Chlorpheniramine
Chlorpheniramine is an antihistamine taken by mouth (tablets, extended-release tablets, liquid, or an oral spray) to temporarily relieve hay fever and other upper respiratory allergy symptoms.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 39 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Chlorpheniramine is an older over-the-counter antihistamine that blocks histamine to temporarily ease sneezing, runny nose, itchy, watery eyes and an itchy nose or throat from hay fever and other upper respiratory allergies; on the market since about 1949 and available as a generic, it is usually a second choice behind newer non-drowsy antihistamines. It is otherwise well tolerated, but the drowsiness can be marked, and children may become excitable instead of sleepy. Drowsiness stacks with alcohol, sedatives and tranquilizers, so avoid that mix and be careful driving or using machinery. Check with your doctor first if you have glaucoma, emphysema, chronic bronchitis or urinary trouble from an enlarged prostate.
Clinical pearls
- Regular tablets and the liquid are taken every 4 to 6 hours, while extended-release tablets are taken about every 12 hours.
- Many multi-symptom cold and allergy products already contain chlorpheniramine, so check labels before doubling up and deepening the drowsiness.
- Children’s age limits differ by product, with some tablets not for under 6 and ClorRelief spray not for under 4.
- Store it well out of children’s reach, and call Poison Control right away after any accidental overdose.
Patient information guide A plain-language walkthrough of Chlorpheniramine, written from its FDA label.
What Chlorpheniramine is used for
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Chlorpheniramine is used for short-term relief of allergy symptoms.
- Hay fever (allergic rhinitis) and other upper respiratory allergies
- Sneezing
- Runny nose
- Itchy, watery eyes
- Itching of the nose or throat
This applies to the tablets, Allergy Relief and Chlorphen-12 extended-release tablets, Ed Chlorped Jr liquid, and ClorRelief and ClorRelief KIDs oral sprays.
Chlorpheniramine dosage
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Chlorpheniramine is taken by mouth. Each product has its own schedule, so follow the label on the one you have.
- Tablets and Ed Chlorped Jr liquid: generally every 4 to 6 hours.
- Allergy Relief and Chlorphen-12 extended-release tablets: generally every 12 hours.
- ClorRelief and ClorRelief KIDs oral sprays: generally every 4 to 6 hours, with a set number of sprays per application.
Do not exceed the recommended dosage. Children's directions depend on age, so check the label or ask a doctor.
Dosing details from the FDA-approved label
From the Chlorpheniramine prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Adults and children 12 years and over (extended-release tablet: Allergy Relief, Chlorphen-12)
- 1 tablet every 12 hours
- Maximum: Do not exceed 2 tablets in 24 hours
- Children under 12 years of age (extended-release tablet)
- Ask a doctor
- Adults and children 12 years and over (spray: ClorRelief, ClorRelief KIDs)
- For each application, spray 4 times every 4 to 6 hours
- Maximum: do not exceed 6 applications in 24 hours
- Children 6 to under 12 years of age (spray)
- For each application, spray 2 times every 4 to 6 hours
- Maximum: Do not exceed 3 applications in 24 hours
- Should be supervised in the use of this product
- Children 4 to under 6 years of age (spray)
- Do not use unless directed by a doctor
- Children under 4 years of age (spray)
- Do not use
- Adults and children 12 years of age and over (Ed Chlorped Jr liquid)
- 2 teaspoonfuls (10 mL) every 4 to 6 hours, or as directed by a doctor
- Maximum: not to exceed 12 teaspoonfuls in 24 hours
- Do not exceed recommended dosage
- Children 6 to under 12 years of age (liquid)
- 1 teaspoonful (5 mL) every 4 to 6 hours, or as directed by a doctor
- Maximum: not to exceed 6 teaspoonfuls in 24 hours
- Adults and children 12 years and over (4 mg immediate-release tablet)
- 1 tablet every 4 to 6 hours
- Maximum: not to exceed 6 tablets in 24 hours
- Children 6 to under 12 years of age (4 mg immediate-release tablet)
- 1/2 tablet (break tablet in half) every 4 to 6 hours
- Maximum: not to exceed 3 whole tablets in 24 hours
- Children under 6 years: ask a doctor (some labels say do not use)
Read the label’s full dosing text
Directions Do not exceed recommended dosage. Adults and children 12 years of age and over: 2 teaspoonfuls (10 mL) every 4 to 6 hours, not to exceed 12 teaspoonfuls in 24 hours, or as directed by a doctor. Children 6 to under 12 years of age: 1 teaspoonful (5 mL) every 4 to 6 hours, not to exceed 6 teaspoonfuls in 24 hours, or as directed by a doctor. Children under 6 years of age: Consult a doctor .
Read the full Dosage and Administration section on DailyMed →
Chlorpheniramine side effects
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The most common effects named for this medicine are:
Common side effects
- Marked drowsiness
- Excitability, especially in children
When to get medical help
- Seek professional help or call Poison Control right away after an accidental overdose.
- Call your doctor if you notice unusual excitability, especially in a child.
- Stop and ask a doctor if you develop breathing trouble, trouble urinating, or other concerning symptoms while using it.
If you take too much, seek professional help or call Poison Control right away.
Chlorpheniramine warnings and precautions
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- Drowsiness can be marked. Use caution when driving or operating machinery.
- Avoid alcohol, which can add to drowsiness.
- Do not exceed the recommended dosage.
- Children may become excitable.
- Keep out of reach of children.
Chlorpheniramine interactions
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Some substances can make chlorpheniramine's drowsiness stronger.
- Sedatives and tranquilizers: they can increase drowsiness, so talk to your doctor before combining them.
- Alcohol: it can add to drowsiness, so avoid it.
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Chlorpheniramine
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- Breathing problems such as emphysema or chronic bronchitis: do not take unless directed by a doctor.
- Glaucoma: do not take unless directed by a doctor.
- Trouble urinating from an enlarged prostate: do not take unless directed by a doctor.
- Pregnant or breastfeeding: ask a health professional before use.
- Young children: age limits vary by product, so check the label or ask a doctor.
Chlorpheniramine overdose
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In case of accidental overdose, seek professional help or contact a Poison Control Center immediately.
How to store Chlorpheniramine
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store at 25ºC (77ºF); excursions permitted between 15º-30ºC (59º-86ºF) protect from excessive moisture see end flap for expiration date and lot number
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Chlorpheniramine
198 supplements and herbal products have documented interactions with Chlorpheniramine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 6
- Moderate · 149
- Minor · 43
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Chlorpheniramine: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Chlorpheniramine — the kind of thing our pharmacy team would talk through with you at the counter.
What is chlorpheniramine for?
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How often do I take it?
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Will it make me sleepy?
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Can I have a drink or take it with my sleep or anxiety medicine?
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Who should check with a doctor first?
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What if someone takes too much?
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Is Chlorpheniramine available over the counter?
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When was Chlorpheniramine first available?
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Who makes Chlorpheniramine?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Chlorpheniramine on HelloPharmacist
Chlorpheniramine forms and strengths (how it comes)
Chlorpheniramine is available in 4 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- These tablets temporarily relieve sneezing, runny nose, itchy, watery eyes, and itchy nose or throat from hay fever or other upper respiratory allergies.
- Allergy Time and Aller-chlor tablets: adults and children 12 and over take 1 tablet every 4 to 6 hours. Children 6 to under 12 take half a tablet. Do not use under age 6.
- Allergy and Allergy Relief tablets: adults and children 12 and over take 1 tablet every 4 to 6 hours. Children 6 to under 12 take half a tablet. For children under 6, ask a doctor.
Oral solution
How this form is used
- Ed Chlorped Jr liquid temporarily relieves runny nose, sneezing, itchy nose or throat, and itchy, watery eyes from hay fever or other respiratory allergies.
- Ed Chlorped Jr: adults and children 12 and over take the measured liquid dose every 4 to 6 hours, or as directed by a doctor.
- Ed Chlorped Jr: children 6 to under 12 take a smaller measured dose every 4 to 6 hours.
- Ed Chlorped Jr: for children under 6, consult a doctor.
Inhaler
How this form is used
- ClorRelief and ClorRelief KIDs oral sprays temporarily relieve runny nose, itchy nose or throat, sneezing, and itchy, watery eyes from hay fever or other upper respiratory allergies.
- ClorRelief and ClorRelief KIDs: adults and children 12 and over spray 4 times per application, every 4 to 6 hours.
- ClorRelief and ClorRelief KIDs: children 6 to under 12 should be supervised and use a smaller number of sprays per application.
- ClorRelief and ClorRelief KIDs: children 4 to under 6 should not use it unless directed by a doctor. Children under 4 should not use it.
Extended-release tablet
How this form is used
- Allergy Relief and Chlorphen-12 extended-release tablets temporarily relieve sneezing, runny nose, itchy, watery eyes, and itchy nose or throat from hay fever or other upper respiratory allergies.
- Allergy Relief and Chlorphen-12 extended-release tablets: adults and children 12 and over take 1 tablet every 12 hours, with no more than 2 tablets in 24 hours.
- Allergy Relief and Chlorphen-12 extended-release tablets: for children under 12, ask a doctor.
Chlorpheniramine on the U.S. market: products, makers and brands
How Chlorpheniramine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
32 companies list 37 Chlorpheniramine product records with the FDA, mostly as tablet, oral solution, inhaler; the earliest marketing or approval year on record is 1949. Brand names on the directory include Aller-chlor, Aller-Chlor Syrup, Chlo-Amine and 13 more; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (9) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Chlorpheniramine is used (Medicaid data)
A general measure of how commonly Chlorpheniramine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Chlorpheniramine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Chlorpheniramine prescribed? Of the 1,601 medications we measure, Chlorpheniramine ranks #878 by Medicaid prescriptions — more than 45% of them.
Utilization by Chlorpheniramine product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
chlorpheniramine maleate 4 MG Oral Tablet Most dispensed
Summed across the 8 of 117 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1363309
chlorpheniramine maleate 0.4 MG/ML Oral Solution
Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1363306
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Chlorpheniramine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 9 of 119 listed Chlorpheniramine NDCs with Medicaid activity.
Compare Chlorpheniramine products
A representative set of FDA-listed product records for Chlorpheniramine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Extended-release tablet | ||||
| 12 mg | Oral | CVS Pharmacy | ANDA | View NDC → |
| 12 mg | Oral | KVK-Tech, Inc. | ANDA | View NDC → |
| 💊Inhaler | ||||
| 5 mg/mL | Oral | Ferrer Medical Innovations Llc | OTC MONOGRAPH DRUG | View NDC → |
| 💊Oral solution | ||||
| 2 mg/5 mL | Oral | Edwards Pharmaceuticals, Inc. | UNAPPROVED DRUG OTHER | View NDC → |
| 💊Tablet | ||||
| 4 mg | Oral | A-S Medication Solutions | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Advance Pharmaceutical Inc. | OTC MONOGRAPH FINAL | View NDC → |
| 4 mg | Oral | Allegiant Health | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Amerisource Bergen | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Athlete's Needs, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Bi-Mart | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Bryant Ranch Prepack × 4 listings | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Cardinal Health 110, LLC. DBA Leader | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Chain Drug Consortium | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Chain Drug Marketing Association, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Chain Drug Marketing Association Inc | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Cvs Pharmacy | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Fortune Pharmacal Company Limited | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Geri-Care Pharmaceutical Corp | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Good Sense | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Major Pharmaceuticals | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Marc Glassman, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | PD-Rx Pharmaceuticals, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Richmond Pharmaceuticals, Inc. | OTC MONOGRAPH FINAL | View NDC → |
| 4 mg | Oral | Rite Aid Corporation | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Rugby Laboratories | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Strategic Sourcing Services LLC | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Time Cap Labs Inc | OTC MONOGRAPH FINAL | View NDC → |
| 4 mg | Oral | Topco Associates, LLC | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Ulai Health LLC | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Unifirst First Aid Corporation | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | United Natural Foods, Inc. dba UNFI | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Walgreen Company | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | Walmart Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 4 mg | Oral | WinCo Foods, LLC | OTC MONOGRAPH DRUG | View NDC → |
Showing 37 of 37 products — FDA National Drug Code Directory. See every product, package size and price: browse all 37 Chlorpheniramine NDCs →
Chlorpheniramine side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Chlorpheniramine — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Chlorpheniramine in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Chlorpheniramine FDA approval history
How Chlorpheniramine went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Chlorpheniramine recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list one Chlorpheniramine recall since July 2021. It is no longer listed as ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.
- Chlorpheniramine Maleate 4 mg tablets, 24-count bottle, Manufactured For: Athlete's Needs, Novi, MI 48377, NDC 53185-277-24 Lots: Lot # 24A27724, Exp 01/31/2027 FDA record D-0029-2025 →
Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 2400 8 dose forms · 9 strengths
-
Dose form (SCDF) Extended Release Oral Tablet RxCUI 371448In current FDA listingsClinical drug / strength (SCD) 12 HR chlorpheniramine maleate 12 MGRxCUI 1363288 -
Dose form (SCDF) Injectable Solution RxCUI 371444No current FDA listingClinical drug / strength (SCD) maleate 10 MG/MLRxCUI 1363242 -
Dose form (SCDF) Mucosal Spray RxCUI 2610304No current FDA listingClinical drug / strength (SCD) maleate 5 MG/MLRxCUI 2610305 -
Dose form (SCDF) Oral Capsule RxCUI 371441No current FDA listingClinical drug / strength (SCD) maleate 8 MGRxCUI 2181319 -
Dose form (SCDF) Oral Lozenge RxCUI 1673790No current FDA listingClinical drug / strength (SCD) maleate 2 MGRxCUI 1673791 -
Dose form (SCDF) Oral Solution RxCUI 371445In current FDA listings -
Dose form (SCDF) Oral Suspension RxCUI 371451No current FDA listingClinical drug / strength (SCD) tannate 0.8 MG/MLRxCUI 1366953 -
Dose form (SCDF) Oral Tablet RxCUI 371447In current FDA listingsClinical drug / strength (SCD) maleate 4 MGRxCUI 1363309
Look up RxCUI 2400 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Chlorpheniramine supply and shortage status
Whether Chlorpheniramine is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
Chlorpheniramine brand names
Chlorpheniramine is sold under 16 brand names in the FDA directory — Aller-chlor, Aller-Chlor Syrup, Chlo-Amine, Chlor-Trimeton 12 Hour Allergy and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Chlorpheniramine: manufacturers and labelers
32 companies list Chlorpheniramine products with the FDA. By number of product records, the largest are Bryant Ranch Prepack, Chain Drug Marketing Association Inc, Cvs Pharmacy. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
…and 8 more on the FDA NDC directory.
Chlorpheniramine drug class (RxNorm)
Chlorpheniramine belongs to the Histamine-1 Receptor Antagonist class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Chlorpheniramine page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. KVK-Tech, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →