Lemborexant

Generic name: Pronounced as (lem'' boe rex' ant)
Brand names
  • Dayvigo®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2022

Lemborexant is used to treat insomnia (difficulty falling asleep or staying asleep). Lemborexant belongs to a class of medications called hypnotics. It works by slowing activity in the brain to allow sleep.

Lemborexant comes as a tablet to take by mouth. It is usually taken as needed, not more than one time a day, immediately before bedtime. Lemborexant will work faster if it is not taken with a meal or immediately after a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lemborexant exactly as directed.

You will probably become very sleepy soon after you take lemborexant and will remain sleepy for some time after you take the medication. Plan to go to bed right after you take lemborexant and to stay in bed for at least 7 hours. Do not take lemborexant if you will be unable to go to bed right away and remain asleep for at least 7 hours after taking the medication.

You should be sleeping well within 7 to 10 days after you start taking lemborexant. Call your doctor if your sleep problems do not improve during this time, if they get worse at any time during your treatment, or if you notice any changes in your thoughts or behavior.

Lemborexant may be habit forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lemborexant and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking lemborexant,

  • tell your doctor and pharmacist if you are allergic to lemborexant, any other medications, or any of the ingredients in lemborexant tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: Bosentan (Tracleer); bupropion (Aplenzin, Forfivo, Wellbutrin); carbamazepine (Carbatrol, Epitol, Tegretol, others); clarithromycin; chlorzoxazone; efavirenz (Sustiva, in Atripla, in Symfi); etravirine (Intelence); fluconazole (Diflucan); itraconazole (Onmel, Sporanox, Tolsura); medications for anxiety and pain; methadone (Dolophine, Methadose); modafinil (Provigil); ranitidine (Zantac); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sedatives, sleeping pills, and tranquilizers; tricyclic antidepressants such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and verapamil (Calan, Verelan, in Tarka). Your doctor may tell you not to take lemborexant, may need to change the doses of your medications, or monitor you carefully for side effects. Many other medications may also interact with lemborexant, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking, especially St. John's wort.

  • tell your doctor if you have narcolepsy (a condition that causes excessive daytime sleepiness). Your doctor will probably tell you not to take lemborexant.

  • tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications. Also tell your doctor if you have or have ever had depression; mental illness; thoughts of harming or killing yourself or trying to do so; a problem with heavy snoring; sleep apnea (condition in which breathing briefly stops many times during the night); other breathing problems or lung diseases such as asthma, bronchitis, and emphysema; cataplexy (episodes of muscle weakness that begin suddenly and last for a short time); or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking lemborexant, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lemborexant.

  • you should know that this medication may cause drowsiness, decreased mental alertness, prolonged reaction time, problems with coordination the day after you take it, blurry or double vision, and may increase the risk that you could fall. Take extra care to be sure you do not fall, especially if you get out of bed in the middle of the night. Your ability to drive or operate machinery the day after you take lemborexant may be impaired even if you feel fully awake. Do not drive a car or operate machinery until you know how lemborexant affects you.

  • do not drink alcohol during your treatment with lemborexant. Alcohol can make the side effects of lemborexant worse.

  • you should know that lemborexant has caused serious or possibly life-threatening sleep behaviors. Some people who took lemborexant got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, sleep-walked, or were involved in other activities while not fully awake. After they woke up, these people were unable to remember what they had done. These activities may occur with lemborexant whether or not you drink alcohol or also take other sleep medications. Call your doctor right away if you have ever had an unusual sleep behavior while taking lemborexant.

Unless your doctor tells you otherwise, continue your normal diet.

  • Lemborexant may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • drowsiness

    • tiredness

    • headache

    • vivid, unusual dreams or nightmares

  • Some side effects can be serious. If you experience any of these symptoms, stop taking lemborexant and call your doctor immediately:

    • temporary inability to move or talk while you are going to sleep or waking up (sleep paralysis)

    • sudden and temporary weakness of legs

    • new or worsening depression or anxiety

    • thoughts of suicide, dying, or hurting yourself, or planning or trying to do so

    • sudden onset of muscle weakness

    • pounding heartbeat

  • Lemborexant may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • drowsiness

Keep all appointments with your doctor.

Do not let anyone else take your medication. Lemborexant is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Lemborexant can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The serum concentration of Nevirapine can be decreased when it is combined with Lemborexant.
Atorvastatin Atorvastatin The serum concentration of Lemborexant can be decreased when it is combined with Atorvastatin.
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Dolasetron is combined with Lemborexant.
Cilostazol Cilostazol The metabolism of Lemborexant can be decreased when combined with Cilostazol.
Clopidogrel Clopidogrel The serum concentration of Clopidogrel can be decreased when it is combined with Lemborexant.
Diphenoxylate Diphenoxylate The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Lemborexant.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Lemborexant can be decreased when combined with Erythromycin.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Guanfacine is combined with Lemborexant.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Naratriptan is combined with Lemborexant.
Paregoric Paregoric The risk or severity of adverse effects can be increased when Morphine is combined with Lemborexant.
Pentazocine Pentazocine The risk or severity of adverse effects can be increased when Pentazocine is combined with Lemborexant.
Reserpine Reserpine The serum concentration of Lemborexant can be decreased when it is combined with Reserpine.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Rizatriptan is combined with Lemborexant.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Sumatriptan is combined with Lemborexant.
Tacrolimus Tacrolimus The metabolism of Lemborexant can be decreased when combined with Tacrolimus.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Lemborexant.
Triamcinolone Triamcinolone The metabolism of Lemborexant can be increased when combined with Triamcinolone.
Zolmitriptan Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Lemborexant.
Fluconazole Injection Fluconazole Injection The serum concentration of Lemborexant can be increased when it is combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The risk or severity of adverse effects can be increased when Hydromorphone is combined with Lemborexant.
Meperidine Injection Meperidine Injection The serum concentration of Lemborexant can be decreased when it is combined with Meperidine.
Methylprednisolone Injection Methylprednisolone Injection The serum concentration of Lemborexant can be decreased when it is combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Lemborexant.
Metronidazole Injection Metronidazole Injection The metabolism of Lemborexant can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The risk or severity of adverse effects can be increased when Morphine is combined with Lemborexant.
Altretamine Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Lemborexant.
Cyclosporine Cyclosporine The metabolism of Lemborexant can be decreased when combined with Cyclosporine.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Ondansetron is combined with Lemborexant.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Granisetron is combined with Lemborexant.
Olanzapine Olanzapine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Alosetron is combined with Lemborexant.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Lemborexant.
Orlistat Orlistat The serum concentration of Lemborexant can be decreased when it is combined with Orlistat.
Oxcarbazepine Oxcarbazepine The serum concentration of Lemborexant can be decreased when it is combined with Oxcarbazepine.
Temozolomide Temozolomide The serum concentration of Lemborexant can be decreased when it is combined with Temozolomide.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Zaleplon is combined with Lemborexant.
Anakinra Anakinra The metabolism of Lemborexant can be increased when combined with Anakinra.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Desloratadine is combined with Lemborexant.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Lemborexant.
Trimipramine Trimipramine The serum concentration of Trimipramine can be decreased when it is combined with Lemborexant.
Etanercept Injection Etanercept Injection The metabolism of Lemborexant can be increased when combined with Etanercept.
Glycopyrrolate Glycopyrrolate Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Modafinil Modafinil The serum concentration of Lemborexant can be increased when it is combined with Modafinil.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Lemborexant.
Sirolimus Sirolimus The metabolism of Lemborexant can be decreased when combined with Sirolimus.
Dutasteride Dutasteride The metabolism of Lemborexant can be decreased when combined with Dutasteride.
Eplerenone Eplerenone The metabolism of Lemborexant can be decreased when combined with Eplerenone.
Escitalopram Escitalopram The risk or severity of adverse effects can be increased when Lemborexant is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Zonisamide is combined with Lemborexant.
Adalimumab Injection Adalimumab Injection The metabolism of Lemborexant can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole Aripiprazole may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Lemborexant.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Dexmethylphenidate is combined with Lemborexant.
Atazanavir Atazanavir The serum concentration of Lemborexant can be increased when it is combined with Atazanavir.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Almotriptan is combined with Lemborexant.
Eletriptan Eletriptan The serum concentration of Lemborexant can be decreased when it is combined with Eletriptan.
Rosuvastatin Rosuvastatin The metabolism of Lemborexant can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Lemborexant can be increased when it is combined with Vardenafil.
Aprepitant Aprepitant The metabolism of Lemborexant can be decreased when combined with Aprepitant.
Tegaserod Tegaserod The serum concentration of Lemborexant can be increased when it is combined with Tegaserod.
Tadalafil Tadalafil The metabolism of Lemborexant can be decreased when combined with Tadalafil.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Frovatriptan is combined with Lemborexant.
Progesterone Progesterone The serum concentration of Lemborexant can be increased when it is combined with Progesterone.
Apomorphine Injection Apomorphine Injection The serum concentration of Lemborexant can be decreased when it is combined with Apomorphine.
Infliximab Injection Infliximab Injection The metabolism of Lemborexant can be increased when combined with Infliximab.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Lemborexant.
Rifaximin Rifaximin The serum concentration of Lemborexant can be decreased when it is combined with Rifaximin.
Duloxetine Duloxetine The risk or severity of adverse effects can be increased when Lemborexant is combined with Duloxetine.
Norethindrone Norethindrone The metabolism of Lemborexant can be decreased when combined with Norethisterone.
Trospium Trospium Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Bosentan Bosentan The serum concentration of Lemborexant can be decreased when it is combined with Bosentan.
Erlotinib Erlotinib The metabolism of Lemborexant can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Lemborexant is combined with Eszopiclone.
Solifenacin Solifenacin Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Voriconazole Voriconazole The metabolism of Lemborexant can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Lemborexant.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Isocarboxazid is combined with Lemborexant.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Ramelteon is combined with Lemborexant.
Darifenacin Darifenacin Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Fentanyl is combined with Lemborexant.
Pregabalin Pregabalin The therapeutic efficacy of Lemborexant can be increased when used in combination with Pregabalin.
Deferasirox Deferasirox The serum concentration of Lemborexant can be decreased when it is combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Lemborexant can be increased when it is combined with Tipranavir.
Felbamate Felbamate The serum concentration of Lemborexant can be decreased when it is combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Lemborexant can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Lemborexant can be increased when combined with Abatacept.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Rasagiline is combined with Lemborexant.
Imatinib Imatinib The metabolism of Lemborexant can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Lemborexant can be increased when it is combined with Sitagliptin.
Gefitinib Gefitinib The metabolism of Lemborexant can be decreased when combined with Gefitinib.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Paliperidone is combined with Lemborexant.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Lemborexant.
Posaconazole Posaconazole The serum concentration of Lemborexant can be increased when it is combined with Posaconazole.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Dimenhydrinate is combined with Lemborexant.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Sorafenib Sorafenib The metabolism of Lemborexant can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Lemborexant can be decreased when combined with Sunitinib.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Lapatinib Lapatinib The serum concentration of Lemborexant can be increased when it is combined with Lapatinib.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Levocetirizine is combined with Lemborexant.
Dasatinib Dasatinib The metabolism of Lemborexant can be decreased when combined with Dasatinib.
Mexiletine Mexiletine The serum concentration of Mexiletine can be decreased when it is combined with Lemborexant.
Armodafinil Armodafinil The serum concentration of Lemborexant can be decreased when it is combined with Armodafinil.
Temsirolimus Temsirolimus The metabolism of Lemborexant can be decreased when combined with Temsirolimus.
Nilotinib Nilotinib The serum concentration of Lemborexant can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Lemborexant can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The serum concentration of Lemborexant can be decreased when it is combined with Bexarotene.
Budesonide Budesonide The serum concentration of Lemborexant can be decreased when it is combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Lemborexant can be decreased when combined with Chloramphenicol.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lemborexant.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Lemborexant.
Etravirine Etravirine The serum concentration of Lemborexant can be decreased when it is combined with Etravirine.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Lemborexant is combined with Desvenlafaxine.
Tretinoin Tretinoin The serum concentration of Tretinoin can be decreased when it is combined with Lemborexant.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Lemborexant.
Certolizumab Injection Certolizumab Injection The metabolism of Lemborexant can be increased when combined with Certolizumab pegol.
Irinotecan Injection Irinotecan Injection The serum concentration of Irinotecan can be decreased when it is combined with Lemborexant.
Praziquantel Praziquantel The metabolism of Lemborexant can be decreased when combined with Praziquantel.
Mitotane Mitotane The serum concentration of Lemborexant can be decreased when it is combined with Mitotane.
Rufinamide Rufinamide The serum concentration of Lemborexant can be decreased when it is combined with Rufinamide.
Silodosin Silodosin The serum concentration of Lemborexant can be increased when it is combined with Silodosin.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Midazolam is combined with Lemborexant.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Lemborexant is combined with Milnacipran.
Fesoterodine Fesoterodine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Iloperidone is combined with Lemborexant.
Prasugrel Prasugrel The serum concentration of Prasugrel can be decreased when it is combined with Lemborexant.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Lacosamide is combined with Lemborexant.
Everolimus Everolimus The serum concentration of Lemborexant can be increased when it is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Lemborexant can be increased when it is combined with Tolvaptan.
Dronedarone Dronedarone The metabolism of Lemborexant can be decreased when combined with Dronedarone.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lemborexant.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Lemborexant.
Saxagliptin Saxagliptin The metabolism of Lemborexant can be decreased when combined with Saxagliptin.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be decreased when it is combined with Lemborexant.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Topotecan Topotecan The serum concentration of Lemborexant can be decreased when it is combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Lemborexant can be increased when combined with Golimumab.
Pazopanib Pazopanib The serum concentration of Lemborexant can be increased when it is combined with Pazopanib.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Asenapine is combined with Lemborexant.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Vigabatrin is combined with Lemborexant.
Levonorgestrel Levonorgestrel The metabolism of Lemborexant can be decreased when combined with Levonorgestrel.
Oxymorphone Oxymorphone The risk or severity of adverse effects can be increased when Oxymorphone is combined with Lemborexant.
Tocilizumab Injection Tocilizumab Injection The serum concentration of Lemborexant can be decreased when it is combined with Tocilizumab.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Lemborexant.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Lemborexant can be decreased when combined with Cabazitaxel.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Lurasidone is combined with Lemborexant.
Acetaminophen Injection Acetaminophen Injection The serum concentration of Lemborexant can be decreased when it is combined with Acetaminophen.
Vilazodone Vilazodone The risk or severity of adverse effects can be increased when Vilazodone is combined with Lemborexant.
Linagliptin Linagliptin The serum concentration of Lemborexant can be increased when it is combined with Linagliptin.
Telaprevir Telaprevir The serum concentration of Lemborexant can be increased when it is combined with Glecaprevir.
Cyclophosphamide Injection Cyclophosphamide Injection The serum concentration of Lemborexant can be decreased when it is combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The serum concentration of Lemborexant can be increased when it is combined with Rivaroxaban.
Ticagrelor Ticagrelor The serum concentration of Lemborexant can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Lemborexant.
Vandetanib Vandetanib The serum concentration of Lemborexant can be increased when it is combined with Vandetanib.
Clobazam Clobazam The serum concentration of Lemborexant can be decreased when it is combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Lemborexant can be increased when it is combined with Vemurafenib.
Ivacaftor Ivacaftor The serum concentration of Lemborexant can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The metabolism of Lemborexant can be decreased when combined with Axitinib.
Crizotinib Crizotinib The serum concentration of Lemborexant can be increased when it is combined with Crizotinib.
Cabergoline Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Lemborexant.
Ambrisentan Ambrisentan The serum concentration of Lemborexant can be increased when it is combined with Ambrisentan.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Tiagabine is combined with Lemborexant.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Lemborexant can be increased when it is combined with Carfilzomib.
Enzalutamide Enzalutamide The serum concentration of Lemborexant can be decreased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Lemborexant can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The serum concentration of Lemborexant can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Lemborexant.
Corticotropin, Repository Injection Corticotropin, Repository Injection The serum concentration of Lemborexant can be decreased when it is combined with Corticotropin.
Ponatinib Ponatinib The metabolism of Lemborexant can be decreased when combined with Ponatinib.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Pomalidomide is combined with Lemborexant.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Lemborexant can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The serum concentration of Lemborexant can be increased when it is combined with Apixaban.
Canagliflozin Canagliflozin The serum concentration of Lemborexant can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Lemborexant can be decreased when it is combined with Dabrafenib.
Ospemifene Ospemifene The serum concentration of Ospemifene can be decreased when it is combined with Lemborexant.
Trametinib Trametinib The serum concentration of Lemborexant can be decreased when it is combined with Trametinib.
Dolutegravir Dolutegravir The serum concentration of Lemborexant can be increased when it is combined with Dolutegravir.
Afatinib Afatinib The serum concentration of Lemborexant can be increased when it is combined with Afatinib.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Lemborexant is combined with Levomilnacipran.
Vortioxetine Vortioxetine The serum concentration of Vortioxetine can be decreased when it is combined with Lemborexant.
Perampanel Perampanel The serum concentration of Lemborexant can be decreased when it is combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Lemborexant can be decreased when combined with Ibrutinib.
Lomitapide Lomitapide The serum concentration of Lemborexant can be increased when it is combined with Lomitapide.
Simeprevir Simeprevir The serum concentration of Lemborexant can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Lemborexant can be increased when it is combined with Sofosbuvir.
Apremilast Apremilast The metabolism of Lemborexant can be increased when combined with Apremilast.
Ceritinib Ceritinib The serum concentration of Lemborexant can be increased when it is combined with Ceritinib.
Siltuximab Injection Siltuximab Injection The serum concentration of Lemborexant can be decreased when it is combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The serum concentration of Lemborexant can be decreased when it is combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Lemborexant can be increased when it is combined with Belinostat.
Idelalisib Idelalisib The serum concentration of Lemborexant can be increased when it is combined with Idelalisib.
Testosterone Injection Testosterone Injection The serum concentration of Lemborexant can be decreased when it is combined with Testosterone.
Oritavancin Injection Oritavancin Injection The serum concentration of Lemborexant can be decreased when it is combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Lemborexant can be increased when it is combined with Vorapaxar.
Hydrocodone Hydrocodone Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant Suvorexant Suvorexant may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Edoxaban Edoxaban The serum concentration of Lemborexant can be increased when it is combined with Edoxaban.
Olaparib Olaparib The metabolism of Lemborexant can be decreased when combined with Olaparib.
Methamphetamine Methamphetamine The risk or severity of adverse effects can be increased when Metamfetamine is combined with Lemborexant.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Tasimelteon is combined with Lemborexant.
Nintedanib Nintedanib The serum concentration of Lemborexant can be increased when it is combined with Nintedanib.
Secukinumab Injection Secukinumab Injection The metabolism of Lemborexant can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Risperidone is combined with Lemborexant.
Palbociclib Palbociclib The serum concentration of Lemborexant can be increased when it is combined with Palbociclib.
Lenvatinib Lenvatinib The serum concentration of Lemborexant can be decreased when it is combined with Lenvatinib.
Panobinostat Panobinostat The serum concentration of Lemborexant can be increased when it is combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Lemborexant.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Lemborexant can be decreased when it is combined with Isavuconazonium.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Flibanserin is combined with Lemborexant.
Rolapitant Rolapitant The serum concentration of Lemborexant can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The serum concentration of Lemborexant can be decreased when it is combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Lemborexant can be increased when it is combined with Daclatasvir.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Brexpiprazole is combined with Lemborexant.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Lemborexant.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Cariprazine is combined with Lemborexant.
Cobimetinib Cobimetinib The serum concentration of Lemborexant can be increased when it is combined with Cobimetinib.
Osimertinib Osimertinib The serum concentration of Lemborexant can be decreased when it is combined with Osimertinib.
Rifapentine Rifapentine The serum concentration of Lemborexant can be decreased when it is combined with Rifapentine.
Lesinurad Lesinurad The serum concentration of Lemborexant can be decreased when it is combined with Lesinurad.
Dexamethasone Injection Dexamethasone Injection The serum concentration of Lemborexant can be decreased when it is combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection The serum concentration of Brivaracetam can be decreased when it is combined with Lemborexant.
Venetoclax Venetoclax The serum concentration of Lemborexant can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Lemborexant can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Lemborexant can be increased when it is combined with Selexipag.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Pimavanserin is combined with Lemborexant.
Diphenhydramine Injection Diphenhydramine Injection Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
Rucaparib Rucaparib The metabolism of Lemborexant can be decreased when combined with Rucaparib.
Brigatinib Brigatinib The serum concentration of Lemborexant can be decreased when it is combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Lemborexant.
Valbenazine Valbenazine The metabolism of Lemborexant can be decreased when combined with Valbenazine.
Deflazacort Deflazacort The metabolism of Lemborexant can be increased when combined with Deflazacort.
Safinamide Safinamide The metabolism of Lemborexant can be decreased when combined with Safinamide.
Sarilumab Injection Sarilumab Injection The serum concentration of Lemborexant can be decreased when it is combined with Sarilumab.
Midostaurin Midostaurin The serum concentration of Lemborexant can be decreased when it is combined with Midostaurin.
Neratinib Neratinib The serum concentration of Lemborexant can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The serum concentration of Lemborexant can be decreased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Lemborexant can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The serum concentration of Lemborexant can be decreased when it is combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Lemborexant.
Delafloxacin Delafloxacin The serum concentration of Lemborexant can be decreased when it is combined with Delafloxacin.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Lemborexant.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Lemborexant.
Acalabrutinib Acalabrutinib The serum concentration of Lemborexant can be increased when it is combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Lemborexant can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The serum concentration of Lemborexant can be increased when it is combined with Ertugliflozin.
Buprenorphine Injection Buprenorphine Injection Buprenorphine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Apalutamide Apalutamide The serum concentration of Lemborexant can be decreased when it is combined with Apalutamide.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Lemborexant.
Baricitinib Baricitinib The serum concentration of Lemborexant can be increased when it is combined with Baricitinib.
Lofexidine Lofexidine The therapeutic efficacy of Lemborexant can be increased when used in combination with Lofexidine.
Eliglustat Eliglustat The serum concentration of Lemborexant can be increased when it is combined with Eliglustat.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Lemborexant.
Ivosidenib Ivosidenib The serum concentration of Lemborexant can be decreased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Lemborexant.
Elagolix Elagolix The serum concentration of Lemborexant can be increased when it is combined with Elagolix.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Lemborexant.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Lemborexant.
Dacomitinib Dacomitinib The serum concentration of Lemborexant can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Lemborexant.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Lemborexant.
Sarecycline Sarecycline The serum concentration of Lemborexant can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The risk or severity of adverse effects can be increased when Stiripentol is combined with Lemborexant.
Talazoparib Talazoparib The serum concentration of Lemborexant can be increased when it is combined with Talazoparib.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Lemborexant.
Glasdegib Glasdegib The serum concentration of Lemborexant can be increased when it is combined with Glasdegib.
Lorlatinib Lorlatinib The serum concentration of Lemborexant can be decreased when it is combined with Lorlatinib.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Lemborexant.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The serum concentration of Lemborexant can be decreased when it is combined with Paclitaxel.
Rifamycin Rifamycin The serum concentration of Lemborexant can be decreased when it is combined with Rifamycin.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Lemborexant can be increased when combined with Emapalumab.
Erdafitinib Erdafitinib The serum concentration of Lemborexant can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The serum concentration of Lemborexant can be decreased when it is combined with Alpelisib.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Brexanolone is combined with Lemborexant.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Lemborexant is combined with Solriamfetol.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Lemborexant.
Entrectinib Entrectinib The serum concentration of Lemborexant can be increased when it is combined with Entrectinib.
Istradefylline Istradefylline The serum concentration of Istradefylline can be decreased when it is combined with Lemborexant.
Pitolisant Pitolisant The serum concentration of Lemborexant can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Lemborexant can be increased when it is combined with Fedratinib.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Lemborexant.
Phenytoin Injection Phenytoin Injection The serum concentration of Lemborexant can be decreased when it is combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The serum concentration of Lemborexant can be decreased when it is combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Lemborexant.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be increased when combined with Lemborexant.
Voxelotor Voxelotor The serum concentration of Voxelotor can be decreased when it is combined with Lemborexant.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Lumateperone is combined with Lemborexant.
Lasmiditan Lasmiditan The serum concentration of Lemborexant can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Lemborexant.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Lemborexant.
Cenobamate Cenobamate The serum concentration of Lemborexant can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Lemborexant can be increased when it is combined with Selumetinib.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Lemborexant.
Tucatinib Tucatinib Tucatinib may decrease the excretion rate of Lemborexant which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Lemborexant.
Ripretinib Ripretinib The serum concentration of Lemborexant can be increased when it is combined with Ripretinib.
Fenfluramine Fenfluramine The risk or severity of adverse effects can be increased when Fenfluramine is combined with Lemborexant.
Fostemsavir Fostemsavir The serum concentration of Lemborexant can be increased when it is combined with Fostemsavir.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Lemborexant.
Pralsetinib Pralsetinib The serum concentration of Lemborexant can be increased when it is combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Lemborexant can be decreased when it is combined with Satralizumab.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Viloxazine is combined with Lemborexant.
Trazodone Trazodone The risk or severity of adverse effects can be increased when Trazodone is combined with Lemborexant.
Phenobarbital Phenobarbital The serum concentration of Lemborexant can be decreased when it is combined with Phenobarbital.
Metaxalone Metaxalone The risk or severity of adverse effects can be increased when Metaxalone is combined with Lemborexant.
Levorphanol Levorphanol The risk or severity of adverse effects can be increased when Levorphanol is combined with Lemborexant.
Primidone Primidone The serum concentration of Lemborexant can be decreased when it is combined with Primidone.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Methsuximide is combined with Lemborexant.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Diethylpropion is combined with Lemborexant.
Chlorpromazine Chlorpromazine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Diazepam is combined with Lemborexant.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Oxazepam is combined with Lemborexant.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Flurazepam is combined with Lemborexant.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Lemborexant.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Lemborexant.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Lemborexant.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Lemborexant.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Lemborexant.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Bromocriptine is combined with Lemborexant.
Tranylcypromine Tranylcypromine The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Lemborexant.
Phenelzine Phenelzine The metabolism of Lemborexant can be decreased when combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Procarbazine is combined with Lemborexant.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Ergoloid mesylate is combined with Lemborexant.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Lemborexant.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Thioridazine is combined with Lemborexant.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Trifluoperazine is combined with Lemborexant.
Dapsone Dapsone The metabolism of Lemborexant can be decreased when combined with Dapsone.
Oxycodone Oxycodone The risk or severity of adverse effects can be increased when Oxycodone is combined with Lemborexant.
Methadone Methadone The risk or severity of adverse effects can be increased when Lemborexant is combined with Methadone.
Oxybutynin Oxybutynin Oxybutynin may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Benztropine Benztropine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Trihexyphenidyl Trihexyphenidyl Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Perphenazine is combined with Lemborexant.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Lemborexant.
Amoxapine Amoxapine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Hydrocortisone Hydrocortisone The serum concentration of Lemborexant can be decreased when it is combined with Hydrocortisone.
Dactinomycin Dactinomycin The serum concentration of Lemborexant can be increased when it is combined with Dactinomycin.
Pyridostigmine Pyridostigmine The serum concentration of Lemborexant can be decreased when it is combined with Pyridostigmine.
Carbamazepine Carbamazepine The serum concentration of Lemborexant can be decreased when it is combined with Carbamazepine.
Molindone Molindone The risk or severity of adverse effects can be increased when Molindone is combined with Lemborexant.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Lemborexant.
Cimetidine Cimetidine The serum concentration of Lemborexant can be increased when it is combined with Cimetidine.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Clonazepam is combined with Lemborexant.
Loperamide Loperamide The serum concentration of Loperamide can be decreased when it is combined with Lemborexant.
Promethazine Promethazine The serum concentration of Promethazine can be decreased when it is combined with Lemborexant.
Daunorubicin Daunorubicin The serum concentration of Lemborexant can be decreased when it is combined with Daunorubicin.
Griseofulvin Griseofulvin The serum concentration of Lemborexant can be decreased when it is combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Lemborexant.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Lemborexant.
Chloroquine Chloroquine The metabolism of Lemborexant can be decreased when combined with Chloroquine.
Quinine Quinine The serum concentration of Lemborexant can be decreased when it is combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Lemborexant.
Calcitriol Calcitriol The serum concentration of Lemborexant can be decreased when it is combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The serum concentration of Lemborexant can be decreased when it is combined with Sulfinpyrazone.
Clindamycin Injection Clindamycin Injection The metabolism of Lemborexant can be decreased when combined with Clindamycin.
Secobarbital Secobarbital The serum concentration of Lemborexant can be decreased when it is combined with Secobarbital.
Desipramine Desipramine The serum concentration of Desipramine can be decreased when it is combined with Lemborexant.
Amitriptyline Amitriptyline The serum concentration of Amitriptyline can be decreased when it is combined with Lemborexant.
Imipramine Imipramine The serum concentration of Imipramine can be decreased when it is combined with Lemborexant.
Probenecid Probenecid The serum concentration of Lemborexant can be decreased when it is combined with Probenecid.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Lemborexant.
Rifampin Rifampin The serum concentration of Lemborexant can be decreased when it is combined with Rifampicin.
Disopyramide Disopyramide Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid Valproic Acid The serum concentration of Valproic acid can be decreased when it is combined with Lemborexant.
Tamoxifen Tamoxifen The serum concentration of Lemborexant can be decreased when it is combined with Tamoxifen.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Lemborexant.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Lemborexant.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Cyclobenzaprine is combined with Lemborexant.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Lemborexant.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Cyproheptadine Cyproheptadine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Lemborexant.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Chlorpheniramine is combined with Lemborexant.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Lemborexant.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Meclizine is combined with Lemborexant.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Dantrolene is combined with Lemborexant.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Lemborexant.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Lemborexant.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Lemborexant.
Disulfiram Disulfiram The metabolism of Lemborexant can be decreased when combined with Disulfiram.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Lemborexant can be decreased when combined with Propranolol.
Nortriptyline Nortriptyline Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
Butorphanol Injection Butorphanol Injection The risk or severity of adverse effects can be increased when Butorphanol is combined with Lemborexant.
Nalbuphine Injection Nalbuphine Injection The risk or severity of adverse effects can be increased when Nalbuphine is combined with Lemborexant.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Trimethobenzamide is combined with Lemborexant.
Clomiphene Clomiphene The serum concentration of Lemborexant can be increased when it is combined with Clomifene.
Flavoxate Flavoxate Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Colchicine Colchicine The serum concentration of Lemborexant can be decreased when it is combined with Colchicine.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Lemborexant.
Ketoconazole Ketoconazole The serum concentration of Lemborexant can be increased when it is combined with Ketoconazole.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Pyrantel is combined with Lemborexant.
Vincristine Injection Vincristine Injection The metabolism of Lemborexant can be decreased when combined with Vincristine.
Vinblastine Vinblastine The serum concentration of Lemborexant can be decreased when it is combined with Vinblastine.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Thiothixene is combined with Lemborexant.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Lemborexant.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Lemborexant.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Triazolam is combined with Lemborexant.
Dicyclomine Dicyclomine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Diltiazem Diltiazem The serum concentration of Lemborexant can be increased when it is combined with Diltiazem.
Nifedipine Nifedipine The serum concentration of Lemborexant can be decreased when it is combined with Nifedipine.
Verapamil Verapamil The serum concentration of Lemborexant can be increased when it is combined with Verapamil.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Pindolol is combined with Lemborexant.
Etoposide Etoposide The serum concentration of Lemborexant can be decreased when it is combined with Etoposide.
Glyburide Glyburide The metabolism of Lemborexant can be decreased when combined with Glyburide.
Dicloxacillin Dicloxacillin The serum concentration of Lemborexant can be decreased when it is combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The serum concentration of Lemborexant can be decreased when it is combined with Nafcillin.
Pentamidine Injection Pentamidine Injection The metabolism of Lemborexant can be decreased when combined with Pentamidine.
Pimozide Pimozide The metabolism of Lemborexant can be decreased when combined with Pimozide.
Amiodarone Amiodarone The serum concentration of Lemborexant can be increased when it is combined with Amiodarone.
Buspirone Buspirone The metabolism of Lemborexant can be decreased when combined with Buspirone.
Lovastatin Lovastatin The metabolism of Lemborexant can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The serum concentration of Lemborexant can be increased when it is combined with Ciprofloxacin.
Diclofenac Diclofenac The serum concentration of Diclofenac can be decreased when it is combined with Lemborexant.
Oxiconazole Oxiconazole The serum concentration of Lemborexant can be decreased when it is combined with Oxiconazole.
Fluoxetine Fluoxetine The serum concentration of Fluoxetine can be decreased when it is combined with Lemborexant.
Clozapine Clozapine The serum concentration of Lemborexant can be decreased when it is combined with Clozapine.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Estazolam is combined with Lemborexant.
Clarithromycin Clarithromycin The serum concentration of Lemborexant can be increased when it is combined with Clarithromycin.
Felodipine Felodipine The metabolism of Lemborexant can be decreased when combined with Felodipine.
Pravastatin Pravastatin The serum concentration of Lemborexant can be increased when it is combined with Pravastatin.
Simvastatin Simvastatin The serum concentration of Lemborexant can be increased when it is combined with Simvastatin.
Teniposide Injection Teniposide Injection The metabolism of Lemborexant can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Lemborexant can be increased when it is combined with Itraconazole.
Rifabutin Rifabutin The serum concentration of Lemborexant can be decreased when it is combined with Rifabutin.
Bisoprolol Bisoprolol The serum concentration of Lemborexant can be increased when it is combined with Bisoprolol.
Zolpidem Zolpidem Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Omeprazole Omeprazole The serum concentration of Lemborexant can be decreased when it is combined with Omeprazole.
Cisapride Cisapride The serum concentration of Cisapride can be decreased when it is combined with Lemborexant.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Gabapentin is combined with Lemborexant.
Fluvastatin Fluvastatin The metabolism of Lemborexant can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Lemborexant.
Fluvoxamine Fluvoxamine The serum concentration of Lemborexant can be increased when it is combined with Fluvoxamine.
Nefazodone Nefazodone The serum concentration of Lemborexant can be increased when it is combined with Nefazodone.
Lamotrigine Lamotrigine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
Tramadol Tramadol The serum concentration of Tramadol can be decreased when it is combined with Lemborexant.
Lansoprazole Lansoprazole The serum concentration of Lemborexant can be decreased when it is combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The serum concentration of Lemborexant can be decreased when it is combined with Ifosfamide.
Nicardipine Nicardipine The serum concentration of Lemborexant can be increased when it is combined with Nicardipine.
Bupropion Bupropion The serum concentration of Bupropion can be decreased when it is combined with Lemborexant.
Saquinavir Saquinavir The metabolism of Lemborexant can be decreased when combined with Saquinavir.
Nisoldipine Nisoldipine The metabolism of Lemborexant can be decreased when combined with Nisoldipine.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Riluzole is combined with Lemborexant.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Lemborexant.
Indinavir Indinavir The serum concentration of Lemborexant can be increased when it is combined with Indinavir.
Ritonavir Ritonavir The serum concentration of Lemborexant can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Lemborexant can be decreased when combined with Docetaxel.
Clomipramine Clomipramine The serum concentration of Clomipramine can be decreased when it is combined with Lemborexant.
Mirtazapine Mirtazapine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Topiramate Topiramate The serum concentration of Lemborexant can be decreased when it is combined with Topiramate.
Pramipexole Pramipexole Lemborexant may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Donepezil is combined with Lemborexant.
Nelfinavir Nelfinavir The serum concentration of Lemborexant can be increased when it is combined with Nelfinavir.
Fexofenadine Fexofenadine The serum concentration of Lemborexant can be increased when it is combined with Fexofenadine.
Carvedilol Carvedilol The serum concentration of Lemborexant can be increased when it is combined with Carvedilol.
Flutamide Flutamide The metabolism of Lemborexant can be decreased when combined with Flutamide.
Selegiline Selegiline The serum concentration of Selegiline can be decreased when it is combined with Lemborexant.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Lemborexant is combined with Sertraline.
Propafenone Propafenone The serum concentration of Lemborexant can be increased when it is combined with Propafenone.
Ropinirole Ropinirole Lemborexant may increase the sedative activities of Ropinirole.
Finasteride Finasteride The metabolism of Lemborexant can be decreased when combined with Finasteride.
Quetiapine Quetiapine Quetiapine may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Lemborexant.
Paroxetine Paroxetine The serum concentration of Lemborexant can be increased when it is combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Lemborexant.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Lemborexant is combined with Citalopram.
Efavirenz Efavirenz The serum concentration of Lemborexant can be decreased when it is combined with Efavirenz.
Sildenafil Sildenafil The serum concentration of Lemborexant can be increased when it is combined with Sildenafil.
Tolterodine Tolterodine Lemborexant may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Thalidomide may increase the central nervous system depressant (CNS depressant) activities of Lemborexant.
Nateglinide Nateglinide The metabolism of Lemborexant can be decreased when combined with Nateglinide.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Levetiracetam is combined with Lemborexant.
Terbinafine Terbinafine The serum concentration of Lemborexant can be decreased when it is combined with Terbinafine.

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