Clorazepate
Clorazepate is a benzodiazepine (a calming, central nervous system–depressing medicine) used to manage anxiety disorders, to help with partial seizures alongside other seizure medicines, and to relieve symptoms of acute alcohol withdrawal.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 11 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Clorazepate is an older benzodiazepine (a sedative) for anxiety disorders, partial seizures (as an add-on) and acute alcohol withdrawal, on the market since the early 1980s, available as a generic and usually not a first choice today; it slows the brain and spinal cord once the body converts it to nordiazepam, a long-lasting active form. Most people tolerate it reasonably well, though drowsiness is common, along with dizziness, especially in older adults. Its boxed warning covers potentially fatal sedation and slowed breathing with opioids (alcohol adds danger), plus abuse, addiction and physical dependence with withdrawal that can be life-threatening, so never stop it without your prescriber's taper plan.
Clinical pearls
- Its active form, nordiazepam, clears slowly, so drowsiness can build over the first days and linger into the next morning.
- Sleep medicines, barbiturates and some antidepressants pile extra sedation onto clorazepate, so share your full medicine list with every prescriber.
- Before any procedure involving sedation, tell the team you take clorazepate, because the reversal drug flumazenil can trigger withdrawal seizures.
- It is a controlled substance, so refills are limited and early ones are usually refused; keep it locked away from others.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾
Taking clorazepate with opioids can cause extreme sleepiness, slowed breathing, coma, and death. Doctors should only combine them when other options are not enough, using the lowest dose for the shortest time.
Clorazepate can also lead to abuse, misuse, and addiction, which can cause overdose or death. The risk is higher when it is mixed with other medicines, alcohol, or illicit substances.
With continued use, your body can become physically dependent. Stopping suddenly or cutting the dose too fast can cause life-threatening withdrawal reactions. The risk grows with longer use and higher doses. Always taper gradually with your prescriber's guidance.
Patient information guide A plain-language walkthrough of Clorazepate, written from its FDA label.
What Clorazepate is used for
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Clorazepate is used for several conditions, based on the Clorazepate Dipotassium oral tablet label:
- Managing anxiety disorders or short-term relief of anxiety symptoms
- Add-on (adjunctive) treatment for partial seizures
- Symptomatic relief of acute alcohol withdrawal
Everyday stress or tension usually does not need this type of medicine.
How Clorazepate works
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Clorazepate acts like other benzodiazepines, with depressant effects on the central nervous system. In other words, it slows brain activity, which brings a calming effect.
After you swallow it, your body quickly converts it to nordiazepam, its main active form. Almost no unchanged clorazepate circulates in the blood.
Clorazepate dosage
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Clorazepate tablets are taken by mouth. Your schedule depends on why you take it.
- Anxiety: usually divided doses through the day, or a single dose at bedtime.
- Alcohol withdrawal: higher doses early, tapered down over several days, and stopped once you are stable.
- Seizures (add-on): started low and increased slowly to limit drowsiness.
Follow your prescriber and the label. When stopping, use a gradual taper plan.
Dosing details from the FDA-approved label
From the Clorazepate prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Symptomatic relief of anxiety
- Administered orally in divided doses
- The usual daily dose is 30 mg
- Adjust gradually within the range of 15 to 60 mg daily according to patient response
- In elderly or debilitated patients, initiate at a daily dose of 7.5 to 15 mg
- Symptomatic relief of anxiety (single daily dose at bedtime)
- Recommended initial dose is 15 mg in a single dose daily at bedtime
- Subsequent dosage may require adjustment based on response
- Lower doses may be indicated in the elderly patient
- Symptomatic relief of acute alcohol withdrawal
- Day 1: 30 mg initially, followed by 30 to 60 mg in divided doses
- Day 2: 45 to 90 mg in divided doses
- Day 3: 22.5 to 45 mg in divided doses
- Day 4: 15 to 30 mg in divided doses
- Thereafter gradually reduce the daily dose to 7.5 to 15 mg
- Maximum: The maximum recommended total daily dose is 90 mg
- Discontinue as soon as the patient's condition is stable; avoid excessive reductions in the total amount given on successive days
- Adjunct to antiepileptic drugs: adults (patients over 12 years old)
- Maximum recommended initial dose is 7.5 mg three times a day
- Increase by no more than 7.5 mg every week
- Maximum: Should not exceed 90 mg/day
- Recommended initial dosages and increments should not be exceeded, to minimize drowsiness
- Adjunct to antiepileptic drugs: children (9 to 12 years)
- Maximum recommended initial dose is 7.5 mg two times a day
- Increase by no more than 7.5 mg every week
- Maximum: Should not exceed 60 mg/day
- Recommended initial dosages and increments should not be exceeded, to minimize drowsiness
- Discontinuation or dosage reduction
- Use a gradual taper to discontinue or reduce the dosage
- If withdrawal reactions develop, consider pausing the taper or increasing the dosage to the previous tapered level, then decrease more slowly
Read the label’s full dosing text
DOSAGE AND ADMINISTRATION For the Symptomatic Relief of Anxiety: Clorazepate dipotassium tablets are administered orally in divided doses. The usual daily dose is 30 mg. The dose should be adjusted gradually within the range of 15 to 60 mg daily in accordance with the response of the patient. In elderly or debilitated patients it is advisable to initiate treatment at a daily dose of 7.5 to 15 mg. Clorazepate dipotassium tablets may also be administered in a single dose daily at bedtime; the recommended initial dose is 15 mg. After the initial dose, the response of the patient may require adjustment of subsequent dosage. Lower doses may be indicated in the elderly patient. Drowsiness may occur at the initiation of treatment and with dosage increment. For the Symptomatic Relief of Acute Alcohol Withdrawal: The following dosage schedule is recommended: 1st 24 hours (Day 1) 30 mg initially; followed by 30 to 60 mg in divided doses 2nd 24 hours (Day 2) 45 to 90 mg in divided doses 3rd 24 hours (Day 3) 22.5 to 45 mg in divided doses Day 4 15 to 30 mg in divided doses Thereafter, gradually reduce the daily dose to 7.5 to 15 mg. Discontinue drug therapy as soon as patient’s condition is stable. The maximum recommended total daily dose is 90 mg. Avoid excessive reductions in the total amount of drug administered on successive days. As an Adjunct to Antiepileptic Drugs: In order to minimize drowsiness, the recommended initial dosages and dosage increments should not be exceeded. Adults: The maximum recommended initial dose in patients over 12 years old is 7.5 mg three times a day. Dosage should be increased by no more than 7.5 mg every week and should not exceed 90 mg/day. Children (9 to 12 years): The maximum recommended initial dose is 7.5 mg two times a day. Dosage should be increased by no more than 7.5 mg every week and should not exceed 60 mg/day. Discontinuation or Dosage Reduction of Clorazepate Dipotassium Tablets: To reduce the risk of withdrawal reactions, use a gradual taper to discontinue clorazepate dipotassium tablets or reduce the dosage. If a patient develops withdrawal reactions, consider pausing the taper or increasing the dosage to the previous tapered dosage level. Subsequently decrease the dosage more slowly (see WARNINGS and DRUG ABUSE AND DEPENDENCE ).
Read the full Dosage and Administration section on DailyMed →
Clorazepate side effects
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The most common side effect is drowsiness. Others include:
Common side effects
- Drowsiness (the most common)
- Dizziness
- Stomach or digestive upset
- Nervousness
- Blurred vision
- Dry mouth
- Headache
- Mental confusion
- Stomach or digestive complaints
When to get medical help
- Get emergency help for extreme sleepiness, slowed or troubled breathing, or trouble waking up, especially if you also take opioids or alcohol.
- Call your doctor right away if you have new or worsening depression, unusual mood or behavior changes, or thoughts of suicide or self-harm.
- Seek help for withdrawal symptoms after cutting back or stopping, such as seizures, which can be life-threatening.
- Tell your doctor if you feel you are using more than prescribed, craving it, or having trouble controlling your use.
- Call your doctor about rash, double vision, tremor, slurred speech, or poor coordination (ataxia).
Less often, people report insomnia, rash, fatigue, poor coordination, tremor, slurred speech, double vision, or depression. Get help right away for breathing trouble, severe sedation, seizures, or suicidal thoughts.
Clorazepate warnings and precautions
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- Opioids: combining can cause profound sedation, slowed breathing, coma, and death.
- Abuse, misuse, and addiction: these can lead to overdose or death.
- Dependence and withdrawal: stopping suddenly can cause life-threatening reactions such as seizures. Some withdrawal symptoms last for months.
- Mood: seizure medicines can raise the risk of suicidal thoughts or behavior.
- Alertness: avoid driving or hazardous work until you know how it affects you.
- Not recommended for depressive neuroses, psychotic reactions, or children under 9.
Clorazepate interactions
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Clorazepate can add to the effects of other drugs that slow the central nervous system.
- Opioids: raise the risk of dangerous slowed breathing.
- Alcohol: effects can be stronger.
- Sleep medicines, barbiturates, phenothiazines, MAO inhibitors, other antidepressants: can increase sedation or boost its effects.
- Flumazenil: can trigger withdrawal reactions, including seizures.
Interactions listed in the FDA-approved label
From the Clorazepate prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Opioids: Concomitant use increases the risk of respiratory depression; benzodiazepines can significantly worsen opioid-related respiratory depression. Limit dosage and duration of concomitant use, and monitor patients closely for respiratory depression and sedation.
- Other CNS-acting drugs: Combining clorazepate with other drugs acting on the central nervous system requires attention to the pharmacology of the agents. Give careful consideration to the pharmacology of the agents to be employed.
- Hexobarbital or ethyl alcohol: In animals, clorazepate dipotassium prolongs the sleeping time after hexobarbital or ethyl alcohol.
- Chlorpromazine: In animals, clorazepate dipotassium increases the inhibitory effects of chlorpromazine.
- Hypnotic medications: Clinical studies have shown increased sedation with concurrent hypnotic medications.
- Barbiturates, narcotics, phenothiazines, monoamine oxidase inhibitors or other antidepressants: The actions of the benzodiazepines may be potentiated by these drugs.
- Monoamine oxidase: Animal experience indicates clorazepate dipotassium does not exhibit monoamine oxidase inhibition.
- Antacids: At therapeutic levels, concurrent administration did not significantly influence the bioavailability of clorazepate dipotassium tablets in normal subjects.
- Concomitant medication in anxiety associated with somatic disease states: Possible drug interactions with concomitant medication may occur. Careful attention must be paid to possible drug interaction with concomitant medication.
Read the label’s full interactions text
DRUG INTERACTIONS The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. Benzodiazepines interact at GABAA sites and opioids interact primarily at mu receptors. When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid-related respiratory depression exists. Limit dosage and duration of concomitant use of benzodiazepines and opioids, and monitor patients closely for respiratory depression and sedation. If clorazepate dipotassium tablets is to be combined with other drugs acting on the central nervous system, careful consideration should be given to the pharmacology of the agents to be employed. Animal experience indicates that clorazepate dipotassium prolongs the sleeping time after hexobarbital or after ethyl alcohol, increases the inhibitory effects of chlorpromazine, but does not exhibit monoamine oxidase inhibition. Clinical studies have shown increased sedation with concurrent hypnotic medications. The actions of the benzodiazepines may be potentiated by barbiturates, narcotics, phenothiazines, monoamine oxidase inhibitors or other antidepressants. If clorazepate dipotassium tablets are used to treat anxiety associated with somatic disease states, careful attention must be paid to possible drug interaction with concomitant medication. In bioavailability studies with normal subjects, the concurrent administration of antacids at therapeutic levels did not significantly influence the bioavailability of clorazepate dipotassium tablets. Pregnancy: Pregnancy Exposure Registry There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to psychiatric medications, including clorazepate dipotassium tablets, during pregnancy.
Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Clorazepate
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- Do not use if you are allergic to it or have acute narrow angle glaucoma.
- Not recommended in children under 9.
- Older or debilitated people are more sensitive and usually start lower.
- Late pregnancy use can cause sedation or withdrawal in newborns.
- Breastfeeding is not recommended.
- Tell your prescriber about any alcohol or substance misuse history and all your medicines.
Clorazepate overdose
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Too much can cause drowsiness, confusion, poor coordination, weak muscles, and in severe cases slowed breathing and coma. Combining it with alcohol or opioids can be fatal. Get emergency help or call Poison Help at 1-800-222-1222.
What Clorazepate does in the body
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Clorazepate has typical benzodiazepine effects, including depressing the central nervous system. In healthy men, prolonged daily dosing at high levels showed no toxic effects. Stopping high doses abruptly led some people to feel nervous, have trouble sleeping, and become irritable. Others had diarrhea, muscle aches, or memory problems.
How your body processes Clorazepate
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After you swallow clorazepate, it is rapidly converted to nordiazepam, which quickly appears in the blood. Nordiazepam has a half-life of about 40 to 50 hours and is highly bound to proteins in plasma. The liver processes it, and most of it leaves in the urine, with some in the stool. Levels rise in proportion to the dose and build up moderately with repeated use.
How to store Clorazepate
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Protect from moisture. Store at 20° to 25°C (68° to 77°F) . Dispense in a USP tight, light-resistant container.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Clorazepate
109 supplements and herbal products have documented interactions with Clorazepate in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 8
- Moderate · 85
- Minor · 16
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Nutrient depletion considerations
Clorazepate has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.
Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.
Clorazepate: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Clorazepate — the kind of thing our pharmacy team would talk through with you at the counter.
What is clorazepate for?
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How should I take it?
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Can I stop it suddenly if I feel better?
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What side effects should I expect?
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Can I drink alcohol or take other medicines with it?
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Is it safe in pregnancy or while breastfeeding?
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Is Clorazepate available over the counter?
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Is Clorazepate a controlled substance?
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When was Clorazepate first available?
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Who makes Clorazepate?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Clorazepate on HelloPharmacist
Clorazepate forms and strengths (how it comes)
Clorazepate is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Clorazepate inactive ingredients by manufacturer.
Tablet
How this form is used
- Clorazepate Dipotassium tablets are used to manage anxiety disorders or give short-term relief of anxiety symptoms.
- Clorazepate Dipotassium tablets are used as add-on therapy for partial seizures.
- Clorazepate Dipotassium tablets are used for symptomatic relief of acute alcohol withdrawal.
- Clorazepate Dipotassium tablets are taken by mouth, usually in divided doses for anxiety.
- Clorazepate Dipotassium tablets may also be taken as a single bedtime dose for anxiety.
- Clorazepate Dipotassium tablets should be stopped or reduced gradually, not suddenly.
Clorazepate on the U.S. market: products, makers and brands
How Clorazepate appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
8 companies list 25 Clorazepate product records with the FDA, mostly as tablet; the earliest marketing or approval year on record is 1972. Brand names on the directory include Gen-Xene, Tranxene, Clorazepate Dipotassium; the rest are generics.
Also listed with the FDA, not a patient dose form: Powder (4) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Clorazepate is used (Medicaid data)
A general measure of how commonly Clorazepate is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Clorazepate is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Clorazepate prescribed? Of the 1,601 medications we measure, Clorazepate ranks #879 by Medicaid prescriptions — more than 45% of them.
Utilization by Clorazepate product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
clorazepate dipotassium 3.75 MG Oral Tablet Most dispensed
Summed across the 7 of 22 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197465
clorazepate dipotassium 7.5 MG Oral Tablet
Summed across the 6 of 28 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197466
clorazepate dipotassium 15 MG Oral Tablet
Summed across the 4 of 25 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 197464
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Clorazepate, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 17 of 75 listed Clorazepate NDCs with Medicaid activity.
Compare Clorazepate products
A representative set of FDA-listed product records for Clorazepate — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Tablet | ||||
| 3.75 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 7.5 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 15 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 3.75 mg/mg | Oral | Apotex Corp. | ANDA | View NDC → |
| 7.5 mg/mg | Oral | Apotex Corp. | ANDA | View NDC → |
| 15 mg/mg | Oral | Apotex Corp. | ANDA | View NDC → |
| 3.75 mg | Oral | Aurolife Pharma LLC × 2 listings | ANDA | View NDC → |
| 7.5 mg | Oral | Aurolife Pharma LLC × 2 listings | ANDA | View NDC → |
| 15 mg | Oral | Aurolife Pharma LLC × 2 listings | ANDA | View NDC → |
| 3.75 mg | Oral | Clinical Solutions Wholesale, LLC | ANDA | View NDC → |
| 7.5 mg | Oral | Clinical Solutions Wholesale, LLC | ANDA | View NDC → |
| 15 mg | Oral | Clinical Solutions Wholesale, LLC | ANDA | View NDC → |
| 7.5 mg | Oral | Coupler LLC | ANDA | View NDC → |
| 15 mg | Oral | Coupler LLC × 2 listings | ANDA | View NDC → |
| 3.75 mg | Oral | Northstar Rx Llc | ANDA | View NDC → |
| 7.5 mg | Oral | Northstar Rx Llc | ANDA | View NDC → |
| 15 mg | Oral | Northstar Rx Llc | ANDA | View NDC → |
| 15 mg | Oral | PD-Rx Pharmaceuticals, Inc. | ANDA | View NDC → |
| 3.75 mg | Oral | Sun Pharmaceutical Industries, Inc. | ANDA | View NDC → |
| 7.5 mg | Oral | Sun Pharmaceutical Industries, Inc. | ANDA | View NDC → |
| 15 mg | Oral | Sun Pharmaceutical Industries, Inc. | ANDA | View NDC → |
Showing 25 of 25 products — FDA National Drug Code Directory. See every product, package size and price: browse all 25 Clorazepate NDCs →
Clorazepate side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Clorazepate — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Clorazepate in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Clorazepate FDA approval history
How Clorazepate went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Clorazepate recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list one Clorazepate recall since July 2021, covering 2 product listings. It is still ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.
- Clorazepate Dipotassium Tablets, USP, 7.5 mg, a) 100 tablets per bottle, NDC 13107-283-01, b) 500 tablets per bottle, NDC 13107-283-05, Rx Only, Distributed by Aurobindo Pharma USA, Inc., 279 Princet… Lots: Lot #s: a) CZB124001B, CZB124002B, CZB124003B, Exp. 12/31/2025; b) CZB124001A, CZB124003A, Exp. 12/31/2025. FDA record D-0492-2024 →
- Clorazepate Dipotassium Tablets, USP, 3.75 mg, a) 100 tablets per bottle, NDC 13107-282-01 b) 500 tablets per bottle, NDC 13107-282-05, Rx Only, Distributed by Aurobindo Pharma USA, Inc., 279 Princet… Lots: Lot #s: a) CZA124001B, CZA124002B, CZA124003B, Exp. 12/31/2025; b) CZA124001A, CZA124003A, Exp. 12/31/2025. FDA record D-0491-2024 →
Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 2353 2 dose forms · 7 strengths
-
Dose form (SCDF) Oral Capsule RxCUI 371586No current FDA listingClinical drug / strength (SCD) dipotassium 15 MGRxCUI 576647dipotassium 7.5 MGRxCUI 618751 -
Dose form (SCDF) Oral Tablet RxCUI 371589In current FDA listingsClinical drug / strength (SCD) dipotassium 11.3 MGRxCUI 1251277dipotassium 15 MGRxCUI 197464dipotassium 22.5 MGRxCUI 618739dipotassium 3.75 MGRxCUI 197465dipotassium 7.5 MGRxCUI 197466
Look up RxCUI 2353 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Clorazepate supply and shortage status
Whether Clorazepate is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Clorazepate costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Tablet · Oral | 15 mg | $0.808 per tablet | NDC details & price history |
| Tablet · Oral | 7.5 mg | $0.839 per tablet | NDC details & price history |
| Tablet · Oral | 3.75 mg | $0.524 per tablet | NDC details & price history |
| Tablet · Oral | 15 mg/mg | $0.808 per tablet | NDC details & price history |
| Tablet · Oral | 7.5 mg/mg | $0.839 per tablet | NDC details & price history |
| Tablet · Oral | 3.75 mg/mg | $0.524 per tablet | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Clorazepate brand names
Clorazepate is sold under 3 brand names in the FDA directory — Gen-Xene, Tranxene, Clorazepate Dipotassium. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Clorazepate: manufacturers and labelers
8 companies list Clorazepate products with the FDA. By number of product records, the largest are Aurolife Pharma LLC, ANI Pharmaceuticals, Inc., Apotex Corp.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Clorazepate drug class (RxNorm)
Clorazepate belongs to the Benzodiazepine class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Clorazepate page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Aurolife Pharma, LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →