Drug & supplement interaction

Angel's Trumpet + Trifluoperazine

Trifluoperazine brand name: Stelazine.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Angel's Trumpet has a moderate interaction with Trifluoperazine. Concomitant use may increase anticholinergic effects and adverse effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Angel's Trumpet and Trifluoperazine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICHOLINERGIC DRUGS

Why this applies to Trifluoperazine

Trifluoperazine falls under ANTICHOLINERGIC DRUGS — the group Angel's Trumpet interacts with.

Concomitant use may increase anticholinergic effects and adverse effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

First, the big picture: Angel's Trumpet is genuinely poisonous and should never be taken as a supplement or home remedy. Setting that aside, here's the pharmacology piece you asked about. Trifluoperazine (Stelazine) already carries its own mild anticholinergic activity, meaning it can dry you out and slow certain body functions. Angel's Trumpet is loaded with atropine and scopolamine, which do the same thing much more strongly.

Stack the two and those drying effects can pile up. Think dry mouth, blurry vision, constipation, trouble urinating, a fast heartbeat, and in worse cases confusion or hallucinations. This concern is based on how the chemicals behave, not hard studies, but with a plant this dangerous I wouldn't risk it. Please loop in your pharmacist or doctor before combining anything with your Stelazine.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Angel's Trumpet Also Interacts With Other Medications

Angel's Trumpet has 194 moderate known drug interactions in our database — the Trifluoperazine one above is one of them. If you take anything else, check it against the full list below.

Moderate 194 No known interaction 2,636 (incl. Trifluoperazine)
Taking anything else?

Check Another of Your Medications Against Angel's Trumpet

Covers the 2,830 medications we’ve checked against Angel's Trumpet. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Trifluoperazine

This page covers Angel's Trumpet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trifluoperazine page lists 76 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Indian Snakeroot (major), Rauvolfia Vomitoria (major) and Scopolia (major).

By severity: 5 major · 48 moderate · 23 minor.

From our pharmacist’s overview on the Trifluoperazine page

“An antipsychotic like trifluoperazine (Stelazine) leaves little slack for supplements that pile on side effects, and this list deserves a careful read. Five of the 76 ingredients on file rate major, and the largest cluster, 30 ingredients, adds anticholinergic load to a drug that already tends to cause dry mouth, constipation, and conf…”

Reviewed by 2 · Jul 18, 2026

Open the Trifluoperazine interaction page

One more smart check

Taking Angel's Trumpet as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3 real supplement products containing Angel's Trumpet, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Angel's Trumpet. Your product may carry other ingredients that interact with Trifluoperazine too, on top of Angel's Trumpet — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Angel's Trumpet and Trifluoperazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Angel's Trumpet
Steady interest

#1,033 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trifluoperazine
Steady interest

#2,710 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Angel's Trumpet

What is Angel's Trumpet?

Angel's Trumpet
  • Traditional folk medicine
  • Asthma or breathing remedies (historical)
  • Pain relief (traditional)
  • Recreational hallucinogen (dangerous misuse)
  • Ornamental garden plant

Angel's Trumpet is a highly poisonous ornamental plant that contains powerful toxins like scopolamine and atropine. There is no safe medicinal dose, and even small amounts can cause hallucinations, dangerous heart effects, coma, or death. It should not be taken as a supplement or remedy.

Read the full Angel's Trumpet monograph & all interactions
Medication

About Trifluoperazine

What Is Trifluoperazine Used For?

Brand name: Stelazine

Trifluoperazine Hydrochloride tablets are used to manage schizophrenia. They are also approved for the short-term treatment of generalized non-psychotic anxiety — meaning anxiety that is not part of a psychotic condition — but only when other treatments (like benzodiazepines) are not appropriate.

When used for anxiety, Trifluoperazine Hydrochloride tablets must not be taken for more than 12 weeks, as longer use raises the risk of serious, potentially permanent movement side effects. It has not been shown effective for anxiety symptoms caused by physical illness, depression, or other non-psychotic conditions.

See full Trifluoperazine drug information
Keep checking

Other Drugs & Angel's Trumpet

Browse every other medication we’ve checked against Angel's Trumpet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
194Moderate
0Minor
2,635No known interaction
194 Moderate 2,635 No interaction
Moderate

194 interactions

Showing 60 of 194 moderate interactions — see all 194 on the Angel's Trumpet page.

No interaction 2,635 drugs checked — show the list

We also checked Angel's Trumpet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,635 medications checked with no known interaction — see the full Angel's Trumpet list.

See the full Angel's Trumpet interactions page
See every supplement checked against Trifluoperazine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Angel's Trumpet monograph › Uses, safety, and every drug interaction in one place Trifluoperazine supplement interactions › Every supplement checked against Trifluoperazine, ranked by severity Trifluoperazine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Angel's Trumpet and Trifluoperazine Together: Common Questions

Can you take Angel's Trumpet with Trifluoperazine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Angel's Trumpet and Trifluoperazine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Trifluoperazine and Angel's Trumpet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.