Drug & supplement interaction

Androsterone + Divalproex Sodium

Divalproex Sodium brand name: Depakote.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Androsterone and Divalproex Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Divalproex Sodium states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Androsterone and Divalproex Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Divalproex Sodium and Androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Androsterone safety at a glance

Androsterone overall Avoid It is a controlled anabolic-androgenic steroid that is illegal to sell as a dietary supplement in the U.S.
Pregnancy Possibly Unsafe When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced ferti... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced ferti... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Divalproex Sodium and Androsterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Divalproex Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Divalproex Sodium is filed under 7 classifications — including valproate, anticonvulsants, cns depressants. Androsterone has documented interactions with 1 drug class — the most serious being androgens (minor) — and none of Divalproex Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Androsterone Does Interact With Other Medications

Androsterone has 9 minor known drug interactions in our database — Divalproex Sodium isn’t one of them. If you take anything else, check it against the full list below.

Minor 9 No known interaction 2,821 (incl. Divalproex Sodium)
Taking anything else?

Check Another of Your Medications Against Androsterone

Covers the 2,830 medications we’ve checked against Androsterone. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Androsterone and Divalproex Sodium May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Androsterone

    “Orally, androsterone is possibly unsafe. As an anabolic androgenic steroid, there is concern that it might cause serious side effects including heart disease and liver injury.”

    Androsterone · Natural Medicines adverse-effect record, reported in cardiovascular disease (cvd).

    Divalproex Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Divalproex Sodium. Read the label on DailyMed ›

Effects for Divalproex Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Androsterone come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 46,266 voluntary FDA FAERS reports for Divalproex Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Androsterone in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally or parenterally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Divalproex Sodium Products Have a Food Rule — Androsterone Should Not Break It

At least one FDA label for a product containing Divalproex Sodium says to take it with food. If you take Androsterone on an empty stomach out of habit, keep them separate — and take Divalproex Sodium with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Divalproex Sodium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

irritation may benefit from administration of the drug with food or by slowly building up the dose from an initial low level.

From the Dosage and Administration section of the FDA label we read for Divalproex Sodium — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Divalproex Sodium Is Prescribed For, and What Androsterone Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Divalproex Sodium is a prescription medicine with approved uses on its FDA label. Androsterone is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Divalproex Sodium is prescribed for: Valproic acid capsules (brands Valproic and Valproic Acid) and valproic acid oral solution (brand Valproic Acid) are both used to treat epilepsy. Specifically, they are approved for complex partial seizures (either alone or with other seizure types) as monotherapy or add-on therapy, and for simple and complex absence seizures as sole therapy or add-on therapy. Both forms are intended for adults and pediatric patients. Always follow your prescriber's guidance on which product and regimen is right for you.

Androsterone has been studied for:

  • Epilepsy studied, not established Androsterone has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Androsterone for epilepsy

    Although there is interest in using oral androsterone for epilepsy, there is insufficient reliable information about the clinical effects of androsterone for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Divalproex Sodium on your own; if you are taking Androsterone for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Androsterone or Divalproex Sodium

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Androsterone or Divalproex Sodium, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Divalproex Sodium

This page covers Androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Divalproex Sodium page lists 134 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 7 major · 110 moderate · 17 minor.

Open the Divalproex Sodium interaction page

One more smart check

Taking Androsterone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing Androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Androsterone. Even though Androsterone itself has no known interaction with Divalproex Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Androsterone and Divalproex Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Androsterone
Steady interest

#989 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Divalproex Sodium
Steady interest

#1,524 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Androsterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Androsterone and Divalproex Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Androsterone

What is Androsterone?

Androsterone
  • Muscle building and athletic performance
  • Boosting testosterone or androgen levels
  • Supporting libido
  • Bodybuilding 'prohormone' stacks

Androsterone is a natural androgenic steroid hormone made in the body, but supplement versions are classified as anabolic-androgenic steroids and are banned from U.S. dietary supplements under the DASCA law. There is no good evidence that taking it is safe or effective, and it carries the same hormone-related risks as other anabolic steroids. Avoid products that contain it, and talk to a pharmacist or doctor about safer, legal options.

Not applicable (a steroid hormone, not a plant) · Historically sold as oral capsules, tablets, and sublingual products in 'prohormone' supplements (now banned in the U.S.)

An interaction check asks whether these two react with each other — it does not ask whether Androsterone is a good idea for someone in your situation. Here is what our Androsterone record says about it on its own.

Androsterone: dosing

There is no established or recommended safe dose of androsterone as a supplement, and it is illegal to sell in U.S. dietary supplements. We do not provide dosing for it.If you see a product that lists androsterone or one of its alternate names on the label, treat it as a banned anabolic steroid rather than a normal supplement.

From our Androsterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Androsterone monograph & all interactions
Medication

About Valproic Acid

What Is Valproic Acid Used For?

Brand name: Depakote

Valproic acid capsules (brands Valproic and Valproic Acid) and valproic acid oral solution (brand Valproic Acid) are both used to treat epilepsy. Specifically, they are approved for complex partial seizures (either alone or with other seizure types) as monotherapy or add-on therapy, and for simple and complex absence seizures as sole therapy or add-on therapy.

Both forms are intended for adults and pediatric patients. Always follow your prescriber's guidance on which product and regimen is right for you.

Most-Reported Side Effects for Divalproex Sodium

From FAERS, the FDA’s public side-effect reporting system (46,266 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Seizure 2,620 reports
Weight increased 2,168 reports
Nausea 2,109 reports
Fatigue 1,963 reports
Somnolence 1,901 reports
See full Valproic Acid drug information
Keep checking

Other Drugs & Androsterone

Browse every other medication we’ve checked against Androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
9Minor
2,820No known interaction
9 Minor 2,820 No interaction
Minor

9 interactions

No interaction 2,820 drugs checked — show the list

We also checked Androsterone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,820 medications checked with no known interaction — see the full Androsterone list.

See the full Androsterone interactions page
See every supplement checked against Divalproex Sodium, ranked by severity
Evidence & sources

Androsterone References

The 1 references that drive our Androsterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Androsterone and Divalproex Sodium Together: Common Questions

Is it safe to take Androsterone with Divalproex Sodium?
We do not list a known interaction between Androsterone and Divalproex Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Androsterone and Divalproex Sodium have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Androsterone and Divalproex Sodium at the same time of day?
At least one FDA label for a product containing Divalproex Sodium says to take it with food. If you take Androsterone on an empty stomach out of habit, keep them separate and take Divalproex Sodium with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Divalproex Sodium products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Are Androsterone and Divalproex Sodium used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Androsterone in each. That is a conversation for your prescriber, especially if Divalproex Sodium is being adjusted to a target.
How was the Androsterone and Divalproex Sodium combination checked?
Interactions in our licensed database are recorded against drug classes. Divalproex Sodium is filed under 7 classifications, and Androsterone has documented interactions with 1 drug class — none of Divalproex Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Androsterone interact with any other medications?
Yes. Androsterone has 9 documented drug interactions in our database — Divalproex Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Divalproex Sodium interact with any supplements?
Yes. Divalproex Sodium has documented interactions with 134 supplements in our database — Androsterone is not one of them. The Divalproex Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Androsterone monograph Uses, safety profile, and every drug interaction in one place Valproic Acid drug information The full plain-English guide to this medication Divalproex Sodium supplement interactions Every supplement checked against Divalproex Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Divalproex Sodium and Androsterone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.