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Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid

Sodium picosulfate, magnesium oxide, and anhydrous citric acid is a combination laxative used to clean the colon before a colonoscopy in adults and children aged 9 and older.

Brand names ClenpiqPrepopik
Drug classes Calculi Dissolution Agent
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 2 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 7, 2026
Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

This small-volume, two-dose colonoscopy prep (Clenpiq, also available generically) clears the colon in adults and children 9 and older, pairing sodium picosulfate, a laxative that makes the colon contract, with magnesium citrate, which pulls water into the bowel. It is usually easier to finish than gallon-jug preps, and besides the expected watery diarrhea, people mostly notice nausea, belly cramps and headache (children vomit more). The real risk is dehydration and electrolyte (body salt) imbalance, which can rarely cause seizures, heart rhythm problems or kidney injury, so drink all the clear liquids after each dose and call your prescriber if you feel faint or keep vomiting.

Clinical pearls

  • Take no other oral medicines within 1 hour before each dose, because the prep can wash them through before they absorb.
  • Tetracycline or fluoroquinolone antibiotics, iron, digoxin, chlorpromazine and penicillamine need at least 2 hours before and 6 hours after each dose.
  • Antibiotics taken around prep time can weaken it, since gut bacteria are needed to switch sodium picosulfate on.
  • Skip solids, dairy, alcohol and red or purple drinks during prep, and stop all fluids at least 2 hours before.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asOral solution
Earliest FDA record2023
Companies listing it with the FDA1
FDA label last updatedApr 15, 2026
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid, written from its FDA label.

What Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid is used for

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This combination of sodium picosulfate, magnesium oxide, and anhydrous citric acid is used for one purpose: clearing the colon so a colonoscopy can be performed safely and effectively.

  • Clenpiq (oral solution) is indicated for colon cleansing before colonoscopy in adults and pediatric patients 9 years of age and older
  • Magnesium Oxide And Anhydrous Citric Acid (oral powder) is indicated for colon cleansing before colonoscopy in adults and pediatric patients 9 years of age and older

How Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid works

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This prep uses two different laxative actions at the same time. Sodium picosulfate is a prodrug — meaning it needs to be activated. Bacteria in the colon convert it into an active substance (BHPM) that directly stimulates the colon wall to contract, pushing contents through. Meanwhile, magnesium oxide and citric acid combine in solution to form magnesium citrate, an osmotic agent that pulls water into the gut and holds it there. Together, these stimulant and osmotic effects produce a powerful purging action: watery diarrhea that flushes the colon clean.

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid dosage

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Both products are taken as two separate oral doses, and drinking plenty of clear liquids around each dose is required. The preferred method for both products is the split-dose regimen: first dose the evening before the colonoscopy, second dose the following morning. The oral powder also has an alternative day-before regimen if split-dosing is not suitable. Clenpiq is ready to drink with no mixing needed; the oral powder must be dissolved in 5 ounces of cold water right before each dose.

  • Do not eat solid food or dairy from the start of the prep until after the colonoscopy
  • Avoid red or purple drinks and alcohol throughout the prep
  • Stop all fluids at least 2 hours before the procedure
  • Do not take other laxatives during the prep

Dosing details from the FDA-approved label

From the Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Split-Dose Dosage Regimen (Preferred Method), Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid - adults and pediatric patients 9 years of age and older
    • Two separate doses (one packet per dose), each packet dissolved in 5 ounces of cold water
    • Dose 1: evening before the colonoscopy (e.g., 5:00 to 9:00 PM), then drink at least five 8-ounce cups of clear liquids (40 ounces total) within 5 hours and before bed
    • Dose 2: next morning, starting approximately 5 hours prior to colonoscopy, then drink at least three
    • If severe bloating, distention, or abdominal pain occurs after the first dose, delay the second dose until the symptoms resolve.
  • Day-Before Dosage Regimen (Alternative Method), Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid - used if Split-Dosing is inappropriate
    • Two separate doses (one packet per dose)
    • Dose 1: during afternoon or early evening before the colonoscopy
    • Dose 2: 6 hours later during the evening before the colonoscopy
    • Recommended for adults and pediatric patients 9 years of age and older; additional fluids must be consumed after every dose.
  • Clenpiq Split-Dose Dosage Regimen
    • Two doses (one bottle per dose, ready to drink, not diluted)
    • First dose: evening before the colonoscopy, followed by five or more 8-ounce cups of clear liquids
    • Second dose: next day, during the morning prior to the colonoscopy, followed by four or more 8-ounce cups of clear liquids
    • Administer oral medications at least 1 hour before starting Clenpiq; stop all liquids at least 2 hours before the colonoscopy.
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION Preparation and Administration • Each packet of sodium picosulfate, magnesium oxide and anhydrous citric acid must be dissolved with water prior to ingestion and administered according to the dosing regimen. Direct ingestion of the undissolved powder may increase the risk of nausea, vomiting and dehydration. ( 2.2 , 5.8 ) • Two doses (one packet per dose) of sodium picosulfate, magnesium oxide and anhydrous citric acid for oral solution are required for a complete preparation for colonoscopy. The preferred method is the “Split-Dose” method. The alternative is the “Day Before” method. ( 2.1 ) • Additional fluids must be consumed after every dose of sodium picosulfate, magnesium oxide and anhydrous citric acid for oral solution in both dosing regimens. ( 2.1 , 5.1 ) • Do not take oral medications within 1 hour of start of each dose. ( 2.1 , 7.2) • If taking tetracycline or fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, or penicillamine, take these medications at least 2 hours before and not less than 6 hours after administration of sodium picosulfate, magnesium oxide and anhydrous citric acid for oral solution. ( 2.1 , 7.3 ) • For complete information on preparation before colonoscopy and administration of the dosage regimen, see full prescribing information. ( 2.1 , 2.2 , 2.3 ) Split-Dose Dosage Regimen (Preferred Method) ( 2.2 ) • First dose: administer during evening before the colonoscopy • Second dose: administer the next day, during the morning prior to the colonoscopy. Day-Before Dosage Regimen (Alternative Method), if Split-Dosing is inappropriate ( 2.3 ) • First dose: administer during afternoon or early evening before the colonoscopy. • Second dose: administer 6 hours later during evening before colonoscopy. 2.1 Important Preparation and Administration Instructions • Correct fluid and electrolyte abnormalities before administration of sodium picosulfate, magnesium oxide and anhydrous citric acid for oral solution [see Warnings and Precautions ( 5.1 )]. • Two doses (one packet per dose) of sodium picosulfate, magnesium oxide and anhydrous citric acid for oral solution are required for a complete preparation for colonoscopy either as a Split-Dose (preferred) or Day-Before dosing regimen.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid side effects

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Most people will experience watery diarrhea — this is expected and means the prep is working. Other commonly reported side effects include:

Common side effects

  • Nausea
  • Headache
  • Abdominal pain
  • Dizziness or dehydration
  • Vomiting (especially in children)
  • High magnesium levels in the blood (usually temporary)
  • Watery diarrhea (an expected part of how it works)
  • Abdominal pain or cramping
  • Temporary rise in blood magnesium levels (hypermagnesemia), which typically returns to normal within a week

When to get medical help

  • Call your doctor if you have severe vomiting, feel faint, or show signs of dehydration such as dizziness when standing up
  • Seek care immediately if you experience a seizure (convulsion) or loss of consciousness
  • Tell your doctor right away if you notice an irregular or fast heartbeat
  • Seek emergency care for severe abdominal pain that does not improve after the first dose

Serious reactions — including seizures, significant irregular heart rhythms, or signs of severe dehydration — are rare but require immediate medical attention.

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid warnings and precautions

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  • Fluid and electrolyte imbalance is the most important risk. Losing too much fluid or having shifts in sodium, potassium, magnesium, or calcium can lead to seizures, dangerous heart rhythms, or kidney injury. Drink all the clear liquids directed and tell your doctor about any excessive vomiting or lightheadedness.
  • Seizures have been reported, mainly linked to low sodium or other electrolyte abnormalities. People with a history of seizures or who take medications that lower the seizure threshold are at higher risk.
  • Cardiac arrhythmias (irregular heart rhythms) have been reported rarely. People with heart failure, recent heart attack, or a history of prolonged QT interval should discuss cardiac monitoring with their doctor before the prep.
  • Kidney impairment: This prep is contraindicated in severe kidney disease. Even mild-to-moderate kidney disease increases the risk of magnesium buildup and kidney injury.
  • Colon lining irritation: The osmotic component can sometimes cause small ulcers in the colon — your doctor should know this when reviewing colonoscopy findings if you have inflammatory bowel disease.
  • Do not swallow the oral powder dry — always dissolve it in water first. Taking it undissolved raises the risk of nausea, vomiting, dehydration, and electrolyte problems.

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid interactions

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This prep can affect how well other medicines work, and some medicines can make the prep riskier. Key interactions to know:

  • Most oral medications: Take them at least 1 hour before starting each dose, since the prep can wash other drugs through before they are absorbed
  • Tetracyclines, fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and penicillamine: Take these at least 2 hours before and no less than 6 hours after each dose, as magnesium in the prep can bind to these drugs and reduce their absorption
  • Antibiotics in general: Taking antibiotics at the same time may reduce how well this prep works, because gut bacteria are needed to activate sodium picosulfate
  • Diuretics (water pills), ACE inhibitors, angiotensin receptor blockers, and NSAIDs: These drugs affect kidney function or fluid balance and increase the risk of kidney injury or dangerous electrolyte shifts when combined with this prep
  • Medications that lower the seizure threshold (such as tricyclic antidepressants): These raise the risk of seizure if electrolytes drop during the prep

Interactions listed in the FDA-approved label

From the Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Drugs that increase risk of fluid and electrolyte abnormalities (or of renal impairment, seizures, arrhythmias, QT prolongation): Other drugs and conditions that increase the risk for fluid and electrolyte disturbances may add to the risks of the bowel preparation. Use caution when prescribing sodium picosulfate, magnesium oxide and anhydrous citric acid to such patients.
  • Oral medications (general): Sodium picosulfate, magnesium oxide and anhydrous citric acid can reduce the absorption of other co-administered drugs. Administer oral medications at least one hour before the start of administration.
  • Tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, penicillamine: Absorption of these drugs can be reduced by the bowel preparation. Administer at least 2 hours before and not less than 6 hours after administration of sodium picosulfate, magnesium oxide and anhydrous citric acid.
  • Antibiotics: Prior or concomitant use of antibiotics may reduce efficacy because conversion of sodium picosulfate to its active metabolite BHPM is mediated by colonic bacteria.
Read the label’s full interactions text

7 DRUG INTERACTIONS Drugs that increase risks due to fluid and electrolyte changes. (7.1) 7.1 Drugs That May Increase Risks of Fluid and Electrolyte Abnormalities Use caution when prescribing sodium picosulfate, magnesium oxide and anhydrous citric acid for patients with conditions and/or who are taking other drugs that increase the risk for fluid and electrolyte disturbances or may increase the risk of renal impairment, seizures, arrhythmias, or QT prolongation in the setting of fluid and electrolyte abnormalities [see Warnings and Precautions ( 5.1 , 5.2 , 5.3 , 5.4 )]. 7.2 Potential for Reduced Drug Absorption Sodium picosulfate, magnesium oxide and anhydrous citric acid can reduce the absorption of other co-administered drugs [see Dosage and Administration ( 2.1 )]: • Administer oral medications at least one hour before of the start of administration of sodium picosulfate, magnesium oxide and anhydrous citric acid. • Administer tetracycline and fluoroquinolone antibiotics [see Drug Interactions ( 7.3 )], iron, digoxin, chlorpromazine, and penicillamine at least 2 hours before and not less than 6 hours after administration of sodium picosulfate, magnesium oxide and anhydrous citric acid. 7.3 Antibiotics Prior or concomitant use of antibiotics with sodium picosulfate, magnesium oxide and anhydrous citric acid for oral solution may reduce efficacy of sodium picosulfate, magnesium oxide and anhydrous citric acid as conversion of sodium picosulfate to its active metabolite BHPM is mediated by colonic bacteria.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿17 supplements and herbs with documented Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid interactions, ranked by severity Check Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid against a supplement or herb →

Before taking Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid

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  • Do not use this medication if you have severe kidney impairment (creatinine clearance less than 30 mL/min)
  • Do not use if you have a blockage in the bowel (obstruction or ileus), bowel perforation, gastric retention, toxic colitis, or toxic megacolon
  • Do not use if you have had a serious allergic reaction to any ingredient in the product
  • Tell your doctor if you have mild or moderate kidney disease, heart problems (including heart failure, arrhythmia, or recent heart attack), a history of seizures, or inflammatory bowel disease
  • Correct any known fluid or electrolyte imbalances before starting this prep
  • Older adults may be more vulnerable to fluid and electrolyte problems and should be monitored carefully
  • Children under 9 years of age: safety and effectiveness have not been established
  • Pregnancy: no human safety data are available; discuss risks and benefits with your doctor
  • Breastfeeding: the active metabolite was not detectable in breast milk in published studies, but discuss with your doctor before use
  • Pediatric patients should be watched for signs of low blood sugar, as this prep provides no calories

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid overdose

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Taking more than the recommended amount of this prep can cause severe electrolyte disturbances and serious dehydration. Signs may include dizziness, weakness, or symptoms related to abnormal salt and fluid levels in the body. If you suspect an overdose, seek medical attention immediately — treatment focuses on monitoring and correcting fluid and electrolyte levels.

What Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid does in the body

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Sodium picosulfate stimulates the colon to contract more actively, while magnesium citrate (formed from magnesium oxide and citric acid) retains water in the gastrointestinal tract by osmosis. Together, these two actions produce a strong purgative — essentially a watery diarrhea — that clears the colon. Drinking additional fluids as directed is important because it supports this effect and reduces the risk of dehydration.

How your body processes Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid

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After the oral powder is taken, peak blood levels of sodium picosulfate (picosulfate) are reached in about 2 hours after the first dose and around 7 hours after the second dose. The drug is a prodrug: it is converted by colonic bacteria into its active form (BHPM), which is found at very low levels in the bloodstream. The half-life of sodium picosulfate — the time it takes for the body to reduce its concentration by half — is about 7.4 hours in adults and approximately 7 hours in children aged 9–16. The drug is cleared mostly through the kidneys, predominantly as a conjugated metabolite in urine. Magnesium levels in the blood rise by roughly 20% after dosing but return to normal within about a week.

How to store Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid

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Store CLENPIQ at 25°C (77°F). Do not refrigerate or freeze.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

17

Supplements & herbs that interact with Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid

17 supplements and herbal products have documented interactions with Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 1
  • Moderate · 7
  • Minor · 9
ACTIVATED CHARCOAL Major COFFEE CHARCOAL Moderate EUROPEAN MANDRAKE Moderate GLUCOMANNAN Moderate GUAR GUM Moderate GUM ARABIC Moderate SLIPPERY ELM Moderate TRAGACANTH Moderate +9 more
Every supplement checked against Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid — ranked by severity The full interaction hub: 1 major · 7 moderate · 9 minor · every one linked to its full report. Check Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid — the kind of thing our pharmacy team would talk through with you at the counter.

What exactly does this prep do to my body?

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It works two ways to flush out your colon. One ingredient stimulates your colon to contract and move things along, while another draws water into your gut to make everything softer and easier to push out. The result is watery diarrhea — which sounds unpleasant, but it's exactly what's needed so your doctor gets a clear view during the colonoscopy. It's completely expected and means the prep is working.

How much should I be drinking during the prep?

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Quite a lot, and it really matters. After each dose of Clenpiq, you need to drink at least five 8-ounce cups of clear liquids after the first bottle and at least four cups after the second. The oral powder version also requires plenty of clear liquids after each dose. Include a balanced electrolyte drink — not just water — to help replace the salts your body is losing. Avoid red or purple drinks, alcohol, and anything solid until after your procedure.

What side effects should I expect versus when should I actually call my doctor?

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Watery diarrhea, some nausea, a headache, and mild abdominal cramping are all pretty common and don't usually need a call to anyone. But if you're vomiting so much you can't keep fluids down, feel very dizzy or faint when you stand up, have severe abdominal pain that doesn't ease up, or experience anything like a seizure or a racing/irregular heartbeat — those are signs to call your doctor or get emergency help right away.

Can I take my regular medications during the prep?

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Most oral medications should be taken at least 1 hour before you start each dose of this prep. A few specific drugs — including certain antibiotics (tetracyclines and fluoroquinolones), iron, digoxin, chlorpromazine, and penicillamine — need a bigger gap: take them at least 2 hours before and no sooner than 6 hours after each prep dose. Make sure your doctor knows everything you're taking so timing can be worked out.

Is this prep safe if I have kidney problems?

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It depends on how serious your kidney problem is. If your kidneys are severely impaired, you should not use this prep at all because magnesium can build up to dangerous levels. If your kidney function is mildly or moderately reduced, your doctor needs to know before you start — you'll need to stay especially well-hydrated and may need blood tests before and after the procedure to check your kidney function and electrolytes.

What if I'm pregnant or breastfeeding?

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There's no solid human safety data on using this prep during pregnancy, so talk to your doctor about whether the colonoscopy is urgent and whether the benefits outweigh any potential risks. If you're breastfeeding, published studies found that the active ingredient was not detectable in breast milk, but you should still loop your doctor in before you use it, so you can make the decision together.

Is Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid available over the counter?

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No. Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid is a prescription medicine: every Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid first available?

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The earliest FDA record we hold for Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid is from 2023: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid was first used.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid on HelloPharmacist

📊Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid supplement interactions17 checked — ranked by severity 🌿Drug & Supplement CheckerSodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid forms and strengths (how it comes)

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid inactive ingredients by manufacturer.

Oral solution

By mouth
Brands Clenpiq
How this form is used
What it may be used for
  • Clenpiq is used to cleanse the colon before colonoscopy in adults and pediatric patients 9 years of age and older
Important instructions
  • Clenpiq is ready to drink and does not need to be mixed or diluted before use
  • Clenpiq: two bottles (one per dose) are required using the split-dose regimen — first bottle during the evening before the colonoscopy, second bottle the morning of the colonoscopy
  • Clenpiq: drink at least five 8-ounce cups of clear liquids after the first dose and at least four 8-ounce cups after the second dose; include a balanced electrolyte solution among those liquids
  • Clenpiq: if severe bloating, distension, or abdominal pain occurs after the first dose, wait for symptoms to ease before taking the second dose
Available strengths 2 strengths
SODIUM PICOSULFATE 10 mg/175 mL; MAGNESIUM OXIDE 3.5 g/175 mL; ANHYDROUS CITRIC ACID 12 g/175 mL 12; 3.5; 10 g/175 mL; g/175 mL; mg/175 mL
2 FDA-listed product records ⓘ

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid on the U.S. market: products, makers and brands

How Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

1 company lists 1 Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid product record with the FDA, mostly as oral solution; the earliest marketing or approval year on record is 2023. Brand names on the directory include Clenpiq, Prepopik; the rest are generics.

1
Dose forms ⓘ
1
Labelers (makers, repackagers, distributors)
1
Brand names
1
FDA-listed product records ⓘ
2023
Earliest FDA record ⓘ

How widely Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid is used (Medicaid data)

A general measure of how commonly Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

13,778
Medicaid prescriptions filled (Q1–Q4 2025)
$2.4M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid prescribed? Of the 1,601 medications we measure, Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid ranks #875 by Medicaid prescriptions — more than 45% of them.

Where Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #875 of 1,601
#870 Docetaxel Injection 13,978 Rx #871 Docetaxel 13,978 Rx #872 Calcium Chloride / Dex... 13,813 Rx #873 Pertuzumab Injection 13,810 Rx #874 Formoterol / Glycopyrr... 13,780 Rx #875 Sodium Picosulfate, Ma... 13,778 Rx #876 Latanoprostene Bunod O... 13,742 Rx #877 Mexiletine 13,632 Rx #878 Chlorpheniramine 13,569 Rx #879 Clorazepate 13,540 Rx #880 Doxylamine 13,518 Rx

Utilization by Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

citric acid 68.6 MG/ML / magnesium oxide 20 MG/ML / picosulfate sodium 0.0571 MG/ML Oral Solution

13,778 Medicaid prescriptions (Q1–Q4 2025) 100% of Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid prescriptions shown $2.4M gross reimbursement (before rebates) ≈ $178 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2626364

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 1 of 3 listed Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid NDCs with Medicaid activity.

Compare Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid products

A representative set of FDA-listed product records for Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category ⓘ Details
💊Oral solution
SODIUM PICOSULFATE 10 mg/175 mL; MAGNESIUM OXIDE 3.5 g/175 mL; ANHYDROUS CITRIC ACID 12 g/175 mL Oral Ferring Pharmaceuticals Inc. NDA View NDC →

Showing 1 of 1 products — FDA National Drug Code Directory. See every product, package size and price: browse all 1 Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid NDCs →

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid recalls since July 2021.

✅No Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

💵 What Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Liquid · Oral 12; 3.5; 10 g/175 mL; g/175 mL; mg/175 mL $0.518 per mL NDC details & price history
Liquid · Oral SODIUM PICOSULFATE 10 mg/175 mL; MAGNESIUM OXIDE 3.5 g/175 mL; ANHYDROUS CITRIC ACID 12 g/175 mL $0.518 per mL NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid brand names

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid is sold under 2 brand names in the FDA directory — Clenpiq, Prepopik. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Clenpiq Prepopik

Who makes Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid: manufacturers and labelers

One company lists Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid products with the FDA. By number of product records, the largest are Ferring Pharmaceuticals Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Ferring Pharmaceuticals Inc. 1

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid drug class (RxNorm)

Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid belongs to the Contact laxatives class.

Drug family (ATC) Contact laxatives

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Apr 15, 2026
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Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid.
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Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Sodium Picosulfate, Magnesium Oxide, and Anhydrous Citric Acid after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
2
Finished products in the current FDA directory
1
Companies listing them (makers, repackagers, distributors)
1
FDA labeler codes behind them ⓘ
1
Linked representative label ⓘ
Ferring Pharmaceuticals Inc.
Linked label effective
Apr 15, 2026
Composite sections available
24
Linked SPL Set ID
e95fff66-4ec0-4001-a727-33e66a5ec7d5
Linked SPL Document ID
aa0cda22-b2c4-4612-abc8-8c91bf421c93
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Ferring Pharmaceuticals Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →