Dimenhydrinate
Dimenhydrinate is an antihistamine-type medicine used to prevent and treat the nausea, vomiting and dizziness (or vertigo) of motion sickness, sold as tablets, chewable tablets, capsules, an oral solution and an injection.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 35 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Dimenhydrinate (Dramamine) is an older antihistamine-type medicine that prevents and treats the nausea, vomiting and dizziness of motion sickness by calming an overactive inner ear balance system, and it is one of the most familiar travel remedies, on the U.S. market since at least the early 1980s and available as a generic. It is generally well tolerated, but drowsiness, often marked, is the main trade-off, along with dry mouth. Take that sleepiness seriously by skipping alcohol and not driving until you know how it affects you. With children, follow the age directions on your specific product exactly, since an overdose in a child can cause hallucinations, seizures or death.
Clinical pearls
- Take the first dose about 30 to 60 minutes before travel starts, because preventing motion sickness works better than chasing it.
- It contains diphenhydramine, the ingredient in Benadryl and many “PM” sleep aids, so do not double up with those.
- Mention any antibiotics you take, since it can hide early hearing or balance warning signs from ear-damaging antibiotics.
- With an enlarged prostate or narrow-angle glaucoma, check before using it, because its drying effect can make urinating difficult or worsen glaucoma.
Patient information guide A plain-language walkthrough of Dimenhydrinate, written from its FDA label.
What Dimenhydrinate is used for
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Dimenhydrinate is used for motion sickness across several products.
- Oral tablets, chewable tablets, capsules and oral solution (including Dramamine, Gravol, Driminate and Airmit Ace): prevent and treat nausea, vomiting and dizziness of motion sickness.
- Dimenhydrinate Injection (muscle or vein): prevents and treats nausea, vomiting or vertigo of motion sickness.
How Dimenhydrinate works
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The exact way dimenhydrinate works is not known. It has a calming (depressant) effect on an overstimulated labyrinth, the balance system in the inner ear. That helps reduce motion sickness symptoms.
Dimenhydrinate dosage
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Oral products are taken by mouth. To prevent motion sickness, the first dose is taken about 1/2 to 1 hour before the activity.
- Doses repeat every few hours, with a daily maximum that depends on age and product.
- Children's amounts are lower, and children under 2 should not use it unless a doctor directs.
- The injection is given into a muscle or vein by a healthcare professional.
Always follow the label or your prescriber.
Dosing details from the FDA-approved label
From the Dimenhydrinate prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- adults and children 12 years and over
- Take 1 to 2 chewable tablets every 4-6 hours
- Maximum: do not take more than 8 chewable tablets in 24 hours, or as directed by a doctor
- first dose 1/2 to 1 hour before starting activity (Dramamine, Motion Sickness Relief and other tablet labels use the same 1 to 2 tablets and 8 tablets)
- children 6 to under 12 years
- Give 1/2 to 1 chewable tablet every 6-8 hours
- Maximum: do not give more than 3 chewable tablets in 24 hours, or as directed by a doctor
- first dose 1/2 to 1 hour before starting activity
- children 2 to under 6 years
- Give 1/2 chewable tablet every 6-8 hours
- Maximum: do not give more than 1-1/2 chewable tablets in 24 hours, or as directed by a doctor
- first dose 1/2 to 1 hour before starting activity
- children 2 to under 6 years (Gravol coated tablet)
- Give 1/4 to 1/2 tablet every 6-8 hours
- Maximum: do not give more than 1-1/2 tablets in 24 hours, or as directed by a doctor
- Gravol label wording
- Adults and children 12 years of age and older (Kids Gravol Chewables)
- Take 4 to 6 tablets every 4 to 6 hours
- Maximum: Do not exceed 24 tablets in 24 hours, or as directed by a doctor
- Kids Gravol Chewables label; first dose 1/2 to 1 hour before activity
- Children 6 to under 12 years of age (Kids Gravol Chewables)
- Take 2 or 3 tablet every 6 to 8 hours
- Maximum: Do not exceed 10 tablets in 24 hours, or as directed by a doctor
- Kids Gravol Chewables label
- Children 2 to under 6 years of age (Kids Gravol Chewables)
- Give 1 tablet every 6-8 hours
- Maximum: Do not give more than 5 tablets in 24 hours, or as directed by a doctor
- Kids Gravol Chewables label
Read the label’s full dosing text
Directions to prevent motion sickness, the first dose should be taken 1/2 to 1 hour before starting activity to prevent or treat motion sickness, see below: adults and children 12 years and over take 1 to 2 chewable tablets every 4-6 hours do not take more than 8 chewable tablets in 24 hours, or as directed by a doctor children 6 to under 12 years give ½ to 1 chewable tablet every 6-8 hours do not give more than 3 chewable tablets in 24 hours, or as directed by a doctor children 2 to under 6 years give ½ chewable tablet every 6-8 hours do not give more than 1-½ chewable tablets in 24 hours, or as directed by a doctor
Read the full Dosage and Administration section on DailyMed →
Dimenhydrinate side effects
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Drowsiness is the most common effect.
Common side effects
- Drowsiness (the most frequent)
- Dizziness
- Dry mouth, nose and throat
- Blurred vision
- Headache
- Difficult or painful urination
- Nervousness, restlessness or trouble sleeping (especially in children)
- Upset stomach or nausea
When to get medical help
- Get medical help for a skin rash or signs of an allergic reaction.
- Get help right away after an overdose, especially in a child. Hallucinations, convulsions (seizures) or death can occur in infants and children.
- Seek care for a fast heartbeat (tachycardia) or trouble passing urine.
- Report severe confusion, excitation or unusual agitation, especially in a young child.
Skin rash, fast heartbeat and excitation have also been reported. Contact a healthcare professional if these occur.
Dimenhydrinate warnings and precautions
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- It can cause marked drowsiness. Be careful driving or operating machinery.
- Overdose in infants and children can cause hallucinations, convulsions or death.
- It can mask warning signs of ear damage from certain antibiotics.
- Use caution with conditions affected by anticholinergic drugs (prostate enlargement, glaucoma, asthma, heart rhythm problems, and certain stomach or bladder blockages).
- The injection must not be given into an artery.
Dimenhydrinate interactions
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Some substances add to dimenhydrinate's effects.
- Alcohol: increases drowsiness.
- Sedatives, tranquilizers and other central nervous system depressants: additive drowsiness.
- Certain antibiotics that can harm the ear: dimenhydrinate may hide early symptoms.
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Dimenhydrinate
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- Do not use if allergic to dimenhydrinate, diphenhydramine or 8-chlorotheophylline.
- Not for newborns. The injection contains benzyl alcohol, linked to “gasping syndrome” in premature and low birth weight infants.
- Do not use in children under 2 unless a doctor directs.
- Check with a doctor first if you have prostate enlargement, glaucoma, asthma, an irregular heartbeat, or stomach or bladder blockage.
Dimenhydrinate overdose
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Drowsiness is the usual sign of too much. Massive overdose can cause convulsions, coma and breathing problems. No specific antidote is known, so treatment supports breathing and controls seizures. Get emergency help right away.
What Dimenhydrinate does in the body
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Dimenhydrinate depresses overstimulated function of the labyrinth in the inner ear. This is thought to be linked to its effect on motion sickness symptoms.
How to store Dimenhydrinate
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store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F) protect from moisture
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Dimenhydrinate
52 supplements and herbal products have documented interactions with Dimenhydrinate in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 3
- Moderate · 38
- Minor · 11
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Dimenhydrinate: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Dimenhydrinate — the kind of thing our pharmacy team would talk through with you at the counter.
What is dimenhydrinate used for?
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When should I take it for a trip?
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Will it make me sleepy?
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Can I take it with other medicines?
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Is it safe for kids?
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Who should check with a doctor first?
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Is Dimenhydrinate available over the counter?
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When was Dimenhydrinate first available?
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Who makes Dimenhydrinate?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Dimenhydrinate on HelloPharmacist
Dimenhydrinate forms and strengths (how it comes)
Dimenhydrinate is available in 5 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Dimenhydrinate inactive ingredients by manufacturer.
Tablet
How this form is used
- Airmit Ace, Dramamine, Driminate and Gravol tablets are used to prevent and treat nausea, vomiting and dizziness from motion sickness.
- Dramamine Original Formula and Driminate tablets: take the first dose 1/2 to 1 hour before activity.
- Driminate: do not take more than directed; adult and child amounts and daily limits differ by age.
Chewable tablet
How this form is used
- Dramamine chewable products and Gravol Chewables are used to prevent and treat nausea, vomiting and dizziness from motion sickness.
- Dramamine chewable products: take the first dose 1/2 to 1 hour before activity; amounts and daily limits depend on age.
- Gravol Chewables: take the first dose 1/2 to 1 hour before activity; follow the age-based directions on the package.
Capsule
How this form is used
- Gravol (liquid-filled capsule) is used to prevent and treat nausea, vomiting and dizziness from motion sickness.
Injection
How this form is used
- Dimenhydrinate Injection is used to prevent and treat nausea, vomiting or vertigo of motion sickness.
- Dimenhydrinate Injection is given into a muscle or vein and must not be injected into an artery.
Oral solution
How this form is used
- Gravol (oral syrup) is used to prevent and treat nausea, vomiting and dizziness from motion sickness.
Dimenhydrinate on the U.S. market: products, makers and brands
How Dimenhydrinate appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
23 companies list 34 Dimenhydrinate product records with the FDA, mostly as tablet, chewable tablet, capsule; the earliest marketing or approval year on record is 1972. Brand names on the directory include Dramamine, Dramamine Chewable, Wal-Dram and 12 more; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (3) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Dimenhydrinate is used (Medicaid data)
A general measure of how commonly Dimenhydrinate is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Dimenhydrinate is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Dimenhydrinate prescribed? Of the 1,601 medications we measure, Dimenhydrinate ranks #1,161 by Medicaid prescriptions — more than 27% of them.
Utilization by Dimenhydrinate product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
dimenhydrinate 50 MG Oral Tablet Most dispensed
Summed across the 3 of 51 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198603
dimenhydrinate 50 MG/ML Injectable Solution
Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309914
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Dimenhydrinate, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 4 of 53 listed Dimenhydrinate NDCs with Medicaid activity.
Compare Dimenhydrinate products
A representative set of FDA-listed product records for Dimenhydrinate — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Capsule | ||||
| 50 mg | Oral | Church & Dwight Co., Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 💊Chewable tablet | ||||
| 15 mg | Oral | Church & Dwight Co., Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Church & Dwight Co., Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Lil' Drug Store Products, Inc. × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 25 mg | Oral | Medtech Products Inc. × 3 listings | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Medtech Products Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 💊Injection | ||||
| 50 mg/mL | Intramuscular, Intravenous | Fresenius Kabi USA, LLC | ANDA | View NDC → |
| 💊Oral solution | ||||
| 15 mg/5 mL | Oral | Church & Dwight Co., Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 💊Tablet | ||||
| 50 mg | Oral | Allegiant Health | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Amerisource Bergen | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Cardinal Health 110, LLC. DBA Leader | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Chain Drug Marketing Association, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Church & Dwight Co., Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | CVS Pharmacy | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | CVS Pharmacy, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Geiss, Destin & Dunn Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | L.N.K. International, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | LEADER/ Cardinal Health 110, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Major Pharmaceuticals × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Medtech Products Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Rite Aid Corporation | OTC MONOGRAPH DRUG | View NDC → |
| 25 mg | Oral | Sato Pharmaceutical Co., Ltd. | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Strategic Sourcing Services LLC | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Target Corporation × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Topco Associates, LLC | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Valu Merchandisers Company | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Wal-Mart Stores Inc | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | Walgreen Company | OTC MONOGRAPH DRUG | View NDC → |
| 50 mg | Oral | WinCo Foods, LLC | OTC MONOGRAPH DRUG | View NDC → |
Showing 34 of 34 products — FDA National Drug Code Directory. See every product, package size and price: browse all 34 Dimenhydrinate NDCs →
Dimenhydrinate side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Dimenhydrinate — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Dimenhydrinate in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Dimenhydrinate FDA approval history
How Dimenhydrinate went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Dimenhydrinate recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Dimenhydrinate recalls since July 2021.
✅No Dimenhydrinate recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 3444 5 dose forms · 8 strengths
-
Dose form (SCDF) Chewable Tablet RxCUI 371861In current FDA listings -
Dose form (SCDF) Injectable Solution RxCUI 371862In current FDA listingsClinical drug / strength (SCD) 50 MG/MLRxCUI 309914 -
Dose form (SCDF) Oral Capsule RxCUI 371859In current FDA listingsClinical drug / strength (SCD) 50 MGRxCUI 309912 -
Dose form (SCDF) Oral Solution RxCUI 371863In current FDA listingsClinical drug / strength (SCD) 3 MG/MLRxCUI 755901 -
Dose form (SCDF) Oral Tablet RxCUI 371866In current FDA listings
Look up RxCUI 3444 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Dimenhydrinate supply and shortage status
Whether Dimenhydrinate is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
Dimenhydrinate brand names
Dimenhydrinate is sold under 15 brand names in the FDA directory — Dramamine, Dramamine Chewable, Wal-Dram, Airmit and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Dimenhydrinate: manufacturers and labelers
23 companies list Dimenhydrinate products with the FDA. By number of product records, the largest are Church & Dwight Co., Inc., Medtech Products Inc., Lil' Drug Store Products, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Dimenhydrinate drug class (RxNorm)
Dimenhydrinate belongs to the Aminoalkyl ethers class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Dimenhydrinate page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Lil' Drug Store Products, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →