Clorazepate

26 interactions 3 explained in plain English
Also sold as: Tranxene
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Omeprazole Hydromorphone Rectal Fentanyl Transdermal Patch Orlistat Morphine Injection
24 Major 2 Moderate
All (26) Major (24) Moderate (2)

Major

Clorazepate Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Clorazepate Omeprazole Gastrobim Explained An increased risk of clorazepate toxicity Details Clorazepate Buprenorphine Belbuca Explained An increased risk of CNS depression and respiratory depression Details Clorazepate Aripiprazole Injection Abilify An increased risk of sedation and orthostatic hypotension Details Clorazepate Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Clorazepate Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Clorazepate Calcifediol Rayaldee Altered serum levels of calcifediol Details Clorazepate Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Clorazepate Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Clorazepate Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Clorazepate Diazepam Rectal Diastat Increased risk of CNS depression Details Clorazepate Esketamine Nasal Spray Spravato Increased risk of sedation Details Clorazepate Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Clorazepate Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Clorazepate Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Clorazepate Lacosamide Injection Motpoly An increased risk of CNS depression Details Clorazepate Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Clorazepate Metoclopramide Injection Gimoti Increased risk of CNS depression Details Clorazepate Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Clorazepate Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Clorazepate Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Clorazepate Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Clorazepate Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Clorazepate Orlistat Alli Reduced efficacy of anticonvulsant Details

Moderate

Clorazepate Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Clorazepate Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.