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Chlordiazepoxide

Chlordiazepoxide is a benzodiazepine used to treat anxiety disorders, alcohol withdrawal symptoms, and anxiety before surgery.

Brand names LibriumA-poxideChlordiazachelH-TranLibrelease +4 more
Drug class Benzodiazepines
Rx Schedule CIV Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 22 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 7, 2026
Chlordiazepoxide at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Chlordiazepoxide (Librium) was the first benzodiazepine, on the U.S. market since about 1960 and available generically, and it calms the brain's emotional centers to treat anxiety disorders, alcohol withdrawal and anxiety before surgery; it is now largely an older standby, most often chosen for alcohol withdrawal. Most people tolerate it reasonably well, though drowsiness and unsteadiness are common, and older adults are more prone to confusion and falls. Its boxed warning flags dangerously slowed breathing with opioids, a risk of misuse and addiction, and withdrawal seizures if stopped suddenly. Plan on the lowest dose for the shortest time, since benefit beyond four months has not been studied.

Clinical pearls

  • Skip alcohol entirely, and treat sleep aids and muscle relaxants with caution, since each stacks on its sedation.
  • Never stop it on your own after regular use; a gradual taper avoids withdrawal reactions, including seizures.
  • Tell surgical and emergency teams you take it, since flumazenil, a benzodiazepine reversal drug, can trigger withdrawal seizures in regular users.
  • Avoid it during the first trimester of pregnancy and while breastfeeding; tell your prescriber if you could become pregnant.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

This medicine carries three serious FDA boxed warnings — the most urgent safety alerts a drug can have.

1. Taking chlordiazepoxide with opioid pain medicines is dangerous. Combining them can cause profound sedation, very slow or stopped breathing, coma, and death. This combination should only happen when there is no safer option, and only under close medical supervision. Watch for signs of slow or difficult breathing and extreme sleepiness.

2. Chlordiazepoxide can be abused and is addictive. Using it in ways other than prescribed — or mixing it with alcohol, other drugs, or illicit substances — significantly raises the risk of overdose or death.

3. Regular use creates physical dependence, and stopping suddenly can be life-threatening. Withdrawal seizures and other serious reactions can occur if you stop abruptly. Never stop taking this medicine on your own — your doctor must help you taper the dose down slowly and safely.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asCapsule
Earliest FDA record1960
Companies listing it with the FDA14
FDA label last updatedApr 4, 2019
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Chlordiazepoxide, written from its FDA label.

What Chlordiazepoxide is used for

▾

Chlordiazepoxide capsules are approved to treat several conditions across the supported products:

  • Anxiety disorders — to manage anxiety disorders or provide short-term relief of anxiety symptoms
  • Acute alcohol withdrawal — to relieve withdrawal symptoms in people going through acute alcoholism withdrawal
  • Pre-surgery anxiety — to reduce apprehension and anxiety before a surgical procedure

Chlordiazepoxide is not appropriate for everyday stress and tension that does not rise to the level of a clinical disorder. Its usefulness beyond 4 months has not been established by systematic studies, so your doctor should regularly reassess whether continued use makes sense for you.

How Chlordiazepoxide works

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Chlordiazepoxide belongs to the benzodiazepine class and works by acting on the brain's central nervous system. It produces anti-anxiety, sedative, and mild appetite-stimulating effects. It is thought to work by blocking arousal signals in the brain stem and influencing the limbic system — the part of the brain that governs emotional responses like fear and aggression. The exact molecular mechanism is not fully understood.

Chlordiazepoxide dosage

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Chlordiazepoxide is taken as an oral capsule, typically several times a day. The exact number of doses and how long you take it depends on what it's being used for — anxiety management, alcohol withdrawal, or pre-surgical anxiety — as well as your individual response. Older adults and people with serious illness usually start at lower doses.

  • Follow your prescriber's instructions exactly — do not change your dose on your own
  • Do not stop taking it suddenly; always taper down gradually under medical supervision
  • If you miss a dose, ask your pharmacist or prescriber for guidance

Dosing details from the FDA-approved label

From the Chlordiazepoxide prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Relief of Mild and Moderate Anxiety Disorders and Symptoms of Anxiety (Adults)
    • 5 mg or 10 mg, 3 or 4 times daily
  • Relief of Severe Anxiety Disorders and Symptoms of Anxiety (Adults)
    • 20 mg or 25 mg, 3 or 4 times daily
  • Geriatric Patients, or in the presence of debilitating disease
    • 5 mg, 2 to 4 times daily
    • Geriatric patients or those with debilitating disease
  • Preoperative Apprehension and Anxiety (Adults)
    • On days preceding surgery, 5 to 10 mg orally, 3 or 4 times daily
    • If used as preoperative medication, 50 to 100 mg IM 1 hour prior to surgery
  • Pediatric patients
    • 5 mg, 2 to 4 times daily (may be increased in some pediatric patients to 10 mg, 2 to 3 times daily)
    • Initiate with the lowest dose and increase as required; use under 6 years of age is not recommended
  • Withdrawal symptoms of acute alcoholism
    • If administered orally, suggested initial dose is 50 to 100 mg, followed by repeated doses as needed until agitation is controlled
    • Dosage should then be reduced to maintenance levels
    • Maximum: up to 300 mg per day
    • Parenteral form is usually used initially
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION Because of the wide range of clinical indications for chlordiazepoxide, the optimum dosage varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects. ADULTS USUAL DAILY DOSE Relief of Mild and Moderate Anxiety Disorders and Symptoms of Anxiety 5 mg or 10 mg, 3 or 4 times daily Relief of Severe Anxiety Disorders and Symptoms of Anxiety 20 mg or 25 mg, 3 or 4 times daily Geriatric Patients, or in the presence of debilitating disease 5 mg, 2 to 4 times daily Preoperative Apprehension and Anxiety: On days preceding surgery, 5 to 10 mg orally, 3 or 4 times daily. If used as preoperative medication, 50 to 100 mg IM * 1 hour prior to surgery PEDIATRIC PATIENTS USUAL DAILY DOSE Because of the varied response of pediatric patients to CNS-acting drugs, therapy should be initiated with the lowest dose and increased as required. Since clinical experience in pediatric patients under 6 years of age is limited, the use of the drug in this age group is not recommended. 5 mg, 2 to 4 times daily (may be increased in some pediatric patients to 10 mg, 2 to 3 times daily) For the relief of withdrawal symptoms of acute alcoholism, the parenteral form * is usually used initially. If the drug is administered orally, the suggested initial dose is 50 to 100 mg, to be followed by repeated doses as needed until agitation is controlled - up to 300 mg per day. Dosage should then be reduced to maintenance levels. * See package insert for Injectable Chlordiazepoxide Hydrochloride Management of Overdose Manifestations of chlordiazepoxide hydrochloride overdosage include somnolence, confusion, coma and diminished reflexes. Respiration, pulse and blood pressure should be monitored, as in all cases of drug overdosage, although, in general, these effects have been minimal following chlordiazepoxide hydrochloride overdosage. General supportive measures should be employed, along with immediate gastric lavage. Intravenous fluids should be administered and an adequate airway maintained. Hypotension may be combated by the use of Levophed ® (norepinephrine) or Aramine (metaraminol). Dialysis is of limited value. There have been occasional reports of excitation in patients following chlordiazepoxide hydrochloride overdosage; if this occurs barbiturates should not be used.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Chlordiazepoxide side effects

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Most people tolerate chlordiazepoxide reasonably well, but side effects are possible. Common ones include:

Common side effects

  • Drowsiness or sleepiness
  • Confusion, especially in older adults
  • Problems with balance or coordination (ataxia)
  • Nausea or constipation
  • Skin rash or swelling (edema)
  • Changes in sex drive (increased or decreased libido)
  • Irregular menstrual periods
  • Fainting (syncope) in rare cases

When to get medical help

  • Call your doctor or seek emergency help if you have slow, shallow, or difficult breathing — especially if you also take opioid pain medicines
  • Get help right away if you feel very confused, unresponsive, or slip into a coma
  • Tell your doctor immediately if you notice signs of dependence — needing more medicine to feel the same effect, or feeling unwell when you miss a dose
  • Do not stop taking chlordiazepoxide suddenly — abrupt stopping can trigger life-threatening seizures; always taper under medical supervision
  • Seek medical attention for signs of liver problems: yellowing of the skin or eyes (jaundice), unusual fatigue, or dark urine
  • Contact your doctor if you notice unusual muscle movements or signs of blood problems such as fever, chills, or unusual bruising
  • Tell your prescriber right away if you feel your medication is no longer working the same way, or if you feel an urge to misuse it

More serious reactions — including slowed breathing, jaundice (yellowing of skin or eyes), signs of blood disorders, or signs of misuse or dependence — need prompt medical attention. If you experience these, contact your doctor right away or call emergency services.

Chlordiazepoxide warnings and precautions

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  • Dependence and withdrawal: Regular use leads to physical dependence. Stopping suddenly can trigger life-threatening withdrawal reactions, including seizures. Always taper with your doctor's help.
  • Abuse and addiction risk: Chlordiazepoxide can be misused. Risk is highest in people who combine it with opioids, alcohol, or other substances.
  • Opioid combination danger: Using chlordiazepoxide with opioid medicines can cause severe breathing problems, coma, or death. This combination should be avoided unless there is no safer option.
  • Impaired driving and alertness: This medicine can slow your thinking and reflexes. Do not drive or operate heavy machinery until you know how it affects you.
  • Pregnancy: Use in the first trimester has been linked in some studies to possible birth defects. Breastfeeding is not recommended because the drug can accumulate in breast milk and affect the baby.
  • Prolonged withdrawal syndrome: In some people, withdrawal symptoms can last weeks to more than a year after stopping.

Chlordiazepoxide interactions

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Chlordiazepoxide interacts with several substances that can make it significantly more dangerous:

  • Opioid pain medicines — combining these sharply raises the risk of respiratory depression (slowed breathing), coma, and death
  • Alcohol — adds to CNS depression and can cause serious harm; avoid alcohol entirely while taking this medicine
  • Other CNS depressants (sleep aids, muscle relaxants, other sedatives) — increase the risk of sedation and breathing problems
  • Flumazenil (a benzodiazepine reversal agent) — can trigger severe acute withdrawal reactions, including seizures, in people who are physically dependent on chlordiazepoxide

Interactions listed in the FDA-approved label

From the Chlordiazepoxide prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Opioids: Concomitant use of benzodiazepines and opioids increases the risk of respiratory depression, and benzodiazepines can significantly worsen opioid-related respiratory depression. Limit dosage and duration of concomitant use, and monitor patients closely for respiratory depression and sedation.
Read the label’s full interactions text

Drug Interactions The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. Benzodiazepines interact at GABA A sites and opioids interact primarily at mu receptors. When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid-related respiratory depression exists. Limit dosage and duration of concomitant use of benzodiazepines and opioids, and monitor patients closely for respiratory depression and sedation. Pregnancy: Pregnancy Exposure Registry There is a pregnancy registry that monitors pregnancy outcomes in women exposed to psychiatric medications, including chlordiazepoxide hydrochloride capsules, during pregnancy. Healthcare providers are encouraged to register patients by calling the National Pregnancy Registry for Psychiatric Medications at 1-866-961-2388 or visiting online at https://womensmentalhealth.org/pregnancyregistry/. Risk Summary Neonates born to mothers using benzodiazepines late in pregnancy have been reported to experience symptoms of sedation and/or neonatal withdrawal (see WARNINGS: Neonatal Sedation and Withdrawal Syndrome and Clinical Considerations ). Available data from published observational studies of pregnant women exposed to benzodiazepines do not report a clear association with benzodiazepines and major birth defects ( see Data ). The background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated risk of major birth defects and of miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. Clinical Considerations Fetal/Neonatal Adverse Reactions Benzodiazepines cross the placenta and may produce respiratory depression, hypotonia and sedation in neonates.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿188 supplements and herbs with documented Chlordiazepoxide interactions, ranked by severity Check Chlordiazepoxide against a supplement or herb →

Before taking Chlordiazepoxide

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  • Allergy: Do not take chlordiazepoxide if you have had an allergic reaction to it before
  • Pregnancy: Use during the first trimester should almost always be avoided; tell your doctor immediately if you become pregnant while taking it
  • Breastfeeding: Not recommended — the drug can accumulate in breast milk and cause sedation or withdrawal in nursing babies
  • Children under 6: Not recommended due to limited safety data
  • Older adults and those with serious illness: Require lower doses; more sensitive to confusion, sedation, and falls
  • History of substance use disorder: Tell your prescriber — you may be at higher risk of misuse or addiction
  • Before surgery: Tell your surgical team you are taking this medicine

Chlordiazepoxide overdose

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Taking too much chlordiazepoxide can cause drowsiness, confusion, slurred speech, poor coordination, and in severe cases, coma and respiratory depression (dangerously slowed breathing). The risk of a fatal outcome rises dramatically when combined with opioids, alcohol, or other CNS depressants.

If an overdose is suspected, call 911 or the Poison Control Center at 1-800-222-1222 immediately. Do not try to manage it at home — prompt medical care is essential.

What Chlordiazepoxide does in the body

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Chlordiazepoxide produces anti-anxiety (anxiolytic), sedative, and mild appetite-stimulating effects, along with weak pain-relieving properties. It reduces fear and aggression by acting on the limbic system of the brain, which governs emotional responses. At therapeutic doses, it can significantly reduce anxiety without necessarily causing strong sedation.

How your body processes Chlordiazepoxide

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After you take chlordiazepoxide by mouth, it takes several hours to reach peak levels in the blood. Its half-life — the time it takes for your body to clear half the drug — is between 24 and 48 hours, meaning it stays in your system for days after you stop taking it. Chlordiazepoxide is cleared mainly through the urine, with only a small fraction leaving the body unchanged.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

188

Supplements & herbs that interact with Chlordiazepoxide

188 supplements and herbal products have documented interactions with Chlordiazepoxide in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 10
  • Moderate · 142
  • Minor · 36
1,4-BUTANEDIOL Major ACTIVATED CHARCOAL Major BEER Major GAMMA-HYDROXYBUTYRATE (GHB) Major GRAPEFRUIT Major HENBANE Major KAVA Major L-TRYPTOPHAN Major +180 more
Every supplement checked against Chlordiazepoxide — ranked by severity The full interaction hub: 10 major · 142 moderate · 36 minor · every one linked to its full report. Check Chlordiazepoxide against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Chlordiazepoxide: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Chlordiazepoxide — the kind of thing our pharmacy team would talk through with you at the counter.

What exactly is chlordiazepoxide used for?

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Chlordiazepoxide is mainly used for three things: managing anxiety disorders, easing the symptoms of going through alcohol withdrawal, and calming pre-surgery anxiety. It's not meant for everyday stress — it's intended for situations where anxiety is clinically significant and needs medical treatment. Your doctor decided it was the right fit based on your specific situation.

Can I stop taking it whenever I want if I feel better?

▾
Please don't stop on your own — this is one of the most important things to know about this medicine. Your body can become physically dependent on chlordiazepoxide, and stopping suddenly can trigger serious withdrawal reactions, including seizures, which can be life-threatening. Always work with your doctor to taper the dose down gradually over time. Even if you feel great, a slow, supervised stop is the safe way to go.

Is it okay to have a drink while I'm taking this?

▾
No — you should avoid alcohol completely while taking chlordiazepoxide. Both alcohol and this medicine slow down your central nervous system, and combining them can cause dangerous levels of sedation, breathing problems, and other serious harm. This is not a 'one drink is probably fine' situation — the interaction is real and the risks are significant.

What side effects should I expect, and which ones are a reason to call my doctor?

▾
The most common side effects are drowsiness, some confusion, and balance or coordination issues — these are most likely when you first start or if the dose is too high, and they often improve with dose adjustment. More serious things to call your doctor about right away include very slow or difficult breathing (especially if you're also taking any opioid pain medicine), yellowing of your skin or eyes, signs of a blood problem like unusual bruising or fever, or feeling like you need to take more medicine than prescribed to feel the same effect.

Is this medicine safe during pregnancy or if I'm breastfeeding?

▾
This is really important to discuss with your doctor. Some early studies suggested a possible link between chlordiazepoxide use in the first trimester and birth defects, so use during pregnancy should generally be avoided unless your doctor decides the benefit clearly outweighs the risk. Breastfeeding is not recommended either — the medicine can build up in breast milk and cause sedation or withdrawal symptoms in your baby. If you're pregnant or planning to become pregnant, let your doctor know right away.

Can I take this with my opioid pain medicine?

▾
This combination is something your prescriber needs to know about and actively manage. Taking chlordiazepoxide together with opioids — like oxycodone, morphine, or codeine — significantly raises the risk of very slow breathing, loss of consciousness, and even death. If you're on both, your doctor should be aware, and you should be on the lowest possible doses of each for the shortest time needed. Never adjust these on your own, and get emergency help immediately if you or someone around you has trouble breathing or becomes very difficult to wake up.

Is Chlordiazepoxide available over the counter?

▾
No. Chlordiazepoxide is a prescription medicine: every Chlordiazepoxide product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

Is Chlordiazepoxide a controlled substance?

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Yes — Chlordiazepoxide is a federally controlled substance (Schedule IV) in the United States, so how it is prescribed, refilled and dispensed is regulated by the DEA.

When was Chlordiazepoxide first available?

▾
The earliest FDA record we hold for Chlordiazepoxide is from 1960: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Chlordiazepoxide was first used.

Who makes Chlordiazepoxide?

▾
14 companies currently list Chlordiazepoxide products in the FDA's NDC Directory, including Epic Pharma, LLC, Chartwell RX, LLC, Remedyrepack Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Chlordiazepoxide on HelloPharmacist

📊Chlordiazepoxide supplement interactions188 checked — ranked by severity 🌿Drug & Supplement CheckerChlordiazepoxide vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Chlordiazepoxide NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Chlordiazepoxide Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Chlordiazepoxide forms and strengths (how it comes)

Chlordiazepoxide is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Chlordiazepoxide inactive ingredients by manufacturer.

Capsule

By mouth
How this form is used
What it may be used for
  • Taken by mouth to manage anxiety disorders or relieve short-term anxiety symptoms
  • Taken by mouth to help ease withdrawal symptoms during acute alcohol withdrawal
  • Taken by mouth in the days before surgery to reduce preoperative anxiety and apprehension
  • Used orally in children 6 years and older (under medical supervision) for anxiety, starting at the lowest effective dose
Important instructions
  • Swallow capsules whole by mouth; doses are taken multiple times daily as directed by your prescriber
  • Your dose will be individualized based on your condition and response — do not adjust the dose on your own
  • Do not stop taking the capsules abruptly; always follow your prescriber's tapering plan to avoid withdrawal
  • Older adults and people with debilitating illness are typically started on lower doses to reduce the risk of side effects like confusion and falls
Available strengths 3 strengths
5 mg 10 mg 25 mg
62 FDA-listed product records ⓘ

Chlordiazepoxide on the U.S. market: products, makers and brands

How Chlordiazepoxide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

14 companies list 28 Chlordiazepoxide product records with the FDA, mostly as capsule; the earliest marketing or approval year on record is 1960. Brand names on the directory include Librium, A-poxide, Chlordiazachel and 6 more; the rest are generics.

1
Dose forms ⓘ
14
Labelers (makers, repackagers, distributors)
1
Brand names
28
FDA-listed product records ⓘ
1960
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (7) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Epic Pharma, LLC18%
Chartwell RX, LLC11%
Remedyrepack Inc.11%
Teva Pharmaceuticals USA, Inc.11%
Clinical Solutions Wholesale, LLC7%
Mylan Institutional Inc.7%
Other makers36%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Chlordiazepoxide is used (Medicaid data)

A general measure of how commonly Chlordiazepoxide is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Chlordiazepoxide is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

107,446
Medicaid prescriptions filled (Q1–Q4 2025)
$1.2M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Chlordiazepoxide prescribed? Of the 1,601 medications we measure, Chlordiazepoxide ranks #499 by Medicaid prescriptions — more than 69% of them.

Where Chlordiazepoxide ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #499 of 1,601
#494 Atropine 111,807 Rx #495 Lifitegrast Ophthalmic 109,594 Rx #496 Midazolam Nasal Spray 109,459 Rx #497 Digoxin 109,371 Rx #498 Upadacitinib 108,976 Rx #499 Chlordiazepoxide 107,446 Rx #500 Alogliptin 105,424 Rx #501 Buprenorphine Transder... 105,289 Rx #502 Telmisartan 104,917 Rx #503 Daptomycin Injection 104,494 Rx #504 Daptomycin 104,494 Rx

Utilization by Chlordiazepoxide product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 25 mg oral capsule is the most-dispensed Chlordiazepoxide product — about 71% of these Medicaid prescriptions.

chlordiazepoxide hydrochloride 25 MG Oral Capsule Most dispensed

76,612 Medicaid prescriptions (Q1–Q4 2025) 71% of Chlordiazepoxide prescriptions shown $899,925 gross reimbursement (before rebates) ≈ $12 per prescription (gross)

Summed across the 5 of 41 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 905495

chlordiazepoxide hydrochloride 10 MG Oral Capsule

17,559 Medicaid prescriptions (Q1–Q4 2025) 16% of Chlordiazepoxide prescriptions shown $176,873 gross reimbursement (before rebates) ≈ $10 per prescription (gross)

Summed across the 3 of 23 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 905369

chlordiazepoxide hydrochloride 5 MG Oral Capsule

13,275 Medicaid prescriptions (Q1–Q4 2025) 12% of Chlordiazepoxide prescriptions shown $136,635 gross reimbursement (before rebates) ≈ $10 per prescription (gross)

Summed across the 2 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 905516

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Chlordiazepoxide, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 10 of 73 listed Chlordiazepoxide NDCs with Medicaid activity.

Compare Chlordiazepoxide products

A representative set of FDA-listed product records for Chlordiazepoxide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 28 of 28 products — FDA National Drug Code Directory. See every product, package size and price: browse all 28 Chlordiazepoxide NDCs →

Chlordiazepoxide recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Chlordiazepoxide recalls since July 2021.

✅No Chlordiazepoxide recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Chlordiazepoxide RxCUI 2356 2 dose forms · 6 strengths
  2. Dose form (SCDF) Oral Tablet RxCUI 371390 No current FDA listing
    Clinical drug / strength (SCD) hydrochloride 10 MG RxCUI 905532 hydrochloride 25 MG RxCUI 905505 hydrochloride 5 MG RxCUI 905521

Look up RxCUI 2356 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Chlordiazepoxide costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Capsule · Oral 25 mg $0.158 per capsule NDC details & price history
Capsule · Oral 10 mg $0.143 per capsule NDC details & price history
Capsule · Oral 5 mg $0.187 per capsule NDC details & price history
Capsule, Gelatin Coated · Oral 10 mg $0.143 per capsule NDC details & price history
Capsule, Gelatin Coated · Oral 25 mg $0.160 per capsule NDC details & price history
Capsule, Gelatin Coated · Oral 5 mg $0.188 per capsule NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Chlordiazepoxide brand names

Chlordiazepoxide is sold under 9 brand names in the FDA directory — Librium, A-poxide, Chlordiazachel, H-Tran and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Librium A-poxide Chlordiazachel H-Tran Librelease Libritabs Lygen Mitran Poxi

Who makes Chlordiazepoxide: manufacturers and labelers

14 companies list Chlordiazepoxide products with the FDA. By number of product records, the largest are Epic Pharma, LLC, Chartwell RX, LLC, Remedyrepack Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Epic Pharma, LLC 5 Chartwell RX, LLC 3 Remedyrepack Inc. 3 Teva Pharmaceuticals USA, Inc. 3 Clinical Solutions Wholesale, LLC 2 Mylan Institutional Inc. 2 NuCare Pharmaceuticals,Inc. 2 Safecor Health, LLC 2 American Health Packaging 1 Bryant Ranch Prepack 1 Couper LLC 1 Coupler LLC 1 PD-Rx Pharmaceuticals, Inc. 1 Unit Dose Solutions, Inc. 1

Chlordiazepoxide drug class (RxNorm)

Chlordiazepoxide belongs to the Benzodiazepine class.

Pharmacologic class Benzodiazepine
Drug family (ATC) Benzodiazepine derivatives

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Chlordiazepoxide page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

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FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Apr 4, 2019
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Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Chlordiazepoxide.
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Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Chlordiazepoxide after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
22
Finished products in the current FDA directory
28
Companies listing them (makers, repackagers, distributors)
14
FDA labeler codes behind them ⓘ
13
Linked representative label ⓘ
Direct Rx
Linked label effective
Apr 4, 2019
Composite sections available
19
Linked SPL Set ID
2f1d49ad-13cb-2a23-e054-00144ff88e88
Linked SPL Document ID
85b6b71f-54fb-8262-e053-2a91aa0a0f89
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Direct Rx is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →