Drug & supplement interaction

Ribose + Clorazepate

Clorazepate brand names: Tranxene, Tranxene T-Tab, Tranxene SD.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Ribose and Clorazepate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ribose and Clorazepate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Clorazepate and Ribose in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ribose safety at a glance

Ribose overall Use caution Often well tolerated short-term, but it can lower blood sugar and long-term safety is not well studied.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Clorazepate and Ribose? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Clorazepate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Clorazepate is filed under 4 classifications — including benzodiazepines, anticonvulsants, cns depressants. Ribose has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and insulin (moderate) — and none of Clorazepate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ribose Does Interact With Other Medications

Ribose has 86 moderate known drug interactions in our database — Clorazepate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Clorazepate)
Taking anything else?

Check Another of Your Medications Against Ribose

Covers the 2,830 medications we’ve checked against Ribose. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Ribose and Clorazepate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Anxiety or restlessness / Dizziness Additional detail

    Ribose

    “Orally, ribose can cause headache. It has also been reported to cause a hyperanxious feeling, lightheadedness, increased appetite, and mild anxiety. In one study, lowering the dose of ribose resolved the feeling of anxiety.”

    Ribose · Natural Medicines adverse-effect record, reported in anxiety.

    3 sources cited
    1. 5664. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
    2. 92891. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed
    3. 15218. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed

    Clorazepate

    Listed in the ADVERSE REACTIONS section of the FDA label for Clorazepate. Read the label on DailyMed ›

  • Headache Additional detail

    Ribose

    “Orally and intravenously, ribose is generally well-tolerated for up to 1 month.

    Most Common Adverse Effects:

    Orally: Diarrhea, gastrointestinal discomfort, headache, hypoglycemia, nausea.

    Intravenously: Hypoglycemia.”

    Ribose · Natural Medicines adverse-effect record, reported in cluster headache.

    Clorazepate

    Listed in the ADVERSE REACTIONS section of the FDA label for Clorazepate. Read the label on DailyMed ›

Reported for Ribose but not commonly for Clorazepate: stomach upset, increased appetite, low blood sugar and diarrhea.

Effects for Clorazepate come from the ADVERSE REACTIONS section of its FDA label; effects for Ribose come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Clorazepate Is Prescribed For, and What Ribose Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Clorazepate is a prescription medicine with approved uses on its FDA label. Ribose is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Clorazepate is prescribed for: Clorazepate dipotassium tablets are used to manage anxiety disorders or for short-term relief of anxiety symptoms. They are also used as an add-on (adjunctive) therapy alongside other seizure medications to help control partial seizures. In addition, clorazepate dipotassium tablets are used for the short-term relief of symptoms during acute alcohol withdrawal, such as agitation and tension that occur when someone stops drinking suddenly.

Ribose has been studied for:

  • Seizures studied, not established Ribose has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Ribose for seizures

    Although there is interest in using oral ribose for seizures, there is insufficient reliable information about the clinical effects of ribose for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Clorazepate on your own; if you are taking Ribose for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Ribose or Clorazepate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ribose or Clorazepate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Clorazepate

This page covers Ribose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Clorazepate page lists 109 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 8 major · 85 moderate · 16 minor.

From our pharmacist’s overview on the Clorazepate page

“Clorazepate (Tranxene) is a benzodiazepine, a sedative for anxiety and seizure control, and the supplements on this page deserve genuine vigilance before you add one to a prescription that already slows the brain. The overwhelming majority of these interactions pile extra drowsiness on top of the drug's own, and a few can push that tow…”

Reviewed by 2 · Jul 18, 2026

Open the Clorazepate interaction page

One more smart check

Taking Ribose as Part of a Dietary Supplement Product? Check It for Interactions

We hold 543 real supplement products containing Ribose, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ribose. Even though Ribose itself has no known interaction with Clorazepate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ribose and Clorazepate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ribose
Top 25%

#312 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Clorazepate
Top half

#793 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ribose reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ribose and Clorazepate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ribose

What is Ribose?

  • Energy and fatigue
  • Athletic performance and recovery
  • Fibromyalgia symptoms
  • Chronic fatigue
  • Heart-related (cardiac) conditions

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditions, but solid human evidence is limited and mostly small or preliminary. It is generally well tolerated in short-term use, but talk to your pharmacist or doctor before trying it, especially if you have diabetes.

Not applicable (a naturally occurring simple sugar) · Powder, capsules, tablets, drink mixes

An interaction check asks whether these two react with each other — it does not ask whether Ribose is a good idea for someone in your situation. Here is what our Ribose record says about it on its own.

Ribose: dosing

There is no official standardized dose of ribose, and the amounts used in studies have varied widely depending on the goal. Because of this, it is best to follow the directions on the product label.To lower the chance of stomach upset or low blood sugar, some people take it with food and start with a smaller amount.

From our Ribose monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ribose monograph & all interactions
Medication

About Clorazepate

What Is Clorazepate Used For?

Brand names: Tranxene, Tranxene T-Tab, Tranxene SD

Clorazepate dipotassium tablets are used to manage anxiety disorders or for short-term relief of anxiety symptoms. They are also used as an add-on (adjunctive) therapy alongside other seizure medications to help control partial seizures.

In addition, clorazepate dipotassium tablets are used for the short-term relief of symptoms during acute alcohol withdrawal, such as agitation and tension that occur when someone stops drinking suddenly.

See full Clorazepate drug information
Keep checking

Other Drugs & Ribose

Browse every other medication we’ve checked against Ribose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Ribose page.

No interaction 2,743 drugs checked — show the list

We also checked Ribose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Ribose list.

See the full Ribose interactions page
See every supplement checked against Clorazepate, ranked by severity
Evidence & sources

Ribose References

The 8 references that drive our Ribose monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ribose and Clorazepate Together: Common Questions

Is it safe to take Ribose with Clorazepate?
We do not list a known interaction between Ribose and Clorazepate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ribose and Clorazepate have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Ribose and Clorazepate used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Ribose in each. That is a conversation for your prescriber, especially if Clorazepate is being adjusted to a target.
How was the Ribose and Clorazepate combination checked?
Interactions in our licensed database are recorded against drug classes. Clorazepate is filed under 4 classifications, and Ribose has documented interactions with 2 drug classes — none of Clorazepate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ribose interact with any other medications?
Yes. Ribose has 86 documented drug interactions in our database — Clorazepate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Clorazepate interact with any supplements?
Yes. Clorazepate has documented interactions with 109 supplements in our database — Ribose is not one of them. The Clorazepate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ribose monograph Uses, safety profile, and every drug interaction in one place Clorazepate drug information The full plain-English guide to this medication Clorazepate supplement interactions Every supplement checked against Clorazepate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Clorazepate and Ribose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.