Herb & supplement monograph

Angel's Trumpet Drug Interactions, Uses, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Angel's Trumpet interacts with medications. The heart of this page is the interaction list — every drug Angel's Trumpet is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Angel's Trumpet is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Angel's Trumpet Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Angel's Trumpet drug interaction appears moderate, and the concern applies mainly to people taking medications with anticholinergic effects. Every listed interaction is rated moderate rather than major, and all of them stem from a single shared concern.

Interactions deserving the most attention

The interactions that deserve the most attention involve anticholinergic drugs, a broad group of medications that can dry secretions, slow the gut, and affect the brain and heart rate. Taking Angel's Trumpet alongside these medicines may add to their effects and increase side effects. This concern is graded as possible, meaning it rests on limited human reports or lab and animal research rather than well-controlled human studies, but the additive nature of the effect makes caution sensible.

What the rest of the list means

Although the list of interacting medications is long, it does not reflect many different problems. Nearly two hundred medications share anticholinergic activity, so they all appear for the same single reason. The interaction has not been confirmed in well-controlled human studies, so for many combinations the effect remains predicted rather than proven.

Check your medications against Angel's Trumpet

Based on HelloPharmacist’s Angel's Trumpet interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Angel's Trumpet

195 medications have a known interaction with Angel's Trumpet, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcepromazineAtravet
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acepromazine interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Caffeine, Pyrilamine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interaction
Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interaction
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interaction
Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Chlorpheniramine, Pseudoephedrine interaction
Acetaminophen, Codeine, DoxylamineMersyndol
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Codeine, Doxylamine interaction
Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interaction
Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction
Acetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Diphenhydramine interaction
Acetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Diphenhydramine, Pseudoephedrine interaction
Acetaminophen, Doxylamine, PseudoephedrineEx Strength Tylenol Sinus Nighttime
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Doxylamine, Pseudoephedrine interaction
Acetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Pamabrom, Pyrilamine interaction
Acetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Acetaminophen, Phenylephrine, Chlorpheniramine interaction
Aclidinium BromideTudorza Pressair
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Aclidinium Bromide interaction
Aclidinium Bromide, Formoterol Fumarate DihydrateDuaklir Pressair
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Aclidinium Bromide, Formoterol Fumarate Dihydrate interaction
Aerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interaction
AmantadineGocovri, Osmolex ER, Symmetrel
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Amantadine interaction Amantadine drug page: uses, dosage & side effects
AminoglutethimideCytadren
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Aminoglutethimide interaction
AmitriptylineElavil
Moderate Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Read the full Angel's Trumpet + Amitriptyline interaction Amitriptyline drug page: uses, dosage & side effects
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Angel's Trumpet combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Angel's Trumpet affects

Every type of medication (drug category) Angel's Trumpet is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Angel's Trumpet interacts with
Anticholinergic Drugs
Anticholinergic Drugs

Concomitant use may increase anticholinergic effects and adverse effects.

Likelihood Possible Evidence D
Monograph

Angel's Trumpet: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Angel's Trumpet is a highly poisonous ornamental plant that contains powerful toxins like scopolamine and atropine. There is no safe medicinal dose, and even small amounts can cause hallucinations, dangerous heart effects, coma, or death. It should not be taken as a supplement or remedy.

Angel's Trumpet
Scientific name
Brugmansia spp.
Family
Solanaceae
Part used
Flowers, leaves, seeds, and roots (all parts are toxic)
Common forms
Ornamental plant; rarely as teas, infusions, or smoked preparations (all unsafe)
People commonly use it for
  • Traditional folk medicine
  • Asthma or breathing remedies (historical)
  • Pain relief (traditional)
  • Recreational hallucinogen (dangerous misuse)
  • Ornamental garden plant

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallBest avoided

All parts of the plant are toxic and can cause life-threatening poisoning.

PregnancyUnsafe

When used orally. The entire plant is considered poisonous; avoid using.

Read the full pregnancy detail
BreastfeedingUnsafe

When used orally. The entire plant is considered poisonous; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Angel's Trumpet refers to several species of plants in the genus Brugmansia, which belong to the nightshade family (Solanaceae). This is the same plant family that includes tomatoes, potatoes, and eggplants, but unlike those food crops, Angel's Trumpet is highly poisonous.

The plant is native to South America and is now grown around the world as an ornamental shrub or small tree. It is best known for its large, fragrant, trumpet-shaped flowers that hang down toward the ground. The flowers can be white, yellow, pink, or orange.

While Angel's Trumpet has a long history in traditional medicine and ritual use in some cultures, it is mainly grown today as a decorative garden plant. Because of its strong toxins, health authorities do not recommend it for medicinal use.

Uses & effectiveness

People have historically used parts of Angel's Trumpet in folk medicine for problems like asthma, pain, skin conditions, and as a sedative or hallucinogen in spiritual rituals. It has also been misused recreationally for its mind-altering effects.

There is no reliable scientific evidence that Angel's Trumpet safely treats any health condition. The plant's effects come from powerful and unpredictable toxins, and the line between a "dose" and a poisoning is extremely thin. Reports in the medical literature mostly describe accidental poisonings and emergency room visits, not benefits.

Because of these serious dangers, no responsible health professional recommends Angel's Trumpet as a treatment for any purpose.

How it works

Angel's Trumpet contains a group of compounds called tropane alkaloids, including scopolamine, atropine, and hyoscyamine. These chemicals block a part of the nervous system that uses a messenger called acetylcholine, producing what doctors call "anticholinergic" effects.

Blocking this system can dry up secretions, speed up the heart, widen the pupils, and affect the brain, causing confusion and hallucinations. Some of these alkaloids, in carefully controlled and purified pharmaceutical forms, are used as approved medicines for very specific situations. However, the amount of toxin in any given plant or homemade preparation varies wildly and cannot be measured safely at home.

This unpredictability is a key reason the raw plant is so dangerous compared with regulated medicines.

Safety & precautions

Angel's Trumpet is poisonous, and every part of the plant — flowers, leaves, seeds, and roots — can cause severe harm if eaten, brewed into a tea, or smoked. Poisonings have led to hospitalizations, coma, and death.

Children and pets are at special risk, and even handling the plant and then touching the eyes or mouth may cause problems. People should avoid growing it where curious children or animals can reach it.

Pregnancy and breastfeeding: Angel's Trumpet should never be used during pregnancy or while breastfeeding. Its toxins can harm both the mother and the baby.

If you suspect someone has eaten or ingested any part of this plant, seek emergency medical care right away or contact a poison control center immediately.

Side effects

Even small amounts can cause serious anticholinergic poisoning. Common signs include:

  • Dry mouth and intense thirst
  • Dilated (widened) pupils and blurred vision
  • Flushed, hot, dry skin
  • Fast heartbeat
  • Confusion, agitation, and vivid hallucinations

More severe effects can include very high body temperature, seizures, dangerous heart rhythm changes, loss of consciousness, coma, and death. Because the toxin levels are unpredictable, there is no "safe" amount.

Angel's Trumpet: Reported Adverse Effects

Documented safety reports on Angel's Trumpet from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Angel's trumpet is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, angel's trumpet can cause acute anticholinergic poisoning requiring medical attention. Angel's trumpet can cause neurologic toxicity, including delirium, dilated pupils, hyperactivity, disorientation, audio-visual disassociation, hyperexcitability, visual hallucinations, anxiety, amnesia, combativeness, ataxia, clonus, muscular weakness, expressive aphasia, muscular paralysis, seizure, alternating levels of consciousness, convulsions, and coma. Additional symptoms of toxicity include intense thirst, dry skin and mucous membranes, flushing of the skin, fever, widened pulse pressure, systolic hypertension, tachycardia, urinary retention, and decreased GI motility. Death due to angel's trumpet toxicity is rare and typically results from respiratory arrest or self-inflicted injury or exposure as a result of hallucinations. Toxic effects have occurred in individuals consuming tea brewed from the flowers, ingestion of the flowers or another part of the plant, or ingestion of juice from the plant. Reports suggest that ingestion of tea made from 3-6 flowers can produce hallucinations, and 9 flowers can produce total paralysis. The tea results in a rapid and complete absorption of alkaloids.

Topically, pupil enlargement and blurred vision have occurred.

Inhalation of the smoke from burning leaves of angel's trumpet has been reported to cause anticholinergic poisoning adverse effects.

  1. McHenry LE, Hall RC. Angel's trumpet. Lethal and psychogenic aspects. J Fla Med Assoc 1978;65:192-6.
  2. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4.
  3. Greene GS, Patterson SG, Warner E. Ingestion of angel's trumpet: an increasingly common source of toxicity. South Med J 1996;89:365-9.
  4. Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5.
  5. McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196.
  6. Isbister GK, Oakley P, Dawson AH, Whyte IM. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg Med (Fremantle). 2003;15(4):376-82.
  7. Gopel, C., Laufer, C., and Marcus, A. Three cases of angel's trumpet tea-induced psychosis in adolescent substance abusers. Nord.J.Psychiatry 2002;56(1):49-52.
  8. Havelius, U. and Asman, P. Accidental mydriasis from exposure to Angel's trumpet (Datura suaveolens). Acta Ophthalmol.Scand. 2002;80(3):332-335.
  9. Isbister, G. K., Oakley, P., Dawson, A. H., and Whyte, I. M. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg.Med.(Fremantle.) 2003;15(4):376-382.
  10. Mobus, U., Demmler, G., and Schulz, K. [Accidental drowning due to tropane alkaloid abuse]. Arch Kriminol. 2002;210(1-2):16-21.
  11. Marneros, A., Gutmann, P., and Uhlmann, F. Self-amputation of penis and tongue after use of Angel's Trumpet. Eur.Arch.Psychiatry Clin.Neurosci. 2006;256(7):458-459.
  12. Hayman, J. Datura poisoning--the Angel's Trumpet. Pathology 1985;17(3):465-466.
  13. Serin HM, Ozen B, Yilmaz S. A rare cause of acute anisocoria in a child: The angel's trumpet plant. J Pediatr Ophthalmol Strabismus. 2018;55:e33-e35.
Reports by condition
Acute respiratory distress syndrome (ARDS) Pulmonary/Respiratory

Orally, angel's trumpet can cause severe toxicity, including respiratory distress and respiratory arrest.

  1. Smith, E. A., Meloan, C. E., Pickell, J. A., and Oehme, F. W. Scopolamine poisoning from homemade 'moon flower' wine. J Anal.Toxicol 1991;15(4):216-219.
Anxiety Neurologic/CNS

Orally and via inhalation, angel's trumpet can cause severe toxicity. The most common neurologic symptoms include acute encephalopathy, delirium, dilated pupils, hyperactivity, and disorientation. Delirium and dilated pupils typically last for about 16 hours and 30 hours after ingestion, respectively. Other neurologic symptoms include audio-visual dissociation, hyperexcitability, visual hallucinations, anxiety, amnesia, combativeness, ataxia, clonus, muscular weakness, expressive aphasia, muscular paralysis, seizure, alternating levels of consciousness, convulsions, and coma. Death may occur due to cerebral anoxia. Hallucinations have led to self-amputations and accidents.

In one case report, a 5-year-old child was diagnosed with acute motor axonal neuropathy-type Guillain-Barre syndrome likely associated with accidental ingestion of angel's trumpet flowers, which were thought to have triggered an immune reaction against myelin on the peripheral nerves, although no diagnostic tests were performed. Treatment with plasmapheresis and intravenous immunoglobulin did not improve symptoms. The patient presented with rapid and shallow breathing, dry mouth with inflamed oral mucosa, difficulty with speech and swallowing, and muscle weakness, and progressed to flaccid paralysis with respiratory failure requiring mechanical ventilation for 35 days.

In another case of accidental angel's trumpet flower ingestion, a 76-year-old female was found in a stuporous state, with head trauma, tachycardia, and moderate thrombocytopenia. The next day the patient developed vomiting, bilateral mydriasis, aphasia, confusion, and hypertension, which all resolved within 48 hours. Chronic complications included ischemic encephalopathy with electroencephalogram abnormalities and two small subcortical stroke-like lesions.

  1. Isbister GK, Oakley P, Dawson AH, Whyte IM. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg Med (Fremantle). 2003;15(4):376-82.
  2. Colosimo E, Clodomiro A, Pirritano D, et al. Ischemic stroke and provoked seizure as a manifestation of Brugmansia suaveolens (angel's trumpet) acute intoxication: a detailed clinical, electroencephalogram, and magnetic resonance imaging description and 5
  3. Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5.
  4. McHenry LE, Hall RC. Angel's trumpet. Lethal and psychogenic aspects. J Fla Med Assoc 1978;65:192-6.
  5. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4.
  6. Gopel, C., Laufer, C., and Marcus, A. Three cases of angel's trumpet tea-induced psychosis in adolescent substance abusers. Nord.J.Psychiatry 2002;56(1):49-52.
  7. Mobus, U., Demmler, G., and Schulz, K. [Accidental drowning due to tropane alkaloid abuse]. Arch Kriminol. 2002;210(1-2):16-21.
  8. Marneros, A., Gutmann, P., and Uhlmann, F. Self-amputation of penis and tongue after use of Angel's Trumpet. Eur.Arch.Psychiatry Clin.Neurosci. 2006;256(7):458-459.
  9. Hayman, J. Datura poisoning--the Angel's Trumpet. Pathology 1985;17(3):465-466.
  10. McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196.
  11. Zhang HL, Wang XF. Angel's trumpet-associated polyneuropathy-is it Guillain-Barré syndrome? Pediatr Neurol. 2011 Jul;45(1):63; author reply 63-4.
  12. Sevketoglu E, Tatli B, Tugcu B, Demirelli Y, Hatipoglu S. An unusual cause of fulminant Guillain-Barré syndrome: angel's trumpet. Pediatr Neurol. 2010;43(5):368-70.
Arrhythmia Cardiovascular

Orally and via inhalation, angel's trumpet can cause severe toxicity. Cardiovascular symptoms include tachycardia and arrhythmias, widened pulse pressure, and hypertension or hypotension. Tachycardia usually resolves within 5 hours.

  1. Marneros, A., Gutmann, P., and Uhlmann, F. Self-amputation of penis and tongue after use of Angel's Trumpet. Eur.Arch.Psychiatry Clin.Neurosci. 2006;256(7):458-459.
  2. Isbister, G. K., Oakley, P., Dawson, A. H., and Whyte, I. M. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg.Med.(Fremantle.) 2003;15(4):376-382.
  3. McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196.
  4. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4.
  5. Colosimo E, Clodomiro A, Pirritano D, et al. Ischemic stroke and provoked seizure as a manifestation of Brugmansia suaveolens (angel's trumpet) acute intoxication: a detailed clinical, electroencephalogram, and magnetic resonance imaging description and 5
  6. Isbister GK, Oakley P, Dawson AH, Whyte IM. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg Med (Fremantle). 2003;15(4):376-82.
Dry skin Dermatologic

Orally and via inhalation, angel's trumpet can cause severe toxicity. Dermatologic symptoms include dry skin and mucous membranes, and flushing.

  1. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4.
  2. McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196.
Nausea and vomiting Gastrointestinal

Orally, angel's trumpet can cause severe toxicity. Gastrointestinal symptoms include vomiting, intense thirst, and decreased gastrointestinal motility.

  1. Marneros, A., Gutmann, P., and Uhlmann, F. Self-amputation of penis and tongue after use of Angel's Trumpet. Eur.Arch.Psychiatry Clin.Neurosci. 2006;256(7):458-459.
  2. Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5.
Poisoning Other

Orally, angel's trumpet can cause severe toxicity, rarely resulting in death. Deaths have been due to respiratory arrest, as well as self-inflicted injury or exposure as a result of hallucinations. In most cases of angel's trumpet poisoning, the actual amount of plant material ingested is unknown. Treatment includes cholinesterase inhibitors, such as physostigmine, and sedation with benzodiazepines to reduce anticholinergic delirium.

  1. Mobus, U., Demmler, G., and Schulz, K. [Accidental drowning due to tropane alkaloid abuse]. Arch Kriminol. 2002;210(1-2):16-21.
  2. Hayman, J. Datura poisoning--the Angel's Trumpet. Pathology 1985;17(3):465-466.
  3. Isbister GK, Oakley P, Dawson AH, Whyte IM. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg Med (Fremantle). 2003;15(4):376-82.
  4. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4.
  5. Isbister, G. K., Oakley, P., Dawson, A. H., and Whyte, I. M. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg.Med.(Fremantle.) 2003;15(4):376-382.
  6. Colosimo E, Clodomiro A, Pirritano D, et al. Ischemic stroke and provoked seizure as a manifestation of Brugmansia suaveolens (angel's trumpet) acute intoxication: a detailed clinical, electroencephalogram, and magnetic resonance imaging description and 5
Urinary retention Genitourinary

Orally and via inhalation, angel's trumpet can cause severe toxicity. Genitourinary symptoms include urinary retention.

  1. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4.
  2. McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no safe or established dose of Angel's Trumpet. The amount of toxin in the plant varies greatly from one plant, flower, or season to another, so even people who think they are using a "small" amount can be seriously poisoned.

Because of these dangers, we cannot provide any dosing guidance, and we strongly advise against using this plant in any form. If you are looking for a safe supplement or remedy, talk with your pharmacist or doctor about evidence-based options instead.

Pregnancy & Breastfeeding

Angel's Trumpet & Pregnancy

Unsafe

When used orally. The entire plant is considered poisonous; avoid using.

  1. McHenry LE, Hall RC. Angel's trumpet. Lethal and psychogenic aspects. J Fla Med Assoc 1978;65:192-6.
  2. Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5.

Angel's Trumpet & Breastfeeding

Unsafe

When used orally. The entire plant is considered poisonous; avoid using.

  1. McHenry LE, Hall RC. Angel's trumpet. Lethal and psychogenic aspects. J Fla Med Assoc 1978;65:192-6.
  2. Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 18 references that drive our Angel's Trumpet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  2. McHenry LE, Hall RC. Angel's trumpet. Lethal and psychogenic aspects. J Fla Med Assoc 1978;65:192-6.
  3. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4. PubMed
  4. Greene GS, Patterson SG, Warner E. Ingestion of angel's trumpet: an increasingly common source of toxicity. South Med J 1996;89:365-9. PubMed
  5. Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5. PubMed
  6. Gopel, C., Laufer, C., and Marcus, A. Three cases of angel's trumpet tea-induced psychosis in adolescent substance abusers. Nord.J.Psychiatry 2002;56(1):49-52. PubMed
  7. Havelius, U. and Asman, P. Accidental mydriasis from exposure to Angel's trumpet (Datura suaveolens). Acta Ophthalmol.Scand. 2002;80(3):332-335.
  8. Mobus, U., Demmler, G., and Schulz, K. [Accidental drowning due to tropane alkaloid abuse]. Arch Kriminol. 2002;210(1-2):16-21.
  9. Isbister, G. K., Oakley, P., Dawson, A. H., and Whyte, I. M. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg.Med.(Fremantle.) 2003;15(4):376-382.
  10. Marneros, A., Gutmann, P., and Uhlmann, F. Self-amputation of penis and tongue after use of Angel's Trumpet. Eur.Arch.Psychiatry Clin.Neurosci. 2006;256(7):458-459. PubMed
  11. Smith, E. A., Meloan, C. E., Pickell, J. A., and Oehme, F. W. Scopolamine poisoning from homemade 'moon flower' wine. J Anal.Toxicol 1991;15(4):216-219. DOI
  12. Hayman, J. Datura poisoning--the Angel's Trumpet. Pathology 1985;17(3):465-466. PubMed
  13. McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196.
  14. Isbister GK, Oakley P, Dawson AH, Whyte IM. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg Med (Fremantle). 2003;15(4):376-82.
  15. Zhang HL, Wang XF. Angel's trumpet-associated polyneuropathy-is it Guillain-Barré syndrome? Pediatr Neurol. 2011 Jul;45(1):63; author reply 63-4. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Angel's Trumpet

2 brands in our database make a supplement containing Angel's Trumpet.

Product directory

Supplement products with Angel's Trumpet

3 products in our database contain Angel's Trumpet. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Angel's Trumpet: Common Questions

Does Angel's Trumpet interact with prescription medications?
Yes. We list 195 medications with a known interaction with Angel's Trumpet. Use the checker above to see how Angel's Trumpet interacts with a specific drug.
How are Angel's Trumpet interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Angel's Trumpet with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Angel's Trumpet interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Is Angel's Trumpet safe to use as a supplement or remedy?
No. Angel's Trumpet is highly poisonous, and there is no safe dose. Even small amounts can cause hallucinations, dangerous heart effects, coma, or death.
What happens if someone eats or drinks Angel's Trumpet?
It can cause anticholinergic poisoning, with symptoms like dry mouth, dilated pupils, fast heartbeat, confusion, hallucinations, seizures, and loss of consciousness. This is a medical emergency — call poison control or seek emergency care immediately.
Can I use Angel's Trumpet while pregnant or breastfeeding?
No. It should be completely avoided during pregnancy and breastfeeding because its toxins can harm both you and your baby.
Is it dangerous to just grow Angel's Trumpet in my garden?
Growing it for decoration is common, but the whole plant is toxic. Keep it away from children and pets, and wash your hands after handling it so you don't accidentally transfer the toxin to your eyes or mouth.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Angel's Trumpet

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