Phenobarbital

Generic name: Pronounced as (fee noe bar' bi tal)

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 05/15/2020

Phenobarbital is used to control seizures. Phenobarbital is also used to relieve anxiety. It is also used to prevent withdrawal symptoms in people who are dependent ('addicted'; feel a need to continue taking the medication) on another barbiturate medication and are going to stop taking the medication. Phenobarbital is in a class of medications called barbiturates. It works by slowing activity in the brain.

Phenobarbital comes as a tablet and an elixir (liquid) to take by mouth. It is usually taken one to three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take phenobarbital exactly as directed.

If you take phenobarbital for a long time, it may not control your symptoms as well as it did at the beginning of your treatment. Talk to your doctor about how you are feeling during your treatment.

Phenobarbital can be habit-forming. Do not take a larger dose, take it more often, or take it for a longer time than prescribed by your doctor.

Do not stop taking phenobarbital without talking to your doctor. If you suddenly stop taking phenobarbital, you may experience withdrawal symptoms such as anxiety, muscle twitching, uncontrollable shaking of a part of the body, weakness, dizziness, changes in vision, nausea, vomiting, seizures, confusion,difficulty falling asleep or staying asleep, or dizziness or fainting when getting up from a lying position. Your doctor will probably decrease your dose gradually.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Before taking phenobarbital,

  • tell your doctor and pharmacist if you are allergic to phenobarbital; other barbiturates such as amobarbital (Amytal), butabarbital (Butisol), pentobarbital, and secobarbital (Seconal); any other medications, or any of the ingredients in phenobarbital tablets or liquid. Ask your doctor or pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); disulfiram (Antabuse); doxycycline (Vibramycin); griseofulvin (Fulvicin); hormone replacement therapy (HRT); monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), seligiline (Eldepryl, Emsam, Zelapar) , or tranylcypromine (Parnate); medications for anxiety, depression, pain, asthma, colds, or allergies; certain medications for seizures such as phenytoin (Dilantin) and valproate (Depakene); oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone);sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.

  • tell your doctor if you have or have ever had porphyria (condition in which certain natural substances build up in the body and may cause stomach pain, changes in thinking and behavior, and other symptoms); any condition that causes shortness of breath or difficulty breathing; or liver disease. Your doctor will probably tell you not to take phenobarbital.

  • tell your doctor if you drink or have ever drunk large amounts of alcohol, used street drugs, or overused prescription medications; if you have pain now or have any condition that causes you ongoing pain; if you have ever thought about harming or killing yourself or planned or tried to do so; and if you have or have ever had depression, any condition that affects your adrenal gland (small gland next to the kidney that produces important natural substances), or kidney disease.

  • tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking phenobarbital, call your doctor. Phenobarbital may harm the fetus.

  • tell your doctor if you are breast-feeding. If you breast-feed during your treatment, your baby may receive some phenobarbital in the breast milk. Watch your baby closely for drowsiness or poor weight gain.

  • talk to your doctor about the risks and benefits of taking phenobarbital if you are 65 years of age or older. Older adults should not usually take phenobarbital because it is not as safe or effective as other medications that can be used to treat the same condition.

  • you should know that phenobarbital may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, injections, implants, or intrauterine devices). Talk to your doctor about methods of birth control that will work for you while you are taking phenobarbital. Tell your doctor if you have a missed period or think you may be pregnant while you are taking phenobarbital.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking phenobarbital.

  • you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • avoid drinking alcohol during your treatment with phenobarbital. Alcohol can make the side effects of phenobarbital worse.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Phenobarbital may cause side effects. Call your doctor if any of the following symptoms are severe or do not go away:

    • drowsiness

    • headache

    • dizziness

    • excitement or increased activity (especially in children)

    • nausea

    • vomiting

  • Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

    • slowed breathing or difficulty breathing

    • swelling of the eyes, lips, or cheeks

    • rash

    • blistering or peeling skin

    • fever

    • confusion

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • uncontrollable movements of the eyes

  • loss of coordination

  • drowsiness

  • slowed breathing

  • drop in body temperature

  • blisters

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to phenobarbital.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The metabolism of Repaglinide can be increased when combined with Phenobarbital.
Montelukast Montelukast The metabolism of Phenobarbital can be decreased when combined with Montelukast.
Leflunomide Leflunomide The metabolism of Phenobarbital can be decreased when combined with Leflunomide.
Delavirdine Delavirdine The metabolism of Phenobarbital can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Phenobarbital.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be increased when combined with Phenobarbital.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Phenobarbital.
Aminophylline Aminophylline The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Aminophylline.
Bisacodyl Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Phenobarbital.
Candesartan Candesartan The metabolism of Phenobarbital can be decreased when combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be increased when combined with Phenobarbital.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Phenobarbital.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Phenobarbital.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be increased when combined with Phenobarbital.
Fenofibrate Fenofibrate The metabolism of Phenobarbital can be decreased when combined with Fenofibrate.
Guanfacine Guanfacine The metabolism of Guanfacine can be increased when combined with Phenobarbital.
Magnesium Gluconate Magnesium Gluconate Magnesium gluconate can cause a decrease in the absorption of Phenobarbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Hydroxide Magnesium Hydroxide Magnesium hydroxide can cause a decrease in the absorption of Phenobarbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Oxide Magnesium Oxide Magnesium oxide can cause a decrease in the absorption of Phenobarbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
Mycophenolate Mycophenolate The metabolism of Mycophenolic acid can be increased when combined with Phenobarbital.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Phenobarbital.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Phenobarbital is combined with Morphine.
Penbutolol Penbutolol The serum concentration of Acebutolol can be decreased when it is combined with Phenobarbital.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Phenobarbital.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Phenobarbital.
Psyllium Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Phenobarbital.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Phenobarbital.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Phenobarbital.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Phenobarbital.
Tacrolimus Tacrolimus The metabolism of Tacrolimus can be increased when combined with Phenobarbital.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Phenobarbital.
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be increased when combined with Phenobarbital.
Zolmitriptan Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Phenobarbital.
Doxycycline Injection Doxycycline Injection The serum concentration of Doxycycline can be decreased when it is combined with Phenobarbital.
Fluconazole Injection Fluconazole Injection The metabolism of Phenobarbital can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Phenobarbital.
Meperidine Injection Meperidine Injection Phenobarbital may increase the hypotensive and central nervous system depressant (CNS depressant) activities of Meperidine.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Phenobarbital.
Metronidazole Injection Metronidazole Injection The metabolism of Phenobarbital can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Phenobarbital is combined with Morphine.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Phenobarbital.
Altretamine Altretamine The serum concentration of Phenobarbital can be decreased when it is combined with Amphetamine.
Cyclosporine Cyclosporine The metabolism of Cyclosporine can be increased when combined with Phenobarbital.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Phenobarbital.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Phenobarbital.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Phenobarbital.
Olanzapine Olanzapine The metabolism of Phenobarbital can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Phenobarbital can be decreased when combined with Alosetron.
Dofetilide Dofetilide The metabolism of Dofetilide can be increased when combined with Phenobarbital.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Phenobarbital.
Eprosartan Eprosartan Phenobarbital may increase the hypotensive activities of Eprosartan.
Hydroxychloroquine Hydroxychloroquine The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Hydroxychloroquine.
Meloxicam Meloxicam The metabolism of Phenobarbital can be decreased when combined with Meloxicam.
Orlistat Orlistat Orlistat can cause a decrease in the absorption of Phenobarbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxcarbazepine Oxcarbazepine The serum concentration of Phenobarbital can be increased when it is combined with Oxcarbazepine.
Pantoprazole Pantoprazole The metabolism of Phenobarbital can be decreased when combined with Pantoprazole.
Telmisartan Telmisartan The metabolism of Phenobarbital can be decreased when combined with Telmisartan.
Zaleplon Zaleplon The metabolism of Zaleplon can be increased when combined with Phenobarbital.
Anakinra Anakinra The metabolism of Phenobarbital can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Phenobarbital.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Phenobarbital.
Rivastigmine Rivastigmine The therapeutic efficacy of Rivastigmine can be decreased when used in combination with Phenobarbital.
Trimipramine Trimipramine The metabolism of Phenobarbital can be decreased when combined with Trimipramine.
Etanercept Injection Etanercept Injection The metabolism of Phenobarbital can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The metabolism of Phenobarbital can be decreased when combined with Modafinil.
Perindopril Perindopril Perindopril may increase the hypotensive activities of Phenobarbital.
Tenofovir Tenofovir The serum concentration of Tenofovir can be decreased when it is combined with Phenobarbital.
Sirolimus Sirolimus The metabolism of Sirolimus can be increased when combined with Phenobarbital.
Dutasteride Dutasteride The metabolism of Dutasteride can be increased when combined with Phenobarbital.
Epinephrine Injection Epinephrine Injection The metabolism of Phenobarbital can be decreased when combined with Epinephrine.
Epirubicin Epirubicin The metabolism of Epirubicin can be increased when combined with Phenobarbital.
Eplerenone Eplerenone The metabolism of Eplerenone can be increased when combined with Phenobarbital.
Escitalopram Escitalopram The risk or severity of adverse effects can be increased when Phenobarbital is combined with Escitalopram.
Olmesartan Olmesartan Phenobarbital may increase the hypotensive activities of Olmesartan.
Zonisamide Zonisamide The metabolism of Phenobarbital can be decreased when combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Phenobarbital can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be increased when combined with Phenobarbital.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Phenobarbital.
Dexmethylphenidate Dexmethylphenidate The serum concentration of the active metabolites of Phenobarbital can be increased when Phenobarbital is used in combination with Dexmethylphenidate.
Ezetimibe Ezetimibe The metabolism of Ezetimibe can be increased when combined with Phenobarbital.
Atazanavir Atazanavir The metabolism of Phenobarbital can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Almotriptan can be increased when combined with Phenobarbital.
Eletriptan Eletriptan The metabolism of Phenobarbital can be decreased when combined with Eletriptan.
Mefloquine Mefloquine The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Phenobarbital.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Phenobarbital.
Vardenafil Vardenafil The metabolism of Vardenafil can be increased when combined with Phenobarbital.
Aprepitant Aprepitant The metabolism of Aprepitant can be decreased when combined with Phenobarbital.
Memantine Memantine The metabolism of Phenobarbital can be decreased when combined with Memantine.
Tegaserod Tegaserod The metabolism of Tegaserod can be decreased when combined with Phenobarbital.
Tadalafil Tadalafil The metabolism of Tadalafil can be increased when combined with Phenobarbital.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Phenobarbital.
Progesterone Progesterone The metabolism of Phenobarbital can be increased when combined with Progesterone.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be increased when combined with Phenobarbital.
Infliximab Injection Infliximab Injection The metabolism of Phenobarbital can be increased when combined with Infliximab.
Oxandrolone Oxandrolone The metabolism of Phenobarbital can be decreased when combined with Oxandrolone.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Phenobarbital.
Rifaximin Rifaximin The metabolism of Phenobarbital can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Phenobarbital can be decreased when combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Phenobarbital can be increased when combined with Norethisterone.
Tinidazole Tinidazole Phenobarbital may increase the excretion rate of Tinidazole which could result in a lower serum level and potentially a reduction in efficacy.
Trospium Trospium Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan The metabolism of Phenobarbital can be decreased when combined with Bosentan.
Erlotinib Erlotinib The metabolism of Erlotinib can be increased when combined with Phenobarbital.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Phenobarbital is combined with Eszopiclone.
Ganciclovir Ganciclovir The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Ganciclovir.
Solifenacin Solifenacin Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Valganciclovir.
Voriconazole Voriconazole The serum concentration of Voriconazole can be decreased when it is combined with Phenobarbital.
Dextroamphetamine Dextroamphetamine The serum concentration of Phenobarbital can be decreased when it is combined with Amphetamine.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The metabolism of Phenobarbital can be increased when combined with Peginterferon alfa-2b.
Sodium Oxybate Sodium Oxybate Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Isocarboxazid Isocarboxazid Phenobarbital may increase the hypotensive activities of Isocarboxazid.
Ramelteon Ramelteon The metabolism of Phenobarbital can be decreased when combined with Ramelteon.
Darifenacin Darifenacin Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Phenobarbital.
Deferasirox Deferasirox The serum concentration of Deferasirox can be decreased when it is combined with Phenobarbital.
Tipranavir Tipranavir The metabolism of Phenobarbital can be decreased when combined with Tipranavir.
Felbamate Felbamate The serum concentration of Phenobarbital, an active metabolite of Phenobarbital, can be increased when used in combination with Felbamate.
Ranolazine Ranolazine The metabolism of Phenobarbital can be increased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Phenobarbital can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Phenobarbital is combined with Rasagiline.
Imatinib Imatinib The metabolism of Imatinib can be increased when combined with Phenobarbital.
Sitagliptin Sitagliptin The metabolism of Sitagliptin can be increased when combined with Phenobarbital.
Gefitinib Gefitinib The metabolism of Gefitinib can be increased when combined with Phenobarbital.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Phenobarbital is combined with Paliperidone.
Exemestane Exemestane The metabolism of Exemestane can be increased when combined with Phenobarbital.
Bortezomib Bortezomib The metabolism of Phenobarbital can be increased when combined with Bortezomib.
Clofarabine Injection Clofarabine Injection Phenobarbital may increase the hypotensive activities of Clofarabine.
Fulvestrant Injection Fulvestrant Injection The metabolism of Fulvestrant can be increased when combined with Phenobarbital.
Lubiprostone Lubiprostone The therapeutic efficacy of Lubiprostone can be decreased when used in combination with Phenobarbital.
Primaquine Primaquine The risk or severity of methemoglobinemia can be increased when Primaquine is combined with Phenobarbital.
Aliskiren Aliskiren Phenobarbital may increase the hypotensive activities of Aliskiren.
Darunavir Darunavir The serum concentration of Darunavir can be decreased when it is combined with Phenobarbital.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Phenobarbital.
Lisdexamfetamine Lisdexamfetamine The serum concentration of Phenobarbital can be decreased when it is combined with Lisdexamfetamine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
Retapamulin Retapamulin The metabolism of Retapamulin can be increased when combined with Phenobarbital.
Sorafenib Sorafenib The metabolism of Phenobarbital can be increased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be increased when combined with Phenobarbital.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
Lapatinib Lapatinib The metabolism of Lapatinib can be increased when combined with Phenobarbital.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Phenobarbital is combined with Levocetirizine.
Dasatinib Dasatinib The metabolism of Dasatinib can be increased when combined with Phenobarbital.
Mexiletine Mexiletine The metabolism of Mexiletine can be increased when combined with Phenobarbital.
Armodafinil Armodafinil The metabolism of Phenobarbital can be decreased when combined with Armodafinil.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Phenobarbital.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be increased when combined with Phenobarbital.
Antipyrine-Benzocaine Otic Antipyrine-Benzocaine Otic The risk or severity of methemoglobinemia can be increased when Benzocaine is combined with Phenobarbital.
Maraviroc Maraviroc The metabolism of Maraviroc can be increased when combined with Phenobarbital.
Nilotinib Nilotinib The metabolism of Phenobarbital can be increased when combined with Nilotinib.
Raltegravir Raltegravir The metabolism of Raltegravir can be increased when combined with Phenobarbital.
Bexarotene Bexarotene The metabolism of Phenobarbital can be decreased when combined with Bexarotene.
Budesonide Budesonide Phenobarbital may increase the excretion rate of Budesonide which could result in a lower serum level and potentially a reduction in efficacy.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Phenobarbital can be decreased when combined with Chloramphenicol.
Betaine Betaine The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Phenobarbital is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Phenobarbital is combined with Botulinum Toxin Type B.
Etravirine Etravirine The metabolism of Etravirine can be increased when combined with Phenobarbital.
Arsenic Trioxide Injection Arsenic Trioxide Injection Phenobarbital may increase the hypotensive activities of Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Phenobarbital can be increased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Phenobarbital is combined with Desvenlafaxine.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Phenobarbital.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Phenobarbital.
Leucovorin Injection Leucovorin Injection The serum concentration of Phenobarbital can be decreased when it is combined with Leucovorin.
Flecainide Flecainide The metabolism of Phenobarbital can be decreased when combined with Flecainide.
Certolizumab Injection Certolizumab Injection The metabolism of Phenobarbital can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be increased when combined with Phenobarbital.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be increased when combined with Phenobarbital.
Levoleucovorin Injection Levoleucovorin Injection The serum concentration of Phenobarbital can be decreased when it is combined with Levoleucovorin.
Praziquantel Praziquantel The metabolism of Praziquantel can be increased when combined with Phenobarbital.
Rufinamide Rufinamide The serum concentration of Phenobarbital can be increased when it is combined with Rufinamide.
Silodosin Silodosin The metabolism of Silodosin can be increased when combined with Phenobarbital.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Phenobarbital.
Naltrexone Injection Naltrexone Injection The risk or severity of adverse effects can be increased when Phenobarbital is combined with Naltrexone.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be increased when combined with Phenobarbital.
Milnacipran Milnacipran The metabolism of Milnacipran can be increased when combined with Phenobarbital.
Dexlansoprazole Dexlansoprazole The metabolism of Phenobarbital can be decreased when combined with Dexlansoprazole.
Sodium Phosphate Sodium Phosphate The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol Betaxolol Phenobarbital may increase the hypotensive activities of Betaxolol.
Iloperidone Iloperidone The metabolism of Iloperidone can be increased when combined with Phenobarbital.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Phenobarbital.
Lacosamide Lacosamide The metabolism of Lacosamide can be increased when combined with Phenobarbital.
Everolimus Everolimus The metabolism of Everolimus can be increased when combined with Phenobarbital.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be increased when combined with Phenobarbital.
Dronedarone Dronedarone The metabolism of Phenobarbital can be increased when combined with Dronedarone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Phenobarbital is combined with Botulinum toxin type A.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Phenobarbital.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be increased when combined with Phenobarbital.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be increased when combined with Phenobarbital.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
Topotecan Topotecan Phenobarbital may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Golimumab Injection Golimumab Injection The metabolism of Phenobarbital can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be increased when combined with Phenobarbital.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Phenobarbital is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Phenobarbital.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Phenobarbital.
Albendazole Albendazole The metabolism of Albendazole can be increased when combined with Phenobarbital.
Ulipristal Ulipristal The metabolism of Ulipristal can be increased when combined with Phenobarbital.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Phenobarbital.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Phenobarbital is combined with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Phenobarbital can be increased when combined with Tocilizumab.
Fingolimod Fingolimod The metabolism of Fingolimod can be decreased when combined with Phenobarbital.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Phenobarbital is combined with Botulinum toxin type A.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be increased when combined with Phenobarbital.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Phenobarbital is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Phenobarbital may increase the hepatotoxic activities of Acetaminophen.
Vilazodone Vilazodone The metabolism of Vilazodone can be increased when combined with Phenobarbital.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Aldesleukin can be decreased when combined with Phenobarbital.
Terbutaline Injection Terbutaline Injection The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Terbutaline.
Azilsartan Azilsartan Phenobarbital may increase the hypotensive activities of Azilsartan medoxomil.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be increased when combined with Phenobarbital.
Roflumilast Roflumilast The metabolism of Roflumilast can be increased when combined with Phenobarbital.
Linagliptin Linagliptin The metabolism of Linagliptin can be increased when combined with Phenobarbital.
Rilpivirine Rilpivirine The serum concentration of Rilpivirine can be decreased when it is combined with Phenobarbital.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Phenobarbital.
Abiraterone Abiraterone The metabolism of Abiraterone can be increased when combined with Phenobarbital.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be increased when combined with Phenobarbital.
Ticagrelor Ticagrelor The metabolism of Phenobarbital can be decreased when combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be increased when combined with Phenobarbital.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be increased when combined with Phenobarbital.
Vandetanib Vandetanib The metabolism of Vandetanib can be increased when combined with Phenobarbital.
Clobazam Clobazam The metabolism of Phenobarbital can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The metabolism of Phenobarbital can be increased when combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Phenobarbital can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The serum concentration of Ivacaftor can be decreased when it is combined with Phenobarbital.
Axitinib Axitinib The metabolism of Axitinib can be increased when combined with Phenobarbital.
Crizotinib Crizotinib The metabolism of Crizotinib can be increased when combined with Phenobarbital.
Cabergoline Cabergoline The metabolism of Phenobarbital can be increased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Naloxone can be increased when combined with Phenobarbital.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be increased when combined with Phenobarbital.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Phenobarbital.
Iloprost Iloprost Phenobarbital may increase the hypotensive activities of Iloprost.
Enzalutamide Enzalutamide The metabolism of Phenobarbital can be decreased when combined with Enzalutamide.
Regorafenib Regorafenib The metabolism of Phenobarbital can be increased when combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be increased when combined with Phenobarbital.
Linaclotide Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Phenobarbital.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be increased when combined with Phenobarbital.
Ponatinib Ponatinib The metabolism of Ponatinib can be increased when combined with Phenobarbital.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be increased when combined with Phenobarbital.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be increased when combined with Phenobarbital.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Phenobarbital.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be decreased when it is combined with Phenobarbital.
Methazolamide Methazolamide Phenobarbital may increase the hypotensive activities of Methazolamide.
Dabrafenib Dabrafenib The serum concentration of Phenobarbital can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Phenobarbital.
Dolutegravir Dolutegravir The metabolism of Dolutegravir can be increased when combined with Phenobarbital.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be increased when combined with Phenobarbital.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be increased when combined with Phenobarbital.
Perampanel Perampanel The metabolism of Perampanel can be increased when combined with Phenobarbital.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be increased when combined with Phenobarbital.
Lomitapide Lomitapide The metabolism of Lomitapide can be increased when combined with Phenobarbital.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Phenobarbital.
Obinutuzumab Injection Obinutuzumab Injection Phenobarbital may increase the hypotensive activities of Obinutuzumab.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Phenobarbital.
Apremilast Apremilast The metabolism of Phenobarbital can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ceritinib can be increased when combined with Phenobarbital.
Siltuximab Injection Siltuximab Injection The metabolism of Phenobarbital can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The serum concentration of Eslicarbazepine can be decreased when it is combined with Phenobarbital.
Belinostat Injection Belinostat Injection The metabolism of Belinostat can be increased when combined with Phenobarbital.
Idelalisib Idelalisib The metabolism of Idelalisib can be increased when combined with Phenobarbital.
Testosterone Injection Testosterone Injection The metabolism of Phenobarbital can be decreased when combined with Testosterone.
Oritavancin Injection Oritavancin Injection The metabolism of Phenobarbital can be decreased when combined with Oritavancin.
Empagliflozin Empagliflozin Phenobarbital may increase the hypotensive activities of Empagliflozin.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be increased when combined with Phenobarbital.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be increased when combined with Phenobarbital.
Suvorexant Suvorexant Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Olaparib Olaparib The metabolism of Olaparib can be increased when combined with Phenobarbital.
Methamphetamine Methamphetamine The serum concentration of Phenobarbital can be decreased when it is combined with Metamfetamine.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be increased when combined with Phenobarbital.
Riociguat Riociguat The metabolism of Riociguat can be increased when combined with Phenobarbital.
Nintedanib Nintedanib The metabolism of Nintedanib can be increased when combined with Phenobarbital.
Secukinumab Injection Secukinumab Injection The metabolism of Phenobarbital can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be increased when combined with Phenobarbital.
Palbociclib Palbociclib The metabolism of Palbociclib can be increased when combined with Phenobarbital.
Lenvatinib Lenvatinib The metabolism of Phenobarbital can be decreased when combined with Lenvatinib.
Naloxegol Naloxegol The metabolism of Phenobarbital can be decreased when combined with Naloxegol.
Panobinostat Panobinostat The metabolism of Panobinostat can be increased when combined with Phenobarbital.
Dinutuximab Injection Dinutuximab Injection Phenobarbital may increase the hypotensive activities of Dinutuximab.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Phenobarbital.
Amiloride Amiloride Phenobarbital may increase the hypotensive activities of Amiloride.
Sonidegib Sonidegib The metabolism of Sonidegib can be increased when combined with Phenobarbital.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Phenobarbital is combined with Flibanserin.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be increased when combined with Phenobarbital.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be increased when combined with Phenobarbital.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Phenobarbital is combined with Ziprasidone.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Phenobarbital is combined with Cariprazine.
Eluxadoline Eluxadoline The risk or severity of constipation can be increased when Phenobarbital is combined with Eluxadoline.
Cobimetinib Cobimetinib The metabolism of Cobimetinib can be increased when combined with Phenobarbital.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be increased when combined with Phenobarbital.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Phenobarbital.
Alectinib Alectinib The metabolism of Alectinib can be increased when combined with Phenobarbital.
Ixazomib Ixazomib The metabolism of Ixazomib can be increased when combined with Phenobarbital.
Rifapentine Rifapentine The metabolism of Phenobarbital can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Phenobarbital.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Phenobarbital may increase the hypotensive activities of Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Phenobarbital can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Phenobarbital.
Venetoclax Venetoclax The metabolism of Venetoclax can be increased when combined with Phenobarbital.
Cobicistat Cobicistat The serum concentration of Cobicistat can be decreased when it is combined with Phenobarbital.
Selexipag Selexipag The metabolism of Selexipag can be increased when combined with Phenobarbital.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Phenobarbital is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Phenobarbital can be decreased when combined with Diphenhydramine.
Furosemide Injection Furosemide Injection The metabolism of Furosemide can be increased when combined with Phenobarbital.
Rucaparib Rucaparib The metabolism of Phenobarbital can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Ribociclib can be increased when combined with Phenobarbital.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Phenobarbital.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Phenobarbital can be decreased when combined with Doxepin.
Plecanatide Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Phenobarbital.
Deutetrabenazine Deutetrabenazine The risk or severity of sedation and somnolence can be increased when Phenobarbital is combined with Deutetrabenazine.
Valbenazine Valbenazine The metabolism of Valbenazine can be increased when combined with Phenobarbital.
Deflazacort Deflazacort The serum concentration of Deflazacort can be decreased when it is combined with Phenobarbital.
Safinamide Safinamide The metabolism of Phenobarbital can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Phenobarbital can be increased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be increased when combined with Phenobarbital.
Enasidenib Enasidenib The metabolism of Phenobarbital can be increased when combined with Enasidenib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Phenobarbital.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be increased when combined with Phenobarbital.
Delafloxacin Delafloxacin The metabolism of Delafloxacin can be increased when combined with Phenobarbital.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be increased when combined with Phenobarbital.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Phenobarbital.
Letermovir Letermovir The metabolism of Phenobarbital can be increased when combined with Letermovir.
Tetrabenazine Tetrabenazine The risk or severity of sedation and somnolence can be increased when Phenobarbital is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin The metabolism of Ertugliflozin can be increased when combined with Phenobarbital.
Buprenorphine Injection Buprenorphine Injection Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide The serum concentration of Phenobarbital can be increased when it is combined with Apalutamide.
Avatrombopag Avatrombopag The metabolism of Phenobarbital can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Baricitinib can be increased when combined with Phenobarbital.
Lofexidine Lofexidine The therapeutic efficacy of Phenobarbital can be increased when used in combination with Lofexidine.
Binimetinib Binimetinib The metabolism of Binimetinib can be increased when combined with Phenobarbital.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be increased when combined with Phenobarbital.
Elagolix Elagolix The metabolism of Elagolix can be increased when combined with Phenobarbital.
Doravirine Doravirine The metabolism of Doravirine can be increased when combined with Phenobarbital.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Phenobarbital.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be increased when combined with Phenobarbital.
Duvelisib Duvelisib The metabolism of Duvelisib can be increased when combined with Phenobarbital.
Stiripentol Stiripentol The serum concentration of Stiripentol can be decreased when it is combined with Phenobarbital.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be increased when combined with Phenobarbital.
Glasdegib Glasdegib The metabolism of Glasdegib can be increased when combined with Phenobarbital.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be increased when combined with Phenobarbital.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be increased when combined with Phenobarbital.
Rifamycin Rifamycin The metabolism of Phenobarbital can be decreased when combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be increased when combined with Phenobarbital.
Magnesium Citrate Magnesium Citrate Magnesium citrate can cause a decrease in the absorption of Phenobarbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Phenobarbital can be increased when combined with Emapalumab.
Siponimod Siponimod The therapeutic efficacy of Siponimod can be decreased when used in combination with Phenobarbital.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be increased when combined with Phenobarbital.
Esomeprazole Injection Esomeprazole Injection The metabolism of Phenobarbital can be decreased when combined with Esomeprazole.
Alpelisib Alpelisib The serum concentration of Alpelisib can be decreased when it is combined with Phenobarbital.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Phenobarbital is combined with Brexanolone.
Polatuzumab vedotin-piiq Injection Polatuzumab vedotin-piiq Injection The risk or severity of adverse effects can be decreased when Phenobarbital is combined with Polatuzumab vedotin.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Phenobarbital is combined with Solriamfetol.
Darolutamide Darolutamide The serum concentration of Phenobarbital can be decreased when it is combined with Darolutamide.
Triclabendazole Triclabendazole The metabolism of Phenobarbital can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be increased when combined with Phenobarbital.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be increased when combined with Phenobarbital.
Upadacitinib Upadacitinib The metabolism of Upadacitinib can be increased when combined with Phenobarbital.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Phenobarbital.
Pitolisant Pitolisant The metabolism of Pitolisant can be increased when combined with Phenobarbital.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Phenobarbital.
Lefamulin Lefamulin The metabolism of Lefamulin can be increased when combined with Phenobarbital.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Fosphenytoin can be decreased when it is combined with Phenobarbital.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Phenobarbital.
Voxelotor Voxelotor The serum concentration of Voxelotor can be decreased when it is combined with Phenobarbital.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Phenobarbital.
Lumateperone Lumateperone The serum concentration of Lumateperone can be decreased when it is combined with Phenobarbital.
Lasmiditan Lasmiditan The risk or severity of adverse effects can be increased when Phenobarbital is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be decreased when it is combined with Phenobarbital.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be increased when combined with Phenobarbital.
Bempedoic Acid Bempedoic Acid The metabolism of Bempedoic acid can be increased when combined with Phenobarbital.
Cenobamate Cenobamate The serum concentration of Cenobamate can be increased when it is combined with Phenobarbital.
Pemigatinib Pemigatinib The metabolism of Pemigatinib can be increased when combined with Phenobarbital.
Ozanimod Ozanimod The metabolism of Ozanimod can be increased when combined with Phenobarbital.
Selumetinib Selumetinib The serum concentration of Selumetinib can be decreased when it is combined with Phenobarbital.
Rimegepant Rimegepant The metabolism of Rimegepant can be increased when combined with Phenobarbital.
Tucatinib Tucatinib The metabolism of Tucatinib can be increased when combined with Phenobarbital.
Sacituzumab govitecan-hziy Injection Sacituzumab govitecan-hziy Injection The serum concentration of Sacituzumab govitecan can be decreased when it is combined with Phenobarbital.
Ripretinib Ripretinib The serum concentration of Ripretinib can be decreased when it is combined with Phenobarbital.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be decreased when it is combined with Phenobarbital.
Capmatinib Capmatinib The serum concentration of Capmatinib can be decreased when it is combined with Phenobarbital.
Lemborexant Lemborexant The serum concentration of Lemborexant can be decreased when it is combined with Phenobarbital.
Fenfluramine Fenfluramine The serum concentration of Phenobarbital can be decreased when it is combined with Fenfluramine.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be decreased when it is combined with Phenobarbital.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be decreased when it is combined with Phenobarbital.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection Phenobarbital may increase the excretion rate of Belantamab mafodotin which could result in a lower serum level and potentially a reduction in efficacy.
Pralsetinib Pralsetinib The serum concentration of Phenobarbital can be decreased when it is combined with Pralsetinib.
Opicapone Opicapone The metabolism of Phenobarbital can be increased when combined with Opicapone.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Phenobarbital can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be decreased when it is combined with Phenobarbital.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be increased when combined with Phenobarbital.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Phenobarbital is combined with Viloxazine.
Indomethacin Indomethacin The metabolism of Phenobarbital can be decreased when combined with Indomethacin.
Mefenamic Acid Mefenamic Acid The metabolism of Phenobarbital can be decreased when combined with Mefenamic acid.
Naproxen Naproxen The metabolism of Phenobarbital can be decreased when combined with Naproxen.
Trazodone Trazodone The serum concentration of Trazodone can be decreased when it is combined with Phenobarbital.
Sucralfate Sucralfate Sucralfate can cause a decrease in the absorption of Phenobarbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
Floxuridine Floxuridine The metabolism of Phenobarbital can be decreased when combined with Floxuridine.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be increased when combined with Phenobarbital.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Phenobarbital.
Primidone Primidone The metabolism of Phenobarbital can be decreased when combined with Primidone.
Methsuximide Methsuximide The metabolism of Phenobarbital can be decreased when combined with Methsuximide.
Diethylpropion Diethylpropion The serum concentration of Phenobarbital can be decreased when it is combined with Diethylpropion.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Phenobarbital.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Phenobarbital.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Phenobarbital.
Flurazepam Flurazepam The metabolism of Phenobarbital can be decreased when combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Phenobarbital.
Lorazepam Lorazepam The metabolism of Lorazepam can be increased when combined with Phenobarbital.
Phenoxybenzamine Phenoxybenzamine Phenobarbital may increase the hypotensive activities of Phenoxybenzamine.
Amantadine Amantadine The risk or severity of adverse effects can be increased when Amantadine is combined with Phenobarbital.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Phenobarbital.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Phenobarbital.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Phenobarbital is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Phenobarbital can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Phenobarbital can be increased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Phenobarbital.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Phenobarbital.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be increased when combined with Phenobarbital.
Thioridazine Thioridazine The metabolism of Phenobarbital can be decreased when combined with Thioridazine.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Phenobarbital.
Dapsone Dapsone The risk or severity of methemoglobinemia can be increased when Dapsone is combined with Phenobarbital.
Sulfadiazine Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Phenobarbital.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Phenobarbital is combined with Oxycodone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Phenobarbital.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be increased when combined with Phenobarbital.
Benztropine Benztropine Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Phenobarbital.
Trihexyphenidyl Trihexyphenidyl Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Phenobarbital.
Fluphenazine Fluphenazine The metabolism of Phenobarbital can be decreased when combined with Fluphenazine.
Phentermine Phentermine The serum concentration of Phenobarbital can be decreased when it is combined with Phentermine.
Methylphenidate Methylphenidate The serum concentration of Phenobarbital can be increased when it is combined with Methylphenidate.
Amoxapine Amoxapine Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Sulfasalazine Sulfasalazine The risk or severity of methemoglobinemia can be increased when Sulfasalazine is combined with Phenobarbital.
Hydrocortisone Hydrocortisone The metabolism of Phenobarbital can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be increased when combined with Phenobarbital.
Mechlorethamine Mechlorethamine The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Mechlorethamine.
Pyridostigmine Pyridostigmine The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Pyridostigmine.
Phenazopyridine Phenazopyridine The risk or severity of methemoglobinemia can be increased when Phenobarbital is combined with Phenazopyridine.
Carbamazepine Carbamazepine Carbamazepine may increase the Change in thyroid function activities of Phenobarbital.
Molindone Molindone The risk or severity of adverse effects can be increased when Phenobarbital is combined with Molindone.
Methyldopa Methyldopa Phenobarbital may increase the hypotensive activities of Methyldopa.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Phenobarbital.
Prazosin Prazosin Phenobarbital may increase the hypotensive activities of Prazosin.
Hydralazine Hydralazine Phenobarbital may increase the hypotensive activities of Hydralazine.
Cimetidine Cimetidine The metabolism of Phenobarbital can be decreased when combined with Cimetidine.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Phenobarbital.
Clonazepam Clonazepam The metabolism of Clonazepam can be increased when combined with Phenobarbital.
Loperamide Loperamide The metabolism of Loperamide can be increased when combined with Phenobarbital.
Promethazine Promethazine The metabolism of Phenobarbital can be decreased when combined with Promethazine.
Daunorubicin Daunorubicin Phenobarbital may increase the excretion rate of Daunorubicin which could result in a lower serum level and potentially a reduction in efficacy.
Nitrofurantoin Nitrofurantoin The risk or severity of methemoglobinemia can be increased when Phenobarbital is combined with Nitrofurantoin.
Griseofulvin Griseofulvin The serum concentration of Griseofulvin can be decreased when it is combined with Phenobarbital.
Digoxin Digoxin Phenobarbital may increase the excretion rate of Digoxin which could result in a lower serum level and potentially a reduction in efficacy.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Phenobarbital.
Chloroquine Chloroquine The metabolism of Chloroquine can be increased when combined with Phenobarbital.
Quinine Quinine The serum concentration of Phenobarbital can be increased when it is combined with Quinine.
Ethosuximide Ethosuximide The metabolism of Phenobarbital can be decreased when combined with Ethosuximide.
Triamterene Triamterene Phenobarbital may increase the hypotensive activities of Triamterene.
Lactulose Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Phenobarbital.
Sulfinpyrazone Sulfinpyrazone The metabolism of Phenobarbital can be decreased when combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The risk or severity of hypotension and orthostatic hypotension can be increased when Phenobarbital is combined with Chlorothiazide.
Chlorthalidone Chlorthalidone The risk or severity of hypotension and orthostatic hypotension can be increased when Phenobarbital is combined with Chlorthalidone.
Metolazone Metolazone The risk or severity of hypotension and orthostatic hypotension can be increased when Phenobarbital is combined with Metolazone.
Isosorbide Isosorbide The metabolism of Isosorbide can be increased when combined with Phenobarbital.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be increased when combined with Phenobarbital.
Secobarbital Secobarbital The metabolism of Phenobarbital can be increased when combined with Secobarbital.
Desipramine Desipramine The metabolism of Phenobarbital can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Phenobarbital.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Phenobarbital.
Probenecid Probenecid The metabolism of Phenobarbital can be decreased when combined with Probenecid.
Quinidine Quinidine The serum concentration of Phenobarbital can be increased when it is combined with Quinidine.
Procainamide Procainamide The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Procainamide.
Isoniazid Isoniazid The metabolism of Phenobarbital can be decreased when combined with Isoniazid.
Rifampin Rifampin The metabolism of Phenobarbital can be increased when combined with Rifampicin.
Disopyramide Disopyramide Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid Valproic Acid The serum concentration of Phenobarbital, an active metabolite of Phenobarbital, can be increased when used in combination with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Phenobarbital can be increased when combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Phenobarbital.
Levothyroxine Levothyroxine The metabolism of Levothyroxine can be increased when combined with Phenobarbital.
Liothyronine Liothyronine The metabolism of Liothyronine can be increased when combined with Phenobarbital.
Methimazole Methimazole The metabolism of Phenobarbital can be decreased when combined with Methimazole.
Chlorpropamide Chlorpropamide The metabolism of Phenobarbital can be decreased when combined with Chlorpropamide.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Phenobarbital.
Tolazamide Tolazamide The metabolism of Phenobarbital can be decreased when combined with Tolazamide.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Phenobarbital.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Phenobarbital is combined with Cyclobenzaprine.
Niacin Niacin The metabolism of Phenobarbital can be decreased when combined with Niacin.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Phenobarbital.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
Cyproheptadine Cyproheptadine Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Phenobarbital.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be increased when combined with Phenobarbital.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Phenobarbital.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Phenobarbital.
Methyclothiazide Methyclothiazide The risk or severity of hypotension and orthostatic hypotension can be increased when Phenobarbital is combined with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of hypotension and orthostatic hypotension can be increased when Phenobarbital is combined with Hydrochlorothiazide.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Phenobarbital is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Phenobarbital.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Phenobarbital.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Phenobarbital.
Pyridoxine Pyridoxine The metabolism of Phenobarbital can be increased when combined with Pyridoxine.
Folic Acid Folic Acid The serum concentration of Phenobarbital can be decreased when it is combined with Folic acid.
Disulfiram Disulfiram The metabolism of Disulfiram can be decreased when combined with Phenobarbital.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be decreased when it is combined with Phenobarbital.
Minoxidil Minoxidil The metabolism of Minoxidil can be increased when combined with Phenobarbital.
Pseudoephedrine Pseudoephedrine The serum concentration of Phenobarbital can be decreased when it is combined with Pseudoephedrine.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be increased when combined with Phenobarbital.
Spironolactone Spironolactone Phenobarbital may increase the excretion rate of Spironolactone which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Phenobarbital may increase the hypotensive activities of Amphotericin B.
Mercaptopurine Mercaptopurine The serum concentration of Mercaptopurine can be decreased when it is combined with Phenobarbital.
Nadolol Nadolol The serum concentration of Nadolol can be decreased when it is combined with Phenobarbital.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Phenobarbital.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Phenobarbital.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Phenobarbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Phenobarbital.
Flavoxate Flavoxate Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine Papaverine Phenobarbital may increase the hypotensive activities of Papaverine.
Fluorouracil Injection Fluorouracil Injection The metabolism of Fluorouracil can be increased when combined with Phenobarbital.
Colchicine Colchicine The metabolism of Phenobarbital can be increased when combined with Colchicine.
Cefaclor Cefaclor Phenobarbital may increase the excretion rate of Cefaclor which could result in a lower serum level and potentially a reduction in efficacy.
Cephalexin Cephalexin The metabolism of Cephalexin can be increased when combined with Phenobarbital.
Acetazolamide Acetazolamide The serum concentration of Phenobarbital can be decreased when it is combined with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Cefotaxime.
Ketoconazole Ketoconazole The metabolism of Phenobarbital can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Phenobarbital is combined with Pyrantel.
Thiotepa Injection Thiotepa Injection The metabolism of Phenobarbital can be increased when combined with Thiotepa.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be increased when combined with Phenobarbital.
Captopril Captopril Phenobarbital may increase the hypotensive activities of Captopril.
Dipyridamole Dipyridamole Phenobarbital may increase the excretion rate of Dipyridamole which could result in a lower serum level and potentially a reduction in efficacy.
Isoxsuprine Isoxsuprine Phenobarbital may increase the hypotensive activities of Isoxsuprine.
Vinblastine Vinblastine The metabolism of Vinblastine can be increased when combined with Phenobarbital.
Ethacrynic Acid Ethacrynic Acid Phenobarbital may increase the hypotensive activities of Etacrynic acid.
Metoprolol Metoprolol The metabolism of Metoprolol can be increased when combined with Phenobarbital.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Phenobarbital is combined with Thiothixene.
Chlorambucil Chlorambucil The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Chlorambucil.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Phenobarbital.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Phenobarbital.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Phenobarbital.
Propantheline Propantheline Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim The metabolism of Phenobarbital can be decreased when combined with Trimethoprim.
Diltiazem Diltiazem The metabolism of Phenobarbital can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Phenobarbital.
Timolol Timolol The serum concentration of Timolol can be decreased when it is combined with Phenobarbital.
Verapamil Verapamil The metabolism of Phenobarbital can be decreased when combined with Verapamil.
Atenolol Atenolol The serum concentration of Atenolol can be decreased when it is combined with Phenobarbital.
Pindolol Pindolol The serum concentration of Pindolol can be decreased when it is combined with Phenobarbital.
Cisplatin Injection Cisplatin Injection The metabolism of Phenobarbital can be decreased when combined with Cisplatin.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Phenobarbital.
Bumetanide Bumetanide Phenobarbital may increase the hypotensive activities of Bumetanide.
Streptozocin Streptozocin The metabolism of Phenobarbital can be increased when combined with Streptozocin.
Etoposide Etoposide The metabolism of Etoposide can be increased when combined with Phenobarbital.
Glyburide Glyburide The metabolism of Phenobarbital can be decreased when combined with Glyburide.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Phenobarbital.
Indapamide Indapamide The risk or severity of hypotension and orthostatic hypotension can be increased when Phenobarbital is combined with Indapamide.
Pentoxifylline Pentoxifylline The serum concentration of Pentoxifylline can be decreased when it is combined with Phenobarbital.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be increased when combined with Phenobarbital.
Labetalol Labetalol The serum concentration of Labetalol can be decreased when it is combined with Phenobarbital.
Gemfibrozil Gemfibrozil The metabolism of Phenobarbital can be decreased when combined with Gemfibrozil.
Ketoprofen Ketoprofen The metabolism of Ketoprofen can be increased when combined with Phenobarbital.
Pimozide Pimozide The metabolism of Phenobarbital can be increased when combined with Pimozide.
Enalapril Enalapril Phenobarbital may increase the hypotensive activities of Enalapril.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Phenobarbital.
Amiodarone Amiodarone The metabolism of Phenobarbital can be increased when combined with Amiodarone.
Buspirone Buspirone The metabolism of Buspirone can be increased when combined with Phenobarbital.
Lovastatin Lovastatin The metabolism of Phenobarbital can be decreased when combined with Lovastatin.
Diclofenac Diclofenac The metabolism of Phenobarbital can be decreased when combined with Diclofenac.
Fluoxetine Fluoxetine Fluoxetine may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
Nimodipine Nimodipine Phenobarbital may increase the hypotensive activities of Nimodipine.
Clozapine Clozapine The metabolism of Phenobarbital can be decreased when combined with Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Phenobarbital is combined with Estazolam.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Phenobarbital.
Ofloxacin Ofloxacin Phenobarbital may increase the excretion rate of Ofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Clarithromycin Clarithromycin The metabolism of Clarithromycin can be increased when combined with Phenobarbital.
Benazepril Benazepril Phenobarbital may increase the hypotensive activities of Benazepril.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Phenobarbital.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Phenobarbital.
Fosinopril Fosinopril Phenobarbital may increase the hypotensive activities of Fosinopril.
Nabumetone Nabumetone The metabolism of Phenobarbital can be decreased when combined with Nabumetone.
Pravastatin Pravastatin Phenobarbital may increase the excretion rate of Pravastatin which could result in a lower serum level and potentially a reduction in efficacy.
Quinapril Quinapril Phenobarbital may increase the hypotensive activities of Quinapril.
Ramipril Ramipril Ramipril may increase the hypotensive activities of Phenobarbital.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Phenobarbital.
Amlodipine Amlodipine Phenobarbital may increase the hypotensive activities of Amlodipine.
Teniposide Injection Teniposide Injection The serum concentration of Teniposide can be decreased when it is combined with Phenobarbital.
Itraconazole Itraconazole The metabolism of Phenobarbital can be decreased when combined with Itraconazole.
Lisinopril Lisinopril Phenobarbital may increase the hypotensive activities of Lisinopril.
Atovaquone Atovaquone The metabolism of Phenobarbital can be decreased when combined with Atovaquone.
Rifabutin Rifabutin The metabolism of Phenobarbital can be increased when combined with Rifabutin.
Sotalol Sotalol The serum concentration of Sotalol can be decreased when it is combined with Phenobarbital.
Bisoprolol Bisoprolol Phenobarbital may increase the hypotensive activities of Bisoprolol.
Zolpidem Zolpidem Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin Doxazosin The metabolism of Phenobarbital can be decreased when combined with Doxazosin.
Terazosin Terazosin Phenobarbital may increase the hypotensive activities of Terazosin.
Isradipine Isradipine Phenobarbital may increase the excretion rate of Isradipine which could result in a lower serum level and potentially a reduction in efficacy.
Omeprazole Omeprazole The metabolism of Phenobarbital can be decreased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Phenobarbital can be decreased when combined with Cisapride.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Phenobarbital.
Fluvastatin Fluvastatin The metabolism of Phenobarbital can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The metabolism of Phenobarbital can be decreased when combined with Venlafaxine.
Nizatidine Nizatidine The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Nizatidine.
Famciclovir Famciclovir The metabolism of Famciclovir can be increased when combined with Phenobarbital.
Fluvoxamine Fluvoxamine The metabolism of Phenobarbital can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Phenobarbital is combined with Nefazodone.
Lamotrigine Lamotrigine Phenobarbital may increase the excretion rate of Lamotrigine which could result in a lower serum level and potentially a reduction in efficacy.
Losartan Losartan The metabolism of Phenobarbital can be decreased when combined with Losartan.
Tramadol Tramadol The metabolism of Phenobarbital can be increased when combined with Tramadol.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be increased when combined with Phenobarbital.
Moexipril Moexipril Phenobarbital may increase the hypotensive activities of Moexipril.
Lansoprazole Lansoprazole The metabolism of Phenobarbital can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Phenobarbital.
Nicardipine Nicardipine The metabolism of Phenobarbital can be decreased when combined with Nicardipine.
Bupropion Bupropion The metabolism of Phenobarbital can be decreased when combined with Bupropion.
Ticlopidine Ticlopidine The metabolism of Phenobarbital can be decreased when combined with Ticlopidine.
Saquinavir Saquinavir The metabolism of Saquinavir can be increased when combined with Phenobarbital.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be increased when combined with Phenobarbital.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Phenobarbital.
Amifostine Injection Amifostine Injection Phenobarbital may increase the hypotensive activities of Amifostine.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Phenobarbital.
Anastrozole Anastrozole The metabolism of Phenobarbital can be increased when combined with Anastrozole.
Indinavir Indinavir The metabolism of Indinavir can be increased when combined with Phenobarbital.
Ritonavir Ritonavir The metabolism of Ritonavir can be increased when combined with Phenobarbital.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be increased when combined with Phenobarbital.
Clomipramine Clomipramine The metabolism of Phenobarbital can be increased when combined with Clomipramine.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Phenobarbital.
Mirtazapine Mirtazapine Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Trandolapril Trandolapril Phenobarbital may increase the hypotensive activities of Trandolapril.
Topiramate Topiramate The metabolism of Phenobarbital can be decreased when combined with Topiramate.
Zileuton Zileuton The metabolism of Phenobarbital can be decreased when combined with Zileuton.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Phenobarbital.
Pramipexole Pramipexole Phenobarbital may increase the sedative activities of Pramipexole.
Donepezil Donepezil The therapeutic efficacy of Donepezil can be decreased when used in combination with Phenobarbital.
Nelfinavir Nelfinavir The metabolism of Phenobarbital can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Azithromycin can be increased when combined with Phenobarbital.
Loratadine Loratadine Phenobarbital may increase the excretion rate of Loratadine which could result in a lower serum level and potentially a reduction in efficacy.
Carvedilol Carvedilol The metabolism of Phenobarbital can be decreased when combined with Carvedilol.
Nilutamide Nilutamide The metabolism of Phenobarbital can be decreased when combined with Nilutamide.
Flutamide Flutamide The risk or severity of methemoglobinemia can be increased when Phenobarbital is combined with Flutamide.
Selegiline Selegiline The metabolism of Phenobarbital can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Phenobarbital can be increased when combined with Bicalutamide.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Phenobarbital.
Propafenone Propafenone The serum concentration of Propafenone can be decreased when it is combined with Phenobarbital.
Letrozole Letrozole The metabolism of Letrozole can be decreased when combined with Phenobarbital.
Raloxifene Raloxifene The metabolism of Raloxifene can be increased when combined with Phenobarbital.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Phenobarbital.
Tamsulosin Tamsulosin Phenobarbital may increase the hypotensive activities of Tamsulosin.
Ropinirole Ropinirole The metabolism of Ropinirole can be increased when combined with Phenobarbital.
Finasteride Finasteride The metabolism of Finasteride can be increased when combined with Phenobarbital.
Quetiapine Quetiapine The metabolism of Quetiapine can be increased when combined with Phenobarbital.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Phenobarbital.
Paroxetine Paroxetine The metabolism of Phenobarbital can be decreased when combined with Paroxetine.
Tolcapone Tolcapone The metabolism of Phenobarbital can be decreased when combined with Tolcapone.
Citalopram Citalopram The metabolism of Citalopram can be decreased when combined with Phenobarbital.
Capecitabine Capecitabine The metabolism of Phenobarbital can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Phenobarbital can be decreased when combined with Efavirenz.
Abacavir Abacavir The metabolism of Abacavir can be increased when combined with Phenobarbital.
Sildenafil Sildenafil The metabolism of Phenobarbital can be decreased when combined with Sildenafil.
Pioglitazone Pioglitazone The metabolism of Pioglitazone can be increased when combined with Phenobarbital.
Celecoxib Celecoxib The metabolism of Phenobarbital can be decreased when combined with Celecoxib.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Phenobarbital.
Tolterodine Tolterodine The metabolism of Phenobarbital can be decreased when combined with Tolterodine.
Thalidomide Thalidomide Phenobarbital may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Aluminum Hydroxide Aluminum Hydroxide Aluminum hydroxide can cause a decrease in the absorption of Phenobarbital resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Phenobarbital.
Galantamine Galantamine The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Galantamine.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Phenobarbital is combined with Levetiracetam.
Rabeprazole Rabeprazole The metabolism of Phenobarbital can be decreased when combined with Rabeprazole.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Phenobarbital.

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