Linezolid
47 interactions 6 explained in plain English
Also sold as:
Zyvox
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Levodopa Oral Inhalation
Maprotiline
Entacapone
Dopamine
Deutetrabenazine
Methyldopa
Contraindicated
Linezolid Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Linezolid Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Linezolid Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Linezolid Diethylpropion Tenuate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Linezolid Dobutamine Increased hypertensive effects Details Linezolid Dopamine Increased hypertensive effects Details Linezolid Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Linezolid Levodopa Oral Inhalation Inbrija Hypertensive crisis Details Linezolid Maprotiline Ludiomil® An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Linezolid Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Linezolid Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Linezolid Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Linezolid Morphine Injection Astramorph® PF Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome DetailsMajor
Linezolid Amitriptyline Elavil Explained An increased risk of serotonin syndrome Details Linezolid Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular adverse effects Details Linezolid Buprenorphine Belbuca Explained An increased risk of serotonin syndrome or opioid-related toxicity Details Linezolid Atropine Ophthalmic Atropine Care 1% Potential to cause hypertensive crisis Details Linezolid Butorphanol Injection Butorphic Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Diphenhydramine Injection Banophen Increased anticholinergic toxicity effects Details Linezolid Diphenhydramine Topical Afterbite with Antihistamine Increased anticholinergic toxicity effects Details Linezolid Dolasetron Anzemet Increased risk of serotonin syndrome Details Linezolid Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Linezolid Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Linezolid Fentanyl Transdermal Patch Duragesic® Potentiation of opioid effects and an increased risk of serotonin syndrome Details Linezolid Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Linezolid Granisetron Injection Granisol Increased risk of serotonin syndrome Details Linezolid Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Hydromorphone Rectal available generically Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Lithium Carbonate Lithobid An increased risk of serotonin syndrome Details Linezolid Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Linezolid Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Linezolid Metoclopramide Injection Gimoti Increased risk of hypertensive crisis Details Linezolid Metoclopramide Nasal Spray Gimoti Increased risk of hypertensive crisis Details Linezolid Nalbuphine Injection Nubain® Increased risk of serotonin syndrome or opioid toxicity Details Linezolid Olodaterol Oral Inhalation Striverdi Potentiated cardiovascular effects Details Linezolid Palonosetron Injection Aloxi® An increased risk of serotonin syndrome DetailsModerate
Linezolid Acarbose Prandase® Explained An increased risk of hypoglycemia Details Linezolid Droxidopa Northera Risk of increased blood pressure Details Linezolid Glimepiride Amaryl An increased risk of hypoglycemia DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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