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Linezolid

Linezolid is an oxazolidinone-class antibiotic used in adults and children for pneumonia, skin infections and vancomycin-resistant Enterococcus faecium infections caused by susceptible Gram-positive bacteria.

Brand name Zyvox
Drug class Oxazolidinone Antibacterial
Rx Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 15 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 7, 2026
Other forms & routes:
Injection
Linezolid at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Linezolid (Zyvox) is an antibiotic that stops staph, strep and enterococcus bacteria from making proteins, used for pneumonia, skin infections and vancomycin-resistant enterococcus infections; on the market since about 2000 and available generically, it is usually saved for resistant germs such as MRSA (methicillin-resistant staph). Most people tolerate a short course well, and diarrhea, nausea, headache or an odd taste are the usual complaints. Respect its weak MAO inhibitor effect (an enzyme-blocking action shared with older antidepressants), which with many antidepressants can trigger serotonin syndrome, so share your full medicine list and get help fast for high fever, stiff or jerking muscles, or confusion.

Clinical pearls

  • Skip pseudoephedrine decongestants, and avoid large amounts of tyramine-rich foods such as aged cheese, cured meats and soy sauce.
  • On longer courses expect weekly blood counts, and report numbness, tingling or any vision change, which mostly appear past 28 days.
  • Severe or watery diarrhea, even weeks after the last dose, can mean C. difficile (a serious gut infection) and needs a call.
  • If you use insulin or diabetes medicines, check your sugar more often, because linezolid can cause low blood sugar.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asInjection, Tablet, Oral suspension
Earliest FDA record2000
Companies listing it with the FDA26
FDA label last updatedJun 23, 2026
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Linezolid, written from its FDA label.

What Linezolid is used for

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Linezolid treats infections caused by susceptible Gram-positive bacteria, in adults and children.

  • Nosocomial pneumonia (pneumonia acquired in a hospital)
  • Community-acquired pneumonia, including cases with bacteremia (bacteria in the blood) from Streptococcus pneumoniae
  • Complicated skin and skin structure infections, including diabetic foot infections without osteomyelitis (bone infection)
  • Uncomplicated skin and skin structure infections
  • Vancomycin-resistant Enterococcus faecium infections

It is not for Gram-negative infections. Oral-only products (tablets and suspension) and Zyvox and Linezolid injection list these same infections. Safety and effectiveness beyond 28 days have not been studied in controlled trials.

How Linezolid works

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Linezolid is an oxazolidinone antibiotic. It binds to the 23S ribosomal RNA of the bacterial 50S ribosomal subunit and stops bacteria from forming a working 70S initiation complex. Bacteria need this complex to reproduce.

It slows the growth of enterococci and staphylococci. For most streptococci, it kills the bacteria.

Linezolid dosage

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Linezolid comes as an intravenous injection, tablets, and an oral suspension. It is usually given every 8 or 12 hours depending on age and infection, for roughly 10 to 28 days. It may be taken with or without food. Switching between the vein and mouth does not require a dose change. Follow your prescriber’s and label’s directions, and ask your pharmacist what to do about a missed dose.

Dosing details from the FDA-approved label

From the Linezolid prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Nosocomial pneumonia
    • Pediatric patients (birth through 11 years): 10 mg/kg intravenous or oral every 8 hours
    • Adults and adolescents (12 years and older): 600 mg intravenous or oral every 12 hours
    • Duration 10 to 14 days
    • Neonates less than 7 days: initiate with 10 mg/kg every 12 hours; may consider 10 mg/kg every 8 hours if sub-optimal clinical response; all neonates should receive 10 mg/kg every 8 hours by 7 days of life
  • Community-acquired pneumonia, including concurrent bacteremia
    • Pediatric patients (birth through 11 years): 10 mg/kg intravenous or oral every 8 hours
    • Adults and adolescents (12 years and older): 600 mg intravenous or oral every 12 hours
    • Duration 10 to 14 days
    • Neonates less than 7 days: initiate with 10 mg/kg every 12 hours; all neonates should receive 10 mg/kg every 8 hours by 7 days of life
  • Complicated skin and skin structure infections
    • Pediatric patients (birth through 11 years): 10 mg/kg intravenous or oral every 8 hours
    • Adults and adolescents (12 years and older): 600 mg intravenous or oral every 12 hours
    • Duration 14 to 28 days
    • Neonates less than 7 days: initiate with 10 mg/kg every 12 hours; all neonates should receive 10 mg/kg every 8 hours by 7 days of life
  • Vancomycin-resistant Enterococcus faecium infections, including concurrent bacteremia
    • Pediatric patients (birth through 11 years): 10 mg/kg intravenous or oral every 8 hours
    • Adults and adolescents (12 years and older): 600 mg intravenous or oral every 12 hours
    • Duration 14 to 28 days
    • Neonates less than 7 days: initiate with 10 mg/kg every 12 hours; all neonates should receive 10 mg/kg every 8 hours by 7 days of life
  • Uncomplicated skin and skin structure infections
    • Less than 5 yrs: 10 mg/kg oral every 8 hours
    • 5-11 yrs: 10 mg/kg oral every 12 hours
    • Adults: 400 mg oral every 12 hours
    • Adolescents: 600 mg oral every 12 hours
    • Duration 10 to 14 days
    • No dose adjustment is necessary when switching from intravenous to oral administration
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION Dosage, Route, and Frequency of Administration Infection Pediatric Patients Adults and Adolescents Duration (days ) Nosocomial pneumonia 10 mg/kg intravenous or oral every 8 hours 600 mg intravenous or oral every 12 hours 10 to 14 Community-acquired pneumonia, including concurrent bacteremia Complicated skin and skin structure infections Vancomycin-resistant Enterococcus faecium infections, including concurrent bacteremia 10 mg/kg intravenous or oral every 8 hours 600 mg intravenous or oral every 12 hours 14 to 28 Uncomplicated skin and skin structure infections Less than 5 yrs: 10 mg/kg oral every 8 hours 5 to 11 yrs: 10 mg/kg oral every 12 hours Adults: 400 mg oral every 12 hours Adolescents: 600 mg oral every 12 hours 10 to 14 2.1 General Dosage and Administration The recommended dosage for linezolid formulations for the treatment of infections is described in Table 1. Table 1. Dosage Guidelines for Linezolid Infection* Dosage and Route of Administration Recommended Duration of Treatment (consecutive days) Pediatric Patients † (Birth through 11 Years of Age) Adults and Adolescents (12 Years and Older) Nosocomial pneumonia 10 mg/kg intravenously or oral ‡ every 8 hours 600 mg intravenously or oral ‡ every 12 hours 10 to 14 Community-acquired pneumonia, including concurrent bacteremia Complicated skin and skin structure infections Vancomycin-resistant Enterococcus faecium infections , including concurrent bacteremia 10 mg/kg intravenously or oral ‡ every 8 hours 600 mg intravenously or oral ‡ every 12 hours 14 to 28 Uncomplicated skin and skin structure infections Less than 5 yrs: 10 mg/kg oral ‡ every 8 hours 5 to 11 yrs: 10 mg/kg oral ‡ every 12 hours Adults: 400 mg oral ‡ every 12 hours Adolescents: 600 mg oral ‡ every 12 hours 10 to 14 * Due to the designated pathogens [ see Indications and Usage ( 1 ) ]. † Neonates less than 7 days : Most pre-term neonates less than 7 days of age (gestational age less than 34 weeks) have lower systemic linezolid clearance values and larger AUC values than many full-term neonates and older infants. These neonates should be initiated with a dosing regimen of 10 mg/kg every 12 hours. Consideration may be given to the use of 10 mg/kg every 8 hours regimen in neonates with a sub-optimal clinical response.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Linezolid side effects

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The most common side effects are:

Common side effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • Anemia (low red blood cells)
  • Dizziness
  • Rash
  • Taste changes

When to get medical help

  • Get help right away for signs of serotonin syndrome: high fever, stiff muscles, muscle jerks, fast heartbeat or blood pressure changes, extreme agitation, or confusion.
  • Call your doctor if you notice blurred vision, color vision changes, or any vision loss.
  • Report numbness or tingling in the hands or feet.
  • Seek care for diarrhea during or after treatment, which can sometimes appear weeks to months later.
  • Seek prompt care for repeated nausea or vomiting, which can be a sign of lactic acidosis (acid buildup in the blood).
  • Seek emergency care for a seizure.
  • Tell your doctor about unusual bleeding or bruising, or signs of low blood counts.
  • If you have diabetes, watch for low blood sugar (hypoglycemia).

Linezolid warnings and precautions

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  • Low blood counts: weekly blood counts are recommended, and treatment may need to stop if counts worsen.
  • Nerve and eye problems: mainly with use beyond 28 days, though blurred vision has occurred sooner.
  • Serotonin syndrome: can be fatal with serotonergic drugs.
  • Catheter-related bloodstream infections: not approved for these, because of a higher death rate in one study.
  • C. difficile diarrhea: can occur even months after treatment.
  • High blood pressure rises: with certain drugs and tyramine-rich foods.
  • Lactic acidosis, seizures and low blood sugar have been reported.
  • Using it without a bacterial infection won’t help and increases resistance.

Linezolid interactions

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Linezolid weakly blocks MAO, so it can clash with several drug types.

  • MAOIs: do not combine, or use within two weeks of stopping one.
  • Antidepressants, triptans, meperidine, bupropion, buspirone: serotonin syndrome risk.
  • Pseudoephedrine, phenylpropanolamine, epinephrine, norepinephrine, dopamine, dobutamine: raise blood pressure.
  • High-tyramine foods and drinks: avoid large amounts.
  • Insulin and diabetes pills: low blood sugar risk.
  • Rifampin: lowers linezolid levels; clinical impact unknown.

Interactions listed in the FDA-approved label

From the Linezolid prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Monoamine oxidase inhibitors: Linezolid is a reversible, nonselective inhibitor of monoamine oxidase.
  • Adrenergic agents (e.g., pseudoephedrine, phenylpropanolamine, dopamine, epinephrine): Some individuals may experience a reversible enhancement of the pressor response to indirect-acting sympathomimetic, vasopressor or dopaminergic agents. Initial doses of adrenergic agents, such as dopamine or epinephrine, should be reduced and titrated to achieve the desired response.
  • Tyramine-containing foods or beverages: A significant pressor response has been observed in normal adult subjects receiving linezolid and tyramine doses of more than 100 mg. Avoid consuming large amounts of foods or beverages with high tyramine content.
  • Serotonergic agents (dextromethorphan): Linezolid has the potential for interaction with serotonergic agents; no serotonin syndrome effects have been observed in normal subjects receiving linezolid and dextromethorphan.
  • Rifampin: Co-administration resulted in a 21% decrease in linezolid Cmax and a 32% decrease in linezolid AUC 0-12; clinical significance is unknown.
  • Other strong inducers of hepatic enzymes (e.g., carbamazepine, phenytoin, phenobarbital): Could cause a similar or smaller decrease in linezolid exposure.
  • Warfarin and phenytoin (CYP2C9 substrates): Linezolid does not substantially alter the pharmacokinetics of (S)-warfarin and is not expected to affect drugs metabolized by major CYP enzymes. May be given with linezolid without changes in dosage regimen.
  • Aztreonam: The pharmacokinetics of linezolid or aztreonam are not altered when administered together.
  • Gentamicin: The pharmacokinetics of linezolid or gentamicin are not altered when administered together.
  • Vitamin C and Vitamin E: Linezolid AUC 0-∞ increased 2.3% with Vitamin C and 10.9% with Vitamin E. No linezolid dose adjustment is recommended during co-administration with Vitamin C or Vitamin E.
Read the label’s full interactions text

7 DRUG INTERACTIONS Monoamine oxidase inhibitors and potential for interaction with adrenergic and serotonergic agents. ( 4.2 , 5.3 , 5.6 , 7 , 12.3 ) 7.1 Monoamine Oxidase Inhibitors Linezolid is a reversible, nonselective inhibitor of monoamine oxidase [ see Contraindications ( 4.2 ) and Clinical Pharmacology ( 12.3 ) ]. 7.2 Adrenergic and Serotonergic Agents Linezolid has the potential for interaction with adrenergic and serotonergic agents [ see Warnings and Precautions ( 5.3 , 5.6 ) and Clinical Pharmacology ( 12.3 ) ].

7.1 Monoamine Oxidase Inhibitors Linezolid is a reversible, nonselective inhibitor of monoamine oxidase [ see Contraindications ( 4.2 ) and Clinical Pharmacology ( 12.3 ) ].

7.2 Adrenergic and Serotonergic Agents Linezolid has the potential for interaction with adrenergic and serotonergic agents [ see Warnings and Precautions ( 5.3 , 5.6 ) and Clinical Pharmacology ( 12.3 ) ].

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿65 supplements and herbs with documented Linezolid interactions, ranked by severity Check Linezolid against a supplement or herb →

Before taking Linezolid

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  • Do not use if allergic to linezolid or its ingredients.
  • Do not use with or within two weeks of an MAOI.
  • Tell your doctor about antidepressants, high blood pressure, thyroid overactivity, pheochromocytoma or carcinoid syndrome.
  • Tell your doctor about low blood counts, seizures, or diabetes.
  • Pregnancy: reports have not identified major risks, but discuss with your doctor.
  • Breastfeeding: the drug passes into milk; watch the baby for diarrhea and vomiting.
  • Male fertility may be reversibly reduced.
  • Children: used from birth with weight-based dosing.
  • Older adults: no overall differences found.

Linezolid overdose

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If too much is taken, supportive care is advised. Hemodialysis may speed removal; about 30% of a dose was removed in a 3-hour session. In animals, high doses caused decreased activity, loss of coordination, vomiting and tremors. Contact poison control or emergency services.

What Linezolid does in the body

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Linezolid stops bacteria from reproducing by blocking protein synthesis. In a study of healthy volunteers, standard and double doses given by vein had no significant effect on the QTc interval (a heart rhythm measure).

How your body processes Linezolid

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Linezolid is well absorbed by mouth, with about 100% bioavailability. Peak levels occur about 1 to 2 hours after dosing. Food delays the peak slightly but does not change total exposure. It spreads into well-perfused tissues and is broken down into inactive metabolites. About 30% of a dose is excreted in urine as unchanged drug. No dose adjustment is needed for older adults.

How to store Linezolid

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Store at 20° to 25°C (68° to 77°F) . Protect from light.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

65

Supplements & herbs that interact with Linezolid

65 supplements and herbal products have documented interactions with Linezolid in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 2
  • Moderate · 51
  • Minor · 12
ACTIVATED CHARCOAL Major LITHIUM Major 5-HTP Moderate ACETYL-L-CARNITINE Moderate AYAHUASCA Moderate BACILLUS COAGULANS Moderate Bacillus Subtilis Moderate BIFIDOBACTERIUM ANIMALIS SUBSP. LACTIS Moderate +57 more
Every supplement checked against Linezolid — ranked by severity The full interaction hub: 2 major · 51 moderate · 12 minor · every one linked to its full report. Check Linezolid against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

7

Nutrient depletion considerations

Linezolid has been associated with lower levels of 7 nutrients in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.

Evidence & significance mix
  • Higher significance · 6
  • Moderate · 1
BIOTIN Insignificant Depletion FOLIC ACID Insignificant Depletion RIBOFLAVIN Insignificant Depletion THIAMINE Insignificant Depletion VITAMIN B12 Insignificant Depletion VITAMIN B6 Insignificant Depletion VITAMIN K Moderate Depletion
See the full Linezolid nutrient depletion report

Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.

Linezolid: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Linezolid — the kind of thing our pharmacy team would talk through with you at the counter.

What is linezolid for?

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It treats certain bacterial infections caused by Gram-positive bacteria. These include hospital- and community-acquired pneumonia, skin infections, and vancomycin-resistant Enterococcus faecium infections. It will not work on viruses or Gram-negative infections.

How should I take it?

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Take it exactly as prescribed, usually every 8 or 12 hours, by mouth or through a vein. You can take it with or without food. Finish the full course your prescriber gave you.

What side effects are normal?

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Diarrhea, nausea, vomiting and headache are the most common. Dizziness, rash and taste changes also happen. Call your doctor if they are severe or don’t go away.

What should I call my doctor about right away?

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Call for blurred vision or color changes, numbness or tingling, severe diarrhea, repeated vomiting, seizures, or unusual bleeding. Also call for high fever, stiff muscles, agitation or confusion. These can be signs of serious problems.

Can I take my other medicines with it?

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Not always. Tell me about any antidepressants, migraine medicines, cold or decongestant products, and diabetes medicines. Linezolid can interact with these. Never use it with an MAOI.

Are there foods I should avoid?

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Yes. Avoid large amounts of foods and drinks high in tyramine, because they can raise your blood pressure sharply. Ask me for examples if you’re unsure.

Is Linezolid available over the counter?

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No. Linezolid is a prescription medicine: every Linezolid product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Linezolid first available?

▾
The earliest FDA record we hold for Linezolid is from 2000: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Linezolid was first used.

Who makes Linezolid?

▾
26 companies currently list Linezolid products in the FDA's NDC Directory, including Hp Halden Pharma AS, Pharmacia & Upjohn Company LLC, American Health Packaging. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Linezolid on HelloPharmacist

📊Linezolid supplement interactions65 checked — ranked by severity 🌿Drug & Supplement CheckerLinezolid vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Linezolid NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Linezolid Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Linezolid forms and strengths (how it comes)

Linezolid is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Linezolid inactive ingredients by manufacturer.

Injection

By injection · Into a vein
Brands Zyvox
How this form is used
What it may be used for
  • Zyvox and Linezolid injection are used for nosocomial pneumonia and community-acquired pneumonia caused by susceptible Gram-positive bacteria.
  • Zyvox and Linezolid injection are used for complicated and uncomplicated skin and skin structure infections.
  • Zyvox and Linezolid injection are used for vancomycin-resistant Enterococcus faecium infections.
Important instructions
  • Zyvox and Linezolid injection are given by intravenous infusion, usually every 8 hours in young children or every 12 hours in adults and adolescents, depending on the infection.
  • Zyvox and Linezolid labels state that dosing is not adjusted when switching between intravenous and oral forms.
Available strengths 4 strengths
2 mg/mL 200 mg/100 mL 600 mg/300 mL 1 kg/kg
52 FDA-listed product records ⓘ

Tablet

By mouth
Brands Zyvox
How this form is used
What it may be used for
  • Linezolid tablets and Zyvox are used for pneumonia and skin infections caused by susceptible Gram-positive bacteria.
  • Linezolid tablets and Zyvox are used for vancomycin-resistant Enterococcus faecium infections.
Important instructions
  • Linezolid tablets and Zyvox are taken by mouth, usually every 12 hours in adults and adolescents.
  • Linezolid tablets and Zyvox can be taken with or without food.
Available strengths 1 strength
600 mg
34 FDA-listed product records ⓘ

Oral suspension

By mouth
Brands Zyvox
How this form is used
What it may be used for
  • Linezolid for oral suspension and Zyvox are used for pneumonia and skin infections caused by susceptible Gram-positive bacteria.
  • Linezolid for oral suspension and Zyvox are used for vancomycin-resistant Enterococcus faecium infections.
Important instructions
  • Linezolid oral suspension and Zyvox are taken by mouth, usually every 8 or 12 hours depending on age and infection.
  • Linezolid oral suspension and Zyvox can be taken with or without food.
Available strengths 1 strength
100 mg/5 mL
15 FDA-listed product records ⓘ

Linezolid on the U.S. market: products, makers and brands

How Linezolid appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

26 companies list 40 Linezolid product records with the FDA, mostly as injection, tablet, oral suspension; the earliest marketing or approval year on record is 2000. Brand names on the directory include Zyvox; the rest are generics.

3
Dose forms ⓘ
26
Labelers (makers, repackagers, distributors)
2
Brand names
40
FDA-listed product records ⓘ
2000
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (19) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Hp Halden Pharma AS10%
Pharmacia & Upjohn Company LLC10%
American Health Packaging5%
Bryant Ranch Prepack5%
Camber Pharmaceuticals, Inc.5%
Hikma Pharmaceuticals USA Inc.5%
Other makers60%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Linezolid is used (Medicaid data)

A general measure of how commonly Linezolid is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Linezolid is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

41,650
Medicaid prescriptions filled (Q1–Q4 2025)
$2.3M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Linezolid prescribed? Of the 1,601 medications we measure, Linezolid ranks #670 by Medicaid prescriptions — more than 58% of them.

Where Linezolid ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #670 of 1,601
#665 Dornase Alfa 42,474 Rx #666 Atenolol / Chlorthalid... 42,330 Rx #667 Ivabradine 42,299 Rx #668 Prucalopride 42,108 Rx #669 Gadoterate Meglumine 42,002 Rx #670 Linezolid 41,650 Rx #671 Trospium 41,279 Rx #672 Tofacitinib 41,140 Rx #673 Gentamicin Topical 41,105 Rx #674 Carbinoxamine 40,978 Rx #675 Estradiol / Norethindr... 40,957 Rx

Utilization by Linezolid product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 600 mg oral tablet is the most-dispensed Linezolid product — about 96% of these Medicaid prescriptions.

linezolid 600 MG Oral Tablet Most dispensed

39,789 Medicaid prescriptions (Q1–Q4 2025) 96% of Linezolid prescriptions shown $1.6M gross reimbursement (before rebates) ≈ $41 per prescription (gross)

Summed across the 7 of 73 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 311347

300 ML linezolid 2 MG/ML Injection

1,300 Medicaid prescriptions (Q1–Q4 2025) 3% of Linezolid prescriptions shown $260,151 gross reimbursement (before rebates) ≈ $200 per prescription (gross)

Summed across the 7 of 31 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1662285

linezolid 20 MG/ML Oral Suspension

561 Medicaid prescriptions (Q1–Q4 2025) 1% of Linezolid prescriptions shown $416,631 gross reimbursement (before rebates) ≈ $743 per prescription (gross)

Summed across the 3 of 7 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 311345

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Linezolid, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 17 of 111 listed Linezolid NDCs with Medicaid activity.

Compare Linezolid products

A representative set of FDA-listed product records for Linezolid — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 40 of 40 products — FDA National Drug Code Directory. See every product, package size and price: browse all 40 Linezolid NDCs →

Linezolid recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Linezolid recalls since July 2021.

✅No Linezolid recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Linezolid RxCUI 190376 3 dose forms · 5 strengths
  2. Dose form (SCDF) Oral Suspension RxCUI 375140 In current FDA listings
    Clinical drug / strength (SCD) 20 MG/ML RxCUI 311345
  3. Dose form (SCDF) Oral Tablet RxCUI 374626 In current FDA listings
    Clinical drug / strength (SCD) 400 MG RxCUI 314079 600 MG RxCUI 311347

Look up RxCUI 190376 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Linezolid brand names

Linezolid is sold under one brand name in the FDA directory — Zyvox. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Zyvox

Who makes Linezolid: manufacturers and labelers

26 companies list Linezolid products with the FDA. By number of product records, the largest are Hp Halden Pharma AS, Pharmacia & Upjohn Company LLC, American Health Packaging. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Hp Halden Pharma AS 4 Pharmacia & Upjohn Company LLC 4 American Health Packaging 2 Bryant Ranch Prepack 2 Camber Pharmaceuticals, Inc. 2 Hikma Pharmaceuticals USA Inc. 2 Piramal Critical Care Inc 2 Sandoz Inc 2 Sportpharm LLC 2 Sun Pharmaceutical Industries, Inc. 2 A-S Medication Solutions 1 Alembic Pharmaceuticals Inc. 1 Alembic Pharmaceuticals Limited 1 Ascend Laboratories, LLC 1 Caplin Steriles Limited 1 Chartwell RX, LLC 1 Coupler LLC 1 Eugia US LLC 1 Fresenius Kabi USA, LLC 1 Hospira, Inc. 1 Lupin Pharmaceuticals,Inc. 1 Macleods Pharmaceuticals Limited 1 Major Pharmaceuticals 1 Mylan Pharmaceuticals Inc. 1

…and 2 more on the FDA NDC directory.

Linezolid drug class (RxNorm)

Linezolid belongs to the Oxazolidinone Antibacterial class.

Pharmacologic class Oxazolidinone Antibacterial
Drug family (ATC) Other antibacterials

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Linezolid page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

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FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jun 23, 2026
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Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Linezolid.
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Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Linezolid after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
15
Finished products in the current FDA directory
40
Companies listing them (makers, repackagers, distributors)
26
FDA labeler codes behind them ⓘ
28
Linked representative label ⓘ
Pharmacia & Upjohn Company LLC
Linked label effective
Jun 23, 2026
Composite sections available
24
Linked SPL Set ID
6e70e63b-bfd5-478d-a8ee-8ba22c9efabd
Linked SPL Document ID
59c9a143-a1fa-4eeb-8fb1-dfe22de98d43
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Pharmacia & Upjohn Company LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →