Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Tri-Ad Mass Ingredients & Drug Interactions

by Alchemy Labs

Tri-Ad Mass label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tri-Ad Mass against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tri-Ad Mass is a dietary supplement by Alchemy Labs with 4 active ingredients. Its ingredients are commonly taken for muscle building and athletic performance, boosting testosterone or androgen levels, supporting libido.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 3,3-Diindolymethane, 3-Alpha-Hydroxy-5-Alpha-Androstan-17-One. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tri-Ad Mass by Alchemy Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Tri-Ad Mass by Alchemy Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tri-Ad Mass by Alchemy Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Extreme Bulking Matrix” is a proprietary blend — the label gives one combined amount (355 mg) without saying how much of each component you get.

Tri-Ad Mass contains 4 active ingredients. Three of them are androsterone compounds—3-Alpha-Hydroxy-5-Alpha-Androstan-17-One, 3alpha-Hydroxy-17-Androstanone, and 3Beta-Hydroxyandrost-5-En-17-One—which are anabolic-androgenic steroids.

The fourth is 3,3-Diindolylmethane (diindolylmethane), a compound derived from cruciferous vegetables that may have effects on hormone metabolism. The product also contains inactive ingredients: rice flour, capsule shell, magnesium stearate, and a delivery system called Rocket Delivery.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: muscle building and athletic performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle strength, Sexual desire, Testosterone support, Lean mass gain.
  • The closest evidence on file: Androsterone is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Androsterone is rated "Insufficient Reliable Evidence To Rate" for Muscle strength, Sexual desire, Exercise-induced muscle damage.

The evidence for androsterone in treating fatigue, sexual dysfunction, obesity, age-related low testosterone, and epilepsy is insufficient to rate—we don't have enough reliable data to say whether it works. The same applies to diindolylmethane for benign prostate enlargement, breast cancer, colorectal cancer, cervical dysplasia, and breast pain: the evidence base is insufficient.

In short, the effectiveness of either ingredient for any condition listed has not been established in our data.

The evidence, ingredient by ingredient Androsterone Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Androsterone is possibly unsafe when taken by mouth as an oral supplement. As an anabolic-androgenic steroid, it carries concern for serious side effects including heart disease and liver injury.

It is also a controlled substance illegal to sell as a dietary supplement in the United States. Diindolylmethane is generally well tolerated in short-term studies, though long-term safety is not well established.

Common side effects of diindolylmethane include diarrhea, gas, headache, nausea, rash, and vomiting. A rare serious side effect—a type of allergic rash called DRESS—has been reported.

One case of stroke was reported in someone taking diindolylmethane, though other factors likely contributed.

Side effects, ingredient by ingredient Androsterone Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Diindolylmethane, Androsterone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Tri-Ad Mass, check with your pharmacist if you take any androgens (like testosterone), estrogen or hormone replacement therapy, water pills (diuretics), or medications metabolized by the liver enzyme CYP1A2. Additionally, be aware that the androsterone compounds in this product are controlled substances illegal to sell as supplements in the U.S., which raises serious legal concerns beyond drug interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains controlled anabolic-androgenic steroids that are illegal to sell as dietary supplements in the U.S., which is a critical legal and safety issue. If you're considering this product, talk to your pharmacist or doctor first—they need to know about the ingredients, any medications you take, and your health history.

Do not use this product if you are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tri-Ad Mass, straight from the product label.

Brand Alchemy Labs
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 242031
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tri-Ad Mass by Alchemy Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
3-Alpha-Hydroxy-5-Alpha-Androstan-17-One0 NP--
3alpha-Hydroxy-17-Androstanone0 NP--
3Beta-Hydroxyandrost-5-En-17-One0 NP--
Extreme Bulking Matrix355 mg--
3,3-Diindolymethane0 NP--

Other ingredients: Rice Flour, Capsule Shell, Magnesium Stearate, Rocket Delivery

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Pro series

Formula

Rocket Delivery

Formulation

Extreme Bulking PH Power Bulk Libido

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tri-Ad Mass by Alchemy Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tri-Ad Mass label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tri-Ad Mass by Alchemy Labs

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Extreme Bulking Matrix

355 mg per serving

Other (inactive) ingredients: Rice Flour, Capsule Shell, Magnesium Stearate, Rocket Delivery. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tri-Ad Mass by Alchemy Labs Drug Interactions

Want to check YOUR meds against Tri-Ad Mass?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
116 Moderate 159 Minor

Ingredients driving the most interactions

3,3-Diindolymethane 269
3-Alpha-Hydroxy-5-Alpha-Androstan-17-One 9

Individual Drug Interactions

The ingredients in Tri-Ad Mass interact with 275 drugs. Click any drug to see the details.

2 of the 4 ingredients in Tri-Ad Mass interact with drugs. Each result below shows which ingredient is responsible. 3,3-Diindolymethane 3-Alpha-Hydroxy-5-Alpha-Androstan-17-One

Each ingredient & the kinds of drugs it affects

For each ingredient in Tri-Ad Mass with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

3,3-Diindolymethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
3,3-Diindolymethane full monograph & interactions

3-Alpha-Hydroxy-5-Alpha-Androstan-17-One1 drug type · 9 drugs

Androgens

Androsterone, as an androgenic hormone, may interact with other androgenic drugs, such as testosterone, due to their similar mechanisms of action. Both androsterone and testosterone bind to androgen receptors in various tissues throughout the body, leading to similar physiological effects related to the development and maintenance of male secondary sexual characteristics. When taken together, these compounds can potentially amplify these effects, leading to an increased risk of androgenic side effects, such as acne, hair loss, and changes in libido. Additionally, combining androsterone with testosterone or other androgenic drugs may also affect hormone levels and balance in the body, potentially leading to hormonal imbalances or disruptions in the endocrine system.

Likelihood Possible Evidence C
3-Alpha-Hydroxy-5-Alpha-Androstan-17-One full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tri-Ad Mass, from the product label.

Alchemy Labs

See all Alchemy Labs products
Name
Alchemy Labs
Pharmacist Counseling Corner

Tri-Ad Mass by Alchemy Labs: Common Questions

Does Tri-Ad Mass by Alchemy Labs interact with any medications?
Yes. Based on its ingredients, Tri-Ad Mass has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tri-Ad Mass contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. The androsterone ingredients in this product can harm a developing baby and should not be used during pregnancy. Hormone exposure may also affect a nursing infant, so you should not use this product while breastfeeding. Talk to your doctor if you have questions about hormone-related supplements and pregnancy.
What are the side effects?
Androsterone is possibly unsafe orally and carries concern for serious side effects including heart disease and liver injury. Diindolylmethane commonly causes diarrhea, gas, headache, nausea, rash, and vomiting. A rare serious rash called DRESS has been reported with diindolylmethane, and one case of stroke occurred in someone using it, though other factors likely played a role.
Is this product legal to buy?
This product contains controlled anabolic-androgenic steroids that are illegal to sell as dietary supplements in the United States. You should not purchase or use this product due to its illegal status.
Does diindolylmethane really work?
The evidence for diindolylmethane is insufficient to rate for any of the conditions listed—benign prostate enlargement, breast cancer, colorectal cancer, cervical dysplasia, and breast pain. We don't have enough reliable data to say whether it works for any of these.
What if I take hormone replacement therapy?
Diindolylmethane, one of the ingredients in this product, may theoretically interfere with how estrogens and hormone replacement work. Talk to your pharmacist before combining this product with any hormone therapy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tri-Ad Mass label
Go deeper

The Full Monographs Behind Tri-Ad Mass’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Androsterone

Interacts with 9 drugs

Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are banned from U.S. dietary supplements und...

Read the full Androsterone monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

Tri-Ad Mass's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Androsterone 1 reference
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

See these in context on the Androsterone monograph →

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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