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Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate

A combination of electrolytes and dextrose (sugar) given by IV to replenish fluids, restore electrolyte balance, and provide calories — used across several intravenous products including Lactated Ringers, Dextrose in Lactated Ringers, Lactated Ringers and Dextrose, and Potassium Chloride in Lactated Ringers and Dextrose.

Brand names Lactated Ringers and DextrosePotassium Chloride in Lactated Ringers and DextroseDextrose in Lactated Ringers
Drug classes Blood Coagulation Factor
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 9 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026
Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Lactated Ringer’s with dextrose is a standard hospital IV fluid that supplies water, electrolytes (body salts) and sugar for calories, plus lactate, which the liver turns into bicarbonate to counter excess acid; it has been on the market since about 1971 and is available generically. Most people tolerate it well, noticing at most some soreness or burning at the IV site. Newborns 28 days or younger must never get it alongside the antibiotic ceftriaxone, even through a separate line, because the pair has formed fatal crystals in the lungs and kidneys. Older adults and anyone with kidney, liver or heart disease need closer monitoring.

Clinical pearls

  • After 28 days of age, ceftriaxone and this fluid can share a line only one after the other, with a thorough flush between.
  • If you take digoxin, tell the care team, since the calcium can strengthen its effect and raise the risk of rhythm problems.
  • Blood pressure medicines like ACE inhibitors or ARBs, and potassium-sparing water pills, can push potassium dangerously high with the potassium version.
  • With diabetes, expect blood sugar checks during the drip, and report new thirst, frequent urination or blurred vision.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asInjection
Earliest FDA record1971
Companies listing it with the FDA5
FDA label last updatedOct 29, 2025
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate, written from its FDA label.

What Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate is used for

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This combination of electrolytes and dextrose is given intravenously to restore fluid and electrolyte balance and provide calories. Specific uses depend on the product:

  • Potassium Chloride in Lactated Ringers and Dextrose: source of water, electrolytes, and calories; alkalinizing agent (helps reduce excess acid in the blood) in adults and pediatric patients
  • Lactated Ringers and Dextrose and Dextrose in Lactated Ringers: source of water, electrolytes, and calories; alkalinizing agent in adults and pediatric patients
  • Lactated Ringers: parenteral (IV) replacement of extracellular fluid and electrolyte losses, with or without minimal carbohydrate calories, based on the patient's clinical needs

How Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate works

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Each component serves a specific physiological role. Sodium controls how water is distributed in the body and maintains blood pressure. Potassium is critical for nerve signals and muscle function, including the heartbeat. Calcium supports blood clotting, heart rhythm, and neuromuscular control. Chloride works alongside sodium and helps balance the body's acidity. Sodium lactate is converted by the liver into bicarbonate, which neutralizes excess acid — a process called alkalinization. Dextrose supplies calories, helps spare body protein from being broken down for energy, and supports liver glycogen (stored sugar) replenishment.

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate dosage

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These solutions are given only by intravenous (IV) infusion in a healthcare setting — not taken by mouth or self-administered. The dose, infusion rate, and length of treatment are determined by the patient's age, weight, medical condition, and other treatments they are receiving.

  • Blood glucose and electrolyte levels are monitored throughout treatment, especially during prolonged infusions
  • In pediatric patients — particularly newborns and low birth weight infants — the infusion rate must be chosen carefully due to the risk of blood sugar swings
  • Your care team will adjust the rate as needed based on your clinical response

Dosing details from the FDA-approved label

From the Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • General dosing (Potassium Chloride in Lactated Ringer's and Dextrose (5%) Injection and Lactated Ringer's and Dextrose (5%) Injection)
    • The recommended dosage and duration are based on the patient's age, weight, clinical condition, and concomitant therapy
    • The label gives no specific numeric dose
    • Monitor blood glucose and electrolyte concentrations, especially during prolonged use
  • Peripheral vein administration
    • Use a peripheral vein if the final dextrose concentration is 5% or less and the osmolarity is less than 900 mOsm/L
  • Hypertonic solutions with osmolarity of 900 mOsm/L or more
    • Consider using a central vein to avoid venous irritation, including phlebitis
  • Neonates (28 days of age or younger)
    • Do not administer simultaneously with ceftriaxone due to serious risks
    • In patients older than 28 days, ceftriaxone and the solution may be given sequentially if lines are thoroughly flushed between infusions with a compatible fluid
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION • The recommended dosage and duration are based on the patient’s age, weight, clinical condition, and concomitant therapy. ( 2.1 ) • To reduce the risk of air embolism, adhere to the preparation instructions. ( 2.2 , 5.2 ) • Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection is for intravenous use. ( 2.3 ) • Use a peripheral vein to administer if the final dextrose concentration is 5% or less, and the osmolarity is less than 900 mOsm/L. ( 2.3 ). • Consider using a central vein to administer hypertonic solutions with osmolarity of 900 mOsm/L or more to avoid venous irritation, including phlebitis. ( 2.3 ) • Do not administer Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection simultaneously with ceftriaxone in neonates (28 days of age or younger) due to serious risks. ( 2.4 ) • See full prescribing information for information dosage considerations, preparation, administration, and drug incompatibilities. ( 2 ) 2.1 Dosage Considerations The recommended dosage and duration of Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection is based on the patient’s age, weight, clinical condition, and concomitant therapy. Evaluate the patient’s clinical status and monitor changes in blood glucose and electrolyte concentrations especially during prolonged use of Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection to optimize clinical status. 2.2 Important Preparation Instructions Visually inspect the Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection solution for particulate matter and discoloration. Do not administer Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection unless the solution is clear and the container seals are intact. If additives are determined to be compatible with Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection then using aseptic technique, mix thoroughly; do not store solutions containing additives. After mixing, do not use if there is discoloration or formation of precipitates. To reduce the risk of air embolism, adhere to the following preparation instructions for Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection [see Warnings and Precautions (5.2) ] : • Use a non-vented infusion set or close the vent on a vented set.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate side effects

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The most commonly reported side effects involve the infusion site or mild hypersensitivity (allergic-type) reactions:

Common side effects

  • Redness, swelling, pain, or burning at the infusion site
  • Itching or rash at or near the infusion site
  • Nausea
  • Headache
  • Flushing
  • Cough or shortness of breath during infusion
  • Fast or slow heartbeat (as part of a hypersensitivity reaction)
  • Rash or hives

When to get medical help

  • Call for emergency help if you notice sudden swelling of the face, throat, or lips, or have trouble breathing — these can be signs of a serious allergic reaction (anaphylaxis)
  • Tell your care team right away if you develop a severe headache, confusion, seizures, or extreme tiredness — these can be signs of low sodium (hyponatremia) affecting the brain
  • Alert your nurse or doctor if you notice swelling in your legs or feel short of breath — this may signal fluid overload or pulmonary edema (fluid in the lungs)
  • Neonates (babies 28 days old or younger) must not receive this IV at the same time as the antibiotic ceftriaxone — this combination has caused deaths
  • Let your care team know immediately if you feel an irregular heartbeat, muscle weakness, or unusual fatigue — these may be signs of potassium imbalance
  • Report any signs of high blood sugar (excessive thirst, frequent urination, blurred vision) during treatment

Serious reactions — including severe allergic reactions (anaphylaxis), dangerous changes in potassium or sodium levels, fluid overload, and high or low blood sugar — can also occur and require immediate medical attention.

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate warnings and precautions

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  • Fatal interaction in newborns with ceftriaxone: Giving these calcium-containing solutions to newborns (28 days old or younger) who are also receiving the antibiotic ceftriaxone — even through separate IV lines — has caused deaths. Crystal-like deposits formed in the lungs and kidneys. This combination is strictly forbidden in neonates.
  • Air embolism (air bubble in the bloodstream): Air entering the IV line can cause stroke, organ damage, or death. Special precautions are taken during setup and infusion to prevent this.
  • Potassium imbalance: Too much potassium (hyperkalemia) can be dangerous, especially in patients with kidney disease, heart failure, burns, or those taking certain blood pressure medications.
  • Low sodium (hyponatremia): Can lead to brain swelling, seizures, and serious neurological complications — risk is highest in young children, older adults, and patients on diuretics or certain psychiatric or seizure medications.
  • High blood sugar (hyperglycemia): People with diabetes or impaired glucose tolerance need close monitoring; anti-diabetic medications may need to be adjusted.
  • Fluid overload: Too much fluid can build up in the lungs (pulmonary edema) or body tissues — greatest risk in patients with kidney or heart problems.
  • Acid-base imbalances: These solutions can cause or worsen metabolic alkalosis (blood becoming too basic). In patients with severe liver disease, lactate may not be processed properly, worsening acidosis instead.

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate interactions

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Several medications can interact with these IV solutions, sometimes seriously:

  • Potassium-sparing diuretics, ACE inhibitors, angiotensin receptor blockers, calcineurin inhibitors: Increase potassium levels — risk of life-threatening hyperkalemia
  • Digoxin (heart medication): Calcium in these solutions can amplify digoxin's effects, raising the risk of dangerous heart rhythm problems
  • Lithium: These fluids may lower lithium levels in the blood, so more frequent monitoring is needed
  • Thiazide diuretics and vitamin D: Raise the risk of high calcium levels (hypercalcemia)
  • Corticosteroids: Can cause sodium and fluid retention, increasing risk of fluid overload and high sodium
  • Diuretics and medications that cause SIADH (e.g., certain seizure, psychiatric, or cancer drugs): Increase risk of dangerously low sodium
  • Drugs cleared through the kidneys based on urine pH: The alkalinizing effect of lactate can speed up removal of some acidic drugs and slow removal of some alkaline drugs

Interactions listed in the FDA-approved label

From the Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Drugs associated with hyperkalemia (e.g., potassium-sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, calcineurin inhibitors): Increases the risk of severe and potentially fatal hyperkalemia, especially with other hyperkalemia risk factors. Avoid use; if concomitant use cannot be avoided, closely monitor serum potassium concentrations.
  • Drugs associated with hyponatremia (diuretics and drugs that cause SIADH, e.g., arginine vasopressin analogs, certain antiepileptic, psychotropic, or cytotoxic drugs): May increase the risk of developing hyponatremia. Avoid use; if use cannot be avoided, closely monitor serum sodium concentrations.
  • Thiazide diuretics or vitamin D: These drugs can increase the risk of hypercalcemia. Avoid use; if use cannot be avoided, closely monitor serum calcium concentrations.
  • Drugs associated with sodium and fluid retention (e.g., corticosteroids or corticotropin): May increase the risk of hypernatremia and volume overload. Avoid use; if use cannot be avoided, closely monitor serum electrolytes, fluid balance, and acid-base balance.
  • Lithium: Renal sodium and lithium clearance may be increased and may result in decreased lithium concentrations. Avoid use; if use cannot be avoided, increase the frequency of monitoring of serum lithium concentrations.
  • Digoxin: Calcium may increase digoxin's effects and lead to digoxin toxicity including serious or fatal cardiac arrhythmias. In digoxin-treated patients, consider reducing the volume and/or rate of administration.
  • Drugs with pH-dependent renal elimination: Due to the alkalinizing action of lactate, renal clearance of alkaline drugs may be decreased and renal clearance of acidic drugs may be increased.
  • Serum lactate measurement in severe metabolic acidosis: Administration may interfere with the interpretation of serum lactate levels in patients with severe metabolic acidosis, including lactic acidosis. Do not rely solely on serum lactate measurement to assess the patient's clinical status.
  • Ceftriaxone: Simultaneous administration in neonates (28 days of age or younger) carries serious risks. Do not administer simultaneously in neonates; in patients older than 28 days, give sequentially with thorough flushing of lines between infusions.
  • Citrate anticoagulated/preserved blood: Likelihood of coagulation precipitated by the calcium content of the solution. Do not administer simultaneously through the same administration set.
Read the label’s full interactions text

7 DRUG INTERACTIONS • Drugs that Affect Electrolyte and/or Fluid Balance : Avoid concomitant use. If concomitant use cannot be avoided, closely monitor electrolyte concentrations and fluid balance. ( 7.1 ) • Lithium : Avoid concomitant use. If concomitant use is unavoidable, monitor serum lithium concentrations more frequently. ( 7.2 ) • Digoxin : Consider reducing the volume or rate of Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection due to the increased risk of digoxin toxicity with calcium-containing solutions. ( 7.3 ) • Drugs with pH-Dependent Renal Elimination : Renal clearance of acidic drugs may be increased. In contrast, renal clearance of alkaline drugs may be decreased. ( 7.4 ) 7.1 Drugs that Affect Electrolyte and/or Fluid Balance Hyperkalemia Administration of Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection to patients concomitantly treated or recently treated with drugs that are associated with hyperkalemia increases the risk of severe and potentially fatal hyperkalemia, especially in the presence of other hyperkalemia risk factors. Avoid use of Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection in patients receiving drugs that are associated with hyperkalemia (e.g., potassium-sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, or calcineurin inhibitors). If concomitant use cannot be avoided, closely monitor serum potassium concentrations during concomitant use [see Warnings and Precautions (5.4) ]. Hyponatremia Administration of Potassium Chloride in Lactated Ringer’s and Dextrose (5%) Injection to patients treated concomitantly with drugs associated with hyponatremia may increase the risk of developing hyponatremia. These drugs include diuretics and those that cause SIADH (e.g., arginine vasopressin analogs, certain antiepileptic, psychotropic, or cytotoxic drugs).

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

Check Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate against a supplement or herb →

Before taking Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate

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  • Tell your doctor if you have high potassium (hyperkalemia) or high blood sugar (hyperglycemia) — these are contraindications for Potassium Chloride in Lactated Ringers and Dextrose
  • Tell your doctor if you have high calcium (hypercalcemia) or a history of calcium kidney stones
  • Tell your doctor if you have severe kidney disease — potassium and fluids can accumulate to dangerous levels
  • Tell your doctor if you have severe liver disease — lactate may not be processed properly, worsening acid-base problems
  • Tell your doctor if you have heart failure or swelling (edema) — sodium-containing solutions require extra caution
  • Newborns (28 days or younger) receiving ceftriaxone must NOT receive calcium-containing solutions — the combination has caused fatal outcomes
  • Premature and very low birth weight infants need close blood sugar monitoring throughout treatment
  • Older adults should be monitored for kidney function and electrolyte balance — start at lower infusion rates
  • Tell your doctor if you are pregnant or breastfeeding — these solutions have been used safely for decades during labor and delivery, but your doctor should guide use

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate overdose

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Receiving too much of these solutions can cause dangerous buildup of potassium or sodium, fluid overload (including fluid in the lungs), high blood sugar, abnormal acid-base levels, or high calcium. If overdose occurs, the infusion is stopped right away, electrolyte and blood sugar imbalances are treated, and fluid balance is closely monitored until levels return to normal.

What Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate does in the body

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The exposure-response relationship and the precise time course of pharmacodynamic effects for Potassium Chloride in Lactated Ringer's and Dextrose (5%) Injection have not been fully characterized, according to the FDA label.

How your body processes Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate

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Once infused, each component is handled by the body through normal metabolic pathways. Potassium is mainly excreted by the kidneys (80–90%), with the rest lost in stool and sweat — and the kidneys do not conserve potassium well during fasting. Sodium and chloride levels are also controlled primarily by the kidneys. Lactate is metabolized in the liver to carbon dioxide and water, consuming hydrogen ions in the process — this is what produces the alkalinizing (acid-neutralizing) effect. Dextrose is broken down (oxidized) to carbon dioxide and water throughout the body.

How to store Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate

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Store at 20 to 25°C (68 to 77°F). Protect from freezing.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate — the kind of thing our pharmacy team would talk through with you at the counter.

Why am I being given this IV drip — what is it actually doing for me?

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This IV solution is replacing fluids and important minerals your body needs to function — things like sodium, potassium, calcium, and chloride. It also contains dextrose (a simple sugar) to give your body some energy. Depending on which specific product you're receiving, it may also help bring your blood chemistry back into balance if it's become too acidic. Think of it as a way to rehydrate and rebalance your body when you can't do it by drinking fluids.

Is it normal to feel some discomfort where the IV goes in?

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Yes, some redness, mild pain, burning, or swelling at the IV site is one of the more common things people notice. Itching or a rash there can also happen. Let your nurse know right away if the discomfort is severe, if you see a lot of swelling, or if the area feels very hot — those might mean the IV needs to be moved or checked.

What signs should make me call for help right away during the infusion?

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Reach out to your care team immediately if you develop sudden shortness of breath, swelling of your face or throat, a racing or very slow heartbeat, hives, or feel like you're having an allergic reaction — these can come on quickly and need prompt treatment. Also alert someone if you get a bad headache, feel confused, or have a seizure — those can be signs your sodium level has dropped too low. Any new or worsening swelling in your legs or trouble breathing could mean too much fluid is building up.

I have diabetes — is this IV drip safe for me?

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Your care team will watch your blood sugar carefully because these solutions contain dextrose (sugar), which can raise glucose levels — and the lactate in them can also make that harder to manage. If your blood sugar runs high, your diabetes medications may need to be adjusted during the infusion. Make sure your doctors know about your diabetes before and during treatment so they can monitor you closely.

My baby is in the NICU — are there any special concerns for newborns?

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Yes, there are some very important things to know for newborns. First and most critically, if your baby is receiving the antibiotic ceftriaxone, these calcium-containing IV solutions must NOT be given at the same time — not even through a different IV line — because the combination has caused fatal reactions in newborns. Also, premature and very low birth weight babies are at higher risk for blood sugar swings (both too low and too high), so blood glucose is monitored very closely. Your NICU team is well aware of these risks and takes precautions.

I take digoxin for my heart. Is there anything I need to watch for?

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Yes — the calcium in these IV solutions can make digoxin work more strongly than usual, which raises the risk of digoxin toxicity (signs include irregular heartbeat, nausea, or visual changes). Your doctor may lower the infusion rate or volume to reduce that risk. Make sure your care team knows you take digoxin before your infusion starts.

Is Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate available over the counter?

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No. Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate is a prescription medicine: every Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate first available?

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The earliest FDA record we hold for Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate is from 1971: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate was first used.

Who makes Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate?

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5 companies currently list Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate products in the FDA's NDC Directory, including Fresenius Kabi USA, LLC, Baxter Healthcare Corporation, ICU Medical Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate on HelloPharmacist

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Detailed data & references for Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate forms and strengths (how it comes)

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

Into a vein
Brands Dextrose in Lactated Ringers Lactated Ringers and Dextrose Potassium Chloride in Lactated Ringers and Dextrose
How this form is used
What it may be used for
  • Potassium Chloride in Lactated Ringers and Dextrose: indicated as a source of water, electrolytes, and calories, or as an alkalinizing agent, in adults and pediatric patients
  • Lactated Ringers and Dextrose and Dextrose in Lactated Ringers: indicated as a source of water, electrolytes, and calories, or as an alkalinizing agent, in adults and pediatric patients
  • Lactated Ringers: indicated for parenteral replacement of extracellular losses of fluid and electrolytes, with or without minimal carbohydrate calories
Important instructions
  • All brands: given intravenously only, in a clinical setting, at a rate and duration determined by the patient's age, weight, and clinical condition
  • Potassium Chloride in Lactated Ringers and Dextrose and Lactated Ringers and Dextrose: do not administer simultaneously with ceftriaxone in neonates 28 days of age or younger
  • Potassium Chloride in Lactated Ringers and Dextrose and Dextrose in Lactated Ringers: use a peripheral vein if the dextrose concentration is 5% or less and osmolarity is below 900 mOsm/L; consider a central vein for higher osmolarity solutions to avoid vein irritation
  • All brands: inspect the solution before use — do not administer if it is cloudy, discolored, or contains particles
Available strengths 12 strengths
DEXTROSE MONOHYDRATE 20 mg/100 mL; SODIUM CHLORIDE 5 g/100 mL; SODIUM LACTATE 30 mg/100 mL; POTASSIUM CHLORIDE 600 mg/100 mL; CALCIUM CHLORIDE 310 mg/100 mL DEXTROSE MONOHYDRATE 20 mg/100 mL; SODIUM CHLORIDE 5 g/100 mL; SODIUM LACTATE 179 mg/100 mL; POTASSIUM CHLORIDE 600 mg/100 mL; CALCIUM CHLORIDE 310 mg/100 mL SODIUM CHLORIDE 600 mg/100 mL; SODIUM LACTATE 310 mg/100 mL; POTASSIUM CHLORIDE 30 mg/100 mL; CALCIUM CHLORIDE 20 mg/100 mL; DEXTROSE MONOHYDRATE 5 g/100 mL POTASSIUM CHLORIDE 1.79 g/1000 mL; SODIUM CHLORIDE 6 g/1000 mL; CALCIUM CHLORIDE 0.2 g/1000 mL; SODIUM LACTATE 3.1 g/1000 mL; DEXTROSE MONOHYDRATE 50 g/1000 mL DEXTROSE MONOHYDRATE 5 g/100 mL; SODIUM CHLORIDE 0.6 g/100 mL; SODIUM LACTATE 0.31 g/100 mL; POTASSIUM CHLORIDE 0.03 g/100 mL; CALCIUM CHLORIDE 0.02 g/100 mL DEXTROSE MONOHYDRATE 5 g/100 mL; SODIUM CHLORIDE 600 mg/100 mL; SODIUM LACTATE 310 mg/100 mL; POTASSIUM CHLORIDE 30 mg/100 mL; CALCIUM CHLORIDE 20 mg/100 mL
Show 6 more strengths Show fewer strengths
DEXTROSE MONOHYDRATE 5 g/100 mL; SODIUM CHLORIDE 600 mg/100 mL; SODIUM LACTATE 310 mg/100 mL; POTASSIUM CHLORIDE 179 mg/100 mL; CALCIUM CHLORIDE 20 mg/100 mL DEXTROSE MONOHYDRATE 5 g/100 mL; SODIUM LACTATE 310 mg/100 mL; SODIUM CHLORIDE 600 mg/100 mL; POTASSIUM CHLORIDE 30 mg/100 mL; CALCIUM CHLORIDE 20 mg/100 mL 0.02; 5; 0.03; 0.6; 0.31 g/100 mL; g/100 mL; g/100 mL; g/100 mL; g/100 mL 0.2; 50; 1.79; 6; 3.1 g/1000 mL; g/1000 mL; g/1000 mL; g/1000 mL; g/1000 mL 20; 5; 30; 600; 310 mg/100 mL; g/100 mL; mg/100 mL; mg/100 mL; mg/100 mL 20; 5; 179; 600; 310 mg/100 mL; g/100 mL; mg/100 mL; mg/100 mL; mg/100 mL
24 FDA-listed product records ⓘ

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate on the U.S. market: products, makers and brands

How Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

5 companies list 9 Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate product records with the FDA, mostly as injection; the earliest marketing or approval year on record is 1971. Brand names on the directory include Lactated Ringers and Dextrose, Potassium Chloride in Lactated Ringers and Dextrose, Dextrose in Lactated Ringers; the rest are generics.

1
Dose forms ⓘ
5
Labelers (makers, repackagers, distributors)
3
Brand names
9
FDA-listed product records ⓘ
1971
Earliest FDA record ⓘ
Fresenius Kabi USA, LLC33%
Baxter Healthcare Corporation22%
ICU Medical Inc.22%
B. Braun Medical Inc.11%
HF Acquisition Co LLC, DBA HealthFirst11%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate is used (Medicaid data)

A general measure of how commonly Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q2 2025 – Q1 2026, summed across every form and brand of the drug.

Think of this as a proxy for how widely Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

13,813
Medicaid prescriptions filled (Q2 2025 – Q1 2026)
$1.3M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate prescribed? Of the 1,601 medications we measure, Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate ranks #872 by Medicaid prescriptions — more than 46% of them.

Where Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate ranks among the drugs we measure · Q2 2025 – Q1 2026 · neighbors ±5
Total prescriptions — #872 of 1,601
#867 Cevimeline 14,121 Rx #868 Natalizumab Injection 14,035 Rx #869 Formoterol Oral Inhala... 14,034 Rx #870 Docetaxel Injection 13,978 Rx #871 Docetaxel 13,978 Rx #872 Calcium Chloride / Dex... 13,813 Rx #873 Pertuzumab Injection 13,810 Rx #874 Formoterol / Glycopyrr... 13,780 Rx #875 Sodium Picosulfate, Ma... 13,778 Rx #876 Latanoprostene Bunod O... 13,742 Rx #877 Mexiletine 13,632 Rx

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 6 of 13 listed Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate NDCs with Medicaid activity.

Compare Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate products

A representative set of FDA-listed product records for Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category ⓘ Details
💊Injection
DEXTROSE MONOHYDRATE 5 g/100 mL; SODIUM CHLORIDE 0.6 g/100 mL; SODIUM LACTATE 0.31 g/100 mL; POTASSIUM CHLORIDE 0.03 g/100 mL; CALCIUM CHLORIDE 0.02 g/100 mL Intravenous B. Braun Medical Inc. NDA View NDC →
DEXTROSE MONOHYDRATE 5 g/100 mL; SODIUM CHLORIDE 600 mg/100 mL; SODIUM LACTATE 310 mg/100 mL; POTASSIUM CHLORIDE 30 mg/100 mL; CALCIUM CHLORIDE 20 mg/100 mL Intravenous Baxter Healthcare Corporation NDA View NDC →
DEXTROSE MONOHYDRATE 5 g/100 mL; SODIUM CHLORIDE 600 mg/100 mL; SODIUM LACTATE 310 mg/100 mL; POTASSIUM CHLORIDE 179 mg/100 mL; CALCIUM CHLORIDE 20 mg/100 mL Intravenous Baxter Healthcare Corporation NDA View NDC →
SODIUM CHLORIDE 600 mg/100 mL; SODIUM LACTATE 310 mg/100 mL; POTASSIUM CHLORIDE 30 mg/100 mL; CALCIUM CHLORIDE 20 mg/100 mL; DEXTROSE MONOHYDRATE 5 g/100 mL Intravenous Fresenius Kabi USA, LLC × 2 listings ANDA View NDC →
POTASSIUM CHLORIDE 1.79 g/1000 mL; SODIUM CHLORIDE 6 g/1000 mL; CALCIUM CHLORIDE 0.2 g/1000 mL; SODIUM LACTATE 3.1 g/1000 mL; DEXTROSE MONOHYDRATE 50 g/1000 mL Intravenous Fresenius Kabi USA, LLC ANDA View NDC →
DEXTROSE MONOHYDRATE 5 g/100 mL; SODIUM LACTATE 310 mg/100 mL; SODIUM CHLORIDE 600 mg/100 mL; POTASSIUM CHLORIDE 30 mg/100 mL; CALCIUM CHLORIDE 20 mg/100 mL Intravenous HF Acquisition Co LLC, DBA HealthFirst NDA View NDC →
SODIUM CHLORIDE 600 mg/100 mL; SODIUM LACTATE 310 mg/100 mL; POTASSIUM CHLORIDE 30 mg/100 mL; CALCIUM CHLORIDE 20 mg/100 mL; DEXTROSE MONOHYDRATE 5 g/100 mL Intravenous ICU Medical Inc. NDA View NDC →
POTASSIUM CHLORIDE 1.79 g/1000 mL; SODIUM CHLORIDE 6 g/1000 mL; CALCIUM CHLORIDE 0.2 g/1000 mL; SODIUM LACTATE 3.1 g/1000 mL; DEXTROSE MONOHYDRATE 50 g/1000 mL Intravenous ICU Medical Inc. NDA View NDC →

Showing 9 of 9 products — FDA National Drug Code Directory. See every product, package size and price: browse all 9 Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate NDCs →

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate recalls since July 2021.

✅No Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate brand names

Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate is sold under 3 brand names in the FDA directory — Lactated Ringers and Dextrose, Potassium Chloride in Lactated Ringers and Dextrose, Dextrose in Lactated Ringers. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Lactated Ringers and Dextrose Potassium Chloride in Lactated Ringers and Dextrose Dextrose in Lactated Ringers

Who makes Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate: manufacturers and labelers

5 companies list Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate products with the FDA. By number of product records, the largest are Fresenius Kabi USA, LLC, Baxter Healthcare Corporation, ICU Medical Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Fresenius Kabi USA, LLC 3 Baxter Healthcare Corporation 2 ICU Medical Inc. 2 B. Braun Medical Inc. 1 HF Acquisition Co LLC, DBA HealthFirst 1

Sources for this Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Oct 29, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Calcium Chloride / Dextrose / Potassium Chloride / Sodium Chloride / Sodium Lactate after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
9
Finished products in the current FDA directory
9
Companies listing them (makers, repackagers, distributors)
5
FDA labeler codes behind them ⓘ
5
Linked representative label ⓘ
Baxter Healthcare Corporation
Linked label effective
Oct 29, 2025
Composite sections available
20
Linked SPL Set ID
05f326e6-10e4-4ceb-8a23-f53c592f00b8
Linked SPL Document ID
127c3c05-ab6d-4c6c-84f9-9552f450f58b
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Baxter Healthcare Corporation is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →