Lemborexant

Lemborexant is used to treat insomnia (difficulty falling asleep or staying asleep). Lemborexant belongs to a class of medications called hypnotics. It works by slowing activity in the brain to allow sleep.

Lemborexant comes as a tablet to take by mouth. It is usually taken as needed, not more than one time a day, immediately before bedtime. Lemborexant will work faster if it is not taken with a meal or immediately after a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lemborexant exactly as directed.

You will probably become very sleepy soon after you take lemborexant and will remain sleepy for some time after you take the medication. Plan to go to bed right after you take lemborexant and to stay in bed for at least 7 hours. Do not take lemborexant if you will be unable to go to bed right away and remain asleep for at least 7 hours after taking the medication.

You should be sleeping well within 7 to 10 days after you start taking lemborexant. Call your doctor if your sleep problems do not improve during this time, if they get worse at any time during your treatment, or if you notice any changes in your thoughts or behavior.

Lemborexant may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lemborexant and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking lemborexant,

• tell your doctor and pharmacist if you are allergic to lemborexant, any other medications, or any of the ingredients in lemborexant tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: Bosentan (Tracleer); bupropion (Aplenzin, Forfivo, Wellbutrin); carbamazepine (Carbatrol, Epitol, Tegretol, others); clarithromycin; chlorzoxazone; efavirenz (Sustiva, in Atripla, in Symfi); etravirine (Intelence); fluconazole (Diflucan); itraconazole (Onmel, Sporanox, Tolsura); medications for anxiety and pain; methadone (Dolophine, Methadose); modafinil (Provigil); ranitidine (Zantac); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sedatives, sleeping pills, and tranquilizers; tricyclic antidepressants such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and verapamil (Calan, Verelan, in Tarka). Your doctor may tell you not to take lemborexant, may need to change the doses of your medications, or monitor you carefully for side effects. Many other medications may also interact with lemborexant, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

• tell your doctor what herbal products you are taking, especially St. John's wort.

• tell your doctor if you have narcolepsy (a condition that causes excessive daytime sleepiness). Your doctor will probably tell you not to take lemborexant.

• tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications. Also tell your doctor if you have or have ever had depression; mental illness; thoughts of harming or killing yourself or trying to do so; a problem with heavy snoring; sleep apnea (condition in which breathing briefly stops many times during the night); other breathing problems or lung diseases such as asthma, bronchitis, and emphysema; cataplexy (episodes of muscle weakness that begin suddenly and last for a short time); or liver disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking lemborexant, call your doctor.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lemborexant.

• you should know that this medication may cause drowsiness, decreased mental alertness, prolonged reaction time, problems with coordination the day after you take it, blurry or double vision, and may increase the risk that you could fall. Take extra care to be sure you do not fall, especially if you get out of bed in the middle of the night. Your ability to drive or operate machinery the day after you take lemborexant may be impaired even if you feel fully awake. Do not drive a car or operate machinery until you know how lemborexant affects you.

• do not drink alcohol during your treatment with lemborexant. Alcohol can make the side effects of lemborexant worse.

• you should know that lemborexant has caused serious or possibly life-threatening sleep behaviors. Some people who took lemborexant got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, sleep-walked, or were involved in other activities while not fully awake. After they woke up, these people were unable to remember what they had done. These activities may occur with lemborexant whether or not you drink alcohol or also take other sleep medications. Call your doctor right away if you have ever had an unusual sleep behavior while taking lemborexant.

Unless your doctor tells you otherwise, continue your normal diet.

• Lemborexant may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • drowsiness

  • tiredness

  • headache

  • vivid, unusual dreams or nightmares

• Some side effects can be serious. If you experience any of these symptoms, stop taking lemborexant and call your doctor immediately:

  • temporary inability to move or talk while you are going to sleep or waking up (sleep paralysis)

  • sudden and temporary weakness of legs

  • new or worsening depression or anxiety

  • thoughts of suicide, dying, or hurting yourself, or planning or trying to do so

  • sudden onset of muscle weakness

  • pounding heartbeat

• Lemborexant may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• drowsiness

Keep all appointments with your doctor.

Do not let anyone else take your medication. Lemborexant is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Delavirdine	Delavirdine The metabolism of Lemborexant can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The serum concentration of Nevirapine can be decreased when it is combined with Lemborexant.
Atorvastatin	Atorvastatin The serum concentration of Lemborexant can be decreased when it is combined with Atorvastatin.
Dolasetron	Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Lemborexant.
Cilostazol	Cilostazol The metabolism of Lemborexant can be decreased when combined with Cilostazol.
Clopidogrel	Clopidogrel The serum concentration of Clopidogrel can be decreased when it is combined with Lemborexant.
Diphenoxylate	Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Lemborexant.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Lemborexant can be decreased when combined with Erythromycin.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Lemborexant.
Naratriptan	Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Lemborexant.
Paregoric	Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Lemborexant.
Pentazocine	Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Lemborexant.
Reserpine	Reserpine The serum concentration of Lemborexant can be decreased when it is combined with Reserpine.
Rizatriptan	Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Lemborexant.
Sumatriptan	Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Lemborexant.
Tacrolimus	Tacrolimus The metabolism of Lemborexant can be decreased when combined with Tacrolimus.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Lemborexant.
Triamcinolone	Triamcinolone The metabolism of Lemborexant can be increased when combined with Triamcinolone.
Zolmitriptan	Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Lemborexant.
Fluconazole Injection	Fluconazole Injection The serum concentration of Lemborexant can be increased when it is combined with Fluconazole.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Lemborexant.
Meperidine Injection	Meperidine Injection The serum concentration of Lemborexant can be decreased when it is combined with Meperidine.
Methylprednisolone Injection	Methylprednisolone Injection The serum concentration of Lemborexant can be decreased when it is combined with Methylprednisolone.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Lemborexant.
Metronidazole Injection	Metronidazole Injection The metabolism of Lemborexant can be decreased when combined with Metronidazole.
Morphine Injection	Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Lemborexant.
Altretamine	Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Lemborexant.
Cyclosporine	Cyclosporine The metabolism of Lemborexant can be decreased when combined with Cyclosporine.
Ondansetron	Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Lemborexant.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Lemborexant.
Olanzapine	Olanzapine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
Alosetron	Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Lemborexant.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Lemborexant.
Orlistat	Orlistat The serum concentration of Lemborexant can be decreased when it is combined with Orlistat.
Oxcarbazepine	Oxcarbazepine The serum concentration of Lemborexant can be decreased when it is combined with Oxcarbazepine.
Temozolomide	Temozolomide The serum concentration of Lemborexant can be decreased when it is combined with Temozolomide.
Zaleplon	Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Lemborexant.
Anakinra	Anakinra The metabolism of Lemborexant can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Lemborexant.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Lemborexant.
Trimipramine	Trimipramine The serum concentration of Trimipramine can be decreased when it is combined with Lemborexant.
Etanercept Injection	Etanercept Injection The metabolism of Lemborexant can be increased when combined with Etanercept.
Glycopyrrolate	Glycopyrrolate Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil	Modafinil The serum concentration of Lemborexant can be increased when it is combined with Modafinil.
Tenofovir	Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Lemborexant.
Sirolimus	Sirolimus The metabolism of Lemborexant can be decreased when combined with Sirolimus.
Dutasteride	Dutasteride The metabolism of Lemborexant can be decreased when combined with Dutasteride.
Eplerenone	Eplerenone The metabolism of Lemborexant can be decreased when combined with Eplerenone.
Escitalopram	Escitalopram The risk or severity of adverse effects can be increased when Lemborexant is combined with Escitalopram.
Zonisamide	Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Lemborexant.
Adalimumab Injection	Adalimumab Injection The metabolism of Lemborexant can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Atomoxetine	Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Lemborexant.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Lemborexant.
Atazanavir	Atazanavir The serum concentration of Lemborexant can be increased when it is combined with Atazanavir.
Almotriptan	Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Lemborexant.
Eletriptan	Eletriptan The serum concentration of Lemborexant can be decreased when it is combined with Eletriptan.
Rosuvastatin	Rosuvastatin The metabolism of Lemborexant can be decreased when combined with Rosuvastatin.
Vardenafil	Vardenafil The serum concentration of Lemborexant can be increased when it is combined with Vardenafil.
Aprepitant	Aprepitant The metabolism of Lemborexant can be decreased when combined with Aprepitant.
Tegaserod	Tegaserod The serum concentration of Lemborexant can be increased when it is combined with Tegaserod.
Tadalafil	Tadalafil The metabolism of Lemborexant can be decreased when combined with Tadalafil.
Frovatriptan	Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Lemborexant.
Progesterone	Progesterone The serum concentration of Lemborexant can be increased when it is combined with Progesterone.
Apomorphine Injection	Apomorphine Injection The serum concentration of Lemborexant can be decreased when it is combined with Apomorphine.
Infliximab Injection	Infliximab Injection The metabolism of Lemborexant can be increased when combined with Infliximab.
Protriptyline	Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Lemborexant.
Rifaximin	Rifaximin The serum concentration of Lemborexant can be decreased when it is combined with Rifaximin.
Duloxetine	Duloxetine The risk or severity of adverse effects can be increased when Lemborexant is combined with Duloxetine.
Norethindrone	Norethindrone The metabolism of Lemborexant can be decreased when combined with Norethisterone.
Trospium	Trospium Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan	Bosentan The serum concentration of Lemborexant can be decreased when it is combined with Bosentan.
Erlotinib	Erlotinib The metabolism of Lemborexant can be decreased when combined with Erlotinib.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Lemborexant is combined with Eszopiclone.
Solifenacin	Solifenacin Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Voriconazole	Voriconazole The metabolism of Lemborexant can be decreased when combined with Voriconazole.
Dextroamphetamine	Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Lemborexant.
Sodium Oxybate	Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Isocarboxazid	Isocarboxazid The risk or severity of adverse effects can be increased when Isocarboxazid is combined with Lemborexant.
Ramelteon	Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Lemborexant.
Darifenacin	Darifenacin Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl	Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Lemborexant.
Pregabalin	Pregabalin The therapeutic efficacy of Lemborexant can be increased when used in combination with Pregabalin.
Deferasirox	Deferasirox The serum concentration of Lemborexant can be decreased when it is combined with Deferasirox.
Tipranavir	Tipranavir The serum concentration of Lemborexant can be increased when it is combined with Tipranavir.
Felbamate	Felbamate The serum concentration of Lemborexant can be decreased when it is combined with Felbamate.
Ranolazine	Ranolazine The serum concentration of Lemborexant can be increased when it is combined with Ranolazine.
Abatacept Injection	Abatacept Injection The metabolism of Lemborexant can be increased when combined with Abatacept.
Rasagiline	Rasagiline The risk or severity of adverse effects can be increased when Rasagiline is combined with Lemborexant.
Imatinib	Imatinib The metabolism of Lemborexant can be decreased when combined with Imatinib.
Sitagliptin	Sitagliptin The serum concentration of Lemborexant can be increased when it is combined with Sitagliptin.
Gefitinib	Gefitinib The metabolism of Lemborexant can be decreased when combined with Gefitinib.
Paliperidone	Paliperidone The risk or severity of adverse effects can be increased when Paliperidone is combined with Lemborexant.
Bortezomib	Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Lemborexant.
Posaconazole	Posaconazole The serum concentration of Lemborexant can be increased when it is combined with Posaconazole.
Dimenhydrinate	Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Lemborexant.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Sorafenib	Sorafenib The metabolism of Lemborexant can be decreased when combined with Sorafenib.
Sunitinib	Sunitinib The metabolism of Lemborexant can be decreased when combined with Sunitinib.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Lapatinib	Lapatinib The serum concentration of Lemborexant can be increased when it is combined with Lapatinib.
Levocetirizine	Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Lemborexant.
Dasatinib	Dasatinib The metabolism of Lemborexant can be decreased when combined with Dasatinib.
Mexiletine	Mexiletine The serum concentration of Mexiletine can be decreased when it is combined with Lemborexant.
Armodafinil	Armodafinil The serum concentration of Lemborexant can be decreased when it is combined with Armodafinil.
Temsirolimus	Temsirolimus The metabolism of Lemborexant can be decreased when combined with Temsirolimus.
Nilotinib	Nilotinib The serum concentration of Lemborexant can be increased when it is combined with Nilotinib.
Toremifene	Toremifene The serum concentration of Lemborexant can be increased when it is combined with Toremifene.
Bexarotene	Bexarotene The serum concentration of Lemborexant can be decreased when it is combined with Bexarotene.
Budesonide	Budesonide The serum concentration of Lemborexant can be decreased when it is combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Lemborexant can be decreased when combined with Chloramphenicol.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lemborexant.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Lemborexant.
Etravirine	Etravirine The serum concentration of Lemborexant can be decreased when it is combined with Etravirine.
Desvenlafaxine	Desvenlafaxine The risk or severity of adverse effects can be increased when Lemborexant is combined with Desvenlafaxine.
Tretinoin	Tretinoin The serum concentration of Tretinoin can be decreased when it is combined with Lemborexant.
Bendamustine Injection	Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Lemborexant.
Certolizumab Injection	Certolizumab Injection The metabolism of Lemborexant can be increased when combined with Certolizumab pegol.
Irinotecan Injection	Irinotecan Injection The serum concentration of Irinotecan can be decreased when it is combined with Lemborexant.
Praziquantel	Praziquantel The metabolism of Lemborexant can be decreased when combined with Praziquantel.
Mitotane	Mitotane The serum concentration of Lemborexant can be decreased when it is combined with Mitotane.
Rufinamide	Rufinamide The serum concentration of Lemborexant can be decreased when it is combined with Rufinamide.
Silodosin	Silodosin The serum concentration of Lemborexant can be increased when it is combined with Silodosin.
Midazolam	Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Lemborexant.
Milnacipran	Milnacipran The risk or severity of adverse effects can be increased when Lemborexant is combined with Milnacipran.
Fesoterodine	Fesoterodine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Iloperidone	Iloperidone The risk or severity of adverse effects can be increased when Iloperidone is combined with Lemborexant.
Prasugrel	Prasugrel The serum concentration of Prasugrel can be decreased when it is combined with Lemborexant.
Lacosamide	Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Lemborexant.
Everolimus	Everolimus The serum concentration of Lemborexant can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The serum concentration of Lemborexant can be increased when it is combined with Tolvaptan.
Dronedarone	Dronedarone The metabolism of Lemborexant can be decreased when combined with Dronedarone.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lemborexant.
Palonosetron Injection	Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Lemborexant.
Saxagliptin	Saxagliptin The metabolism of Lemborexant can be decreased when combined with Saxagliptin.
Romidepsin Injection	Romidepsin Injection The serum concentration of Romidepsin can be decreased when it is combined with Lemborexant.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Topotecan	Topotecan The serum concentration of Lemborexant can be decreased when it is combined with Topotecan.
Golimumab Injection	Golimumab Injection The metabolism of Lemborexant can be increased when combined with Golimumab.
Pazopanib	Pazopanib The serum concentration of Lemborexant can be increased when it is combined with Pazopanib.
Asenapine	Asenapine The risk or severity of adverse effects can be increased when Asenapine is combined with Lemborexant.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Lemborexant.
Levonorgestrel	Levonorgestrel The metabolism of Lemborexant can be decreased when combined with Levonorgestrel.
Oxymorphone	Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Lemborexant.
Tocilizumab Injection	Tocilizumab Injection The serum concentration of Lemborexant can be decreased when it is combined with Tocilizumab.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lemborexant.
Cabazitaxel Injection	Cabazitaxel Injection The metabolism of Lemborexant can be decreased when combined with Cabazitaxel.
Lurasidone	Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Lemborexant.
Acetaminophen Injection	Acetaminophen Injection The serum concentration of Lemborexant can be decreased when it is combined with Acetaminophen.
Vilazodone	Vilazodone The risk or severity of adverse effects can be increased when Vilazodone is combined with Lemborexant.
Linagliptin	Linagliptin The serum concentration of Lemborexant can be increased when it is combined with Linagliptin.
Telaprevir	Telaprevir The serum concentration of Lemborexant can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection	Cyclophosphamide Injection The serum concentration of Lemborexant can be decreased when it is combined with Cyclophosphamide.
Rivaroxaban	Rivaroxaban The serum concentration of Lemborexant can be increased when it is combined with Rivaroxaban.
Ticagrelor	Ticagrelor The serum concentration of Lemborexant can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Lemborexant.
Vandetanib	Vandetanib The serum concentration of Lemborexant can be increased when it is combined with Vandetanib.
Clobazam	Clobazam The serum concentration of Lemborexant can be decreased when it is combined with Clobazam.
Vemurafenib	Vemurafenib The serum concentration of Lemborexant can be increased when it is combined with Vemurafenib.
Ivacaftor	Ivacaftor The serum concentration of Lemborexant can be increased when it is combined with Ivacaftor.
Axitinib	Axitinib The metabolism of Lemborexant can be decreased when combined with Axitinib.
Crizotinib	Crizotinib The serum concentration of Lemborexant can be increased when it is combined with Crizotinib.
Cabergoline	Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Lemborexant.
Ambrisentan	Ambrisentan The serum concentration of Lemborexant can be increased when it is combined with Ambrisentan.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Lemborexant.
Carfilzomib Injection	Carfilzomib Injection The serum concentration of Lemborexant can be increased when it is combined with Carfilzomib.
Enzalutamide	Enzalutamide The serum concentration of Lemborexant can be decreased when it is combined with Enzalutamide.
Mirabegron	Mirabegron The serum concentration of Lemborexant can be increased when it is combined with Mirabegron.
Regorafenib	Regorafenib The serum concentration of Lemborexant can be increased when it is combined with Regorafenib.
Bosutinib	Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Lemborexant.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The serum concentration of Lemborexant can be decreased when it is combined with Corticotropin.
Ponatinib	Ponatinib The metabolism of Lemborexant can be decreased when combined with Ponatinib.
Pomalidomide	Pomalidomide The risk or severity of adverse effects can be increased when Pomalidomide is combined with Lemborexant.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The metabolism of Lemborexant can be decreased when combined with Trastuzumab emtansine.
Apixaban	Apixaban The serum concentration of Lemborexant can be increased when it is combined with Apixaban.
Canagliflozin	Canagliflozin The serum concentration of Lemborexant can be increased when it is combined with Canagliflozin.
Dabrafenib	Dabrafenib The serum concentration of Lemborexant can be decreased when it is combined with Dabrafenib.
Ospemifene	Ospemifene The serum concentration of Ospemifene can be decreased when it is combined with Lemborexant.
Trametinib	Trametinib The serum concentration of Lemborexant can be decreased when it is combined with Trametinib.
Dolutegravir	Dolutegravir The serum concentration of Lemborexant can be increased when it is combined with Dolutegravir.
Afatinib	Afatinib The serum concentration of Lemborexant can be increased when it is combined with Afatinib.
Levomilnacipran	Levomilnacipran The risk or severity of adverse effects can be increased when Lemborexant is combined with Levomilnacipran.
Vortioxetine	Vortioxetine The serum concentration of Vortioxetine can be decreased when it is combined with Lemborexant.
Perampanel	Perampanel The serum concentration of Lemborexant can be decreased when it is combined with Perampanel.
Ibrutinib	Ibrutinib The metabolism of Lemborexant can be decreased when combined with Ibrutinib.
Lomitapide	Lomitapide The serum concentration of Lemborexant can be increased when it is combined with Lomitapide.
Simeprevir	Simeprevir The serum concentration of Lemborexant can be increased when it is combined with Simeprevir.
Sofosbuvir	Sofosbuvir The serum concentration of Lemborexant can be increased when it is combined with Sofosbuvir.
Apremilast	Apremilast The metabolism of Lemborexant can be increased when combined with Apremilast.
Ceritinib	Ceritinib The serum concentration of Lemborexant can be increased when it is combined with Ceritinib.
Siltuximab Injection	Siltuximab Injection The serum concentration of Lemborexant can be decreased when it is combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine The serum concentration of Lemborexant can be decreased when it is combined with Eslicarbazepine.
Belinostat Injection	Belinostat Injection The serum concentration of Lemborexant can be increased when it is combined with Belinostat.
Idelalisib	Idelalisib The serum concentration of Lemborexant can be increased when it is combined with Idelalisib.
Testosterone Injection	Testosterone Injection The serum concentration of Lemborexant can be decreased when it is combined with Testosterone.
Oritavancin Injection	Oritavancin Injection The serum concentration of Lemborexant can be decreased when it is combined with Oritavancin.
Vorapaxar	Vorapaxar The serum concentration of Lemborexant can be increased when it is combined with Vorapaxar.
Hydrocodone	Hydrocodone Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant	Suvorexant Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Edoxaban	Edoxaban The serum concentration of Lemborexant can be increased when it is combined with Edoxaban.
Olaparib	Olaparib The metabolism of Lemborexant can be decreased when combined with Olaparib.
Methamphetamine	Methamphetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Lemborexant.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Lemborexant.
Nintedanib	Nintedanib The serum concentration of Lemborexant can be increased when it is combined with Nintedanib.
Secukinumab Injection	Secukinumab Injection The metabolism of Lemborexant can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Lemborexant.
Palbociclib	Palbociclib The serum concentration of Lemborexant can be increased when it is combined with Palbociclib.
Lenvatinib	Lenvatinib The serum concentration of Lemborexant can be decreased when it is combined with Lenvatinib.
Panobinostat	Panobinostat The serum concentration of Lemborexant can be increased when it is combined with Panobinostat.
Haloperidol Injection	Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Lemborexant.
Isavuconazonium Injection	Isavuconazonium Injection The serum concentration of Lemborexant can be decreased when it is combined with Isavuconazonium.
Flibanserin	Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Lemborexant.
Rolapitant	Rolapitant The serum concentration of Lemborexant can be increased when it is combined with Rolapitant.
Prednisolone	Prednisolone The serum concentration of Lemborexant can be decreased when it is combined with Prednisolone.
Daclatasvir	Daclatasvir The serum concentration of Lemborexant can be increased when it is combined with Daclatasvir.
Brexpiprazole	Brexpiprazole The risk or severity of adverse effects can be increased when Brexpiprazole is combined with Lemborexant.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Lemborexant.
Cariprazine	Cariprazine The risk or severity of adverse effects can be increased when Cariprazine is combined with Lemborexant.
Cobimetinib	Cobimetinib The serum concentration of Lemborexant can be increased when it is combined with Cobimetinib.
Osimertinib	Osimertinib The serum concentration of Lemborexant can be decreased when it is combined with Osimertinib.
Rifapentine	Rifapentine The serum concentration of Lemborexant can be decreased when it is combined with Rifapentine.
Lesinurad	Lesinurad The serum concentration of Lemborexant can be decreased when it is combined with Lesinurad.
Dexamethasone Injection	Dexamethasone Injection The serum concentration of Lemborexant can be decreased when it is combined with Dexamethasone.
Brivaracetam Injection	Brivaracetam Injection The serum concentration of Brivaracetam can be decreased when it is combined with Lemborexant.
Venetoclax	Venetoclax The serum concentration of Lemborexant can be increased when it is combined with Venetoclax.
Cobicistat	Cobicistat The serum concentration of Lemborexant can be increased when it is combined with Cobicistat.
Selexipag	Selexipag The serum concentration of Lemborexant can be increased when it is combined with Selexipag.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Pimavanserin is combined with Lemborexant.
Diphenhydramine Injection	Diphenhydramine Injection Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
Rucaparib	Rucaparib The metabolism of Lemborexant can be decreased when combined with Rucaparib.
Brigatinib	Brigatinib The serum concentration of Lemborexant can be decreased when it is combined with Brigatinib.
Doxepin (Insomnia)	Doxepin (Insomnia) Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Lemborexant.
Valbenazine	Valbenazine The metabolism of Lemborexant can be decreased when combined with Valbenazine.
Deflazacort	Deflazacort The metabolism of Lemborexant can be increased when combined with Deflazacort.
Safinamide	Safinamide The metabolism of Lemborexant can be decreased when combined with Safinamide.
Sarilumab Injection	Sarilumab Injection The serum concentration of Lemborexant can be decreased when it is combined with Sarilumab.
Midostaurin	Midostaurin The serum concentration of Lemborexant can be decreased when it is combined with Midostaurin.
Neratinib	Neratinib The serum concentration of Lemborexant can be increased when it is combined with Neratinib.
Enasidenib	Enasidenib The serum concentration of Lemborexant can be decreased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection	Inotuzumab Ozogamicin Injection The serum concentration of Lemborexant can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The serum concentration of Lemborexant can be decreased when it is combined with Fosaprepitant.
Copanlisib Injection	Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Lemborexant.
Delafloxacin	Delafloxacin The serum concentration of Lemborexant can be decreased when it is combined with Delafloxacin.
Abemaciclib	Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Lemborexant.
Betrixaban	Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Lemborexant.
Acalabrutinib	Acalabrutinib The serum concentration of Lemborexant can be increased when it is combined with Acalabrutinib.
Letermovir	Letermovir The metabolism of Lemborexant can be decreased when combined with Letermovir.
Ertugliflozin	Ertugliflozin The serum concentration of Lemborexant can be increased when it is combined with Ertugliflozin.
Buprenorphine Injection	Buprenorphine Injection Buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Apalutamide	Apalutamide The serum concentration of Lemborexant can be decreased when it is combined with Apalutamide.
Avatrombopag	Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Lemborexant.
Baricitinib	Baricitinib The serum concentration of Lemborexant can be increased when it is combined with Baricitinib.
Lofexidine	Lofexidine The therapeutic efficacy of Lemborexant can be increased when used in combination with Lofexidine.
Eliglustat	Eliglustat The serum concentration of Lemborexant can be increased when it is combined with Eliglustat.
Binimetinib	Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Lemborexant.
Ivosidenib	Ivosidenib The serum concentration of Lemborexant can be decreased when it is combined with Ivosidenib.
Lusutrombopag	Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Lemborexant.
Elagolix	Elagolix The serum concentration of Lemborexant can be increased when it is combined with Elagolix.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Lemborexant.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Lemborexant.
Dacomitinib	Dacomitinib The serum concentration of Lemborexant can be increased when it is combined with Dacomitinib.
Duvelisib	Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Lemborexant.
Omadacycline	Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Lemborexant.
Sarecycline	Sarecycline The serum concentration of Lemborexant can be increased when it is combined with Sarecycline.
Stiripentol	Stiripentol The risk or severity of adverse effects can be increased when Stiripentol is combined with Lemborexant.
Talazoparib	Talazoparib The serum concentration of Lemborexant can be increased when it is combined with Talazoparib.
Gilteritinib	Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Lemborexant.
Glasdegib	Glasdegib The serum concentration of Lemborexant can be increased when it is combined with Glasdegib.
Lorlatinib	Lorlatinib The serum concentration of Lemborexant can be decreased when it is combined with Lorlatinib.
Larotrectinib	Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Lemborexant.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The serum concentration of Lemborexant can be decreased when it is combined with Paclitaxel.
Rifamycin	Rifamycin The serum concentration of Lemborexant can be decreased when it is combined with Rifamycin.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Lemborexant can be increased when combined with Emapalumab.
Erdafitinib	Erdafitinib The serum concentration of Lemborexant can be increased when it is combined with Erdafitinib.
Alpelisib	Alpelisib The serum concentration of Lemborexant can be decreased when it is combined with Alpelisib.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Lemborexant.
Solriamfetol	Solriamfetol The risk or severity of adverse effects can be increased when Lemborexant is combined with Solriamfetol.
Darolutamide	Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Lemborexant.
Entrectinib	Entrectinib The serum concentration of Lemborexant can be increased when it is combined with Entrectinib.
Istradefylline	Istradefylline The serum concentration of Istradefylline can be decreased when it is combined with Lemborexant.
Pitolisant	Pitolisant The serum concentration of Lemborexant can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib The serum concentration of Lemborexant can be increased when it is combined with Fedratinib.
Lefamulin	Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Lemborexant.
Phenytoin Injection	Phenytoin Injection The serum concentration of Lemborexant can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The serum concentration of Lemborexant can be decreased when it is combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection	Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Lemborexant.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Lemborexant.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be decreased when it is combined with Lemborexant.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Lemborexant.
Lasmiditan	Lasmiditan The serum concentration of Lemborexant can be increased when it is combined with Lasmiditan.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Lemborexant.
Tazemetostat	Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Lemborexant.
Cenobamate	Cenobamate The serum concentration of Lemborexant can be decreased when it is combined with Cenobamate.
Selumetinib	Selumetinib The serum concentration of Lemborexant can be increased when it is combined with Selumetinib.
Rimegepant	Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Lemborexant.
Tucatinib	Tucatinib Tucatinib may decrease the excretion rate of Lemborexant which could result in a higher serum level.
Remdesivir Injection	Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Lemborexant.
Ripretinib	Ripretinib The serum concentration of Lemborexant can be increased when it is combined with Ripretinib.
Fenfluramine	Fenfluramine The risk or severity of adverse effects can be increased when Fenfluramine is combined with Lemborexant.
Fostemsavir	Fostemsavir The serum concentration of Lemborexant can be increased when it is combined with Fostemsavir.
Belantamab Mafodotin-blmf Injection	Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Lemborexant.
Pralsetinib	Pralsetinib The serum concentration of Lemborexant can be increased when it is combined with Pralsetinib.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Lemborexant can be decreased when it is combined with Satralizumab.
Viloxazine	Viloxazine The risk or severity of adverse effects can be increased when Viloxazine is combined with Lemborexant.
Trazodone	Trazodone The risk or severity of adverse effects can be increased when Trazodone is combined with Lemborexant.
Phenobarbital	Phenobarbital The serum concentration of Lemborexant can be decreased when it is combined with Phenobarbital.
Metaxalone	Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Lemborexant.
Levorphanol	Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Lemborexant.
Primidone	Primidone The serum concentration of Lemborexant can be decreased when it is combined with Primidone.
Methsuximide	Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Lemborexant.
Diethylpropion	Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Lemborexant.
Chlorpromazine	Chlorpromazine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Lemborexant.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Lemborexant.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Lemborexant.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Lemborexant.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Lemborexant.
Codeine	Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Lemborexant.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Lemborexant.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lemborexant.
Bromocriptine	Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Lemborexant.
Tranylcypromine	Tranylcypromine The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Lemborexant.
Phenelzine	Phenelzine The metabolism of Lemborexant can be decreased when combined with Phenelzine.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Lemborexant.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Lemborexant.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Prochlorperazine	Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Lemborexant.
Thioridazine	Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Lemborexant.
Trifluoperazine	Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Lemborexant.
Dapsone	Dapsone The metabolism of Lemborexant can be decreased when combined with Dapsone.
Oxycodone	Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Lemborexant.
Methadone	Methadone The risk or severity of adverse effects can be increased when Lemborexant is combined with Methadone.
Oxybutynin	Oxybutynin Oxybutynin may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Benztropine	Benztropine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline	Maprotiline Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Trihexyphenidyl	Trihexyphenidyl Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Lemborexant.
Fluphenazine	Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Lemborexant.
Amoxapine	Amoxapine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Hydrocortisone	Hydrocortisone The serum concentration of Lemborexant can be decreased when it is combined with Hydrocortisone.
Dactinomycin	Dactinomycin The serum concentration of Lemborexant can be increased when it is combined with Dactinomycin.
Pyridostigmine	Pyridostigmine The serum concentration of Lemborexant can be decreased when it is combined with Pyridostigmine.
Carbamazepine	Carbamazepine The serum concentration of Lemborexant can be decreased when it is combined with Carbamazepine.
Molindone	Molindone The risk or severity of adverse effects can be increased when Molindone is combined with Lemborexant.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Lemborexant.
Cimetidine	Cimetidine The serum concentration of Lemborexant can be increased when it is combined with Cimetidine.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Lemborexant.
Loperamide	Loperamide The serum concentration of Loperamide can be decreased when it is combined with Lemborexant.
Promethazine	Promethazine The serum concentration of Promethazine can be decreased when it is combined with Lemborexant.
Daunorubicin	Daunorubicin The serum concentration of Lemborexant can be decreased when it is combined with Daunorubicin.
Griseofulvin	Griseofulvin The serum concentration of Lemborexant can be decreased when it is combined with Griseofulvin.
Digoxin	Digoxin The serum concentration of Digoxin can be increased when it is combined with Lemborexant.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Lemborexant.
Chloroquine	Chloroquine The metabolism of Lemborexant can be decreased when combined with Chloroquine.
Quinine	Quinine The serum concentration of Lemborexant can be decreased when it is combined with Quinine.
Ethosuximide	Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Lemborexant.
Calcitriol	Calcitriol The serum concentration of Lemborexant can be decreased when it is combined with Calcitriol.
Sulfinpyrazone	Sulfinpyrazone The serum concentration of Lemborexant can be decreased when it is combined with Sulfinpyrazone.
Clindamycin Injection	Clindamycin Injection The metabolism of Lemborexant can be decreased when combined with Clindamycin.
Secobarbital	Secobarbital The serum concentration of Lemborexant can be decreased when it is combined with Secobarbital.
Desipramine	Desipramine The serum concentration of Desipramine can be decreased when it is combined with Lemborexant.
Amitriptyline	Amitriptyline The serum concentration of Amitriptyline can be decreased when it is combined with Lemborexant.
Imipramine	Imipramine The serum concentration of Imipramine can be decreased when it is combined with Lemborexant.
Probenecid	Probenecid The serum concentration of Lemborexant can be decreased when it is combined with Probenecid.
Quinidine	Quinidine The serum concentration of Quinidine can be increased when it is combined with Lemborexant.
Rifampin	Rifampin The serum concentration of Lemborexant can be decreased when it is combined with Rifampicin.
Disopyramide	Disopyramide Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid	Valproic Acid The serum concentration of Valproic acid can be decreased when it is combined with Lemborexant.
Tamoxifen	Tamoxifen The serum concentration of Lemborexant can be decreased when it is combined with Tamoxifen.
Butabarbital	Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Lemborexant.
Dextromethorphan	Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Lemborexant.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Lemborexant.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Lemborexant.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Cyproheptadine	Cyproheptadine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine	Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Lemborexant.
Chlorpheniramine	Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Lemborexant.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Lemborexant.
Meclizine	Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Lemborexant.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Lemborexant.
Chlorzoxazone	Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Lemborexant.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Lemborexant.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Lemborexant.
Disulfiram	Disulfiram The metabolism of Lemborexant can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The metabolism of Lemborexant can be decreased when combined with Propranolol.
Nortriptyline	Nortriptyline Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
Butorphanol Injection	Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Lemborexant.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Lemborexant.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Lemborexant.
Clomiphene	Clomiphene The serum concentration of Lemborexant can be increased when it is combined with Clomifene.
Flavoxate	Flavoxate Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Colchicine	Colchicine The serum concentration of Lemborexant can be decreased when it is combined with Colchicine.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Lemborexant.
Ketoconazole	Ketoconazole The serum concentration of Lemborexant can be increased when it is combined with Ketoconazole.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Lemborexant.
Vincristine Injection	Vincristine Injection The metabolism of Lemborexant can be decreased when combined with Vincristine.
Vinblastine	Vinblastine The serum concentration of Lemborexant can be decreased when it is combined with Vinblastine.
Hydroxyzine	Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Thiothixene is combined with Lemborexant.
Alprazolam	Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Lemborexant.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Lemborexant.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Lemborexant.
Dicyclomine	Dicyclomine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine	Hyoscyamine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline	Propantheline Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Diltiazem	Diltiazem The serum concentration of Lemborexant can be increased when it is combined with Diltiazem.
Nifedipine	Nifedipine The serum concentration of Lemborexant can be decreased when it is combined with Nifedipine.
Verapamil	Verapamil The serum concentration of Lemborexant can be increased when it is combined with Verapamil.
Pindolol	Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Lemborexant.
Etoposide	Etoposide The serum concentration of Lemborexant can be decreased when it is combined with Etoposide.
Glyburide	Glyburide The metabolism of Lemborexant can be decreased when combined with Glyburide.
Dicloxacillin	Dicloxacillin The serum concentration of Lemborexant can be decreased when it is combined with Dicloxacillin.
Nafcillin Injection	Nafcillin Injection The serum concentration of Lemborexant can be decreased when it is combined with Nafcillin.
Pentamidine Injection	Pentamidine Injection The metabolism of Lemborexant can be decreased when combined with Pentamidine.
Pimozide	Pimozide The metabolism of Lemborexant can be decreased when combined with Pimozide.
Amiodarone	Amiodarone The serum concentration of Lemborexant can be increased when it is combined with Amiodarone.
Buspirone	Buspirone The metabolism of Lemborexant can be decreased when combined with Buspirone.
Lovastatin	Lovastatin The metabolism of Lemborexant can be decreased when combined with Lovastatin.
Ciprofloxacin	Ciprofloxacin The serum concentration of Lemborexant can be increased when it is combined with Ciprofloxacin.
Diclofenac	Diclofenac The serum concentration of Diclofenac can be decreased when it is combined with Lemborexant.
Oxiconazole	Oxiconazole The serum concentration of Lemborexant can be decreased when it is combined with Oxiconazole.
Fluoxetine	Fluoxetine The serum concentration of Fluoxetine can be decreased when it is combined with Lemborexant.
Clozapine	Clozapine The serum concentration of Lemborexant can be decreased when it is combined with Clozapine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Estazolam is combined with Lemborexant.
Clarithromycin	Clarithromycin The serum concentration of Lemborexant can be increased when it is combined with Clarithromycin.
Felodipine	Felodipine The metabolism of Lemborexant can be decreased when combined with Felodipine.
Pravastatin	Pravastatin The serum concentration of Lemborexant can be increased when it is combined with Pravastatin.
Simvastatin	Simvastatin The serum concentration of Lemborexant can be increased when it is combined with Simvastatin.
Teniposide Injection	Teniposide Injection The metabolism of Lemborexant can be decreased when combined with Teniposide.
Itraconazole	Itraconazole The serum concentration of Lemborexant can be increased when it is combined with Itraconazole.
Rifabutin	Rifabutin The serum concentration of Lemborexant can be decreased when it is combined with Rifabutin.
Bisoprolol	Bisoprolol The serum concentration of Lemborexant can be increased when it is combined with Bisoprolol.
Zolpidem	Zolpidem Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Omeprazole	Omeprazole The serum concentration of Lemborexant can be decreased when it is combined with Omeprazole.
Cisapride	Cisapride The serum concentration of Cisapride can be decreased when it is combined with Lemborexant.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Lemborexant.
Fluvastatin	Fluvastatin The metabolism of Lemborexant can be decreased when combined with Fluvastatin.
Venlafaxine	Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Lemborexant.
Fluvoxamine	Fluvoxamine The serum concentration of Lemborexant can be increased when it is combined with Fluvoxamine.
Nefazodone	Nefazodone The serum concentration of Lemborexant can be increased when it is combined with Nefazodone.
Lamotrigine	Lamotrigine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
Tramadol	Tramadol The serum concentration of Tramadol can be decreased when it is combined with Lemborexant.
Lansoprazole	Lansoprazole The serum concentration of Lemborexant can be decreased when it is combined with Lansoprazole.
Ifosfamide Injection	Ifosfamide Injection The serum concentration of Lemborexant can be decreased when it is combined with Ifosfamide.
Nicardipine	Nicardipine The serum concentration of Lemborexant can be increased when it is combined with Nicardipine.
Bupropion	Bupropion The serum concentration of Bupropion can be decreased when it is combined with Lemborexant.
Saquinavir	Saquinavir The metabolism of Lemborexant can be decreased when combined with Saquinavir.
Nisoldipine	Nisoldipine The metabolism of Lemborexant can be decreased when combined with Nisoldipine.
Riluzole	Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Lemborexant.
Gemcitabine Injection	Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Lemborexant.
Indinavir	Indinavir The serum concentration of Lemborexant can be increased when it is combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of Lemborexant can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The metabolism of Lemborexant can be decreased when combined with Docetaxel.
Clomipramine	Clomipramine The serum concentration of Clomipramine can be decreased when it is combined with Lemborexant.
Mirtazapine	Mirtazapine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Topiramate	Topiramate The serum concentration of Lemborexant can be decreased when it is combined with Topiramate.
Pramipexole	Pramipexole Lemborexant may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Lemborexant.
Nelfinavir	Nelfinavir The serum concentration of Lemborexant can be increased when it is combined with Nelfinavir.
Fexofenadine	Fexofenadine The serum concentration of Lemborexant can be increased when it is combined with Fexofenadine.
Carvedilol	Carvedilol The serum concentration of Lemborexant can be increased when it is combined with Carvedilol.
Flutamide	Flutamide The metabolism of Lemborexant can be decreased when combined with Flutamide.
Selegiline	Selegiline The serum concentration of Selegiline can be decreased when it is combined with Lemborexant.
Sertraline	Sertraline The risk or severity of adverse effects can be increased when Lemborexant is combined with Sertraline.
Propafenone	Propafenone The serum concentration of Lemborexant can be increased when it is combined with Propafenone.
Ropinirole	Ropinirole Lemborexant may increase the sedative activities of Ropinirole.
Finasteride	Finasteride The metabolism of Lemborexant can be decreased when combined with Finasteride.
Quetiapine	Quetiapine Quetiapine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Lemborexant.
Paroxetine	Paroxetine The serum concentration of Lemborexant can be increased when it is combined with Paroxetine.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Lemborexant.
Citalopram	Citalopram The risk or severity of adverse effects can be increased when Lemborexant is combined with Citalopram.
Efavirenz	Efavirenz The serum concentration of Lemborexant can be decreased when it is combined with Efavirenz.
Sildenafil	Sildenafil The serum concentration of Lemborexant can be increased when it is combined with Sildenafil.
Tolterodine	Tolterodine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide	Thalidomide Thalidomide may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Nateglinide	Nateglinide The metabolism of Lemborexant can be decreased when combined with Nateglinide.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Lemborexant.
Terbinafine	Terbinafine The serum concentration of Lemborexant can be decreased when it is combined with Terbinafine.