Linezolid

47 interactions 6 explained in plain English
Also sold as: Zyvox
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levodopa Oral Inhalation Maprotiline Entacapone Dopamine Deutetrabenazine Methyldopa
13 Contraindicated 24 Major 10 Moderate
All (47) Contraindicated (13) Major (24) Moderate (10)

Contraindicated

Linezolid Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Linezolid Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Linezolid Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Linezolid Diethylpropion Tenuate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Linezolid Dobutamine Increased hypertensive effects Details Linezolid Dopamine Increased hypertensive effects Details Linezolid Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Linezolid Levodopa Oral Inhalation Inbrija Hypertensive crisis Details Linezolid Maprotiline Ludiomil® An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Linezolid Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Linezolid Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Linezolid Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Linezolid Morphine Injection Astramorph® PF Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.