone References

The 1 references that drive our Androsterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Androsterone and Pyrazinamide Together: Common Questions

Is it safe to take Androsterone with Pyrazinamide?
We do not list a known interaction between Androsterone and Pyrazinamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Androsterone and Pyrazinamide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Androsterone and Pyrazinamide combination checked?
Interactions in our licensed database are recorded against drug classes. Pyrazinamide is filed under 5 classifications, and Androsterone has documented interactions with 1 drug class — none of Pyrazinamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Androsterone interact with any other medications?
Yes. Androsterone has 9 documented drug interactions in our database — Pyrazinamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pyrazinamide interact with any supplements?
Yes. Pyrazinamide has documented interactions with 102 supplements in our database — Androsterone is not one of them. The Pyrazinamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Androsterone monograph Uses, safety profile, and every drug interaction in one place Pyrazinamide drug information The full plain-English guide to this medication Pyrazinamide supplement interactions Every supplement checked against Pyrazinamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pyrazinamide and Androsterone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.