Medication interaction hub

What Supplements Interact with Clorazepate?

Clorazepate brand names: Tranxene, Tranxene T-Tab, Tranxene SD. Every interaction below applies to the brands too.

109 Interactions 8 Major 85 Moderate 16 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Clorazepate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Clorazepate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Clorazepate (Tranxene) is a benzodiazepine, a sedative for anxiety and seizure control, and the supplements on this page deserve genuine vigilance before you add one to a prescription that already slows the brain. The overwhelming majority of these interactions pile extra drowsiness on top of the drug's own, and a few can push that toward dangerous levels of sedation and slowed breathing. Alcohol, whether beer or wine, tops the list with the strongest evidence, kava carries the same major-level warning, and grapefruit juice is the sneaky one, raising blood levels of some benzodiazepines rather than adding sedation of its own.

A smaller set changes how the pill itself behaves, with some blocking absorption in the gut (space those well apart from your dose) and caffeine-containing herbs working against the calming effect. Of the 109 ingredients on file, 8 rate major, 85 moderate, and 16 minor, and those eight majors are worth reading first.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 85 Minor 16 No known interaction 1,343

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Clorazepate: Top Interactions at a Glance

The Clorazepate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 109 interacting ingredients — plus 1,343 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Clorazepate Combinations Today

The Clorazepate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Lemon Balm + Clorazepatei

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.

Read the full interaction Moderate Likelihood Possible Ketogenic Diet + Clorazepatei

Following the ketogenic diet may reduce the levels of certain anticonvulsants, although the clinical significance of this effect is unclear.

Read the full interaction Moderate Likelihood Possible Glutamine + Clorazepatei

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.

Read the full interaction Moderate Likelihood Possible Gamma Butyrolactone (gbl) + Clorazepatei

Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Clorazepatei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Likely Beer + Clorazepatei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Clorazepate

All 1,452 ingredients in our database, ranked by severity — 109 with a Clorazepate interaction on file and 1,343 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Clorazepate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Lemon Balm with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.

Full Lemon Balm + Clorazepate answer

Can you take Ketogenic Diet with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Following the ketogenic diet may reduce the levels of certain anticonvulsants, although the clinical significance of this effect is unclear.

Full Ketogenic Diet + Clorazepate answer

Can you take Glutamine with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glutamine might antagonize the effects of anticonvulsant medications.

Full Glutamine + Clorazepate answer

Can you take Gamma Butyrolactone (gbl) with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of GBL with CNS depressants may potentiate respiratory and CNS depression.

Full Gamma Butyrolactone (gbl) + Clorazepate answer

Can you take 1,4-butanediol with Clorazepate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Full 1,4-butanediol + Clorazepate answer

Can you take Cannabichromene (cbc) with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.

Full Cannabichromene (cbc) + Clorazepate answer

Can you take Cannabidiol (cbd) with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might have additive effects if used with other CNS depressants.

Full Cannabidiol (cbd) + Clorazepate answer

Can you take Cannabis with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might have additive effects if used with other CNS depressants.

Full Cannabis + Clorazepate answer

Can you take Caraway with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caraway might increase the effects and adverse effects of CNS depressants.

Full Caraway + Clorazepate answer

Can you take Catnip with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Catnip + Clorazepate answer

Can you take Cnidium with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In laboratory research, cnidium has been shown to have sedative and hypnotic effects, possibly related to constituent coumarins.

Full Cnidium + Clorazepate answer

Can you take Coriander with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.

Full Coriander + Clorazepate answer

Can you take Corn Poppy with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of corn poppy with CNS depressants might increase the risk of sedation.

Full Corn Poppy + Clorazepate answer

Can you take Corydalis Yanhusuo with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.

Full Corydalis Yanhusuo + Clorazepate answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might have additive effects if used with other CNS depressants.

Full Delta-9-tetrahydrocannabinol (thc) + Clorazepate answer

Can you take Dendrobium with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Clorazepate answer

Can you take Elecampane with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, elecampane may cause additive sedative effects when taken with CNS depressants.

Full Elecampane + Clorazepate answer

Can you take Ephedra with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ephedra may reduce the effects of anticonvulsants.

Full Ephedra + Clorazepate answer

Can you take European Barberry with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full European Barberry + Clorazepate answer

Can you take Galphimia Glauca with Clorazepate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Galphimia glauca with CNS depressants may increase the risk of sedation.

Full Galphimia Glauca + Clorazepate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Clorazepate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Clorazepate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Clorazepate sits in 4 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Clorazepate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Clorazepate through this category.

Anticonvulsants 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Clorazepate through this category.

Benzodiazepines 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Clorazepate through this category.

About Clorazepate

Clorazepate is a benzodiazepine used to treat anxiety, seizures, and alcohol withdrawal symptoms.

Generic name: Clorazepate  ·  Brand names: Tranxene, Tranxene T-Tab, Tranxene SD.

See the full Clorazepate drug information

Related: does Clorazepate deplete any nutrients?

Clorazepate has 3 reported nutrient associations in the research literature — see the Clorazepate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Clorazepate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Clorazepate.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Products that contain Clorazepate-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Clorazepate.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Clorazepate & Supplements: Common Questions

What supplements interact with Clorazepate?
Our database currently documents 109 ingredients with a known Clorazepate interaction (8 major, 85 moderate, 16 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 109. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Clorazepate supplement interactions are the most serious?
The 8 major-rated combinations — led by Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Clorazepate?
Plenty of supplements coexist fine with Clorazepate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Tranxene have the same supplement interactions as Clorazepate?
Yes — Tranxene, Tranxene T-Tab, Tranxene SD all contain Clorazepate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Clorazepate deplete any vitamins or nutrients?
It might — Clorazepate has 3 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Clorazepate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Clorazepate and my other medications?
This page covers Clorazepate against supplements and herbal ingredients. Checking Clorazepate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Clorazepate drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.