Linezolid with Doxylamine Interaction Details

Brand Names Associated with Linezolid

  • Linezolid
  • Zyvox®

Brand Names Associated with Doxylamine

  • Aldex AN®
  • Alka-Seltzer Plus® Night Cold Formula (as a combination product containing Aspirin, Dextromethorphan, Doxylamine, Phenylephrine)
  • Coricidin® HBP Nighttime Multi-Symptom Cold (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
  • Doxylamine
  • Nighttime Sleep Aid
  • Tylenol® Cold and Cough Nighttime (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
  • Unisom® SleepTabs
  • Vicks NyQuil® Cold and Flu Relief (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
  • Vicks NyQuil® Cold and Flu Symptom Relief Plus Vitamin C (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)
  • Vicks NyQuil® Cough (as a combination product containing Dextromethorphan, Doxylamine)
  • Vicks NyQuil® Sinex Nighttime Sinus Relief (as a combination product containing Acetaminophen, Doxylamine, Phenylephrine)
  • Zicam® Multi-Symptom Cold and Flu Nighttime (as a combination product containing Acetaminophen, Dextromethorphan, Doxylamine)

Medical Content Editor
Last updated Nov 13, 2023

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Interaction Effect

Prolonged and intensified anticholinergic effects (eg, severe dry mouth, constipation, decreased urination or sweating)

Interaction Summary

Concomitant use of doxylamine with an MAOI may prolong and intensify the anticholinergic effects of doxylamine and is contraindicated.

Severity

Contraindicated

Onset

Unspecified

Evidence

Theoretical

How To Manage Interaction

Concomitant use of doxylamine and an MAOI is contraindicated due to the potential for prolonged and intensified anticholinergic effects.

Mechanism Of Interaction

Unknown

Linezolid Overview

  • Linezolid is used to treat infections, including pneumonia, and infections of the skin . Linezolid is in a class of antibacterials called oxazolidinones. It works by stopping the growth of bacteria.

  • Antibiotics such as linezolid will not work for colds, flu, and other viral infections. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.

See More information Regarding Linezolid

Doxylamine Overview

  • Doxylamine is used in the short-term treatment of insomnia (difficulty falling asleep or staying asleep). Doxylamine is also used in combination with decongestants and other medications to relieve sneezing, runny nose, and nasal congestion caused by the common cold. Doxylamine should not be used to cause sleepiness in children. Doxylamine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.

See More information Regarding Doxylamine

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Definitions

Severity Categories

Contraindicated

These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.


Major

This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.


Moderate

This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.


Minor

While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.

Onset

Rapid: Onset of drug interaction typically occurs within 24 hours of co-administration.

Delayed: Onset of drug interaction typically occurs more than 24 hours after co-administration.

Evidence

Level of documentation of the interaction.

Established: The interaction is documented and substantiated in peer-reviewed medical literature.

Theoretical: This interaction is not fully supported by current medical evidence or well-documented sources, but it is based on known drug mechanisms, drug effects, and other relevant information.

How To Manage The Interaction

Provides a detailed discussion on how patients and clinicians can approach the identified drug interaction as well as offers guidance on what to expect and strategies to potentially mitigate the effects of the interaction. This may include recommendations on adjusting medication dosages, altering the timing of drug administration, or closely monitoring for specific symptoms.

It's important to note that all medical situations are unique, and management approaches should be tailored to individual circumstances. Patients should always consult their healthcare provider for personalized advice and guidance on managing drug interactions effectively.

Mechanism Of Interaction

The theorized or clinically determined reason (i.e., mechanism) why the drug-drug interaction occurs.

Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.

Where Does Our Information Come From?

Information for our drug interactions is compiled from several drug compendia, including:

The prescribing information for each drug, as published on DailyMED, is also used. 

Individual drug-drug interaction detail pages contain references specific to that interaction. You can click on the reference number within brackets '[]' to see what reference was utilized.

The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.