Drug & supplement interaction

Angel's Trumpet + Codeine, Papaverine

Codeine, Papaverine brand name: Copavin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Angel's Trumpet and Codeine, Papaverine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Angel's Trumpet and Codeine, Papaverine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Codeine, Papaverine and Angel's Trumpet in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Angel's Trumpet safety at a glance

Angel's Trumpet overall Avoid All parts of the plant are toxic and can cause life-threatening poisoning.
Pregnancy Unsafe When used orally. The entire plant is considered poisonous; avoid using. Read the full pregnancy detail
Breastfeeding Unsafe When used orally. The entire plant is considered poisonous; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Codeine, Papaverine and Angel's Trumpet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Codeine, Papaverine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Codeine, Papaverine is filed under 7 classifications — including vasodilators, narcotic drugs, cytochrome p450 2d6 (cyp2d6) substrates. Angel's Trumpet has documented interactions with 1 drug class — the most serious being anticholinergic drugs (moderate) — and none of Codeine, Papaverine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Angel's Trumpet Does Interact With Other Medications

Angel's Trumpet has 195 moderate known drug interactions in our database — Codeine, Papaverine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 195 No known interaction 2,635 (incl. Codeine, Papaverine)
Taking anything else?

Check Another of Your Medications Against Angel's Trumpet

Covers the 2,830 medications we’ve checked against Angel's Trumpet. Pick one to open its full report.

What to actually watch for

What Angel's Trumpet Itself Has Been Linked To

This is not an interaction — nothing below involves Codeine, Papaverine. It is the side-effect record for Angel's Trumpet on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Angel's Trumpet, this list is the first place to look. 4 entries are worth acting on rather than waiting out — marked below.

  • Muscle weakness / Memory problems / Unsteadiness / Hallucinations / Confusion / Seizures / Raised blood pressure Worth acting on Additional detail

    “Angel's trumpet is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, angel's trumpet can cause acute anticholinergic poisoning requiring medical attention.”

    Angel's Trumpet · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 5624. McHenry LE, Hall RC. Angel's trumpet. Lethal and psychogenic aspects. J Fla Med Assoc 1978;65:192-6.
    2. 5625. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4. PubMed
    3. 5626. Greene GS, Patterson SG, Warner E. Ingestion of angel's trumpet: an increasingly common source of toxicity. South Med J 1996;89:365-9. PubMed
    4. 5627. Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5. PubMed
    5. 31300. McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196.
    6. 97759. Isbister GK, Oakley P, Dawson AH, Whyte IM. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg Med (Fremantle). 2003;15(4):376-82.

    “Orally and via inhalation, angel's trumpet can cause severe toxicity. The most common neurologic symptoms include acute encephalopathy, delirium, dilated pupils, hyperactivity, and disorientation. Delirium and dilated pupils typically last for about 16 hours and 30 hours after ingestion, respectively.”

    Angel's Trumpet · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 97759. Isbister GK, Oakley P, Dawson AH, Whyte IM. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg Med (Fremantle). 2003;15(4):376-82.
    2. 109906. Colosimo E, Clodomiro A, Pirritano D, et al. Ischemic stroke and provoked seizure as a manifestation of Brugmansia suaveolens (angel's trumpet) acute intoxication: a detailed clinical, electroencephalogram, and magnetic resonance imaging description and 5
    3. 5627. Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5. PubMed
    4. 5624. McHenry LE, Hall RC. Angel's trumpet. Lethal and psychogenic aspects. J Fla Med Assoc 1978;65:192-6.
    5. 5625. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4. PubMed
    6. 31289. Gopel, C., Laufer, C., and Marcus, A. Three cases of angel's trumpet tea-induced psychosis in adolescent substance abusers. Nord.J.Psychiatry 2002;56(1):49-52. PubMed
  • Trouble passing urine Worth acting on Additional detail

    “Orally and via inhalation, angel's trumpet can cause severe toxicity. Genitourinary symptoms include urinary retention.”

    Angel's Trumpet · Natural Medicines adverse-effect record, reported in urinary retention.

    2 sources cited
    1. 5625. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4. PubMed
    2. 31300. McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196.
  • A low platelet count Worth acting on Additional detail

    Recorded for Angel's Trumpet in the same Natural Medicines adverse-effect record shown under Muscle weakness / Memory problems / Unsteadiness / Hallucinations / Confusion / Seizures / Raised blood pressure above.

  • Shortness of breath Worth acting on Additional detail

    “Orally, angel's trumpet can cause severe toxicity, including respiratory distress and respiratory arrest.”

    Angel's Trumpet · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    1 source cited
    1. 31297. Smith, E. A., Meloan, C. E., Pickell, J. A., and Oehme, F. W. Scopolamine poisoning from homemade 'moon flower' wine. J Anal.Toxicol 1991;15(4):216-219. DOI

Showing the 10 most notable of 21 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Angel's Trumpet — expand a row for the licensed statement it rests on. We haven’t matched Codeine, Papaverine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Codeine, Papaverine.

Special populations

Angel's Trumpet in Pregnancy & Breastfeeding

Pregnancy And Lactation Unsafe

When used orally. The entire plant is considered poisonous; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Codeine, Papaverine

This page covers Angel's Trumpet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Codeine, Papaverine page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), American Mistletoe (major), Beer (major) and Gamma-hydroxybutyrate (ghb) (major).

By severity: 8 major · 114 moderate · 23 minor.

From our pharmacist’s overview on the Codeine, Papaverine page

“Codeine combined with papaverine (Copavin) is an opioid product, and I read its supplement list as one that calls for genuine care. More than half of the 145 entries pile sedation on top of the drug's own, and the standouts are everyday alcohol (beer and wine each carry a major rating, well documented in people) and kava, combinations…”

Reviewed by 2 · Jul 18, 2026

Open the Codeine, Papaverine interaction page

One more smart check

Taking Angel's Trumpet as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Angel's Trumpet, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Angel's Trumpet. Even though Angel's Trumpet itself has no known interaction with Codeine, Papaverine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Angel's Trumpet and Codeine, Papaverine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Angel's Trumpet
Steady interest

#1,171 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Codeine, Papaverine
Steady interest

#1,697 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Angel's Trumpet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Angel's Trumpet and Codeine, Papaverine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Angel's Trumpet

What is Angel's Trumpet?

Angel's Trumpet
  • Traditional folk medicine
  • Asthma or breathing remedies (historical)
  • Pain relief (traditional)
  • Recreational hallucinogen (dangerous misuse)
  • Ornamental garden plant

Angel's Trumpet is a highly poisonous ornamental plant that contains powerful toxins like scopolamine and atropine. There is no safe medicinal dose, and even small amounts can cause hallucinations, dangerous heart effects, coma, or death. It should not be taken as a supplement or remedy.

Brugmansia spp. · Solanaceae · Flowers, leaves, seeds, and roots (all parts are toxic) · Ornamental plant; rarely as teas, infusions, or smoked preparations (all unsafe)

An interaction check asks whether these two react with each other — it does not ask whether Angel's Trumpet is a good idea for someone in your situation. Here is what our Angel's Trumpet record says about it on its own.

Angel's Trumpet: dosing

There is no safe or established dose of Angel's Trumpet. The amount of toxin in the plant varies greatly from one plant, flower, or season to another, so even people who think they are using a "small" amount can be seriously poisoned.Because of these dangers, we cannot provide any dosing guidance, and we strongly advise against using this plant in any form.

From our Angel's Trumpet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Angel's Trumpet monograph & all interactions
Keep checking

Other Drugs & Angel's Trumpet

Browse every other medication we’ve checked against Angel's Trumpet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
195Moderate
0Minor
2,634No known interaction
195 Moderate 2,634 No interaction
Moderate

195 interactions

Showing 60 of 195 moderate interactions — see all 195 on the Angel's Trumpet page.

No interaction 2,634 drugs checked — show the list

We also checked Angel's Trumpet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,634 medications checked with no known interaction — see the full Angel's Trumpet list.

See the full Angel's Trumpet interactions page
See every supplement checked against Codeine, Papaverine, ranked by severity
Evidence & sources

Angel's Trumpet References

The 18 references that drive our Angel's Trumpet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  2. McHenry LE, Hall RC. Angel's trumpet. Lethal and psychogenic aspects. J Fla Med Assoc 1978;65:192-6.
  3. Hall RC, Popkin MK, Mchenry LE. Angel's Trumpet psychosis: a central nervous system anticholinergic syndrome. Am J Psychiatry 1977;134:312-4. PubMed
  4. Greene GS, Patterson SG, Warner E. Ingestion of angel's trumpet: an increasingly common source of toxicity. South Med J 1996;89:365-9. PubMed
  5. Francis PD, Clarke CF. Angel trumpet lily poisoning in five adolescents: clinical findings and management. J Paediatr Child Health 1999;35:93-5. PubMed
  6. Gopel, C., Laufer, C., and Marcus, A. Three cases of angel's trumpet tea-induced psychosis in adolescent substance abusers. Nord.J.Psychiatry 2002;56(1):49-52. PubMed
  7. Havelius, U. and Asman, P. Accidental mydriasis from exposure to Angel's trumpet (Datura suaveolens). Acta Ophthalmol.Scand. 2002;80(3):332-335.
  8. Mobus, U., Demmler, G., and Schulz, K. [Accidental drowning due to tropane alkaloid abuse]. Arch Kriminol. 2002;210(1-2):16-21.
  9. Isbister, G. K., Oakley, P., Dawson, A. H., and Whyte, I. M. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg.Med.(Fremantle.) 2003;15(4):376-382.
  10. Marneros, A., Gutmann, P., and Uhlmann, F. Self-amputation of penis and tongue after use of Angel's Trumpet. Eur.Arch.Psychiatry Clin.Neurosci. 2006;256(7):458-459. PubMed
  11. Smith, E. A., Meloan, C. E., Pickell, J. A., and Oehme, F. W. Scopolamine poisoning from homemade 'moon flower' wine. J Anal.Toxicol 1991;15(4):216-219. DOI
  12. Hayman, J. Datura poisoning--the Angel's Trumpet. Pathology 1985;17(3):465-466. PubMed
  13. McHenry, L. E. and Hall, R. C. Angel's trumpet. Lethal and psychogenic aspects. J.Fla.Med.Assoc. 1978;65(3):192-196.
  14. Isbister GK, Oakley P, Dawson AH, Whyte IM. Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology. Emerg Med (Fremantle). 2003;15(4):376-82.
  15. Zhang HL, Wang XF. Angel's trumpet-associated polyneuropathy-is it Guillain-Barré syndrome? Pediatr Neurol. 2011 Jul;45(1):63; author reply 63-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Angel's Trumpet and Codeine, Papaverine Together: Common Questions

Is it safe to take Angel's Trumpet with Codeine, Papaverine?
We do not list a known interaction between Angel's Trumpet and Codeine, Papaverine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Angel's Trumpet and Codeine, Papaverine combination checked?
Interactions in our licensed database are recorded against drug classes. Codeine, Papaverine is filed under 7 classifications, and Angel's Trumpet has documented interactions with 1 drug class — none of Codeine, Papaverine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Angel's Trumpet interact with any other medications?
Yes. Angel's Trumpet has 195 documented drug interactions in our database — Codeine, Papaverine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Codeine, Papaverine interact with any supplements?
Yes. Codeine, Papaverine has documented interactions with 145 supplements in our database — Angel's Trumpet is not one of them. The Codeine, Papaverine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Angel's Trumpet monograph Uses, safety profile, and every drug interaction in one place Codeine, Papaverine supplement interactions Every supplement checked against Codeine, Papaverine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Codeine, Papaverine and Angel's Trumpet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.