Linezolid

47 interactions 6 explained in plain English
Also sold as: Zyvox
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Linezolid Amitriptyline Elavil Explained An increased risk of serotonin syndrome Details Linezolid Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular adverse effects Details Linezolid Buprenorphine Belbuca Explained An increased risk of serotonin syndrome or opioid-related toxicity Details Linezolid Atropine Ophthalmic Atropine Care 1% Potential to cause hypertensive crisis Details Linezolid Butorphanol Injection Butorphic Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Diphenhydramine Injection Banophen Increased anticholinergic toxicity effects Details Linezolid Diphenhydramine Topical Afterbite with Antihistamine Increased anticholinergic toxicity effects Details Linezolid Dolasetron Anzemet Increased risk of serotonin syndrome Details Linezolid Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Linezolid Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Linezolid Fentanyl Transdermal Patch Duragesic® Potentiation of opioid effects and an increased risk of serotonin syndrome Details Linezolid Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Linezolid Granisetron Injection Granisol Increased risk of serotonin syndrome Details Linezolid Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Hydromorphone Rectal available generically Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Lithium Carbonate Lithobid An increased risk of serotonin syndrome Details Linezolid Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Linezolid Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Linezolid Metoclopramide Injection Gimoti Increased risk of hypertensive crisis Details Linezolid Metoclopramide Nasal Spray Gimoti Increased risk of hypertensive crisis Details Linezolid Nalbuphine Injection Nubain® Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Olodaterol Oral Inhalation Striverdi Potentiated cardiovascular effects Details Linezolid Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.