Chlordiazepoxide

24 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Diazepam Nasal Spray Nalbuphine Injection Butorphanol Injection Butorphanol Nasal Spray Midazolam Nasal Spray
21 Major 2 Moderate 1 Minor
All (24) Major (21) Moderate (2) Minor (1)

Major

Chlordiazepoxide Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Chlordiazepoxide Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Chlordiazepoxide Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Chlordiazepoxide Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Chlordiazepoxide Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Chlordiazepoxide Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Chlordiazepoxide Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Chlordiazepoxide Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Chlordiazepoxide Diazepam Rectal Diastat Increased risk of CNS depression Details Chlordiazepoxide Esketamine Nasal Spray Spravato Increased risk of sedation Details Chlordiazepoxide Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Chlordiazepoxide Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Chlordiazepoxide Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Chlordiazepoxide Lacosamide Injection Motpoly Increased risk of PR interval prolongation, an increased risk of AV block, bradycardia, and ventricular tachyarrhythmia and an inc... Details Chlordiazepoxide Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Chlordiazepoxide Metoclopramide Injection Gimoti Increased risk of CNS depression Details Chlordiazepoxide Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Chlordiazepoxide Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Chlordiazepoxide Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Chlordiazepoxide Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Chlordiazepoxide Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Chlordiazepoxide Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Chlordiazepoxide Ketoconazole Topical Extina® Foam Decreased chlordiazepoxide clearance and potentially increased chlordiazepoxide toxicity (excessive sedation and prolonged hypnoti... Details

Minor

Chlordiazepoxide Disulfiram Antabuse An increased risk of chlordiazepoxide toxicity (CNS depression) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.