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Disopyramide

Disopyramide is an antiarrhythmic medicine (a drug that steadies the heartbeat) used to treat life-threatening ventricular arrhythmias, such as sustained ventricular tachycardia.

Brand names NorpaceNorpace CR
Drug class Antiarrhythmic
Rx Form 1
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 5 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 5, 2026
Disopyramide at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Disopyramide (Norpace) is an older antiarrhythmic (heart rhythm drug) that quiets overexcitable heart cells and slows their electrical recovery. It is kept for life-threatening ventricular arrhythmias, which start in the heart's lower chambers, and has been around since the late 1970s and is available as a generic. Its drying effects, like dry mouth, constipation, blurred vision and trouble starting to urinate, are common and often bothersome. Its boxed warning notes more deaths with related rhythm drugs used for milder rhythm problems after a heart attack, and disopyramide can itself trigger dangerous new rhythms, so report fainting, palpitations or a worsening heartbeat right away. It can also weaken the heart's pumping, so report new breathlessness or swelling promptly.

Clinical pearls

  • Treatment starts in the hospital, where your heart tracing (ECG) is watched closely while the dose is settled.
  • Clarithromycin and erythromycin can cause life-threatening interactions, so remind anyone prescribing an antibiotic that you take disopyramide.
  • Men with an enlarged prostate face a higher risk of urinary retention, and being unable to urinate needs a call right away.
  • Alcohol and beta-blockers raise the risk of low blood sugar, so watch for shakiness, sweating or sudden confusion.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Disopyramide should be reserved for life-threatening ventricular arrhythmias. A large study (CAST) of related heart rhythm drugs, encainide and flecainide, found more deaths and cardiac arrests than placebo in people with a prior heart attack. Those people had rhythm problems that were not life-threatening.

Disopyramide can itself trigger dangerous rhythm problems. No antiarrhythmic drug has been shown to improve survival in people without life-threatening arrhythmias. Report any new fainting, palpitations, or worsening of your heartbeat to your doctor right away.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asCapsule
Earliest FDA record1977
Companies listing it with the FDA4
FDA label last updatedAug 24, 2026
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Disopyramide, written from its FDA label.

What Disopyramide is used for

▾

Disopyramide treats serious heart rhythm problems.

  • Norpace and Norpace CR (oral capsules) are for documented, life-threatening ventricular arrhythmias, such as sustained ventricular tachycardia.
  • Disopyramide phosphate capsules have the same use.
  • Its use for lesser arrhythmias is generally not recommended.
  • Treatment of asymptomatic ventricular premature contractions should be avoided.

How Disopyramide works

▾

Disopyramide is a Type 1 antiarrhythmic, like procainamide and quinidine. In animal studies, it slowed the electrical firing of overactive heart cells. It also lengthened the electrical recovery of normal heart cells. It reduced differences in recovery time between damaged and healthy heart tissue after a heart attack.

It has no effect on alpha- or beta-adrenergic receptors.

Disopyramide dosage

▾

Disopyramide is taken by mouth as capsules in divided doses. Your dose is individualized based on your response, tolerance, body weight, and kidney and liver function.

  • Immediate-release capsules (Norpace and disopyramide phosphate) are taken several times a day.
  • Norpace CR is extended-release and is taken less often.
  • Norpace CR is not recommended for severe kidney disease.
  • Treatment should begin in the hospital. Follow your prescriber and label directions.

Dosing details from the FDA-approved label

From the Disopyramide prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Usual adult dosage
    • 400 to 800 mg per day given in divided doses
    • Individualize on the basis of response and tolerance
  • Most adults
    • 600 mg/day given in divided doses (150 mg every 6 hours for immediate-release Norpace or 300 mg every 12 hours for Norpace CR)
    • If anticholinergic side effects increase, monitor plasma levels; a reduction from 600 mg/day to 400 mg/day would be reasonable without changing the dosing interval
  • Adults with body weight less than 110 pounds (50 kg)
    • 400 mg/day given in divided doses (100 mg every 6 hours for immediate-release Norpace or 200 mg every 12 hours for Norpace CR)
    • Loading dose of 200 mg if rapid control of ventricular arrhythmia is essential
  • Cardiomyopathy or possible cardiac decompensation
    • Initial dosage limited to 100 mg of immediate-release Norpace every 6 to 8 hours
    • No loading dose
    • Adjust subsequent dosage gradually, monitoring for hypotension and/or congestive heart failure
  • Moderate renal insufficiency (creatinine clearance greater than 40 ml/min) or hepatic insufficiency
    • 400 mg/day given in divided doses (100 mg every 6 hours for immediate-release Norpace or 200 mg every 12 hours for Norpace CR)
  • Severe renal insufficiency (Ccr 40 ml/min or less)
    • Immediate-release Norpace 100 mg at intervals by creatinine clearance: 40-30 ml/min q 8 hr
    • 30-15 ml/min q 12 hr
    • Less than 15 ml/min q 24 hr
    • With or without an initial loading dose of 150 mg
    • Norpace CR is not recommended for severe renal insufficiency
  • Rapid control of ventricular arrhythmia essential
    • Initial loading dose of 300 mg of immediate-release Norpace (200 mg if body weight less than 110 pounds), followed by the appropriate maintenance dosage
    • If no response or toxicity within 6 hours, 200 mg every 6 hours may be used instead of 150 mg; if no response within 48 hours, discontinue or consider hospitalization with 250 mg or 300 mg every 6 hours
  • Severe refractory ventricular tachycardia
    • Daily doses up to 1600 mg per day (400 mg every 6 hours) tolerated by a limited number of patients
    • Maximum: 1600 mg per day
    • Patients must be hospitalized for close evaluation and continuous monitoring
  • Transferring from quinidine sulfate or procainamide (normal renal function)
    • Start Norpace or Norpace CR on the regular maintenance schedule without a loading dose, 6 to 12 hours after the last dose of quinidine sulfate or 3 to 6 hours after the last dose of procainamide
    • From immediate-release Norpace to Norpace CR, start CR maintenance 6 hours after the last immediate-release dose
  • Pediatric patients
    • Total daily dosage in mg/kg body weight/day, divided into equal doses every 6 hours or as individual needs require: under 1 year 10 to 30
    • 1 to 4 years 10 to 20
    • 4 to 12 years 10 to 15
    • 12 to 18 years 6 to 15
    • Hospitalize during initial treatment; start titration at the lower end of the range; monitor plasma levels
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION The dosage of Norpace or Norpace CR must be individualized for each patient on the basis of response and tolerance. The usual adult dosage of Norpace or Norpace CR is 400 to 800 mg per day given in divided doses. The recommended dosage for most adults is 600 mg/day given in divided doses (either 150 mg every 6 hours for immediate-release Norpace or 300 mg every 12 hours for Norpace CR). For patients whose body weight is less than 110 pounds (50 kg), the recommended dosage is 400 mg/day given in divided doses (either 100 mg every 6 hours for immediate-release Norpace or 200 mg every 12 hours for Norpace CR). In the event of increased anticholinergic side effects, plasma levels of disopyramide should be monitored and the dose of the drug adjusted accordingly. A reduction of the dose by one third, from the recommended 600 mg/day to 400 mg/day, would be reasonable, without changing the dosing interval. For patients with cardiomyopathy or possible cardiac decompensation, a loading dose, as discussed below, should not be given, and initial dosage should be limited to 100 mg of immediate-release Norpace every 6 to 8 hours. Subsequent dosage adjustments should be made gradually, with close monitoring for the possible development of hypotension and/or congestive heart failure (see Warnings ). For patients with moderate renal insufficiency (creatinine clearance greater than 40 ml/min) or hepatic insufficiency, the recommended dosage is 400 mg/day given in divided doses (either 100 mg every 6 hours for immediate-release Norpace or 200 mg every 12 hours for Norpace CR). For patients with severe renal insufficiency (C cr 40 ml/min or less), the recommended dosage regimen of immediate-release Norpace is 100 mg at intervals shown in the table below, with or without an initial loading dose of 150 mg. IMMEDIATE-RELEASE NORPACE DOSAGE INTERVAL FOR PATIENTS WITH RENAL INSUFFICIENCY Creatinine Clearance (ml/min) 40–30 30–15 Less than 15 Approximate Maintenance-dosing interval q 8 hr q 12 hr Q 24 hr The above dosing schedules are for Norpace immediate-release capsules; Norpace CR is not recommended for patients with severe renal insufficiency.

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Disopyramide side effects

▾

Most common side effects come from its anticholinergic (drying) effects and depend on dose.

Common side effects

  • Dry mouth
  • Trouble starting urination (urinary hesitancy)
  • Constipation
  • Blurred vision
  • Dry nose, eyes or throat
  • Nausea
  • Dizziness
  • Tiredness or muscle weakness
  • Nausea, bloating or gas
  • Dizziness, fatigue, headache

When to get medical help

  • Call your doctor right away if you have trouble urinating or cannot urinate. Urinary retention is the most serious anticholinergic effect.
  • Get help for new or worsening shortness of breath, swelling, or weight gain. These can signal heart failure.
  • Seek care if you feel faint, pass out, have chest pain, or have a very low blood pressure.
  • Report a rapid, irregular or worsening heartbeat. Disopyramide can cause new rhythm problems, including torsade de pointes.
  • Tell your doctor about shakiness, sweating or confusion that could mean low blood sugar.
  • Report yellowing of the skin or eyes, fever, or breathing trouble.
  • Report sudden confusion or psychosis (rare); symptoms cleared when the drug was stopped.

Disopyramide warnings and precautions

▾

Disopyramide should be reserved for life-threatening ventricular arrhythmias, because it can cause dangerous rhythm problems itself.

  • It may cause or worsen heart failure or low blood pressure.
  • It can widen the QRS complex and prolong the Q-T interval, and has been linked to torsade de pointes.
  • Heart block may require lowering the dose or stopping the drug.
  • It can cause urinary retention and worsen glaucoma and myasthenia gravis.
  • Rarely, it can cause low blood sugar.
  • Using it with other antiarrhythmic drugs is reserved for special cases.

Disopyramide interactions

▾

Several drugs can change disopyramide levels or add to its heart effects.

  • Clarithromycin and erythromycin: life-threatening interactions reported.
  • Other CYP3A4 inhibitors (such as ketoconazole): may raise disopyramide levels.
  • Phenytoin and other enzyme inducers: may lower levels, making it less effective.
  • Other antiarrhythmics: risk of serious heart effects.
  • Verapamil: avoid within 48 hours before or 24 hours after.
  • Alcohol and beta-blockers: may raise the risk of low blood sugar.

Interactions listed in the FDA-approved label

From the Disopyramide prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Clarithromycin and erythromycin: Cases of life-threatening interactions have been reported with disopyramide; erythromycin inhibits the metabolism of disopyramide in vitro.
  • Cytochrome P450 3A4 inhibitors (e.g., ketoconazole): May elevate plasma levels of disopyramide and could result in a potentially fatal interaction.
  • Phenytoin or other hepatic enzyme inducers: Lower plasma levels of disopyramide may occur. Monitor disopyramide plasma levels to avoid ineffective therapy.
  • Other antiarrhythmic drugs (quinidine, procainamide, lidocaine, propranolol): Excessive widening of the QRS complex and/or prolongation of the Q-T interval may occur.
  • Quinidine: Slight increases in plasma disopyramide levels and slight decreases in plasma quinidine levels.
  • Propranolol or diazepam: No significant drug-drug interaction was observed in healthy subjects.
  • Digoxin: Norpace does not increase serum digoxin levels.
  • Verapamil: Data on possible interactions between verapamil and disopyramide phosphate are lacking. Do not administer disopyramide within 48 hours before or 24 hours after verapamil.
  • Oleandomycin: Inhibits the metabolism of disopyramide in vitro.
Read the label’s full interactions text

Drug Interactions Effects of other drugs on disopyramide pharmacokinetics: In vitro metabolic studies indicated that disopyramide is metabolized by cytochrome P450 3A4 and that inhibitors of this enzyme may result in elevation of plasma levels of disopyramide. Although specific drug interaction studies have not been done, cases of life-threatening interactions have been reported for disopyramide when given with clarithromycin and erythromycin.

Drug Interactions If phenytoin or other hepatic enzyme inducers are taken concurrently with Norpace or Norpace CR, lower plasma levels of disopyramide may occur. Monitoring of disopyramide plasma levels is recommended in such concurrent use to avoid ineffective therapy. Other antiarrhythmic drugs (e.g., quinidine, procainamide, lidocaine, propranolol) have occasionally been used concurrently with Norpace. Excessive widening of the QRS complex and/or prolongation of the Q-T interval may occur in these situations (see Warnings ). In healthy subjects, no significant drug-drug interaction was observed when Norpace was coadministered with either propranolol or diazepam. Concomitant administration of Norpace and quinidine resulted in slight increases in plasma disopyramide levels and slight decreases in plasma quinidine levels. Norpace does not increase serum digoxin levels. Until data on possible interactions between verapamil and disopyramide phosphate are obtained, disopyramide should not be administered within 48 hours before or 24 hours after verapamil administration. Although potent inhibitors of cytochrome P450 3A4 (e.g., ketoconazole) have not been studied clinically, in vitro studies have shown that erythromycin and oleandomycin inhibit the metabolism of disopyramide. Cases of life-threatening interactions have been reported for disopyramide when given with clarithromycin and erythromycin indicating that coadministration of disopyramide with inhibitors of cytochrome 3A4 could result in potentially fatal interaction.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿169 supplements and herbs with documented Disopyramide interactions, ranked by severity Check Disopyramide against a supplement or herb →

Before taking Disopyramide

▾
  • Do not use with cardiogenic shock, second- or third-degree heart block without a pacemaker, congenital Q-T prolongation, or known allergy to the drug.
  • Tell your doctor about heart failure, cardiomyopathy or low blood pressure.
  • Tell your doctor about glaucoma, myasthenia gravis or urinary retention.
  • Men with an enlarged prostate are at higher risk of urinary retention.
  • Kidney or liver problems and low body weight need lower doses.

Disopyramide overdose

▾

Too much disopyramide can cause stopped breathing, loss of consciousness, dangerous heart rhythms and death. It can also cause low blood pressure, worsening heart failure and strong anticholinergic effects. Get emergency help right away, even if there are no symptoms yet. There is no specific antidote, so treatment supports the heart and breathing.

What Disopyramide does in the body

▾

At usual blood levels, disopyramide shortens sinus node recovery time and lengthens the atrium's refractory period (its rest period between beats). It has minimal effect on the AV node. It rarely changes blood pressure in people without heart failure at recommended oral doses. Its anticholinergic activity is much weaker than atropine's, but the doses used are larger.

How your body processes Disopyramide

▾

Immediate-release capsules are quickly and almost completely absorbed, with peak levels usually within 2 hours. The half-life (time for the level to drop by half) is about 6.7 hours in healthy people. It can be 8 to 18 hours with kidney impairment. About half of a dose leaves in the urine unchanged. Norpace CR peaks later and lasts longer than the immediate-release capsules.

How to store Disopyramide

▾

Store at 25°C (77°F); excursions permitted to 15–30°C (59–86°F).

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

169

Supplements & herbs that interact with Disopyramide

169 supplements and herbal products have documented interactions with Disopyramide in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 10
  • Moderate · 117
  • Minor · 42
ACTIVATED CHARCOAL Major AMERICAN HELLEBORE Major ARSENIC Major CESIUM Major EPHEDRA Major GRAPEFRUIT Major HENBANE Major SCOPOLIA Major +161 more
Every supplement checked against Disopyramide — ranked by severity The full interaction hub: 10 major · 117 moderate · 42 minor · every one linked to its full report. Check Disopyramide against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Disopyramide: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Disopyramide — the kind of thing our pharmacy team would talk through with you at the counter.

What is disopyramide for?

▾
It treats life-threatening ventricular arrhythmias, which are dangerous heart rhythms from the lower heart chambers. An example is sustained ventricular tachycardia. It is not meant for milder rhythm problems.

How do I take it?

▾
You take it by mouth as capsules, in divided doses through the day. Norpace CR is extended-release and taken less often. Your doctor sets the dose for you, so follow the label and your prescriber's directions exactly.

What side effects are normal?

▾
Dry mouth, constipation, trouble starting urination and blurred vision are common. They come from its drying effects. Tell me or your doctor if they bother you or are severe.

When should I call my doctor?

▾
Call right away if you cannot urinate, faint, or have chest pain or a worsening heartbeat. Also call for shortness of breath, swelling or weight gain, which can mean heart failure. Shakiness or sweating could mean low blood sugar.

What medicines should I avoid with it?

▾
Clarithromycin and erythromycin have caused life-threatening interactions. Verapamil should be kept 48 hours before and 24 hours after disopyramide. Always tell me about any new prescription or other antiarrhythmic drug.

Why is this drug used only for serious rhythm problems?

▾
Disopyramide can cause dangerous rhythm problems itself. No heart rhythm drug has been shown to help people live longer if their arrhythmia is not life-threatening. That is why your doctor reserves it for serious cases.

Is Disopyramide available over the counter?

▾
No. Disopyramide is a prescription medicine: every Disopyramide product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Disopyramide first available?

▾
The earliest FDA record we hold for Disopyramide is from 1977: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Disopyramide was first used.

Who makes Disopyramide?

▾
4 companies currently list Disopyramide products in the FDA's NDC Directory, including Dr. Reddy's Labratories Inc., Mylan Pharmaceuticals Inc., Pfizer Laboratories Div Pfizer Inc. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Disopyramide on HelloPharmacist

📊Disopyramide supplement interactions169 checked — ranked by severity 🌿Drug & Supplement CheckerDisopyramide vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Disopyramide NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Disopyramide Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Disopyramide forms and strengths (how it comes)

Disopyramide is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Capsule

By mouth
Brands Norpace
How this form is used
What it may be used for
  • Disopyramide Phosphate capsules are used for documented, life-threatening ventricular arrhythmias such as sustained ventricular tachycardia.
  • Norpace is used for documented, life-threatening ventricular arrhythmias.
Important instructions
  • Disopyramide Phosphate capsules are dosed in divided doses, individualized to your response and tolerance.
  • Disopyramide Phosphate treatment should be started in the hospital.
  • Disopyramide Phosphate dosing is lowered for people under 110 pounds and for those with kidney or liver problems.
Available strengths 2 strengths
100 mg 150 mg
20 FDA-listed product records ⓘ

Disopyramide on the U.S. market: products, makers and brands

How Disopyramide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

4 companies list 8 Disopyramide product records with the FDA, mostly as capsule; the earliest marketing or approval year on record is 1977. Brand names on the directory include Norpace, Norpace CR; the rest are generics.

1
Dose forms ⓘ
4
Labelers (makers, repackagers, distributors)
2
Brand names
8
FDA-listed product records ⓘ
1977
Earliest FDA record ⓘ

Also listed with the FDA, not a patient dose form: Powder (3) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Dr. Reddy's Labratories Inc.25%
Mylan Pharmaceuticals Inc.25%
Pfizer Laboratories Div Pfizer Inc25%
Teva Pharmaceuticals USA, Inc.25%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Disopyramide is used (Medicaid data)

A general measure of how commonly Disopyramide is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Disopyramide is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

467
Medicaid prescriptions filled (Q1–Q4 2025)
$49,454 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Disopyramide prescribed? Of the 1,601 medications we measure, Disopyramide ranks #1,367 by Medicaid prescriptions — more than 15% of them.

Where Disopyramide ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #1,367 of 1,601
#1,362 Elagolix, Estradiol, a... 500 Rx #1,363 Eflornithine 490 Rx #1,364 Laronidase 479 Rx #1,365 Caspofungin Injection 476 Rx #1,366 Phendimetrazine 468 Rx #1,367 Disopyramide 467 Rx #1,368 Pazopanib 466 Rx #1,369 Cefuroxime Injection 465 Rx #1,370 Satralizumab-mwge Inje... 462 Rx #1,371 Siponimod 459 Rx #1,372 Eliglustat 453 Rx

Utilization by Disopyramide product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 100 mg oral capsule is the most-dispensed Disopyramide product — about 57% of these Medicaid prescriptions.

disopyramide 100 MG Oral Capsule Most dispensed

268 Medicaid prescriptions (Q1–Q4 2025) 57% of Disopyramide prescriptions shown $27,081 gross reimbursement (before rebates) ≈ $101 per prescription (gross)

Summed across the 3 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309958

disopyramide 150 MG Oral Capsule

199 Medicaid prescriptions (Q1–Q4 2025) 43% of Disopyramide prescriptions shown $22,373 gross reimbursement (before rebates) ≈ $112 per prescription (gross)

Summed across the 2 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 309960

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Disopyramide, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 5 of 12 listed Disopyramide NDCs with Medicaid activity.

Compare Disopyramide products

A representative set of FDA-listed product records for Disopyramide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Strength Route Manufacturer / Labeler Category ⓘ Details
💊Capsule
100 mg Oral Dr. Reddy's Labratories Inc. ANDA View NDC →
150 mg Oral Dr. Reddy's Labratories Inc. ANDA View NDC →
100 mg Oral Mylan Pharmaceuticals Inc. NDA AUTHORIZED GENERIC View NDC →
150 mg Oral Mylan Pharmaceuticals Inc. NDA AUTHORIZED GENERIC View NDC →
100 mg Oral Pfizer Laboratories Div Pfizer Inc NDA View NDC →
150 mg Oral Pfizer Laboratories Div Pfizer Inc NDA View NDC →
100 mg Oral Teva Pharmaceuticals USA, Inc. ANDA View NDC →
150 mg Oral Teva Pharmaceuticals USA, Inc. ANDA View NDC →

Showing 8 of 8 products — FDA National Drug Code Directory. See every product, package size and price: browse all 8 Disopyramide NDCs →

Disopyramide recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list no Disopyramide recalls since July 2021.

✅No Disopyramide recalls on record since July 2021

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Disopyramide RxCUI 3541 4 dose forms · 8 strengths
  2. Dose form (SCDF) Extended Release Oral Tablet RxCUI 371938 No current FDA listing
    Clinical drug / strength (SCD) 150 MG RxCUI 199824 250 MG RxCUI 199730
  3. Dose form (SCDF) Injectable Solution RxCUI 371937 No current FDA listing
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 199543
  4. Dose form (SCDF) Oral Capsule RxCUI 371935 In current FDA listings
    Clinical drug / strength (SCD) 100 MG RxCUI 309958 150 MG RxCUI 309960

Look up RxCUI 3541 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Disopyramide costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Capsule · Oral 100 mg $0.801 per capsule NDC details & price history
Capsule · Oral 150 mg $1.53 per capsule NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Disopyramide brand names

Disopyramide is sold under 2 brand names in the FDA directory — Norpace, Norpace CR. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Norpace Norpace CR

Who makes Disopyramide: manufacturers and labelers

4 companies list Disopyramide products with the FDA. By number of product records, the largest are Dr. Reddy's Labratories Inc., Mylan Pharmaceuticals Inc., Pfizer Laboratories Div Pfizer Inc. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Dr. Reddy's Labratories Inc. 2 Mylan Pharmaceuticals Inc. 2 Pfizer Laboratories Div Pfizer Inc 2 Teva Pharmaceuticals USA, Inc. 2

Disopyramide drug class (RxNorm)

Disopyramide belongs to the Antiarrhythmic class.

Pharmacologic class Antiarrhythmic
Drug family (ATC) Antiarrhythmics, class Ia

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Disopyramide page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Aug 24, 2026
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Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Disopyramide.
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Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
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Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Disopyramide after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
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Finished products in the current FDA directory
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Companies listing them (makers, repackagers, distributors)
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FDA labeler codes behind them ⓘ
4
Linked representative label ⓘ
Pfizer Laboratories Div Pfizer Inc
Linked label effective
Aug 24, 2026
Composite sections available
18
Linked SPL Set ID
e2aa1642-d262-4520-bc6a-9fd3ad795677
Linked SPL Document ID
6790ba4d-7819-4ed5-96d9-2126ef99f109
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Pfizer Laboratories Div Pfizer Inc is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →