Trospium

Trospium is used to treat an overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination). Trospium is in a class of medications called antimuscarinics. It works by relaxing the bladder muscles to prevent urgent, frequent, or uncontrolled urination.

Trospium comes as a tablet and an extended-release capsule to take by mouth. The tablet is usually taken twice a day on an empty stomach or 1 hour before meals,or is sometimes taken once a day at bedtime. Trospium extended-release capsule is usually taken once daily in the morning with water on an empty stomach, at least 1 hour before a meal. To help you remember to take trospium, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trospium exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking trospium,

• tell your doctor and pharmacist if you are allergic to trospium, any other medications, or any of the ingredients in trospium tablets or extended-release capsules. Ask your pharmacist for a list of the ingredients.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: antacids; antihistamines; cold medications; ipratropium (Atrovent); medications for depression or mental illness; medications for inflammatory bowel disease or diarrhea, motion sickness, Parkinson's disease, ulcers, or urinary problems; metformin (Glucophage); morphine (MSIR, Oramorph, others); muscle relaxants; procainamide; tenofovir (Viread); and vancomycin (Vancocin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor if you have or have ever had glaucoma (an eye disease that can cause vision loss) or any type of blockage in the bladder or digestive system which causes delays or causes difficulty in emptying your bladder or stomach. Your doctor may tell you not to take trospium.

• tell your doctor if you have or have ever had myasthenia gravis (a disorder of the nervous system that causes muscle weakness); ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum); any disease of the stomach or intestines; frequently occurring constipation; problems emptying your bladder;or benign prostatic hypertrophy (BPH, enlargement of the prostate, a male reproductive organ); or liver or kidney disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking trospium, call your doctor.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trospium.

• you should know that trospium may make you drowsy or dizzy and may cause blurred vision. Do not drive a car or operate machinery until you know how this medication affects you.

• remember that alcohol can add to the drowsiness caused by this medication. You should not drink alcohol within 2 hours of taking trospium.

• you should know that trospium may make it harder for your body to cool down when it gets very hot. Avoid exposure to extreme heat, and call your doctor or get emergency medical treatment if you have fever or other signs of heat stroke such as dizziness, upset stomach, headache, confusion, and fast heartbeat after you are exposed to heat.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose 1 hour before your next meal. However, if you are due to take your next dose at that time, skip the missed dose and continue your normal dosing schedule. Do not take a double dose to make up for a missed one.

• Trospium may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dry mouth, eyes, or nose

  • constipation

  • headache

  • confusion

  • gas

• Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

  • difficulty urinating

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

  • rash

  • hives

  • itching

  • difficulty breathing or swallowing

  • hallucinations (seeing things or hearing voices that do not exist)

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

• fast heartbeat

• widened pupils (black circle in the middle of the eye)

• sensitivity to light

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Delavirdine	Delavirdine The metabolism of Delavirdine can be decreased when combined with Trospium.
Nevirapine	Nevirapine The metabolism of Nevirapine can be decreased when combined with Trospium.
Dolasetron	Dolasetron Dolasetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Anagrelide	Anagrelide The risk or severity of Tachycardia can be increased when Trospium is combined with Anagrelide.
Bisacodyl	Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Trospium.
Cilostazol	Cilostazol The metabolism of Cilostazol can be decreased when combined with Trospium.
Diphenoxylate	Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Trospium.
Guanfacine	Guanfacine Guanfacine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Magnesium Hydroxide	Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Trospium.
Magnesium Oxide	Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Trospium.
Naratriptan	Naratriptan Naratriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Paregoric	Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Trospium.
Penbutolol	Penbutolol The metabolism of Acebutolol can be decreased when combined with Trospium.
Pentazocine	Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Trospium.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Trospium.
Psyllium	Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Trospium.
Reserpine	Reserpine Reserpine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Rizatriptan	Rizatriptan Rizatriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Sumatriptan	Sumatriptan Sumatriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tizanidine	Tizanidine Tizanidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Zolmitriptan	Zolmitriptan Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Trospium.
Meperidine Injection	Meperidine Injection The risk or severity of adverse effects can be increased when Trospium is combined with Meperidine.
Metoclopramide Injection	Metoclopramide Injection The therapeutic efficacy of Trospium can be decreased when used in combination with Metoclopramide.
Morphine Injection	Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Trospium.
Altretamine	Altretamine Amphetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ondansetron	Ondansetron Ondansetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Granisetron	Granisetron Granisetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Olanzapine	Olanzapine Olanzapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Alosetron	Alosetron Alosetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Entacapone	Entacapone Entacapone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Trospium.
Oxcarbazepine	Oxcarbazepine Oxcarbazepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Zaleplon	Zaleplon Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Desloratadine	Desloratadine Trospium may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
Linezolid	Linezolid Linezolid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Rivastigmine	Rivastigmine The therapeutic efficacy of Trospium can be decreased when used in combination with Rivastigmine.
Trimipramine	Trimipramine The metabolism of Trospium can be decreased when combined with Trimipramine.
Glycopyrrolate	Glycopyrrolate The risk or severity of adverse effects can be increased when Trospium is combined with Glycopyrronium.
Epinephrine Injection	Epinephrine Injection The risk or severity of Tachycardia can be increased when Trospium is combined with Epinephrine.
Escitalopram	Escitalopram Escitalopram may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Zonisamide	Zonisamide Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Trospium.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Trospium.
Dexmethylphenidate	Dexmethylphenidate Dexmethylphenidate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Almotriptan	Almotriptan Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Eletriptan	Eletriptan Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Mefloquine	Mefloquine The therapeutic efficacy of Trospium can be decreased when used in combination with Mefloquine.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Trospium.
Memantine	Memantine The therapeutic efficacy of Trospium can be decreased when used in combination with Memantine.
Tegaserod	Tegaserod The therapeutic efficacy of Tegaserod can be decreased when used in combination with Trospium.
Frovatriptan	Frovatriptan Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Progesterone	Progesterone The metabolism of Progesterone can be decreased when combined with Trospium.
Apomorphine Injection	Apomorphine Injection Apomorphine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Protriptyline	Protriptyline Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Duloxetine	Duloxetine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Trospium.
Eszopiclone	Eszopiclone Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Solifenacin	Solifenacin The risk or severity of adverse effects can be increased when Trospium is combined with Solifenacin.
Dextroamphetamine	Dextroamphetamine Amphetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Pramlintide Injection	Pramlintide Injection The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Trospium.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Isocarboxazid	Isocarboxazid Isocarboxazid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ramelteon	Ramelteon Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Darifenacin	Darifenacin The risk or severity of adverse effects can be increased when Trospium is combined with Darifenacin.
Fentanyl	Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Trospium.
Pregabalin	Pregabalin Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Phenylephrine	Phenylephrine The risk or severity of Tachycardia can be increased when Trospium is combined with Phenylephrine.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Trospium.
Felbamate	Felbamate Felbamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ranolazine	Ranolazine The metabolism of Ranolazine can be decreased when combined with Trospium.
Rasagiline	Rasagiline Rasagiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Imatinib	Imatinib The metabolism of Imatinib can be decreased when combined with Trospium.
Gefitinib	Gefitinib The metabolism of Gefitinib can be decreased when combined with Trospium.
Albuterol	Albuterol The risk or severity of Tachycardia can be increased when Trospium is combined with Salbutamol.
Paliperidone	Paliperidone Paliperidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bortezomib	Bortezomib The metabolism of Bortezomib can be decreased when combined with Trospium.
Lubiprostone	Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Trospium.
Dimenhydrinate	Dimenhydrinate Dimenhydrinate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lisdexamfetamine	Lisdexamfetamine The risk or severity of Tachycardia can be increased when Trospium is combined with Lisdexamfetamine.
Nabilone	Nabilone The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Nabilone.
Dronabinol	Dronabinol The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Dronabinol.
Levocetirizine	Levocetirizine Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Mexiletine	Mexiletine The metabolism of Mexiletine can be decreased when combined with Trospium.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Trospium.
Betaine	Betaine The therapeutic efficacy of Trospium can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Trospium is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Trospium is combined with Botulinum Toxin Type B.
Desvenlafaxine	Desvenlafaxine Desvenlafaxine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cevimeline	Cevimeline The metabolism of Cevimeline can be decreased when combined with Trospium.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Trospium.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Trospium.
Rufinamide	Rufinamide Rufinamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Midazolam	Midazolam Midazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Naltrexone Injection	Naltrexone Injection The risk or severity of adverse effects can be increased when Trospium is combined with Naltrexone.
Milnacipran	Milnacipran Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Sodium Phosphate	Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Trospium.
Fesoterodine	Fesoterodine The risk or severity of adverse effects can be increased when Trospium is combined with Fesoterodine.
Betaxolol	Betaxolol The metabolism of Betaxolol can be decreased when combined with Trospium.
Iloperidone	Iloperidone Iloperidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lacosamide	Lacosamide Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Trospium is combined with Botulinum toxin type A.
Palonosetron Injection	Palonosetron Injection Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tapentadol	Tapentadol The risk or severity of adverse effects can be increased when Tapentadol is combined with Trospium.
Pazopanib	Pazopanib The metabolism of Pazopanib can be decreased when combined with Trospium.
Asenapine	Asenapine Asenapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Vigabatrin	Vigabatrin Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Oxymorphone	Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Trospium.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Trospium is combined with Botulinum toxin type A.
Lurasidone	Lurasidone Lurasidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Trospium.
Vilazodone	Vilazodone Vilazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Terbutaline Injection	Terbutaline Injection The therapeutic efficacy of Trospium can be decreased when used in combination with Terbutaline.
Clobazam	Clobazam Clobazam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cabergoline	Cabergoline Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ezogabine	Ezogabine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Mirabegron	Mirabegron The risk or severity of urinary retention can be increased when Trospium is combined with Mirabegron.
Linaclotide	Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Trospium.
Alogliptin	Alogliptin The metabolism of Alogliptin can be decreased when combined with Trospium.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Trospium.
Pomalidomide	Pomalidomide Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Levomilnacipran	Levomilnacipran Levomilnacipran may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Vortioxetine	Vortioxetine Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Trospium.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Trospium.
Droxidopa	Droxidopa The risk or severity of Tachycardia can be increased when Trospium is combined with Droxidopa.
Eslicarbazepine	Eslicarbazepine Eslicarbazepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Hydrocodone	Hydrocodone The risk or severity of adverse effects can be increased when Hydrocodone is combined with Trospium.
Suvorexant	Suvorexant Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Methamphetamine	Methamphetamine Metamfetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tasimelteon	Tasimelteon Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Risperidone Injection	Risperidone Injection Risperidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Haloperidol Injection	Haloperidol Injection The serum concentration of Trospium can be increased when it is combined with Haloperidol.
Flibanserin	Flibanserin Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Brexpiprazole	Brexpiprazole Brexpiprazole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ziprasidone Injection	Ziprasidone Injection Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cariprazine	Cariprazine Cariprazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Eluxadoline	Eluxadoline The risk or severity of constipation can be increased when Trospium is combined with Eluxadoline.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Trospium.
Brivaracetam Injection	Brivaracetam Injection Brivaracetam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Midodrine	Midodrine The risk or severity of Tachycardia can be increased when Trospium is combined with Midodrine.
Pimavanserin	Pimavanserin Pimavanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Diphenhydramine Injection	Diphenhydramine Injection Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Rucaparib	Rucaparib The metabolism of Rucaparib can be decreased when combined with Trospium.
Doxepin (Insomnia)	Doxepin (Insomnia) Doxepin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Plecanatide	Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Trospium.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Trospium.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Trospium.
Safinamide	Safinamide Safinamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Enasidenib	Enasidenib The metabolism of Enasidenib can be decreased when combined with Trospium.
Letermovir	Letermovir The metabolism of Letermovir can be decreased when combined with Trospium.
Tetrabenazine	Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Trospium.
Buprenorphine Injection	Buprenorphine Injection The risk or severity of adverse effects can be increased when Buprenorphine is combined with Trospium.
Lofexidine	Lofexidine Lofexidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Trospium.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Trospium.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Trospium.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Trospium.
Cannabidiol	Cannabidiol The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Cannabidiol.
Dacomitinib	Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Trospium.
Stiripentol	Stiripentol Stiripentol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Prucalopride	Prucalopride The therapeutic efficacy of Prucalopride can be decreased when used in combination with Trospium.
Magnesium Citrate	Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Trospium.
Brexanolone Injection	Brexanolone Injection Brexanolone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Solriamfetol	Solriamfetol The risk or severity of Tachycardia can be increased when Solriamfetol is combined with Trospium.
Triclabendazole	Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Trospium.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Trospium.
Pitolisant	Pitolisant The metabolism of Pitolisant can be decreased when combined with Trospium.
Phenytoin Injection	Phenytoin Injection Phenytoin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Fosphenytoin Injection	Fosphenytoin Injection Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lumateperone	Lumateperone Lumateperone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lasmiditan	Lasmiditan Lasmiditan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lemborexant	Lemborexant Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Fenfluramine	Fenfluramine Fenfluramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Vibegron	Vibegron Trospium may increase the smooth muscle relaxing activities of Vibegron.
Viloxazine	Viloxazine Viloxazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Trospium.
Trazodone	Trazodone Trazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Phenobarbital	Phenobarbital Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Metaxalone	Metaxalone Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Levorphanol	Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Trospium.
Primidone	Primidone Primidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Methsuximide	Methsuximide Methsuximide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Diethylpropion	Diethylpropion Diethylpropion may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Chlorpromazine	Chlorpromazine Chlorpromazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Diazepam	Diazepam Diazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Oxazepam	Oxazepam Oxazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Flurazepam	Flurazepam Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Clorazepate	Clorazepate Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lorazepam	Lorazepam Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Amantadine	Amantadine The risk or severity of adverse effects can be increased when Trospium is combined with Amantadine.
Codeine	Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Trospium.
Meprobamate	Meprobamate Meprobamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Chlordiazepoxide	Chlordiazepoxide Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bromocriptine	Bromocriptine Bromocriptine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Metaproterenol	Metaproterenol The risk or severity of Tachycardia can be increased when Trospium is combined with Orciprenaline.
Tranylcypromine	Tranylcypromine Tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Phenelzine	Phenelzine Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Procarbazine	Procarbazine Procarbazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ergoloid Mesylates	Ergoloid Mesylates Ergoloid mesylate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Prochlorperazine	Prochlorperazine Prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Thioridazine	Thioridazine Thioridazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Trifluoperazine	Trifluoperazine Trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Oxycodone	Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Trospium.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Trospium.
Oxybutynin	Oxybutynin The risk or severity of adverse effects can be increased when Trospium is combined with Oxybutynin.
Benztropine	Benztropine The risk or severity of adverse effects can be increased when Trospium is combined with Benzatropine.
Maprotiline	Maprotiline Maprotiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Trihexyphenidyl	Trihexyphenidyl The risk or severity of adverse effects can be increased when Trospium is combined with Trihexyphenidyl.
Orphenadrine	Orphenadrine Orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Perphenazine	Perphenazine Perphenazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Fluphenazine	Fluphenazine Fluphenazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Phentermine	Phentermine The risk or severity of Tachycardia can be increased when Phentermine is combined with Trospium.
Amoxapine	Amoxapine The metabolism of Trospium can be decreased when combined with Amoxapine.
Mechlorethamine	Mechlorethamine The therapeutic efficacy of Trospium can be decreased when used in combination with Mechlorethamine.
Pyridostigmine	Pyridostigmine The therapeutic efficacy of Trospium can be decreased when used in combination with Pyridostigmine.
Carbamazepine	Carbamazepine Carbamazepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Molindone	Molindone Molindone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Clonidine	Clonidine The metabolism of Trospium can be decreased when combined with Clonidine.
Clonazepam	Clonazepam Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Loperamide	Loperamide The metabolism of Loperamide can be decreased when combined with Trospium.
Promethazine	Promethazine Promethazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Loxapine	Loxapine Loxapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Chloroquine	Chloroquine The metabolism of Chloroquine can be decreased when combined with Trospium.
Quinine	Quinine Quinine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ethosuximide	Ethosuximide Ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lactulose	Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Trospium.
Chlorothiazide	Chlorothiazide The serum concentration of Chlorothiazide can be increased when it is combined with Trospium.
Chlorthalidone	Chlorthalidone The serum concentration of Chlorthalidone can be increased when it is combined with Trospium.
Metolazone	Metolazone The serum concentration of Metolazone can be increased when it is combined with Trospium.
Secobarbital	Secobarbital Secobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Desipramine	Desipramine The metabolism of Trospium can be decreased when combined with Desipramine.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Trospium.
Imipramine	Imipramine The metabolism of Trospium can be decreased when combined with Imipramine.
Quinidine	Quinidine The risk or severity of adverse effects can be increased when Trospium is combined with Quinidine.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Trospium.
Disopyramide	Disopyramide The risk or severity of adverse effects can be increased when Trospium is combined with Disopyramide.
Valproic Acid	Valproic Acid Valproic acid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tamoxifen	Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Trospium.
Butabarbital	Butabarbital Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Glucagon Injection	Glucagon Injection Trospium may increase the gastrointestinal motility reducing activities of Glucagon.
Dextromethorphan	Dextromethorphan Dextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cyclobenzaprine	Cyclobenzaprine Cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Baclofen	Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cyproheptadine	Cyproheptadine Cyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Clemastine	Clemastine Clemastine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Chlorpheniramine	Chlorpheniramine Chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Brompheniramine	Brompheniramine Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Meclizine	Meclizine Meclizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Methyclothiazide	Methyclothiazide The serum concentration of Methyclothiazide can be increased when it is combined with Trospium.
Hydrochlorothiazide	Hydrochlorothiazide The serum concentration of Hydrochlorothiazide can be increased when it is combined with Trospium.
Dantrolene	Dantrolene Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Chlorzoxazone	Chlorzoxazone Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Carisoprodol	Carisoprodol Carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Methocarbamol	Methocarbamol Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Trospium.
Pseudoephedrine	Pseudoephedrine The risk or severity of Tachycardia can be increased when Trospium is combined with Pseudoephedrine.
Nortriptyline	Nortriptyline The metabolism of Trospium can be decreased when combined with Nortriptyline.
Nadolol	Nadolol The metabolism of Nadolol can be decreased when combined with Trospium.
Butorphanol Injection	Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Trospium.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Trospium.
Trimethobenzamide	Trimethobenzamide Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Flavoxate	Flavoxate The risk or severity of adverse effects can be increased when Trospium is combined with Flavoxate.
Acetazolamide	Acetazolamide Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Pyrantel	Pyrantel Pyrantel may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Thiotepa Injection	Thiotepa Injection The therapeutic efficacy of Trospium can be decreased when used in combination with Thiotepa.
Isoxsuprine	Isoxsuprine The risk or severity of Tachycardia can be increased when Trospium is combined with Isoxsuprine.
Metoprolol	Metoprolol The metabolism of Metoprolol can be decreased when combined with Trospium.
Hydroxyzine	Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Thiothixene	Thiothixene Thiothixene may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Alprazolam	Alprazolam Alprazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Temazepam	Temazepam Temazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Triazolam	Triazolam Triazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Dicyclomine	Dicyclomine The risk or severity of adverse effects can be increased when Trospium is combined with Dicyclomine.
Hyoscyamine	Hyoscyamine The risk or severity of adverse effects can be increased when Trospium is combined with Hyoscyamine.
Propantheline	Propantheline The risk or severity of adverse effects can be increased when Trospium is combined with Propantheline.
Diltiazem	Diltiazem The metabolism of Diltiazem can be decreased when combined with Trospium.
Nifedipine	Nifedipine The metabolism of Nifedipine can be decreased when combined with Trospium.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Trospium.
Atenolol	Atenolol The metabolism of Atenolol can be decreased when combined with Trospium.
Pindolol	Pindolol Pindolol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cisplatin Injection	Cisplatin Injection The therapeutic efficacy of Trospium can be decreased when used in combination with Cisplatin.
Indapamide	Indapamide The serum concentration of Indapamide can be increased when it is combined with Trospium.
Pentamidine Injection	Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Trospium.
Labetalol	Labetalol The risk or severity of Tachycardia can be increased when Trospium is combined with Labetalol.
Guanabenz	Guanabenz The risk or severity of Tachycardia can be increased when Trospium is combined with Guanabenz.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Trospium.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Trospium.
Fluoxetine	Fluoxetine Fluoxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Clozapine	Clozapine Clozapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Estazolam	Estazolam Estazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Idarubicin	Idarubicin The metabolism of Idarubicin can be decreased when combined with Trospium.
Simvastatin	Simvastatin The metabolism of Simvastatin can be decreased when combined with Trospium.
Sotalol	Sotalol The metabolism of Sotalol can be decreased when combined with Trospium.
Zolpidem	Zolpidem Zolpidem may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Doxazosin	Doxazosin The metabolism of Doxazosin can be decreased when combined with Trospium.
Cisapride	Cisapride Cisapride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Gabapentin	Gabapentin Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Trospium.
Venlafaxine	Venlafaxine Venlafaxine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Nizatidine	Nizatidine The therapeutic efficacy of Trospium can be decreased when used in combination with Nizatidine.
Fluvoxamine	Fluvoxamine Fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Nefazodone	Nefazodone Nefazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lamotrigine	Lamotrigine Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tramadol	Tramadol The metabolism of Trospium can be decreased when combined with Tramadol.
Nicardipine	Nicardipine The risk or severity of adverse effects can be increased when Trospium is combined with Nicardipine.
Bupropion	Bupropion Bupropion may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ticlopidine	Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Trospium.
Metformin	Metformin The serum concentration of Trospium can be decreased when it is combined with Metformin.
Riluzole	Riluzole Riluzole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ritonavir	Ritonavir The metabolism of Ritonavir can be decreased when combined with Trospium.
Clomipramine	Clomipramine The metabolism of Trospium can be decreased when combined with Clomipramine.
Mirtazapine	Mirtazapine Mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Topiramate	Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Trospium is combined with Topiramate.
Donepezil	Donepezil The therapeutic efficacy of Trospium can be decreased when used in combination with Donepezil.
Loratadine	Loratadine Trospium may increase the anticholinergic activities of Loratadine.
Carvedilol	Carvedilol The metabolism of Carvedilol can be decreased when combined with Trospium.
Selegiline	Selegiline Selegiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Sertraline	Sertraline Sertraline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Propafenone	Propafenone The metabolism of Propafenone can be decreased when combined with Trospium.
Tamsulosin	Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Trospium.
Ropinirole	Ropinirole Ropinirole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Quetiapine	Quetiapine Quetiapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cetirizine	Cetirizine Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Paroxetine	Paroxetine Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tolcapone	Tolcapone Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Citalopram	Citalopram Citalopram may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Efavirenz	Efavirenz Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Sildenafil	Sildenafil The metabolism of Sildenafil can be decreased when combined with Trospium.
Celecoxib	Celecoxib The metabolism of Celecoxib can be decreased when combined with Trospium.
Tolterodine	Tolterodine The risk or severity of adverse effects can be increased when Trospium is combined with Tolterodine.
Thalidomide	Thalidomide Thalidomide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Trospium.
Galantamine	Galantamine The therapeutic efficacy of Trospium can be decreased when used in combination with Galantamine.
Levetiracetam	Levetiracetam Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Trospium.