Lemborexant
Generic name: Pronounced as (lem'' boe rex' ant)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 02/15/2022
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
Why is this medication prescribed?
Lemborexant is used to treat insomnia (difficulty falling asleep or staying asleep). Lemborexant belongs to a class of medications called hypnotics. It works by slowing activity in the brain to allow sleep.
How should this medicine be used?
Lemborexant comes as a tablet to take by mouth. It is usually taken as needed, not more than one time a day, immediately before bedtime. Lemborexant will work faster if it is not taken with a meal or immediately after a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lemborexant exactly as directed.
You will probably become very sleepy soon after you take lemborexant and will remain sleepy for some time after you take the medication. Plan to go to bed right after you take lemborexant and to stay in bed for at least 7 hours. Do not take lemborexant if you will be unable to go to bed right away and remain asleep for at least 7 hours after taking the medication.
You should be sleeping well within 7 to 10 days after you start taking lemborexant. Call your doctor if your sleep problems do not improve during this time, if they get worse at any time during your treatment, or if you notice any changes in your thoughts or behavior.
Lemborexant may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lemborexant and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking lemborexant,
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tell your doctor and pharmacist if you are allergic to lemborexant, any other medications, or any of the ingredients in lemborexant tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
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tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: Bosentan (Tracleer); bupropion (Aplenzin, Forfivo, Wellbutrin); carbamazepine (Carbatrol, Epitol, Tegretol, others); clarithromycin; chlorzoxazone; efavirenz (Sustiva, in Atripla, in Symfi); etravirine (Intelence); fluconazole (Diflucan); itraconazole (Onmel, Sporanox, Tolsura); medications for anxiety and pain; methadone (Dolophine, Methadose); modafinil (Provigil); ranitidine (Zantac); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sedatives, sleeping pills, and tranquilizers; tricyclic antidepressants such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and verapamil (Calan, Verelan, in Tarka). Your doctor may tell you not to take lemborexant, may need to change the doses of your medications, or monitor you carefully for side effects. Many other medications may also interact with lemborexant, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
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tell your doctor what herbal products you are taking, especially St. John's wort.
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tell your doctor if you have narcolepsy (a condition that causes excessive daytime sleepiness). Your doctor will probably tell you not to take lemborexant.
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tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications. Also tell your doctor if you have or have ever had depression; mental illness; thoughts of harming or killing yourself or trying to do so; a problem with heavy snoring; sleep apnea (condition in which breathing briefly stops many times during the night); other breathing problems or lung diseases such as asthma, bronchitis, and emphysema; cataplexy (episodes of muscle weakness that begin suddenly and last for a short time); or liver disease.
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tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking lemborexant, call your doctor.
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if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lemborexant.
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you should know that this medication may cause drowsiness, decreased mental alertness, prolonged reaction time, problems with coordination the day after you take it, blurry or double vision, and may increase the risk that you could fall. Take extra care to be sure you do not fall, especially if you get out of bed in the middle of the night. Your ability to drive or operate machinery the day after you take lemborexant may be impaired even if you feel fully awake. Do not drive a car or operate machinery until you know how lemborexant affects you.
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do not drink alcohol during your treatment with lemborexant. Alcohol can make the side effects of lemborexant worse.
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you should know that lemborexant has caused serious or possibly life-threatening sleep behaviors. Some people who took lemborexant got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, sleep-walked, or were involved in other activities while not fully awake. After they woke up, these people were unable to remember what they had done. These activities may occur with lemborexant whether or not you drink alcohol or also take other sleep medications. Call your doctor right away if you have ever had an unusual sleep behavior while taking lemborexant.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What side effects can this medication cause?
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Lemborexant may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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drowsiness
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tiredness
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headache
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vivid, unusual dreams or nightmares
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Some side effects can be serious. If you experience any of these symptoms, stop taking lemborexant and call your doctor immediately:
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temporary inability to move or talk while you are going to sleep or waking up (sleep paralysis)
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sudden and temporary weakness of legs
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new or worsening depression or anxiety
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thoughts of suicide, dying, or hurting yourself, or planning or trying to do so
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sudden onset of muscle weakness
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pounding heartbeat
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Lemborexant may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include:
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drowsiness
What OTHER INFORMATION should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Lemborexant is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Delavirdine | Delavirdine The metabolism of Lemborexant can be decreased when combined with Delavirdine. |
Nevirapine | Nevirapine The serum concentration of Nevirapine can be decreased when it is combined with Lemborexant. |
Atorvastatin | Atorvastatin The serum concentration of Lemborexant can be decreased when it is combined with Atorvastatin. |
Dolasetron | Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Lemborexant. |
Cilostazol | Cilostazol The metabolism of Lemborexant can be decreased when combined with Cilostazol. |
Clopidogrel | Clopidogrel The serum concentration of Clopidogrel can be decreased when it is combined with Lemborexant. |
Diphenoxylate | Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Lemborexant. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The metabolism of Lemborexant can be decreased when combined with Erythromycin. |
Guanfacine | Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Lemborexant. |
Naratriptan | Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Lemborexant. |
Paregoric | Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Lemborexant. |
Pentazocine | Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Lemborexant. |
Reserpine | Reserpine The serum concentration of Lemborexant can be decreased when it is combined with Reserpine. |
Rizatriptan | Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Lemborexant. |
Sumatriptan | Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Lemborexant. |
Tacrolimus | Tacrolimus The metabolism of Lemborexant can be decreased when combined with Tacrolimus. |
Tizanidine | Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Lemborexant. |
Triamcinolone | Triamcinolone The metabolism of Lemborexant can be increased when combined with Triamcinolone. |
Zolmitriptan | Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Lemborexant. |
Fluconazole Injection | Fluconazole Injection The serum concentration of Lemborexant can be increased when it is combined with Fluconazole. |
Hydromorphone Injection | Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Lemborexant. |
Meperidine Injection | Meperidine Injection The serum concentration of Lemborexant can be decreased when it is combined with Meperidine. |
Methylprednisolone Injection | Methylprednisolone Injection The serum concentration of Lemborexant can be decreased when it is combined with Methylprednisolone. |
Metoclopramide Injection | Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Lemborexant. |
Metronidazole Injection | Metronidazole Injection The metabolism of Lemborexant can be decreased when combined with Metronidazole. |
Morphine Injection | Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Lemborexant. |
Altretamine | Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Lemborexant. |
Cyclosporine | Cyclosporine The metabolism of Lemborexant can be decreased when combined with Cyclosporine. |
Ondansetron | Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Lemborexant. |
Granisetron | Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Lemborexant. |
Olanzapine | Olanzapine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Olanzapine. |
Alosetron | Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Lemborexant. |
Entacapone | Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Lemborexant. |
Orlistat | Orlistat The serum concentration of Lemborexant can be decreased when it is combined with Orlistat. |
Oxcarbazepine | Oxcarbazepine The serum concentration of Lemborexant can be decreased when it is combined with Oxcarbazepine. |
Temozolomide | Temozolomide The serum concentration of Lemborexant can be decreased when it is combined with Temozolomide. |
Zaleplon | Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Lemborexant. |
Anakinra | Anakinra The metabolism of Lemborexant can be increased when combined with Anakinra. |
Desloratadine | Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Lemborexant. |
Linezolid | Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Lemborexant. |
Trimipramine | Trimipramine The serum concentration of Trimipramine can be decreased when it is combined with Lemborexant. |
Etanercept Injection | Etanercept Injection The metabolism of Lemborexant can be increased when combined with Etanercept. |
Glycopyrrolate | Glycopyrrolate Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium. |
Modafinil | Modafinil The serum concentration of Lemborexant can be increased when it is combined with Modafinil. |
Tenofovir | Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Lemborexant. |
Sirolimus | Sirolimus The metabolism of Lemborexant can be decreased when combined with Sirolimus. |
Dutasteride | Dutasteride The metabolism of Lemborexant can be decreased when combined with Dutasteride. |
Eplerenone | Eplerenone The metabolism of Lemborexant can be decreased when combined with Eplerenone. |
Escitalopram | Escitalopram The risk or severity of adverse effects can be increased when Lemborexant is combined with Escitalopram. |
Zonisamide | Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Lemborexant. |
Adalimumab Injection | Adalimumab Injection The metabolism of Lemborexant can be increased when combined with Adalimumab. |
Aripiprazole | Aripiprazole Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Atomoxetine | Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Lemborexant. |
Dexmethylphenidate | Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Lemborexant. |
Atazanavir | Atazanavir The serum concentration of Lemborexant can be increased when it is combined with Atazanavir. |
Almotriptan | Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Lemborexant. |
Eletriptan | Eletriptan The serum concentration of Lemborexant can be decreased when it is combined with Eletriptan. |
Rosuvastatin | Rosuvastatin The metabolism of Lemborexant can be decreased when combined with Rosuvastatin. |
Vardenafil | Vardenafil The serum concentration of Lemborexant can be increased when it is combined with Vardenafil. |
Aprepitant | Aprepitant The metabolism of Lemborexant can be decreased when combined with Aprepitant. |
Tegaserod | Tegaserod The serum concentration of Lemborexant can be increased when it is combined with Tegaserod. |
Tadalafil | Tadalafil The metabolism of Lemborexant can be decreased when combined with Tadalafil. |
Frovatriptan | Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Lemborexant. |
Progesterone | Progesterone The serum concentration of Lemborexant can be increased when it is combined with Progesterone. |
Apomorphine Injection | Apomorphine Injection The serum concentration of Lemborexant can be decreased when it is combined with Apomorphine. |
Infliximab Injection | Infliximab Injection The metabolism of Lemborexant can be increased when combined with Infliximab. |
Protriptyline | Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Lemborexant. |
Rifaximin | Rifaximin The serum concentration of Lemborexant can be decreased when it is combined with Rifaximin. |
Duloxetine | Duloxetine The risk or severity of adverse effects can be increased when Lemborexant is combined with Duloxetine. |
Norethindrone | Norethindrone The metabolism of Lemborexant can be decreased when combined with Norethisterone. |
Trospium | Trospium Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Trospium. |
Bosentan | Bosentan The serum concentration of Lemborexant can be decreased when it is combined with Bosentan. |
Erlotinib | Erlotinib The metabolism of Lemborexant can be decreased when combined with Erlotinib. |
Eszopiclone | Eszopiclone The risk or severity of CNS depression can be increased when Lemborexant is combined with Eszopiclone. |
Solifenacin | Solifenacin Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Solifenacin. |
Voriconazole | Voriconazole The metabolism of Lemborexant can be decreased when combined with Voriconazole. |
Dextroamphetamine | Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Lemborexant. |
Sodium Oxybate | Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Isocarboxazid | Isocarboxazid The risk or severity of adverse effects can be increased when Isocarboxazid is combined with Lemborexant. |
Ramelteon | Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Lemborexant. |
Darifenacin | Darifenacin Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Darifenacin. |
Fentanyl | Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Lemborexant. |
Pregabalin | Pregabalin The therapeutic efficacy of Lemborexant can be increased when used in combination with Pregabalin. |
Deferasirox | Deferasirox The serum concentration of Lemborexant can be decreased when it is combined with Deferasirox. |
Tipranavir | Tipranavir The serum concentration of Lemborexant can be increased when it is combined with Tipranavir. |
Felbamate | Felbamate The serum concentration of Lemborexant can be decreased when it is combined with Felbamate. |
Ranolazine | Ranolazine The serum concentration of Lemborexant can be increased when it is combined with Ranolazine. |
Abatacept Injection | Abatacept Injection The metabolism of Lemborexant can be increased when combined with Abatacept. |
Rasagiline | Rasagiline The risk or severity of adverse effects can be increased when Rasagiline is combined with Lemborexant. |
Imatinib | Imatinib The metabolism of Lemborexant can be decreased when combined with Imatinib. |
Sitagliptin | Sitagliptin The serum concentration of Lemborexant can be increased when it is combined with Sitagliptin. |
Gefitinib | Gefitinib The metabolism of Lemborexant can be decreased when combined with Gefitinib. |
Paliperidone | Paliperidone The risk or severity of adverse effects can be increased when Paliperidone is combined with Lemborexant. |
Bortezomib | Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Lemborexant. |
Posaconazole | Posaconazole The serum concentration of Lemborexant can be increased when it is combined with Posaconazole. |
Dimenhydrinate | Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Lemborexant. |
Nabilone | Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Sorafenib | Sorafenib The metabolism of Lemborexant can be decreased when combined with Sorafenib. |
Sunitinib | Sunitinib The metabolism of Lemborexant can be decreased when combined with Sunitinib. |
Dronabinol | Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Lapatinib | Lapatinib The serum concentration of Lemborexant can be increased when it is combined with Lapatinib. |
Levocetirizine | Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Lemborexant. |
Dasatinib | Dasatinib The metabolism of Lemborexant can be decreased when combined with Dasatinib. |
Mexiletine | Mexiletine The serum concentration of Mexiletine can be decreased when it is combined with Lemborexant. |
Armodafinil | Armodafinil The serum concentration of Lemborexant can be decreased when it is combined with Armodafinil. |
Temsirolimus | Temsirolimus The metabolism of Lemborexant can be decreased when combined with Temsirolimus. |
Nilotinib | Nilotinib The serum concentration of Lemborexant can be increased when it is combined with Nilotinib. |
Toremifene | Toremifene The serum concentration of Lemborexant can be increased when it is combined with Toremifene. |
Bexarotene | Bexarotene The serum concentration of Lemborexant can be decreased when it is combined with Bexarotene. |
Budesonide | Budesonide The serum concentration of Lemborexant can be decreased when it is combined with Budesonide. |
Chloramphenicol Injection | Chloramphenicol Injection The metabolism of Lemborexant can be decreased when combined with Chloramphenicol. |
OnabotulinumtoxinA Injection | OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lemborexant. |
RimabotulinumtoxinB Injection | RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Lemborexant. |
Etravirine | Etravirine The serum concentration of Lemborexant can be decreased when it is combined with Etravirine. |
Desvenlafaxine | Desvenlafaxine The risk or severity of adverse effects can be increased when Lemborexant is combined with Desvenlafaxine. |
Tretinoin | Tretinoin The serum concentration of Tretinoin can be decreased when it is combined with Lemborexant. |
Bendamustine Injection | Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Lemborexant. |
Certolizumab Injection | Certolizumab Injection The metabolism of Lemborexant can be increased when combined with Certolizumab pegol. |
Irinotecan Injection | Irinotecan Injection The serum concentration of Irinotecan can be decreased when it is combined with Lemborexant. |
Praziquantel | Praziquantel The metabolism of Lemborexant can be decreased when combined with Praziquantel. |
Mitotane | Mitotane The serum concentration of Lemborexant can be decreased when it is combined with Mitotane. |
Rufinamide | Rufinamide The serum concentration of Lemborexant can be decreased when it is combined with Rufinamide. |
Silodosin | Silodosin The serum concentration of Lemborexant can be increased when it is combined with Silodosin. |
Midazolam | Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Lemborexant. |
Milnacipran | Milnacipran The risk or severity of adverse effects can be increased when Lemborexant is combined with Milnacipran. |
Fesoterodine | Fesoterodine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine. |
Iloperidone | Iloperidone The risk or severity of adverse effects can be increased when Iloperidone is combined with Lemborexant. |
Prasugrel | Prasugrel The serum concentration of Prasugrel can be decreased when it is combined with Lemborexant. |
Lacosamide | Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Lemborexant. |
Everolimus | Everolimus The serum concentration of Lemborexant can be increased when it is combined with Everolimus. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The serum concentration of Lemborexant can be increased when it is combined with Tolvaptan. |
Dronedarone | Dronedarone The metabolism of Lemborexant can be decreased when combined with Dronedarone. |
AbobotulinumtoxinA Injection | AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lemborexant. |
Palonosetron Injection | Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Lemborexant. |
Saxagliptin | Saxagliptin The metabolism of Lemborexant can be decreased when combined with Saxagliptin. |
Romidepsin Injection | Romidepsin Injection The serum concentration of Romidepsin can be decreased when it is combined with Lemborexant. |
Tapentadol | Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Topotecan | Topotecan The serum concentration of Lemborexant can be decreased when it is combined with Topotecan. |
Golimumab Injection | Golimumab Injection The metabolism of Lemborexant can be increased when combined with Golimumab. |
Pazopanib | Pazopanib The serum concentration of Lemborexant can be increased when it is combined with Pazopanib. |
Asenapine | Asenapine The risk or severity of adverse effects can be increased when Asenapine is combined with Lemborexant. |
Vigabatrin | Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Lemborexant. |
Levonorgestrel | Levonorgestrel The metabolism of Lemborexant can be decreased when combined with Levonorgestrel. |
Oxymorphone | Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Lemborexant. |
Tocilizumab Injection | Tocilizumab Injection The serum concentration of Lemborexant can be decreased when it is combined with Tocilizumab. |
IncobotulinumtoxinA Injection | IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lemborexant. |
Cabazitaxel Injection | Cabazitaxel Injection The metabolism of Lemborexant can be decreased when combined with Cabazitaxel. |
Lurasidone | Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Lemborexant. |
Acetaminophen Injection | Acetaminophen Injection The serum concentration of Lemborexant can be decreased when it is combined with Acetaminophen. |
Vilazodone | Vilazodone The risk or severity of adverse effects can be increased when Vilazodone is combined with Lemborexant. |
Linagliptin | Linagliptin The serum concentration of Lemborexant can be increased when it is combined with Linagliptin. |
Telaprevir | Telaprevir The serum concentration of Lemborexant can be increased when it is combined with Glecaprevir. |
Cyclophosphamide Injection | Cyclophosphamide Injection The serum concentration of Lemborexant can be decreased when it is combined with Cyclophosphamide. |
Rivaroxaban | Rivaroxaban The serum concentration of Lemborexant can be increased when it is combined with Rivaroxaban. |
Ticagrelor | Ticagrelor The serum concentration of Lemborexant can be increased when it is combined with Ticagrelor. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Lemborexant. |
Vandetanib | Vandetanib The serum concentration of Lemborexant can be increased when it is combined with Vandetanib. |
Clobazam | Clobazam The serum concentration of Lemborexant can be decreased when it is combined with Clobazam. |
Vemurafenib | Vemurafenib The serum concentration of Lemborexant can be increased when it is combined with Vemurafenib. |
Ivacaftor | Ivacaftor The serum concentration of Lemborexant can be increased when it is combined with Ivacaftor. |
Axitinib | Axitinib The metabolism of Lemborexant can be decreased when combined with Axitinib. |
Crizotinib | Crizotinib The serum concentration of Lemborexant can be increased when it is combined with Crizotinib. |
Cabergoline | Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Lemborexant. |
Ambrisentan | Ambrisentan The serum concentration of Lemborexant can be increased when it is combined with Ambrisentan. |
Ezogabine | Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Lemborexant. |
Carfilzomib Injection | Carfilzomib Injection The serum concentration of Lemborexant can be increased when it is combined with Carfilzomib. |
Enzalutamide | Enzalutamide The serum concentration of Lemborexant can be decreased when it is combined with Enzalutamide. |
Mirabegron | Mirabegron The serum concentration of Lemborexant can be increased when it is combined with Mirabegron. |
Regorafenib | Regorafenib The serum concentration of Lemborexant can be increased when it is combined with Regorafenib. |
Bosutinib | Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Lemborexant. |
Corticotropin, Repository Injection | Corticotropin, Repository Injection The serum concentration of Lemborexant can be decreased when it is combined with Corticotropin. |
Ponatinib | Ponatinib The metabolism of Lemborexant can be decreased when combined with Ponatinib. |
Pomalidomide | Pomalidomide The risk or severity of adverse effects can be increased when Pomalidomide is combined with Lemborexant. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The metabolism of Lemborexant can be decreased when combined with Trastuzumab emtansine. |
Apixaban | Apixaban The serum concentration of Lemborexant can be increased when it is combined with Apixaban. |
Canagliflozin | Canagliflozin The serum concentration of Lemborexant can be increased when it is combined with Canagliflozin. |
Dabrafenib | Dabrafenib The serum concentration of Lemborexant can be decreased when it is combined with Dabrafenib. |
Ospemifene | Ospemifene The serum concentration of Ospemifene can be decreased when it is combined with Lemborexant. |
Trametinib | Trametinib The serum concentration of Lemborexant can be decreased when it is combined with Trametinib. |
Dolutegravir | Dolutegravir The serum concentration of Lemborexant can be increased when it is combined with Dolutegravir. |
Afatinib | Afatinib The serum concentration of Lemborexant can be increased when it is combined with Afatinib. |
Levomilnacipran | Levomilnacipran The risk or severity of adverse effects can be increased when Lemborexant is combined with Levomilnacipran. |
Vortioxetine | Vortioxetine The serum concentration of Vortioxetine can be decreased when it is combined with Lemborexant. |
Perampanel | Perampanel The serum concentration of Lemborexant can be decreased when it is combined with Perampanel. |
Ibrutinib | Ibrutinib The metabolism of Lemborexant can be decreased when combined with Ibrutinib. |
Lomitapide | Lomitapide The serum concentration of Lemborexant can be increased when it is combined with Lomitapide. |
Simeprevir | Simeprevir The serum concentration of Lemborexant can be increased when it is combined with Simeprevir. |
Sofosbuvir | Sofosbuvir The serum concentration of Lemborexant can be increased when it is combined with Sofosbuvir. |
Apremilast | Apremilast The metabolism of Lemborexant can be increased when combined with Apremilast. |
Ceritinib | Ceritinib The serum concentration of Lemborexant can be increased when it is combined with Ceritinib. |
Siltuximab Injection | Siltuximab Injection The serum concentration of Lemborexant can be decreased when it is combined with Siltuximab. |
Eslicarbazepine | Eslicarbazepine The serum concentration of Lemborexant can be decreased when it is combined with Eslicarbazepine. |
Belinostat Injection | Belinostat Injection The serum concentration of Lemborexant can be increased when it is combined with Belinostat. |
Idelalisib | Idelalisib The serum concentration of Lemborexant can be increased when it is combined with Idelalisib. |
Testosterone Injection | Testosterone Injection The serum concentration of Lemborexant can be decreased when it is combined with Testosterone. |
Oritavancin Injection | Oritavancin Injection The serum concentration of Lemborexant can be decreased when it is combined with Oritavancin. |
Vorapaxar | Vorapaxar The serum concentration of Lemborexant can be increased when it is combined with Vorapaxar. |
Hydrocodone | Hydrocodone Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
Suvorexant | Suvorexant Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Edoxaban | Edoxaban The serum concentration of Lemborexant can be increased when it is combined with Edoxaban. |
Olaparib | Olaparib The metabolism of Lemborexant can be decreased when combined with Olaparib. |
Methamphetamine | Methamphetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Lemborexant. |
Tasimelteon | Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Lemborexant. |
Nintedanib | Nintedanib The serum concentration of Lemborexant can be increased when it is combined with Nintedanib. |
Secukinumab Injection | Secukinumab Injection The metabolism of Lemborexant can be increased when combined with Secukinumab. |
Risperidone Injection | Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Lemborexant. |
Palbociclib | Palbociclib The serum concentration of Lemborexant can be increased when it is combined with Palbociclib. |
Lenvatinib | Lenvatinib The serum concentration of Lemborexant can be decreased when it is combined with Lenvatinib. |
Panobinostat | Panobinostat The serum concentration of Lemborexant can be increased when it is combined with Panobinostat. |
Haloperidol Injection | Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Lemborexant. |
Isavuconazonium Injection | Isavuconazonium Injection The serum concentration of Lemborexant can be decreased when it is combined with Isavuconazonium. |
Flibanserin | Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Lemborexant. |
Rolapitant | Rolapitant The serum concentration of Lemborexant can be increased when it is combined with Rolapitant. |
Prednisolone | Prednisolone The serum concentration of Lemborexant can be decreased when it is combined with Prednisolone. |
Daclatasvir | Daclatasvir The serum concentration of Lemborexant can be increased when it is combined with Daclatasvir. |
Brexpiprazole | Brexpiprazole The risk or severity of adverse effects can be increased when Brexpiprazole is combined with Lemborexant. |
Ziprasidone Injection | Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Lemborexant. |
Cariprazine | Cariprazine The risk or severity of adverse effects can be increased when Cariprazine is combined with Lemborexant. |
Cobimetinib | Cobimetinib The serum concentration of Lemborexant can be increased when it is combined with Cobimetinib. |
Osimertinib | Osimertinib The serum concentration of Lemborexant can be decreased when it is combined with Osimertinib. |
Rifapentine | Rifapentine The serum concentration of Lemborexant can be decreased when it is combined with Rifapentine. |
Lesinurad | Lesinurad The serum concentration of Lemborexant can be decreased when it is combined with Lesinurad. |
Dexamethasone Injection | Dexamethasone Injection The serum concentration of Lemborexant can be decreased when it is combined with Dexamethasone. |
Brivaracetam Injection | Brivaracetam Injection The serum concentration of Brivaracetam can be decreased when it is combined with Lemborexant. |
Venetoclax | Venetoclax The serum concentration of Lemborexant can be increased when it is combined with Venetoclax. |
Cobicistat | Cobicistat The serum concentration of Lemborexant can be increased when it is combined with Cobicistat. |
Selexipag | Selexipag The serum concentration of Lemborexant can be increased when it is combined with Selexipag. |
Pimavanserin | Pimavanserin The risk or severity of adverse effects can be increased when Pimavanserin is combined with Lemborexant. |
Diphenhydramine Injection | Diphenhydramine Injection Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine. |
Rucaparib | Rucaparib The metabolism of Lemborexant can be decreased when combined with Rucaparib. |
Brigatinib | Brigatinib The serum concentration of Lemborexant can be decreased when it is combined with Brigatinib. |
Doxepin (Insomnia) | Doxepin (Insomnia) Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Doxepin. |
Deutetrabenazine | Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Lemborexant. |
Valbenazine | Valbenazine The metabolism of Lemborexant can be decreased when combined with Valbenazine. |
Deflazacort | Deflazacort The metabolism of Lemborexant can be increased when combined with Deflazacort. |
Safinamide | Safinamide The metabolism of Lemborexant can be decreased when combined with Safinamide. |
Sarilumab Injection | Sarilumab Injection The serum concentration of Lemborexant can be decreased when it is combined with Sarilumab. |
Midostaurin | Midostaurin The serum concentration of Lemborexant can be decreased when it is combined with Midostaurin. |
Neratinib | Neratinib The serum concentration of Lemborexant can be increased when it is combined with Neratinib. |
Enasidenib | Enasidenib The serum concentration of Lemborexant can be decreased when it is combined with Enasidenib. |
Inotuzumab Ozogamicin Injection | Inotuzumab Ozogamicin Injection The serum concentration of Lemborexant can be increased when it is combined with Inotuzumab ozogamicin. |
Aprepitant/Fosaprepitant Injection | Aprepitant/Fosaprepitant Injection The serum concentration of Lemborexant can be decreased when it is combined with Fosaprepitant. |
Copanlisib Injection | Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Lemborexant. |
Delafloxacin | Delafloxacin The serum concentration of Lemborexant can be decreased when it is combined with Delafloxacin. |
Abemaciclib | Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Lemborexant. |
Betrixaban | Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Lemborexant. |
Acalabrutinib | Acalabrutinib The serum concentration of Lemborexant can be increased when it is combined with Acalabrutinib. |
Letermovir | Letermovir The metabolism of Lemborexant can be decreased when combined with Letermovir. |
Ertugliflozin | Ertugliflozin The serum concentration of Lemborexant can be increased when it is combined with Ertugliflozin. |
Buprenorphine Injection | Buprenorphine Injection Buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Apalutamide | Apalutamide The serum concentration of Lemborexant can be decreased when it is combined with Apalutamide. |
Avatrombopag | Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Lemborexant. |
Baricitinib | Baricitinib The serum concentration of Lemborexant can be increased when it is combined with Baricitinib. |
Lofexidine | Lofexidine The therapeutic efficacy of Lemborexant can be increased when used in combination with Lofexidine. |
Eliglustat | Eliglustat The serum concentration of Lemborexant can be increased when it is combined with Eliglustat. |
Binimetinib | Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Lemborexant. |
Ivosidenib | Ivosidenib The serum concentration of Lemborexant can be decreased when it is combined with Ivosidenib. |
Lusutrombopag | Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Lemborexant. |
Elagolix | Elagolix The serum concentration of Lemborexant can be increased when it is combined with Elagolix. |
Doravirine | Doravirine The metabolism of Doravirine can be decreased when combined with Lemborexant. |
Cannabidiol | Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Lemborexant. |
Dacomitinib | Dacomitinib The serum concentration of Lemborexant can be increased when it is combined with Dacomitinib. |
Duvelisib | Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Lemborexant. |
Omadacycline | Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Lemborexant. |
Sarecycline | Sarecycline The serum concentration of Lemborexant can be increased when it is combined with Sarecycline. |
Stiripentol | Stiripentol The risk or severity of adverse effects can be increased when Stiripentol is combined with Lemborexant. |
Talazoparib | Talazoparib The serum concentration of Lemborexant can be increased when it is combined with Talazoparib. |
Gilteritinib | Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Lemborexant. |
Glasdegib | Glasdegib The serum concentration of Lemborexant can be increased when it is combined with Glasdegib. |
Lorlatinib | Lorlatinib The serum concentration of Lemborexant can be decreased when it is combined with Lorlatinib. |
Larotrectinib | Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Lemborexant. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The serum concentration of Lemborexant can be decreased when it is combined with Paclitaxel. |
Rifamycin | Rifamycin The serum concentration of Lemborexant can be decreased when it is combined with Rifamycin. |
Emapalumab-lzsg Injection | Emapalumab-lzsg Injection The metabolism of Lemborexant can be increased when combined with Emapalumab. |
Erdafitinib | Erdafitinib The serum concentration of Lemborexant can be increased when it is combined with Erdafitinib. |
Alpelisib | Alpelisib The serum concentration of Lemborexant can be decreased when it is combined with Alpelisib. |
Brexanolone Injection | Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Lemborexant. |
Solriamfetol | Solriamfetol The risk or severity of adverse effects can be increased when Lemborexant is combined with Solriamfetol. |
Darolutamide | Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Lemborexant. |
Entrectinib | Entrectinib The serum concentration of Lemborexant can be increased when it is combined with Entrectinib. |
Istradefylline | Istradefylline The serum concentration of Istradefylline can be decreased when it is combined with Lemborexant. |
Pitolisant | Pitolisant The serum concentration of Lemborexant can be decreased when it is combined with Pitolisant. |
Fedratinib | Fedratinib The serum concentration of Lemborexant can be increased when it is combined with Fedratinib. |
Lefamulin | Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Lemborexant. |
Phenytoin Injection | Phenytoin Injection The serum concentration of Lemborexant can be decreased when it is combined with Phenytoin. |
Fosphenytoin Injection | Fosphenytoin Injection The serum concentration of Lemborexant can be decreased when it is combined with Fosphenytoin. |
Enfortumab vedotin-ejfv Injection | Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Lemborexant. |
Zanubrutinib | Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Lemborexant. |
Voxelotor | Voxelotor The serum concentration of Voxelotor can be decreased when it is combined with Lemborexant. |
Lumateperone | Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Lemborexant. |
Lasmiditan | Lasmiditan The serum concentration of Lemborexant can be increased when it is combined with Lasmiditan. |
Ubrogepant | Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Lemborexant. |
Tazemetostat | Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Lemborexant. |
Cenobamate | Cenobamate The serum concentration of Lemborexant can be decreased when it is combined with Cenobamate. |
Selumetinib | Selumetinib The serum concentration of Lemborexant can be increased when it is combined with Selumetinib. |
Rimegepant | Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Lemborexant. |
Tucatinib | Tucatinib Tucatinib may decrease the excretion rate of Lemborexant which could result in a higher serum level. |
Remdesivir Injection | Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Lemborexant. |
Ripretinib | Ripretinib The serum concentration of Lemborexant can be increased when it is combined with Ripretinib. |
Fenfluramine | Fenfluramine The risk or severity of adverse effects can be increased when Fenfluramine is combined with Lemborexant. |
Fostemsavir | Fostemsavir The serum concentration of Lemborexant can be increased when it is combined with Fostemsavir. |
Belantamab Mafodotin-blmf Injection | Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Lemborexant. |
Pralsetinib | Pralsetinib The serum concentration of Lemborexant can be increased when it is combined with Pralsetinib. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Lemborexant can be decreased when it is combined with Satralizumab. |
Viloxazine | Viloxazine The risk or severity of adverse effects can be increased when Viloxazine is combined with Lemborexant. |
Trazodone | Trazodone The risk or severity of adverse effects can be increased when Trazodone is combined with Lemborexant. |
Phenobarbital | Phenobarbital The serum concentration of Lemborexant can be decreased when it is combined with Phenobarbital. |
Metaxalone | Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Lemborexant. |
Levorphanol | Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Lemborexant. |
Primidone | Primidone The serum concentration of Lemborexant can be decreased when it is combined with Primidone. |
Methsuximide | Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Lemborexant. |
Diethylpropion | Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Lemborexant. |
Chlorpromazine | Chlorpromazine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine. |
Diazepam | Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Lemborexant. |
Oxazepam | Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Lemborexant. |
Flurazepam | Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Lemborexant. |
Clorazepate | Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Lemborexant. |
Lorazepam | Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Lemborexant. |
Codeine | Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Lemborexant. |
Meprobamate | Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Lemborexant. |
Chlordiazepoxide | Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lemborexant. |
Bromocriptine | Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Lemborexant. |
Tranylcypromine | Tranylcypromine The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Lemborexant. |
Phenelzine | Phenelzine The metabolism of Lemborexant can be decreased when combined with Phenelzine. |
Procarbazine | Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Lemborexant. |
Ergoloid Mesylates | Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Lemborexant. |
Minocycline | Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Prochlorperazine | Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Lemborexant. |
Thioridazine | Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Lemborexant. |
Trifluoperazine | Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Lemborexant. |
Dapsone | Dapsone The metabolism of Lemborexant can be decreased when combined with Dapsone. |
Oxycodone | Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Lemborexant. |
Methadone | Methadone The risk or severity of adverse effects can be increased when Lemborexant is combined with Methadone. |
Oxybutynin | Oxybutynin Oxybutynin may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Benztropine | Benztropine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Benzatropine. |
Maprotiline | Maprotiline Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Maprotiline. |
Trihexyphenidyl | Trihexyphenidyl Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl. |
Orphenadrine | Orphenadrine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
Perphenazine | Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Lemborexant. |
Fluphenazine | Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Lemborexant. |
Amoxapine | Amoxapine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Amoxapine. |
Hydrocortisone | Hydrocortisone The serum concentration of Lemborexant can be decreased when it is combined with Hydrocortisone. |
Dactinomycin | Dactinomycin The serum concentration of Lemborexant can be increased when it is combined with Dactinomycin. |
Pyridostigmine | Pyridostigmine The serum concentration of Lemborexant can be decreased when it is combined with Pyridostigmine. |
Carbamazepine | Carbamazepine The serum concentration of Lemborexant can be decreased when it is combined with Carbamazepine. |
Molindone | Molindone The risk or severity of adverse effects can be increased when Molindone is combined with Lemborexant. |
Clonidine | Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Lemborexant. |
Cimetidine | Cimetidine The serum concentration of Lemborexant can be increased when it is combined with Cimetidine. |
Clonazepam | Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Lemborexant. |
Loperamide | Loperamide The serum concentration of Loperamide can be decreased when it is combined with Lemborexant. |
Promethazine | Promethazine The serum concentration of Promethazine can be decreased when it is combined with Lemborexant. |
Daunorubicin | Daunorubicin The serum concentration of Lemborexant can be decreased when it is combined with Daunorubicin. |
Griseofulvin | Griseofulvin The serum concentration of Lemborexant can be decreased when it is combined with Griseofulvin. |
Digoxin | Digoxin The serum concentration of Digoxin can be increased when it is combined with Lemborexant. |
Loxapine | Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Lemborexant. |
Chloroquine | Chloroquine The metabolism of Lemborexant can be decreased when combined with Chloroquine. |
Quinine | Quinine The serum concentration of Lemborexant can be decreased when it is combined with Quinine. |
Ethosuximide | Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Lemborexant. |
Calcitriol | Calcitriol The serum concentration of Lemborexant can be decreased when it is combined with Calcitriol. |
Sulfinpyrazone | Sulfinpyrazone The serum concentration of Lemborexant can be decreased when it is combined with Sulfinpyrazone. |
Clindamycin Injection | Clindamycin Injection The metabolism of Lemborexant can be decreased when combined with Clindamycin. |
Secobarbital | Secobarbital The serum concentration of Lemborexant can be decreased when it is combined with Secobarbital. |
Desipramine | Desipramine The serum concentration of Desipramine can be decreased when it is combined with Lemborexant. |
Amitriptyline | Amitriptyline The serum concentration of Amitriptyline can be decreased when it is combined with Lemborexant. |
Imipramine | Imipramine The serum concentration of Imipramine can be decreased when it is combined with Lemborexant. |
Probenecid | Probenecid The serum concentration of Lemborexant can be decreased when it is combined with Probenecid. |
Quinidine | Quinidine The serum concentration of Quinidine can be increased when it is combined with Lemborexant. |
Rifampin | Rifampin The serum concentration of Lemborexant can be decreased when it is combined with Rifampicin. |
Disopyramide | Disopyramide Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Disopyramide. |
Valproic Acid | Valproic Acid The serum concentration of Valproic acid can be decreased when it is combined with Lemborexant. |
Tamoxifen | Tamoxifen The serum concentration of Lemborexant can be decreased when it is combined with Tamoxifen. |
Butabarbital | Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Lemborexant. |
Dextromethorphan | Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Lemborexant. |
Cyclobenzaprine | Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Lemborexant. |
Baclofen | Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Lemborexant. |
Doxylamine | Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Cyproheptadine | Cyproheptadine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine. |
Clemastine | Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Lemborexant. |
Chlorpheniramine | Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Lemborexant. |
Brompheniramine | Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Lemborexant. |
Meclizine | Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Lemborexant. |
Dantrolene | Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Lemborexant. |
Chlorzoxazone | Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Lemborexant. |
Carisoprodol | Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Lemborexant. |
Methocarbamol | Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Lemborexant. |
Disulfiram | Disulfiram The metabolism of Lemborexant can be decreased when combined with Disulfiram. |
Propranolol (Cardiovascular) | Propranolol (Cardiovascular) The metabolism of Lemborexant can be decreased when combined with Propranolol. |
Nortriptyline | Nortriptyline Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline. |
Butorphanol Injection | Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Lemborexant. |
Nalbuphine Injection | Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Lemborexant. |
Trimethobenzamide | Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Lemborexant. |
Clomiphene | Clomiphene The serum concentration of Lemborexant can be increased when it is combined with Clomifene. |
Flavoxate | Flavoxate Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Flavoxate. |
Colchicine | Colchicine The serum concentration of Lemborexant can be decreased when it is combined with Colchicine. |
Acetazolamide | Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Lemborexant. |
Ketoconazole | Ketoconazole The serum concentration of Lemborexant can be increased when it is combined with Ketoconazole. |
Pyrantel | Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Lemborexant. |
Vincristine Injection | Vincristine Injection The metabolism of Lemborexant can be decreased when combined with Vincristine. |
Vinblastine | Vinblastine The serum concentration of Lemborexant can be decreased when it is combined with Vinblastine. |
Hydroxyzine | Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Thiothixene | Thiothixene The risk or severity of adverse effects can be increased when Thiothixene is combined with Lemborexant. |
Alprazolam | Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Lemborexant. |
Temazepam | Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Lemborexant. |
Triazolam | Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Lemborexant. |
Dicyclomine | Dicyclomine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine. |
Hyoscyamine | Hyoscyamine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine. |
Propantheline | Propantheline Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Propantheline. |
Diltiazem | Diltiazem The serum concentration of Lemborexant can be increased when it is combined with Diltiazem. |
Nifedipine | Nifedipine The serum concentration of Lemborexant can be decreased when it is combined with Nifedipine. |
Verapamil | Verapamil The serum concentration of Lemborexant can be increased when it is combined with Verapamil. |
Pindolol | Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Lemborexant. |
Etoposide | Etoposide The serum concentration of Lemborexant can be decreased when it is combined with Etoposide. |
Glyburide | Glyburide The metabolism of Lemborexant can be decreased when combined with Glyburide. |
Dicloxacillin | Dicloxacillin The serum concentration of Lemborexant can be decreased when it is combined with Dicloxacillin. |
Nafcillin Injection | Nafcillin Injection The serum concentration of Lemborexant can be decreased when it is combined with Nafcillin. |
Pentamidine Injection | Pentamidine Injection The metabolism of Lemborexant can be decreased when combined with Pentamidine. |
Pimozide | Pimozide The metabolism of Lemborexant can be decreased when combined with Pimozide. |
Amiodarone | Amiodarone The serum concentration of Lemborexant can be increased when it is combined with Amiodarone. |
Buspirone | Buspirone The metabolism of Lemborexant can be decreased when combined with Buspirone. |
Lovastatin | Lovastatin The metabolism of Lemborexant can be decreased when combined with Lovastatin. |
Ciprofloxacin | Ciprofloxacin The serum concentration of Lemborexant can be increased when it is combined with Ciprofloxacin. |
Diclofenac | Diclofenac The serum concentration of Diclofenac can be decreased when it is combined with Lemborexant. |
Oxiconazole | Oxiconazole The serum concentration of Lemborexant can be decreased when it is combined with Oxiconazole. |
Fluoxetine | Fluoxetine The serum concentration of Fluoxetine can be decreased when it is combined with Lemborexant. |
Clozapine | Clozapine The serum concentration of Lemborexant can be decreased when it is combined with Clozapine. |
Estazolam | Estazolam The risk or severity of adverse effects can be increased when Estazolam is combined with Lemborexant. |
Clarithromycin | Clarithromycin The serum concentration of Lemborexant can be increased when it is combined with Clarithromycin. |
Felodipine | Felodipine The metabolism of Lemborexant can be decreased when combined with Felodipine. |
Pravastatin | Pravastatin The serum concentration of Lemborexant can be increased when it is combined with Pravastatin. |
Simvastatin | Simvastatin The serum concentration of Lemborexant can be increased when it is combined with Simvastatin. |
Teniposide Injection | Teniposide Injection The metabolism of Lemborexant can be decreased when combined with Teniposide. |
Itraconazole | Itraconazole The serum concentration of Lemborexant can be increased when it is combined with Itraconazole. |
Rifabutin | Rifabutin The serum concentration of Lemborexant can be decreased when it is combined with Rifabutin. |
Bisoprolol | Bisoprolol The serum concentration of Lemborexant can be increased when it is combined with Bisoprolol. |
Zolpidem | Zolpidem Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
Omeprazole | Omeprazole The serum concentration of Lemborexant can be decreased when it is combined with Omeprazole. |
Cisapride | Cisapride The serum concentration of Cisapride can be decreased when it is combined with Lemborexant. |
Gabapentin | Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Lemborexant. |
Fluvastatin | Fluvastatin The metabolism of Lemborexant can be decreased when combined with Fluvastatin. |
Venlafaxine | Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Lemborexant. |
Fluvoxamine | Fluvoxamine The serum concentration of Lemborexant can be increased when it is combined with Fluvoxamine. |
Nefazodone | Nefazodone The serum concentration of Lemborexant can be increased when it is combined with Nefazodone. |
Lamotrigine | Lamotrigine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine. |
Tramadol | Tramadol The serum concentration of Tramadol can be decreased when it is combined with Lemborexant. |
Lansoprazole | Lansoprazole The serum concentration of Lemborexant can be decreased when it is combined with Lansoprazole. |
Ifosfamide Injection | Ifosfamide Injection The serum concentration of Lemborexant can be decreased when it is combined with Ifosfamide. |
Nicardipine | Nicardipine The serum concentration of Lemborexant can be increased when it is combined with Nicardipine. |
Bupropion | Bupropion The serum concentration of Bupropion can be decreased when it is combined with Lemborexant. |
Saquinavir | Saquinavir The metabolism of Lemborexant can be decreased when combined with Saquinavir. |
Nisoldipine | Nisoldipine The metabolism of Lemborexant can be decreased when combined with Nisoldipine. |
Riluzole | Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Lemborexant. |
Gemcitabine Injection | Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Lemborexant. |
Indinavir | Indinavir The serum concentration of Lemborexant can be increased when it is combined with Indinavir. |
Ritonavir | Ritonavir The serum concentration of Lemborexant can be increased when it is combined with Ritonavir. |
Docetaxel Injection | Docetaxel Injection The metabolism of Lemborexant can be decreased when combined with Docetaxel. |
Clomipramine | Clomipramine The serum concentration of Clomipramine can be decreased when it is combined with Lemborexant. |
Mirtazapine | Mirtazapine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
Topiramate | Topiramate The serum concentration of Lemborexant can be decreased when it is combined with Topiramate. |
Pramipexole | Pramipexole Lemborexant may increase the sedative activities of Pramipexole. |
Donepezil | Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Lemborexant. |
Nelfinavir | Nelfinavir The serum concentration of Lemborexant can be increased when it is combined with Nelfinavir. |
Fexofenadine | Fexofenadine The serum concentration of Lemborexant can be increased when it is combined with Fexofenadine. |
Carvedilol | Carvedilol The serum concentration of Lemborexant can be increased when it is combined with Carvedilol. |
Flutamide | Flutamide The metabolism of Lemborexant can be decreased when combined with Flutamide. |
Selegiline | Selegiline The serum concentration of Selegiline can be decreased when it is combined with Lemborexant. |
Sertraline | Sertraline The risk or severity of adverse effects can be increased when Lemborexant is combined with Sertraline. |
Propafenone | Propafenone The serum concentration of Lemborexant can be increased when it is combined with Propafenone. |
Ropinirole | Ropinirole Lemborexant may increase the sedative activities of Ropinirole. |
Finasteride | Finasteride The metabolism of Lemborexant can be decreased when combined with Finasteride. |
Quetiapine | Quetiapine Quetiapine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Cetirizine | Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Lemborexant. |
Paroxetine | Paroxetine The serum concentration of Lemborexant can be increased when it is combined with Paroxetine. |
Tolcapone | Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Lemborexant. |
Citalopram | Citalopram The risk or severity of adverse effects can be increased when Lemborexant is combined with Citalopram. |
Efavirenz | Efavirenz The serum concentration of Lemborexant can be decreased when it is combined with Efavirenz. |
Sildenafil | Sildenafil The serum concentration of Lemborexant can be increased when it is combined with Sildenafil. |
Tolterodine | Tolterodine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Tolterodine. |
Thalidomide | Thalidomide Thalidomide may increase the central nervous system depressant (CNS depressant) activities of Lemborexant. |
Nateglinide | Nateglinide The metabolism of Lemborexant can be decreased when combined with Nateglinide. |
Levetiracetam | Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Lemborexant. |
Terbinafine | Terbinafine The serum concentration of Lemborexant can be decreased when it is combined with Terbinafine. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists