Trospium

Generic name: Pronounced as (trose' pee um)
Brand names
  • Sanctura®
  • Sanctura® XR
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2016

Trospium is used to treat an overactive bladder (a condition in which the bladder muscles contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination). Trospium is in a class of medications called antimuscarinics. It works by relaxing the bladder muscles to prevent urgent, frequent, or uncontrolled urination.

Trospium comes as a tablet and an extended-release capsule to take by mouth. The tablet is usually taken twice a day on an empty stomach or 1 hour before meals,or is sometimes taken once a day at bedtime. Trospium extended-release capsule is usually taken once daily in the morning with water on an empty stomach, at least 1 hour before a meal. To help you remember to take trospium, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take trospium exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking trospium,

  • tell your doctor and pharmacist if you are allergic to trospium, any other medications, or any of the ingredients in trospium tablets or extended-release capsules. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: antacids; antihistamines; cold medications; ipratropium (Atrovent); medications for depression or mental illness; medications for inflammatory bowel disease or diarrhea, motion sickness, Parkinson's disease, ulcers, or urinary problems; metformin (Glucophage); morphine (MSIR, Oramorph, others); muscle relaxants; procainamide; tenofovir (Viread); and vancomycin (Vancocin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had glaucoma (an eye disease that can cause vision loss) or any type of blockage in the bladder or digestive system which causes delays or causes difficulty in emptying your bladder or stomach. Your doctor may tell you not to take trospium.

  • tell your doctor if you have or have ever had myasthenia gravis (a disorder of the nervous system that causes muscle weakness); ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum); any disease of the stomach or intestines; frequently occurring constipation; problems emptying your bladder;or benign prostatic hypertrophy (BPH, enlargement of the prostate, a male reproductive organ); or liver or kidney disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking trospium, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking trospium.

  • you should know that trospium may make you drowsy or dizzy and may cause blurred vision. Do not drive a car or operate machinery until you know how this medication affects you.

  • remember that alcohol can add to the drowsiness caused by this medication. You should not drink alcohol within 2 hours of taking trospium.

  • you should know that trospium may make it harder for your body to cool down when it gets very hot. Avoid exposure to extreme heat, and call your doctor or get emergency medical treatment if you have fever or other signs of heat stroke such as dizziness, upset stomach, headache, confusion, and fast heartbeat after you are exposed to heat.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose 1 hour before your next meal. However, if you are due to take your next dose at that time, skip the missed dose and continue your normal dosing schedule. Do not take a double dose to make up for a missed one.

  • Trospium may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • dry mouth, eyes, or nose

    • constipation

    • headache

    • confusion

    • gas

  • Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

    • difficulty urinating

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • rash

    • hives

    • itching

    • difficulty breathing or swallowing

    • hallucinations (seeing things or hearing voices that do not exist)

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • fast heartbeat

  • widened pupils (black circle in the middle of the eye)

  • sensitivity to light

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Delavirdine can be decreased when combined with Trospium.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Trospium.
Dolasetron Dolasetron Dolasetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Anagrelide Anagrelide The risk or severity of Tachycardia can be increased when Trospium is combined with Anagrelide.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Trospium.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Trospium.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Trospium.
Guanfacine Guanfacine Guanfacine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Magnesium Hydroxide Magnesium Hydroxide The therapeutic efficacy of Magnesium hydroxide can be decreased when used in combination with Trospium.
Magnesium Oxide Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Trospium.
Naratriptan Naratriptan Naratriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Trospium.
Penbutolol Penbutolol The metabolism of Acebutolol can be decreased when combined with Trospium.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Trospium.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Trospium.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Trospium.
Reserpine Reserpine Reserpine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Rizatriptan Rizatriptan Rizatriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Sumatriptan Sumatriptan Sumatriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tizanidine Tizanidine Tizanidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Zolmitriptan Zolmitriptan Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Trospium.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Trospium is combined with Meperidine.
Metoclopramide Injection Metoclopramide Injection The therapeutic efficacy of Trospium can be decreased when used in combination with Metoclopramide.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Trospium.
Altretamine Altretamine Amphetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ondansetron Ondansetron Ondansetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Granisetron Granisetron Granisetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Olanzapine Olanzapine Olanzapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Alosetron Alosetron Alosetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Entacapone Entacapone Entacapone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Hydroxychloroquine Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Trospium.
Oxcarbazepine Oxcarbazepine Oxcarbazepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Zaleplon Zaleplon Zaleplon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Desloratadine Desloratadine Trospium may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
Linezolid Linezolid Linezolid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Rivastigmine Rivastigmine The therapeutic efficacy of Trospium can be decreased when used in combination with Rivastigmine.
Trimipramine Trimipramine The metabolism of Trospium can be decreased when combined with Trimipramine.
Glycopyrrolate Glycopyrrolate The risk or severity of adverse effects can be increased when Trospium is combined with Glycopyrronium.
Epinephrine Injection Epinephrine Injection The risk or severity of Tachycardia can be increased when Trospium is combined with Epinephrine.
Escitalopram Escitalopram Escitalopram may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Zonisamide Zonisamide Zonisamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Trospium.
Atomoxetine Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Trospium.
Dexmethylphenidate Dexmethylphenidate Dexmethylphenidate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Almotriptan Almotriptan Almotriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Eletriptan Eletriptan Eletriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Mefloquine Mefloquine The therapeutic efficacy of Trospium can be decreased when used in combination with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Trospium.
Memantine Memantine The therapeutic efficacy of Trospium can be decreased when used in combination with Memantine.
Tegaserod Tegaserod The therapeutic efficacy of Tegaserod can be decreased when used in combination with Trospium.
Frovatriptan Frovatriptan Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Trospium.
Apomorphine Injection Apomorphine Injection Apomorphine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Protriptyline Protriptyline Protriptyline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Duloxetine Duloxetine Duloxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Trospium.
Eszopiclone Eszopiclone Eszopiclone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Solifenacin Solifenacin The risk or severity of adverse effects can be increased when Trospium is combined with Solifenacin.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Pramlintide Injection Pramlintide Injection The risk or severity of reduced gastrointestinal motility can be increased when Pramlintide is combined with Trospium.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ramelteon Ramelteon Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Darifenacin Darifenacin The risk or severity of adverse effects can be increased when Trospium is combined with Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Trospium.
Pregabalin Pregabalin Pregabalin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Phenylephrine Phenylephrine The risk or severity of Tachycardia can be increased when Trospium is combined with Phenylephrine.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Trospium.
Felbamate Felbamate Felbamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ranolazine Ranolazine The metabolism of Ranolazine can be decreased when combined with Trospium.
Rasagiline Rasagiline Rasagiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Imatinib Imatinib The metabolism of Imatinib can be decreased when combined with Trospium.
Gefitinib Gefitinib The metabolism of Gefitinib can be decreased when combined with Trospium.
Albuterol Albuterol The risk or severity of Tachycardia can be increased when Trospium is combined with Salbutamol.
Paliperidone Paliperidone Paliperidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Trospium.
Lubiprostone Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Trospium.
Dimenhydrinate Dimenhydrinate Dimenhydrinate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lisdexamfetamine Lisdexamfetamine The risk or severity of Tachycardia can be increased when Trospium is combined with Lisdexamfetamine.
Nabilone Nabilone The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Nabilone.
Dronabinol Dronabinol The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Dronabinol.
Levocetirizine Levocetirizine Levocetirizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Trospium.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Trospium.
Betaine Betaine The therapeutic efficacy of Trospium can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Trospium is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Trospium is combined with Botulinum Toxin Type B.
Desvenlafaxine Desvenlafaxine Desvenlafaxine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cevimeline Cevimeline The metabolism of Cevimeline can be decreased when combined with Trospium.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Trospium.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Trospium.
Rufinamide Rufinamide Rufinamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Midazolam Midazolam Midazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Naltrexone Injection Naltrexone Injection The risk or severity of adverse effects can be increased when Trospium is combined with Naltrexone.
Milnacipran Milnacipran Milnacipran may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Trospium.
Fesoterodine Fesoterodine The risk or severity of adverse effects can be increased when Trospium is combined with Fesoterodine.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Trospium.
Iloperidone Iloperidone Iloperidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lacosamide Lacosamide Lacosamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Trospium is combined with Botulinum toxin type A.
Palonosetron Injection Palonosetron Injection Palonosetron may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tapentadol Tapentadol The risk or severity of adverse effects can be increased when Tapentadol is combined with Trospium.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Trospium.
Asenapine Asenapine Asenapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Vigabatrin Vigabatrin Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Trospium.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Trospium is combined with Botulinum toxin type A.
Lurasidone Lurasidone Lurasidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be decreased when combined with Trospium.
Vilazodone Vilazodone Vilazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Terbutaline Injection Terbutaline Injection The therapeutic efficacy of Trospium can be decreased when used in combination with Terbutaline.
Clobazam Clobazam Clobazam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cabergoline Cabergoline Cabergoline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ezogabine Ezogabine Tiagabine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Mirabegron Mirabegron The risk or severity of urinary retention can be increased when Trospium is combined with Mirabegron.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Trospium.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Trospium.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Trospium.
Pomalidomide Pomalidomide Pomalidomide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Levomilnacipran Levomilnacipran Levomilnacipran may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Vortioxetine Vortioxetine Vortioxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Trospium.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Trospium.
Droxidopa Droxidopa The risk or severity of Tachycardia can be increased when Trospium is combined with Droxidopa.
Eslicarbazepine Eslicarbazepine Eslicarbazepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Hydrocodone Hydrocodone The risk or severity of adverse effects can be increased when Hydrocodone is combined with Trospium.
Suvorexant Suvorexant Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Methamphetamine Methamphetamine Metamfetamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tasimelteon Tasimelteon Tasimelteon may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Risperidone Injection Risperidone Injection Risperidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Haloperidol Injection Haloperidol Injection The serum concentration of Trospium can be increased when it is combined with Haloperidol.
Flibanserin Flibanserin Flibanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Brexpiprazole Brexpiprazole Brexpiprazole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ziprasidone Injection Ziprasidone Injection Ziprasidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cariprazine Cariprazine Cariprazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Trospium is combined with Eluxadoline.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Trospium.
Brivaracetam Injection Brivaracetam Injection Brivaracetam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Midodrine Midodrine The risk or severity of Tachycardia can be increased when Trospium is combined with Midodrine.
Pimavanserin Pimavanserin Pimavanserin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Diphenhydramine Injection Diphenhydramine Injection Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Rucaparib Rucaparib The metabolism of Rucaparib can be decreased when combined with Trospium.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Trospium.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Trospium.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Trospium.
Safinamide Safinamide Safinamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Trospium.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Trospium.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Trospium.
Buprenorphine Injection Buprenorphine Injection The risk or severity of adverse effects can be increased when Buprenorphine is combined with Trospium.
Lofexidine Lofexidine Lofexidine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Trospium.
Encorafenib Encorafenib The metabolism of Encorafenib can be decreased when combined with Trospium.
Elagolix Elagolix The metabolism of Elagolix can be decreased when combined with Trospium.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Trospium.
Cannabidiol Cannabidiol The risk or severity of Tachycardia and drowsiness can be increased when Trospium is combined with Cannabidiol.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Trospium.
Stiripentol Stiripentol Stiripentol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Prucalopride Prucalopride The therapeutic efficacy of Prucalopride can be decreased when used in combination with Trospium.
Magnesium Citrate Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Trospium.
Brexanolone Injection Brexanolone Injection Brexanolone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Solriamfetol Solriamfetol The risk or severity of Tachycardia can be increased when Solriamfetol is combined with Trospium.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Trospium.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Trospium.
Pitolisant Pitolisant The metabolism of Pitolisant can be decreased when combined with Trospium.
Phenytoin Injection Phenytoin Injection Phenytoin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Fosphenytoin Injection Fosphenytoin Injection Fosphenytoin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lumateperone Lumateperone Lumateperone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lasmiditan Lasmiditan Lasmiditan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lemborexant Lemborexant Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Fenfluramine Fenfluramine Fenfluramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Vibegron Vibegron Trospium may increase the smooth muscle relaxing activities of Vibegron.
Viloxazine Viloxazine Viloxazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Trospium.
Trazodone Trazodone Trazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Phenobarbital Phenobarbital Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Metaxalone Metaxalone Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Trospium.
Primidone Primidone Primidone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Methsuximide Methsuximide Methsuximide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Diethylpropion Diethylpropion Diethylpropion may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Chlorpromazine Chlorpromazine Chlorpromazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Diazepam Diazepam Diazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Oxazepam Oxazepam Oxazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Flurazepam Flurazepam Flurazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Clorazepate Clorazepate Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lorazepam Lorazepam Lorazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Amantadine Amantadine The risk or severity of adverse effects can be increased when Trospium is combined with Amantadine.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Trospium.
Meprobamate Meprobamate Meprobamate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Chlordiazepoxide Chlordiazepoxide Chlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bromocriptine Bromocriptine Bromocriptine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Metaproterenol Metaproterenol The risk or severity of Tachycardia can be increased when Trospium is combined with Orciprenaline.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Phenelzine Phenelzine Phenelzine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Procarbazine Procarbazine Procarbazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ergoloid Mesylates Ergoloid Mesylates Ergoloid mesylate may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Prochlorperazine Prochlorperazine Prochlorperazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Thioridazine Thioridazine Thioridazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Trifluoperazine Trifluoperazine Trifluoperazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Trospium.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Trospium.
Oxybutynin Oxybutynin The risk or severity of adverse effects can be increased when Trospium is combined with Oxybutynin.
Benztropine Benztropine The risk or severity of adverse effects can be increased when Trospium is combined with Benzatropine.
Maprotiline Maprotiline Maprotiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Trihexyphenidyl Trihexyphenidyl The risk or severity of adverse effects can be increased when Trospium is combined with Trihexyphenidyl.
Orphenadrine Orphenadrine Orphenadrine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Perphenazine Perphenazine Perphenazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Fluphenazine Fluphenazine Fluphenazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Phentermine Phentermine The risk or severity of Tachycardia can be increased when Phentermine is combined with Trospium.
Amoxapine Amoxapine The metabolism of Trospium can be decreased when combined with Amoxapine.
Mechlorethamine Mechlorethamine The therapeutic efficacy of Trospium can be decreased when used in combination with Mechlorethamine.
Pyridostigmine Pyridostigmine The therapeutic efficacy of Trospium can be decreased when used in combination with Pyridostigmine.
Carbamazepine Carbamazepine Carbamazepine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Molindone Molindone Molindone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Clonidine Clonidine The metabolism of Trospium can be decreased when combined with Clonidine.
Clonazepam Clonazepam Clonazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Loperamide Loperamide The metabolism of Loperamide can be decreased when combined with Trospium.
Promethazine Promethazine Promethazine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Loxapine Loxapine Loxapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Trospium.
Quinine Quinine Quinine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ethosuximide Ethosuximide Ethosuximide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Trospium.
Chlorothiazide Chlorothiazide The serum concentration of Chlorothiazide can be increased when it is combined with Trospium.
Chlorthalidone Chlorthalidone The serum concentration of Chlorthalidone can be increased when it is combined with Trospium.
Metolazone Metolazone The serum concentration of Metolazone can be increased when it is combined with Trospium.
Secobarbital Secobarbital Secobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Desipramine Desipramine The metabolism of Trospium can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Trospium.
Imipramine Imipramine The metabolism of Trospium can be decreased when combined with Imipramine.
Quinidine Quinidine The risk or severity of adverse effects can be increased when Trospium is combined with Quinidine.
Procainamide Procainamide The metabolism of Procainamide can be decreased when combined with Trospium.
Disopyramide Disopyramide The risk or severity of adverse effects can be increased when Trospium is combined with Disopyramide.
Valproic Acid Valproic Acid Valproic acid may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Trospium.
Butabarbital Butabarbital Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Glucagon Injection Glucagon Injection Trospium may increase the gastrointestinal motility reducing activities of Glucagon.
Dextromethorphan Dextromethorphan Dextromethorphan may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cyclobenzaprine Cyclobenzaprine Cyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Baclofen Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cyproheptadine Cyproheptadine Cyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Clemastine Clemastine Clemastine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Chlorpheniramine Chlorpheniramine Chlorpheniramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Brompheniramine Brompheniramine Dexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Meclizine Meclizine Meclizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Methyclothiazide Methyclothiazide The serum concentration of Methyclothiazide can be increased when it is combined with Trospium.
Hydrochlorothiazide Hydrochlorothiazide The serum concentration of Hydrochlorothiazide can be increased when it is combined with Trospium.
Dantrolene Dantrolene Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Carisoprodol Carisoprodol Carisoprodol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Methocarbamol Methocarbamol Methocarbamol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Trospium.
Pseudoephedrine Pseudoephedrine The risk or severity of Tachycardia can be increased when Trospium is combined with Pseudoephedrine.
Nortriptyline Nortriptyline The metabolism of Trospium can be decreased when combined with Nortriptyline.
Nadolol Nadolol The metabolism of Nadolol can be decreased when combined with Trospium.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Trospium.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Trospium.
Trimethobenzamide Trimethobenzamide Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Flavoxate Flavoxate The risk or severity of adverse effects can be increased when Trospium is combined with Flavoxate.
Acetazolamide Acetazolamide Acetazolamide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Pyrantel Pyrantel Pyrantel may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Thiotepa Injection Thiotepa Injection The therapeutic efficacy of Trospium can be decreased when used in combination with Thiotepa.
Isoxsuprine Isoxsuprine The risk or severity of Tachycardia can be increased when Trospium is combined with Isoxsuprine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Trospium.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Thiothixene Thiothixene Thiothixene may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Alprazolam Alprazolam Alprazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Temazepam Temazepam Temazepam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Triazolam Triazolam Triazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Dicyclomine Dicyclomine The risk or severity of adverse effects can be increased when Trospium is combined with Dicyclomine.
Hyoscyamine Hyoscyamine The risk or severity of adverse effects can be increased when Trospium is combined with Hyoscyamine.
Propantheline Propantheline The risk or severity of adverse effects can be increased when Trospium is combined with Propantheline.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Trospium.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Trospium.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Trospium.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Trospium.
Pindolol Pindolol Pindolol may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cisplatin Injection Cisplatin Injection The therapeutic efficacy of Trospium can be decreased when used in combination with Cisplatin.
Indapamide Indapamide The serum concentration of Indapamide can be increased when it is combined with Trospium.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Trospium.
Labetalol Labetalol The risk or severity of Tachycardia can be increased when Trospium is combined with Labetalol.
Guanabenz Guanabenz The risk or severity of Tachycardia can be increased when Trospium is combined with Guanabenz.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Trospium.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Trospium.
Fluoxetine Fluoxetine Fluoxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Clozapine Clozapine Clozapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Estazolam Estazolam Estazolam may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Trospium.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Trospium.
Sotalol Sotalol The metabolism of Sotalol can be decreased when combined with Trospium.
Zolpidem Zolpidem Zolpidem may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Trospium.
Cisapride Cisapride Cisapride may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Gabapentin Gabapentin Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Trospium.
Venlafaxine Venlafaxine Venlafaxine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Nizatidine Nizatidine The therapeutic efficacy of Trospium can be decreased when used in combination with Nizatidine.
Fluvoxamine Fluvoxamine Fluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Nefazodone Nefazodone Nefazodone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Lamotrigine Lamotrigine Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tramadol Tramadol The metabolism of Trospium can be decreased when combined with Tramadol.
Nicardipine Nicardipine The risk or severity of adverse effects can be increased when Trospium is combined with Nicardipine.
Bupropion Bupropion Bupropion may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Trospium.
Metformin Metformin The serum concentration of Trospium can be decreased when it is combined with Metformin.
Riluzole Riluzole Riluzole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Ritonavir Ritonavir The metabolism of Ritonavir can be decreased when combined with Trospium.
Clomipramine Clomipramine The metabolism of Trospium can be decreased when combined with Clomipramine.
Mirtazapine Mirtazapine Mirtazapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Topiramate Topiramate The risk or severity of hyperthermia and oligohydrosis can be increased when Trospium is combined with Topiramate.
Donepezil Donepezil The therapeutic efficacy of Trospium can be decreased when used in combination with Donepezil.
Loratadine Loratadine Trospium may increase the anticholinergic activities of Loratadine.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Trospium.
Selegiline Selegiline Selegiline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Sertraline Sertraline Sertraline may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Propafenone Propafenone The metabolism of Propafenone can be decreased when combined with Trospium.
Tamsulosin Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Trospium.
Ropinirole Ropinirole Ropinirole may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Quetiapine Quetiapine Quetiapine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cetirizine Cetirizine Cetirizine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Paroxetine Paroxetine Paroxetine may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Tolcapone Tolcapone Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Citalopram Citalopram Citalopram may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Efavirenz Efavirenz Efavirenz may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Trospium.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Trospium.
Tolterodine Tolterodine The risk or severity of adverse effects can be increased when Trospium is combined with Tolterodine.
Thalidomide Thalidomide Thalidomide may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Trospium.
Galantamine Galantamine The therapeutic efficacy of Trospium can be decreased when used in combination with Galantamine.
Levetiracetam Levetiracetam Levetiracetam may increase the central nervous system depressant (CNS depressant) activities of Trospium.

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