Can You Take 5-HTP Supplements With Valproic Acid?

Quick Answer

Currently, there is no recorded evidence specifically indicating a clinically significant interaction between 5-HTP supplements and Sodium Valproate (and similar substances such as valproic acid [i.e., Depakote]) in epilepsy patients.

Detailed Answer

5-Hydroxytryptophan, often abbreviated as 5-HTP, is a compound synthesized within the body from the essential amino acid L-tryptophan. 5-HTP is converted into a neurotransmitter called serotonin, which plays a significant role in regulating mood, sleep, and appetite (among other things). 5-HTP is also available as a dietary supplement.

Sodium Valproate and similar compounds, like valproic acid, are drugs used to treat epilepsy and bipolar disorders.

Although we are not completely sure about how the drug exactly works for seizure disorders, it is thought that valproic acid increases the brain's levels of a certain chemical called gamma-aminobutyric acid (GABA), which plays a role in preventing nerves in the brain from becoming overly excited. The drug might also slow down the absorption of GABA by nerve cells, or block parts of the nerve cells responsible for breaking down GABA.

Based on our current knowledge, there is no known explicit harmful interaction between 5-HTP and sodium valproate (Valproic Acid) when used together.

However, it is important to note that we do not have a complete understanding of how serotonin or drugs that affect this neurotransmitter could impact seizure activity.

For instance, let's consider SSRIs as an example.

SSRIs, or selective serotonin reuptake inhibitors, such as popular medications like Zoloft and Lexapro, work by modulating serotonin levels in the brain.

In individuals with epilepsy or other seizure disorders, there is concern that SSRIs might either increase the likelihood of seizures or lower the threshold for their occurrence. Generally, the FDA-approved prescribing information for these drugs will caution their use in individuals with a seizure disorder.

However, it's important to note though, that some studies have suggested that certain SSRIs possess anticonvulsant properties, indicating a potential to reduce seizure activity.

Overall, there is complexity in the neural mechanisms involved in epilepsy, and predicting how introducing a dietary supplement like 5-HTP could impact someone's seizure susceptibility is challenging.

The bottom line is that there does not appear to be a clinically significant interaction between valproate and 5-HTP, as no studies have documented clinically significant adverse events after using both substances. However, data is certainly limited.

As always, it's essential to talk to your doctor before making any changes or additions to your medication or supplement regimen to ensure appropriate monitoring.

As a final note in this section, I want to point out valproate and 5-HTP have both been noted as causing sedation, so there is a risk of additive sedative effects with the two.

Final Words

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