Herb & supplement monograph

Jimson Weed Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Jimson Weed interacts with medications. The heart of this page is the interaction list — every drug Jimson Weed is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Jimson Weed is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Jimson Weed Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the risk of a clinically significant Jimson Weed drug interaction is moderate for anyone taking medications with anticholinergic effects, which is the one concern driving this entire profile. Every listed interaction is rated moderate, and all of them trace back to a single issue: additive anticholinergic effects.

Interactions deserving the most attention

Jimson Weed naturally contains atropine and scopolamine, chemicals that block a nerve signal many medicines also block. Taking it alongside anticholinergic drugs could stack these effects and increase side effects such as those seen with this drug class. This is the interaction that deserves the most attention, and it applies broadly because so many common medicines have some anticholinergic activity. That said, the concern is theoretical, based on what these plant chemicals are known to do rather than on documented cases in people.

What the rest of the list means

Although the number of interacting medications looks large, it does not mean each combination has been shown to cause harm. The whole list reflects one predicted mechanism, and the interaction has not been confirmed in human studies. The length of the list simply shows how many medicines share anticholinergic properties, not how many proven problems exist.

Check your medications against Jimson Weed

Based on HelloPharmacist’s Jimson Weed interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Jimson Weed

195 medications have a known interaction with Jimson Weed, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcepromazineAtravet› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief› Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength› Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG› Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid› Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR› Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus› Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more› Acetaminophen, Codeine, DoxylamineMersyndol› Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil› Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps› Acetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength› Acetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief› Acetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime› Acetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES› Acetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs› Aclidinium BromideTudorza Pressair› Aclidinium Bromide, Formoterol Fumarate DihydrateDuaklir Pressair› Aerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri› AmantadineGocovri, Osmolex ER, Symmetrel› AminoglutethimideCytadren› AmitriptylineElavil›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Jimson Weed combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Jimson Weed affects

Every type of medication (drug category) Jimson Weed is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Jimson Weed interacts with
Anticholinergic Drugs
Anticholinergic Drugs

Theoretically, jimson weed may increase anticholinergic effects and adverse effects.
Jimson weed contains alkaloids with anticholinergic effects, such as atropine and scopolamine. Use with other anticholinergic drugs may cause additive effects.

Likelihood Possible Evidence D
Monograph

Jimson Weed: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Jimson Weed is a highly poisonous plant that contains powerful nerve-affecting compounds, and even small amounts can cause severe poisoning, hallucinations, or death. It is not a safe supplement, and there is no reliable evidence supporting its use for any health condition. Do not use Jimson Weed in any form.

Scientific name
Datura stramonium
Family
Solanaceae
Part used
Leaves, seeds, flowers, and roots
Common forms
Dried plant material, smoked preparations, teas, and folk extracts (none are recommended for self-use)
People commonly use it for
  • Asthma and breathing problems (historical/folk use)
  • Pain relief
  • Recreational hallucinogen (highly dangerous misuse)
  • Muscle spasms
  • Skin conditions (traditional topical use)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

Jimson Weed is toxic and can cause life-threatening poisoning even at small doses.

PregnancyUnsafe

When used orally; avoid using.

Read the full pregnancy detail
BreastfeedingUnsafe

When used orally; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Jimson Weed (Datura stramonium) is a tall, weedy plant in the nightshade family. It is also sometimes called thorn apple, devil's snare, or moonflower. It has large white or purple trumpet-shaped flowers and spiny seed pods filled with many small dark seeds.

The plant grows wild in many parts of the world, including fields, roadsides, and disturbed soil across North America, Europe, and Asia. Every part of the plant is poisonous.

Historically, parts of the plant have been used in folk medicine and traditional remedies, and some people misuse it as a recreational drug for its mind-altering effects. Because it is so toxic, Jimson Weed is not used as a safe supplement and should not be taken at home.

How it works

Jimson Weed contains powerful compounds called tropane alkaloids, mainly atropine, scopolamine, and hyoscyamine. These chemicals block a part of the nervous system that uses a messenger called acetylcholine (this is called an anticholinergic effect).

By blocking this system, the alkaloids can widen the pupils, speed up the heart, dry up secretions, relax some muscles, and affect the brain. These same effects are what make the plant dangerous, causing confusion, hallucinations, and dangerous changes in heart rate.

Much of what we know comes from the known pharmacology of atropine and scopolamine, which are studied as drugs, but in the raw plant the doses are uncontrolled and unsafe.

Effectiveness

Does Jimson Weed work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 4 uses evaluated
4 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Jimson Weed, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 4 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Asthma
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral jimson weed for asthma, there is insufficient reliable information about the clinical effects of jimson weed for this purpose.

Insufficient Reliable Evidence To Rate Bronchitis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral jimson weed for bronchitis, there is insufficient reliable information about the clinical effects of jimson weed for this purpose.

Insufficient Reliable Evidence To Rate Cough
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral jimson weed for cough, there is insufficient reliable information about the clinical effects of jimson weed for this purpose.

Insufficient Reliable Evidence To Rate Influenza
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral jimson weed for influenza, there is insufficient reliable information about the clinical effects of jimson weed for this purpose.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Jimson Weed is poisonous and should not be used. Even small amounts can cause serious harm. Children, teens, older adults, and anyone with heart disease, glaucoma, or urinary problems are at especially high risk.

Poisonings often happen by accident when the plant is mistaken for an edible plant, or on purpose when people try to use it as a drug. Because the strength varies so much, there is no "safe" amount.

Pregnancy and breastfeeding: Do not use Jimson Weed at all. It is toxic and can harm both the parent and the baby.

If you suspect Jimson Weed poisoning, call your local poison control center or emergency services right away.

Side effects

Even small exposures can cause an anticholinergic toxidrome, often described with the phrase: "hot as a hare, dry as a bone, red as a beet, blind as a bat, mad as a hatter."

Common and serious effects include:

  • Dry mouth, dry skin, and flushed red skin
  • Blurred vision and widely dilated pupils
  • Fast heartbeat and high blood pressure
  • Fever and trouble urinating
  • Confusion, agitation, hallucinations, and delirium
  • Seizures, coma, and death in severe cases

These effects can last many hours to days because the plant chemicals leave the body slowly. Severe poisoning is a medical emergency.

Jimson Weed: Reported Adverse Effects

Documented safety reports on Jimson Weed from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, jimson weed is unsafe.

Most Common Adverse Effects:

Orally: Anticholinergic effects, such as abdominal pain, altered mental status, dry eyes, dry mouth, dry skin, nausea, tachycardia, urinary retention, and vomiting.

Serious Adverse Effects (Rare):

Orally: Anticholinergic toxicity, death.

Reports by condition
Arrhythmia Cardiovascular

Orally, jimson weed can cause anticholinergic side effects such as hypertension, tachycardia, and arrhythmia.

  1. Matsuda, K., Morinaga, M., Okamoto, M., Miyazaki, S., Isimaru, T., Suzuki, K., and Tohyama, K. [Toxicological analysis of a case of Datura stramonium poisoning]. Rinsho Byori 2006;54(10):1003-1007.
  2. Tiongson, J. and Salen, P. Mass ingestion of Jimson Weed by eleven teenagers. Del.Med.J 1998;70(11):471-476.
  3. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
  4. Rwiza, H. T. Jimson weed food poisoning. An epidemic at Usangi rural government hospital. Trop.Geogr.Med. 1991;43(1-2):85-90.
  5. Dewitt, M. S., Swain, R., and Gibson, L. B., Jr. The dangers of jimson weed and its abuse by teenagers in the Kanawha Valley of West Virginia. W.V.Med J 1997;93(4):182-185.
  6. Amlo, H., Haugeng, K. L., Wickstrom, E., Koss, A., Husebye, T., and Jacobsen, D. [Poisoning with Jimson weed. Five cases treated with physostigmine]. Tidsskr.Nor Laegeforen. 8-10-1997;117(18):2610-2612.
  7. Shervette, R. E., III, Schydlower, M., Lampe, R. M., and Fearnow, R. G. Jimson "loco" weed abuse in adolescents. Pediatrics 1979;63(4):520-523.
  8. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.
  9. Ahmed M, Mridha D. Unintentional Jimson Weed Poisoning in a Family: A Case Report. Cureus 2023;15(9):e45604.
Arrhythmia Other

Orally, jimson weed can block muscarinic cholinergic neurons and cause anticholinergic side effects. Larger amounts of jimson weed intake can also lead to toxicity and anticholinergic syndrome. Central anticholinergic symptoms, which are dose-dependent, include muscle tremor and rigidity, leg cramps, hallucinations, slurred speech, psychosis, agitated delirium, seizures, coma, cardiovascular collapse, or respiratory failure. Peripheral anticholinergic symptoms include dilated pupils, blurry vision, dry mouth, flushed skin, tachycardia, arrhythmias, fever, hypertension or hypotension, and difficulty urinating. There are also numerous reports of death after jimson weed ingestion. The lethal dose of jimson weed for adults is 15-100 grams of leaf or 15-25 grams of the seeds (equivalent to 100 mg atropine). Jimson weed toxicity seems to occur 1-12 hours after ingestion.

Children and adolescents are more susceptible to jimson weed toxicity. The lethal dose of atropine in this population is 10 mg or less. There are numerous case reports of anticholinergic toxicity in children and adolescents ingesting jimson weed seeds accidentally and recreationally. Some children ingested leaves that were packed into jimson weed cigarettes; others ingested several hundred seeds.

  1. Hassell LH, MacMillan MW. Acute anticholinergic syndrome following ingestion of Angel's trumpet tea. Hawaii Med J 1995;54:669-70.
  2. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
  3. Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325.
  4. Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.
  5. Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459.
  6. Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61.
  7. Parissis, D., Mellidis, C., Boutis, A., Apostolidis, K., Ignatiadis, M., Kiosses, V., and Milonas, I. Neurological findings in a case of coma secondary to Datura stramonium poisoning. Eur J Neurol. 2003;10(6):745-746.
  8. Forrester, M. B. Jimsonweed (Datura stramonium) exposures in Texas, 1998-2004. J Toxicol.Environ.Health A 2006;69(19):1757-1762.
  9. Rwiza, H. T. Jimson weed food poisoning. An epidemic at Usangi rural government hospital. Trop.Geogr.Med. 1991;43(1-2):85-90.
  10. Diker, D., Markovitz, D., Rothman, M., and Sendovski, U. Coma as a presenting sign of Datura stramonium seed tea poisoning. Eur J Intern.Med. 2007;18(4):336-338.
  11. Spina, S. P. and Taddei, A. Teenagers with Jimson weed (Datura stramonium) poisoning. CJEM. 2007;9(6):467-468.
  12. Germond-Burquier, V., Narring, F., and Broers, B. [Intentional datura stramonium intoxication and circumstances of use in two adolescents]. Presse Med. 2008;37(6 Pt 1):982-985.
  13. O'Grady, T. C., Brown, J., and Jacamo, J. Outbreak of Jimson Weed abuse among Marine Corps personnel at Camp Pendleton. Mil.Med. 1983;148(9):732-734.
  14. Suda, K., Komatsu, K., and Hashimoto, K. A histopathological study on the islets of Langerhans and ductal epithelial metaplasia in atrophic lobuli of pancreas. Acta Pathol.Jpn. 1976;26(5):561-572.
  15. Dewitt, M. S., Swain, R., and Gibson, L. B., Jr. The dangers of jimson weed and its abuse by teenagers in the Kanawha Valley of West Virginia. W.V.Med J 1997;93(4):182-185.
  16. Amlo, H., Haugeng, K. L., Wickstrom, E., Koss, A., Husebye, T., and Jacobsen, D. [Poisoning with Jimson weed. Five cases treated with physostigmine]. Tidsskr.Nor Laegeforen. 8-10-1997;117(18):2610-2612.
  17. Tiongson, J. and Salen, P. Mass ingestion of Jimson Weed by eleven teenagers. Del.Med.J 1998;70(11):471-476.
  18. Ahmed M, Mridha D. Unintentional Jimson Weed Poisoning in a Family: A Case Report. Cureus 2023;15(9):e45604.
  19. Urich RW, Bowerman DL, Levisky JA, Pflug JL. Datura stramonium: a fatal poisoning. J Forensic Sci 1982;27:948-54.
  20. Boumba, V. A., Mitselou, A., and Vougiouklakis, T. Fatal poisoning from ingestion of Datura stramonium seeds. Vet.Hum.Toxicol. 2004;46(2):81-82.
  21. Steenkamp, P. A., Harding, N. M., van Heerden, F. R., and van Wyk, B. E. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry. Forensic Sci.Int 10-4-2004;145(1):31
  22. Mutebi RR, Ario AR, Nabatanzi M, et al. Large outbreak of Jimsonweed (Datura stramonium) poisoning due to consumption of contaminated humanitarian relief food: Uganda, March-April 2019. BMC Public Health 2022;22(1):623.
  23. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  24. Al Shaikh, A. M. and Sablay, Z. M. Hallucinogenic plant poisoning in children. Saudi.Med.J 2005;26(1):118-121.
  25. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.
  26. Shervette, R. E., III, Schydlower, M., Lampe, R. M., and Fearnow, R. G. Jimson "loco" weed abuse in adolescents. Pediatrics 1979;63(4):520-523.
  27. Taha, S. A. and Mahdi, A. H. Datura intoxication in Riyadh. Trans.R.Soc.Trop.Med.Hyg. 1984;78(1):134-135.
  28. Adegoke SA, Alo LA. Datura stramonium poisoning in children. Niger J Clin Pract. 2013;16(1):116-8.
  29. Melvin K, Hourani D. Datura stramonium toxicity mistakenly diagnosed as "bath salt" intoxication: a case report. W V Med J. 2014;110(1):22-5.
  30. Özkaya AK, Güler E, Karabel N, Namli AR, Göksügür Y. Datura stramonium poisoning in a child. Turk J Pediatr. 2015;57(1):82-4.
  31. Ricard F, Abe E, Duverneuil-Mayer C, Charlier P, de la Grandmaison G, Alvarez JC. Measurement of atropine and scopolamine in hair by LC-MS/MS after Datura stramonium chronic exposure. Forensic Sci Int. 2012;223(1-3):256-60.
  32. Sanlidag B, Derinöz O, Yildiz N. A case of pediatric age anticholinergic intoxication due to accidental Datura stramonium ingestion admitting with visual hallucination. Turk J Pediatr. 2014;56(3):313-5.
Epilepsy Neurologic/CNS

Orally, jimson weed can cause anticholinergic side effects such as memory loss, attention impairment, confusion, hallucinations, slurred speech, psychosis, agitated delirium, seizures, and coma.

  1. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
  2. Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325.
  3. Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.
  4. Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459.
  5. Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61.
  6. Parissis, D., Mellidis, C., Boutis, A., Apostolidis, K., Ignatiadis, M., Kiosses, V., and Milonas, I. Neurological findings in a case of coma secondary to Datura stramonium poisoning. Eur J Neurol. 2003;10(6):745-746.
  7. Forrester, M. B. Jimsonweed (Datura stramonium) exposures in Texas, 1998-2004. J Toxicol.Environ.Health A 2006;69(19):1757-1762.
  8. Rwiza, H. T. Jimson weed food poisoning. An epidemic at Usangi rural government hospital. Trop.Geogr.Med. 1991;43(1-2):85-90.
  9. Diker, D., Markovitz, D., Rothman, M., and Sendovski, U. Coma as a presenting sign of Datura stramonium seed tea poisoning. Eur J Intern.Med. 2007;18(4):336-338.
  10. Spina, S. P. and Taddei, A. Teenagers with Jimson weed (Datura stramonium) poisoning. CJEM. 2007;9(6):467-468.
  11. Germond-Burquier, V., Narring, F., and Broers, B. [Intentional datura stramonium intoxication and circumstances of use in two adolescents]. Presse Med. 2008;37(6 Pt 1):982-985.
  12. O'Grady, T. C., Brown, J., and Jacamo, J. Outbreak of Jimson Weed abuse among Marine Corps personnel at Camp Pendleton. Mil.Med. 1983;148(9):732-734.
  13. Suda, K., Komatsu, K., and Hashimoto, K. A histopathological study on the islets of Langerhans and ductal epithelial metaplasia in atrophic lobuli of pancreas. Acta Pathol.Jpn. 1976;26(5):561-572.
  14. Dewitt, M. S., Swain, R., and Gibson, L. B., Jr. The dangers of jimson weed and its abuse by teenagers in the Kanawha Valley of West Virginia. W.V.Med J 1997;93(4):182-185.
  15. Amlo, H., Haugeng, K. L., Wickstrom, E., Koss, A., Husebye, T., and Jacobsen, D. [Poisoning with Jimson weed. Five cases treated with physostigmine]. Tidsskr.Nor Laegeforen. 8-10-1997;117(18):2610-2612.
  16. Tiongson, J. and Salen, P. Mass ingestion of Jimson Weed by eleven teenagers. Del.Med.J 1998;70(11):471-476.
  17. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.
  18. Ahmed M, Mridha D. Unintentional Jimson Weed Poisoning in a Family: A Case Report. Cureus 2023;15(9):e45604.
Hepatitis Hepatic

Orally, jimson weed can cause hepatotoxic events, including fulminant hepatitis.

  1. Ertekin, V., Selimoglu, M. A., and Altinkaynak, S. A combination of unusual presentations of Datura stramonium intoxication in a child: rhabdomyolysis and fulminant hepatitius. J Emerg.Med. 2005;28(2):227-228.
Muscle breakdown Musculoskeletal

Orally, jimson weed can cause anticholinergic side effects such as leg cramps, muscle tremor, muscle rigidity, and rhabdomyolysis.

  1. DeFrates, L. J., Hoehns, J. D., Sakornbut, E. L., Glascock, D. G., and Tew, A. R. Antimuscarinic intoxication resulting from the ingestion of moonflower seeds. Ann.Pharmacother. 2005;39(1):173-176.
  2. Nogue, S., Pujol, L., Sanz, P., and de la, Torre R. Datura stramonium poisoning. Identification of tropane alkaloids in urine by gas chromatography-mass spectrometry. J Int Med.Res. 1995;23(2):132-137.
  3. Ahmed M, Mridha D. Unintentional Jimson Weed Poisoning in a Family: A Case Report. Cureus 2023;15(9):e45604.
Nausea and vomiting Gastrointestinal

Orally, jimson weed can cause anticholinergic side effects such as abdominal pain, nausea and vomiting, decreased bowel sounds, and difficulty swallowing.

  1. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Anon. Jimson weed poisoning- Texas, New York, and California, 1994. MMWR Morb Mortal Wkly Rep 1995;44:41-4.
  4. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.
  5. Ahmed M, Mridha D. Unintentional Jimson Weed Poisoning in a Family: A Case Report. Cureus 2023;15(9):e45604.
Thrombocytopenia Hematologic

Orally, jimson weed has been reported to cause thrombocytopenia in one patient.

  1. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.
Urinary retention Genitourinary

Orally, jimson weed can cause anticholinergic side effects such as urinary retention.

  1. Shervette, R. E., III, Schydlower, M., Lampe, R. M., and Fearnow, R. G. Jimson "loco" weed abuse in adolescents. Pediatrics 1979;63(4):520-523.
  2. Amlo, H., Haugeng, K. L., Wickstrom, E., Koss, A., Husebye, T., and Jacobsen, D. [Poisoning with Jimson weed. Five cases treated with physostigmine]. Tidsskr.Nor Laegeforen. 8-10-1997;117(18):2610-2612.
  3. Dewitt, M. S., Swain, R., and Gibson, L. B., Jr. The dangers of jimson weed and its abuse by teenagers in the Kanawha Valley of West Virginia. W.V.Med J 1997;93(4):182-185.
  4. Senthil S, Ravichandran U. Datura Poisoning in a Family - A Tale of Mistaken Identity. Curr Health Sci J 2020;46(3):305-308.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no safe or established dose of Jimson Weed. The amount of toxic alkaloids varies widely from plant to plant, season to season, and even between different parts of the same plant, so there is no way to take a predictable amount.

Because of this, no responsible pharmacist or doctor recommends using it. The atropine and scopolamine found in the plant are used as carefully measured prescription drugs in hospitals, but the raw plant should never be self-dosed.

If you are looking for help with asthma or another condition, talk with your pharmacist or doctor about proven, safe treatments.

Pregnancy & Breastfeeding

Jimson Weed & Pregnancy

Unsafe

When used orally; avoid using.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

Jimson Weed & Breastfeeding

Unsafe

When used orally; avoid using.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 43 references that drive our Jimson Weed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Robbers JE, Speedie MK, Tyler VE. Pharmacognosy and Pharmacobiotechnology. Baltimore, MD: Williams & Wilkins, 1996.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  5. Hassell LH, MacMillan MW. Acute anticholinergic syndrome following ingestion of Angel's trumpet tea. Hawaii Med J 1995;54:669-70.
  6. Urich RW, Bowerman DL, Levisky JA, Pflug JL. Datura stramonium: a fatal poisoning. J Forensic Sci 1982;27:948-54.
  7. Anon. Jimson weed poisoning- Texas, New York, and California, 1994. MMWR Morb Mortal Wkly Rep 1995;44:41-4.
  8. Djibo, A. and Bouzou, S. B. [Acute intoxication with "sobi-lobi" (Datura). Four cases in Niger]. Bull.Soc.Pathol.Exot. 2000;93(4):294-297.
  9. Mikolich, J. R., Paulson, G. W., and Cross, C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann.Intern.Med. 1975;83(3):321-325. PubMed
  10. Onen, C. L., Othol, D., Mbwana, S. K., and Manuel, I. L. Datura stramonium mass poisoning in Botswana. S.Afr.Med.J 2002;92(3):213-214.
  11. Oberndorfer, S., Grisold, W., Hinterholzer, G., and Rosner, M. Coma with focal neurological signs caused by Datura stramonium intoxication in a young man. J Neurol.Neurosurg.Psychiatry 2002;73(4):458-459. PubMed
  12. Sasaki, T., Yamazaki, K., Yamori, T., and Endo, T. Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin. Br.J Cancer 10-7-2002;87(8):918-923. PubMed
  13. Levy, R. Jimson seed poisoning-- a new hallucinogen on the horizon. JACEP. 1977;6(2):58-61. PubMed
  14. Parissis, D., Mellidis, C., Boutis, A., Apostolidis, K., Ignatiadis, M., Kiosses, V., and Milonas, I. Neurological findings in a case of coma secondary to Datura stramonium poisoning. Eur J Neurol. 2003;10(6):745-746.
  15. Boumba, V. A., Mitselou, A., and Vougiouklakis, T. Fatal poisoning from ingestion of Datura stramonium seeds. Vet.Hum.Toxicol. 2004;46(2):81-82.
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Jimson Weed

1 brand in our database make a supplement containing Jimson Weed.

Product directory

Supplement products with Jimson Weed

1 product in our database contain Jimson Weed. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Jimson Weed: Common Questions

What is Jimson Weed used for, and does it work?
People use Jimson Weed for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Jimson Weed interact with prescription medications?
Yes. We list 195 medications with a known interaction with Jimson Weed. Use the checker above to see how Jimson Weed interacts with a specific drug.
How are Jimson Weed interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Jimson Weed with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Jimson Weed interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Jimson Weed safe to use as a natural remedy?
No. Jimson Weed is highly poisonous, and even small amounts can cause severe poisoning, hallucinations, or death. It should not be used as a home remedy.
Why do some people use Jimson Weed even though it is dangerous?
Some people misuse it for its mind-altering effects, and it has a history in folk medicine for breathing and pain problems. These uses are unsafe and not supported by reliable evidence.
What should I do if someone swallows Jimson Weed?
Treat it as a medical emergency. Call your local poison control center or emergency services right away, especially if there is confusion, a fast heartbeat, fever, or hallucinations.
Can I use Jimson Weed during pregnancy or breastfeeding?
No. It is toxic and must never be used during pregnancy or while breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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