Oxazepam
Oxazepam is a benzodiazepine (a calming, anti-anxiety medicine) used to manage anxiety disorders, short-term anxiety symptoms, and anxiety linked to depression or alcohol withdrawal.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 5 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Oxazepam is a benzodiazepine, a calming medicine that boosts the brain's natural braking signal, used for anxiety disorders, short-term anxiety, anxiety with depression and alcohol withdrawal. It is an older standby, on the market since about 1965 and available as a generic, and is usually a short-term option rather than a first choice for ongoing anxiety. It is generally well tolerated, and the effects people notice most are drowsiness and dizziness, mostly in the first few days. Its boxed warning flags dangerous, even fatal, slowed breathing when taken with opioids (alcohol adds to this), plus misuse, addiction and withdrawal reactions, including seizures, if it is stopped suddenly.
Clinical pearls
- Never stop it on your own after regular use, because your prescriber should plan a slow, gradual taper.
- Skip alcohol, and remind any prescriber or dentist that you take oxazepam before accepting an opioid painkiller.
- It is a common pick for older adults because it is cleared simply, though they usually start on a lower dose.
- Benefit beyond about four months has not been studied, so ask at refill time whether you still need it.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾
Taking oxazepam with opioid medicines can cause extreme sleepiness, slowed or stopped breathing, coma, and death. Doctors should reserve this combination for people with no other good options, using the lowest dose for the shortest time.
Oxazepam can also lead to abuse, misuse and addiction, which can cause overdose or death. The risk is higher when it is combined with other medicines, alcohol or illegal substances.
With continued use, your body can become physically dependent. Stopping suddenly or cutting the dose too fast can cause life-threatening withdrawal reactions, such as seizures. The risk rises with higher doses and longer use, so a slow, planned taper is important.
Patient information guide A plain-language walkthrough of Oxazepam, written from its FDA label.
What Oxazepam is used for
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Oxazepam capsules are used for several anxiety-related needs:
- Managing anxiety disorders
- Short-term relief of anxiety symptoms
- Anxiety associated with depression
- Anxiety, tension, agitation and irritability in older adults
- Acute tremulousness, inebriation, or anxiety during alcohol withdrawal
How Oxazepam works
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Oxazepam is a benzodiazepine that acts on the central nervous system (the brain and spinal cord). The label's mechanism details focus on how it works with receptors when combined with opioids, so the main takeaway is that it has calming, sedating effects.
Oxazepam dosage
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Oxazepam capsules are taken by mouth, usually 3 or 4 times a day. Your prescriber individualizes the amount based on your condition and age. Older adults generally start lower.
- Follow your prescription label exactly.
- Do not stop suddenly. A gradual taper lowers the risk of withdrawal.
- If withdrawal symptoms appear during a taper, your prescriber may slow it down.
Dosing details from the FDA-approved label
From the Oxazepam prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Mild-to-moderate anxiety, with associated tension, irritability, agitation, or related symptoms of functional origin or secondary to organic disease
- 10 to 15 mg, 3 or 4 times daily
- Severe anxiety syndromes, agitation, or anxiety associated with depression
- 15 to 30 mg, 3 or 4 times daily
- Older patients with anxiety, tension, irritability and agitation
- Initial dosage: 10 mg, 3 times daily
- If necessary, increase cautiously to 15 mg, 3 or 4 times daily
- Older patients: increase cautiously
- Alcoholics with acute inebriation, tremulousness, or anxiety on withdrawal
- 15 to 30 mg, 3 or 4 times daily
- Pediatric patients 6 to 12 years of age
- Absolute dosage is not established
- Not indicated in pediatric patients under 6 years of age
Read the label’s full dosing text
DOSAGE AND ADMINISTRATION Because of the flexibility of this product and the range of emotional disturbances responsive to it, dosage should be individualized for maximum beneficial effects. Oxazepam Usual Dose Mild-to-moderate anxiety, with associated tension, irritability, agitation, or related symptoms of functional origin or secondary to organic disease. 10 to 15 mg, 3 or 4 times daily Severe anxiety syndromes, agitation, or anxiety associated with depression. 15 to 30 mg, 3 or 4 times daily Older patients with anxiety, tension, irritability and agitation. Initial dosage: 10 mg, 3 times daily. If necessary, increase cautiously to 15 mg, 3 or 4 times daily. Alcoholics with acute inebriation, tremulousness, or anxiety on withdrawal. 15 to 30 mg, 3 or 4 times daily This product is not indicated in pediatric patients under 6 years of age. Absolute dosage for pediatric patients 6 to 12 years of age is not established. Discontinuation or Dosage Reduction of Oxazepam To reduce the risk of withdrawal reactions, use a gradual taper to discontinue oxazepam or reduce the dosage. If a patient develops withdrawal reactions, consider pausing the taper or increasing the dosage to the previous tapered dosage level. Subsequently decrease the dosage more slowly [see WARNINGS : Dependence and Withdrawal Reactions and DRUG ABUSE AND DEPENDENCE : Dependence ] .
Read the full Dosage and Administration section on DailyMed →
Oxazepam side effects
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Most side effects are mild and often fade or improve with a lower dose.
Common side effects
- Mild drowsiness, especially in the first few days
- Dizziness or vertigo (spinning feeling)
- Headache
- Lethargy (low energy)
- Nausea
- Slurred speech
- Tremor (shakiness)
- Minor skin rashes
When to get medical help
- Call for emergency help if you have extreme sleepiness, trouble breathing, or cannot be woken, especially if you also take opioids or alcohol.
- Seek help right away for seizures or severe withdrawal symptoms after stopping or cutting back too quickly.
- Call your doctor if you faint or have ongoing drowsiness that does not ease.
- Tell your doctor about yellowing of the skin or eyes (jaundice), which can signal liver problems.
- Tell your doctor about unusual excitement or stimulation, which can happen in the first two weeks.
- Tell your doctor if you feel you are using more than prescribed or craving the medicine, as this can signal misuse or addiction.
- Report any widespread or severe rash.
Seek help for fainting, seizures, yellowing skin or eyes, trouble breathing, or severe sleepiness. Rare effects include low white blood cell count (leukopenia) and liver problems, so periodic blood counts and liver tests are advisable.
Oxazepam warnings and precautions
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- Opioids: combined use can cause profound sedation, slowed breathing, coma and death.
- Abuse, misuse and addiction: these can lead to overdose or death.
- Dependence and withdrawal: abrupt stops can cause life-threatening reactions like seizures. Some people have withdrawal symptoms lasting weeks to more than 12 months.
- Driving: avoid driving or dangerous machinery until you know it does not make you drowsy or dizzy.
- Newborns: late-pregnancy use can cause sedation or withdrawal in the baby.
Oxazepam interactions
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Oxazepam can add to the effects of other sedating substances.
- Opioids: greatly increase the risk of slowed breathing and sedation.
- Alcohol: effects add together.
- Other CNS depressants: may need dose adjustment or avoidance.
- Stimulants: avoid or minimize use together because of misuse risk.
- Flumazenil: can trigger withdrawal and seizures.
Interactions listed in the FDA-approved label
From the Oxazepam prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Opioids: Concomitant use of benzodiazepines and opioids increases the risk of respiratory depression, and benzodiazepines can significantly worsen opioid-related respiratory depression. Limit dosage and duration of concomitant use of benzodiazepines and opioids, and monitor patients closely for respiratory depression and sedation.
Read the label’s full interactions text
Drug Interactions: The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. Benzodiazepines interact at GABAA sites and opioids interact primarily at mu receptors. When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid- related respiratory depression exists. Limit dosage and duration of concomitant use of benzodiazepines and opioids, and monitor patients closely for respiratory depression and sedation.
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Oxazepam
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- Do not use if you are allergic to oxazepam.
- Not for psychoses.
- Tell your doctor about any substance use or addiction history.
- Tell your doctor if you are pregnant or become pregnant.
- Older adults usually start low, and people over 80 may clear it more slowly.
- Not indicated for children under 6. Dosing for ages 6 to 12 is not established.
Oxazepam overdose
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Too much oxazepam can cause drowsiness, confusion, slurred speech, poor coordination, and in severe cases slowed breathing and coma. It can be fatal when combined with alcohol or opioids. Call a poison center at 1-800-222-1222 or seek emergency care right away.
How your body processes Oxazepam
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Oxazepam capsules are absorbed with levels peaking in about 3 hours. The average half-life (time for the level to fall by half) is about 8 hours. The body turns it into one main inactive byproduct that leaves in the urine. In people over 80, it clears more slowly.
How to store Oxazepam
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Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (between 59°F and 86°F) . Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Oxazepam
119 supplements and herbal products have documented interactions with Oxazepam in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 8
- Moderate · 94
- Minor · 17
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Nutrient depletion considerations
Oxazepam has been associated with lower levels of 1 nutrient in the clinical literature. This does not mean a deficiency will occur — it means these may be worth discussing with your pharmacist or healthcare provider, especially with long-term use.
Educational information from a licensed clinical database (Natural Medicines) — not medical advice. Do not start or stop medications or supplements without professional guidance.
Oxazepam: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Oxazepam — the kind of thing our pharmacy team would talk through with you at the counter.
What is oxazepam for?
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How should I take it?
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What side effects should I expect?
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Can I drink alcohol or take pain medicine with it?
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Can I stop it if I feel better?
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Is it safe in pregnancy?
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Is Oxazepam available over the counter?
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Is Oxazepam a controlled substance?
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When was Oxazepam first available?
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Who makes Oxazepam?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Oxazepam on HelloPharmacist
Oxazepam forms and strengths (how it comes)
Oxazepam is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Oxazepam inactive ingredients by manufacturer.
Capsule
How this form is used
- Oxazepam capsules are used to manage anxiety disorders or short-term anxiety symptoms.
- Oxazepam capsules are used for anxiety with depression and for anxiety or tremulousness during alcohol withdrawal.
- Oxazepam capsules are taken by mouth, generally 3 or 4 times daily, as set by your prescriber.
- Oxazepam capsules should be lowered or stopped gradually, not abruptly, to reduce withdrawal risk.
Oxazepam on the U.S. market: products, makers and brands
How Oxazepam appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
5 companies list 13 Oxazepam product records with the FDA, mostly as capsule; the earliest marketing or approval year on record is 1965. Brand names on the directory include Serax; the rest are generics.
Also listed with the FDA, not a patient dose form: Powder (5) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Oxazepam is used (Medicaid data)
A general measure of how commonly Oxazepam is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Oxazepam is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Oxazepam prescribed? Of the 1,601 medications we measure, Oxazepam ranks #1,195 by Medicaid prescriptions — more than 25% of them.
Utilization by Oxazepam product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
oxazepam 15 MG Oral Capsule Most dispensed
Summed across the 2 of 18 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312134
oxazepam 10 MG Oral Capsule
Summed across the 1 of 16 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198057
oxazepam 30 MG Oral Capsule
Summed across the 1 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198059
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Oxazepam, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 4 of 45 listed Oxazepam NDCs with Medicaid activity.
Compare Oxazepam products
A representative set of FDA-listed product records for Oxazepam — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Capsule | ||||
| 10 mg | Oral | Actavis Pharma, Inc. | ANDA | View NDC → |
| 15 mg | Oral | Actavis Pharma, Inc. | ANDA | View NDC → |
| 30 mg | Oral | Actavis Pharma, Inc. | ANDA | View NDC → |
| 10 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 15 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 30 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 15 mg | Oral | Aphena Pharma Solutions - Tennessee, LLC | ANDA | View NDC → |
| 10 mg | Oral | Leading Pharma, LLC | ANDA | View NDC → |
| 15 mg | Oral | Leading Pharma, LLC | ANDA | View NDC → |
| 30 mg | Oral | Leading Pharma, LLC | ANDA | View NDC → |
| 10 mg | Oral | TruPharma, LLC | ANDA | View NDC → |
| 15 mg | Oral | TruPharma, LLC | ANDA | View NDC → |
| 30 mg | Oral | TruPharma, LLC | ANDA | View NDC → |
Showing 13 of 13 products — FDA National Drug Code Directory. See every product, package size and price: browse all 13 Oxazepam NDCs →
Oxazepam side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Oxazepam — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Oxazepam in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Oxazepam FDA approval history
How Oxazepam went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Oxazepam recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Oxazepam recalls since July 2021.
✅No Oxazepam recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 7781 2 dose forms · 6 strengths
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Dose form (SCDF) Oral Capsule RxCUI 373173In current FDA listings -
Dose form (SCDF) Oral Tablet RxCUI 373174No current FDA listingClinical drug / strength (SCD) 10 MGRxCUI 31213315 MGRxCUI 19805830 MGRxCUI 312135
Look up RxCUI 7781 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Oxazepam supply and shortage status
Whether Oxazepam is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Oxazepam costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Capsule, Gelatin Coated · Oral | 10 mg | $0.725 per capsule | NDC details & price history |
| Capsule, Gelatin Coated · Oral | 15 mg | $0.884 per capsule | NDC details & price history |
| Capsule, Gelatin Coated · Oral | 30 mg | $1.35 per capsule | NDC details & price history |
| Capsule · Oral | 15 mg | $1.11 per capsule | NDC details & price history |
| Capsule · Oral | 10 mg | $0.828 per capsule | NDC details & price history |
| Capsule · Oral | 30 mg | $1.34 per capsule | NDC details & price history |
| Capsule, Gelatin Coated | 10 mg | $0.725 per capsule | NDC details & price history |
| Capsule, Gelatin Coated | 15 mg | $0.884 per capsule | NDC details & price history |
| Capsule, Gelatin Coated | 30 mg | $1.35 per capsule | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Oxazepam brand names
Oxazepam is sold under one brand name in the FDA directory — Serax. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Oxazepam: manufacturers and labelers
5 companies list Oxazepam products with the FDA. By number of product records, the largest are Actavis Pharma, Inc., American Health Packaging, Leading Pharma, LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Oxazepam drug class (RxNorm)
Oxazepam belongs to the Benzodiazepine class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Oxazepam page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Leading Pharma, LLC is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →