Medication interaction hub

What Supplements Interact with Linezolid?

Linezolid brand names: Zyvox, Zyvox Injection. Every interaction below applies to the brands too.

65 Interactions 2 Major 51 Moderate 12 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Linezolid? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Linezolid against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Linezolid (Zyvox) fights serious infections, but it also blocks an enzyme called monoamine oxidase, which is why I treat this page with real respect. Twenty of the 65 supplements here raise serotonin, and stacking them on linezolid risks serotonin syndrome, a dangerous overload of that chemical. Lithium is one of the two major-rated entries for exactly that reason. The other, activated charcoal, instead soaks up the drug before your body can absorb it.

The rest is mostly a timing problem. Twenty-seven entries are probiotics, which linezolid kills the same way it kills infection, and 17 can change how oral medicines are absorbed, so space those well apart from your dose. Fifty-one of the 65 sit at moderate and 12 at minor, but read the serotonin entries first, and call your prescriber the same day if agitation, fever, or a racing heartbeat shows up after adding a supplement.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 51 Minor 12 No known interaction 1,387

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Linezolid: Top Interactions at a Glance

The Linezolid supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 65 interacting ingredients — plus 1,387 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Linezolid Combinations Today

The Linezolid + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Probiotics + Linezolidi

Theoretically, taking antibiotic drugs with certain probiotics might decrease the effectiveness of probiotics.

Read the full interaction Moderate Likelihood Possible L-tryptophan + Linezolidi

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.

Read the full interaction Moderate Likelihood Possible Methylene Blue + Linezolidi

Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.

Read the full interaction Moderate Likelihood Probable Levilactobacillus Brevis + Linezolidi

Theoretically, taking Levilactobacillus brevis with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction Moderate Likelihood Probable Lactobacillus Jensenii + Linezolidi

Theoretically, taking Lactobacillus jensenii with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction Moderate Likelihood Probable Lacticaseibacillus Rhamnosus + Linezolidi

Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction
The complete list

Every Supplement Checked Against Linezolid

All 1,452 ingredients in our database, ranked by severity — 65 with a Linezolid interaction on file and 1,387 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Linezolid?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Probiotics with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotic drugs with certain probiotics might decrease the effectiveness of probiotics.

Full Probiotics + Linezolid answer

Can you take L-tryptophan with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.

Full L-tryptophan + Linezolid answer

Can you take Methylene Blue with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining serotonergic drugs with methylene blue can cause additive serotonergic effects, including serotonin syndrome.

Full Methylene Blue + Linezolid answer

Can you take Levilactobacillus Brevis with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Levilactobacillus brevis with antibiotic drugs might decrease the effectiveness of L.

Full Levilactobacillus Brevis + Linezolid answer

Can you take Lactobacillus Jensenii with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus jensenii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Jensenii + Linezolid answer

Can you take Activated Charcoal with Linezolid?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Linezolid answer

Can you take Lithium with Linezolid?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Full Lithium + Linezolid answer

Can you take Bacillus Coagulans with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Linezolid answer

Can you take Bacillus Subtilis with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B.

Full Bacillus Subtilis + Linezolid answer

Can you take Bifidobacterium Animalis Subsp. Lactis with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Animalis Subsp. Lactis + Linezolid answer

Can you take Bifidobacterium Bifidum with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Linezolid answer

Can you take Bifidobacterium Breve with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Linezolid answer

Can you take Bifidobacterium Longum with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Linezolid answer

Can you take Coffee Charcoal with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Linezolid answer

Can you take European Mandrake with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Linezolid answer

Can you take Fermented Milk with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Linezolid answer

Can you take Glucomannan with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Linezolid answer

Can you take Lacticaseibacillus Casei with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Casei + Linezolid answer

Can you take Lacticaseibacillus Paracasei with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus paracasei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Paracasei + Linezolid answer

Can you take Lacticaseibacillus Rhamnosus with Linezolid?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Rhamnosus + Linezolid answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Linezolid is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Linezolid, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Linezolid sits in 4 interaction categories. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Linezolid through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Linezolid through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Linezolid through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Linezolid through this category.

About Linezolid

Linezolid is an antibiotic used to treat bacterial infections like pneumonia and skin infections.

Generic name: Linezolid  ·  Brand names: Zyvox, Zyvox Injection.

See the full Linezolid drug information

Related: does Linezolid deplete any nutrients?

Linezolid has 14 reported nutrient associations in the research literature — see the Linezolid nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Linezolid

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Linezolid.

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Pharmacist Counseling Corner

Linezolid & Supplements: Common Questions

What supplements interact with Linezolid?
In our interaction database, 65 supplement and herbal ingredients have an interaction with Linezolid on file — 2 rated major, 51 moderate, and 12 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Lithium, Bacillus Coagulans.
Which Linezolid supplement interactions are the most serious?
Focus on the major group: Activated Charcoal and Lithium. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Linezolid?
That depends entirely on which supplement. The honest answer for Linezolid is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Zyvox have the same supplement interactions as Linezolid?
Yes — Zyvox, Zyvox Injection all contain Linezolid, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Linezolid deplete any vitamins or nutrients?
It might — Linezolid has 14 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Linezolid nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Linezolid and my other medications?
This page covers Linezolid against supplements and herbal ingredients. Checking Linezolid against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Linezolid drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.