Prochlorperazine
Prochlorperazine is a phenothiazine medicine used to control severe nausea and vomiting and to treat schizophrenia, and some oral tablets are also used for short-term non-psychotic anxiety.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 46 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Prochlorperazine (Compazine) is a familiar standby for severe nausea and vomiting, on the market since the 1950s and available generically; it calms the brain area that triggers vomiting, and its antipsychotic effect also treats schizophrenia and short-term anxiety. Short courses are usually well tolerated, with drowsiness, dizziness and dry mouth the usual complaints. It carries a boxed warning for higher risk of death in older adults with dementia-related psychosis, and everyone should watch for movement side effects, from sudden neck or jaw spasms early on to tardive dyskinesia (involuntary face and tongue movements that can become permanent). The lowest dose for the shortest time keeps that risk down.
Clinical pearls
- Skip alcohol, since prochlorperazine deepens and prolongs its sedating effect, as it does with opioid pain medicines and barbiturates.
- If you take lithium, say so, since the combination has been linked to a serious brain syndrome needing close monitoring.
- A high fever with stiff muscles, confusion or an irregular pulse is an emergency, a possible sign of neuroleptic malignant syndrome.
- Rise slowly from sitting or lying, since it can drop blood pressure on standing and cause falls, especially in older adults.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾
Older adults with dementia-related psychosis who take antipsychotic drugs have a higher risk of death. In trials, about 4.5% of drug-treated patients died over roughly 10 weeks, compared with about 2.6% on placebo. Most deaths appeared to be heart-related (such as heart failure or sudden death) or infections (such as pneumonia).
Observational studies suggest older antipsychotics may carry a similar risk. Prochlorperazine is not approved to treat dementia-related psychosis.
Patient information guide A plain-language walkthrough of Prochlorperazine, written from its FDA label.
What Prochlorperazine is used for
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Prochlorperazine is used for several conditions, depending on the product.
- Severe nausea and vomiting: tablets, injection, and rectal suppositories (Compro and Prochlorperazine, for adults).
- Schizophrenia: tablets and injection.
- Short-term generalized non-psychotic anxiety: the tablets only, and usually not the first drug tried.
It has not been shown effective for behavioral complications in patients with mental retardation.
How Prochlorperazine works
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Prochlorperazine is a phenothiazine. It eases nausea and vomiting by calming the chemoreceptor trigger zone in the brain, which sets off vomiting. It also has a clinically useful antipsychotic effect.
Prochlorperazine dosage
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The form decides how it is taken. Dosing is adjusted to your response, starting low. Older adults and debilitated patients are dosed more gradually.
- Tablets: taken by mouth, usually 3 or 4 times daily for nausea and vomiting.
- Suppositories (Compro, Prochlorperazine): used rectally, usually twice daily.
- Injection (Prochlorperazine Edisylate): given into a muscle or vein by a healthcare professional.
Follow your prescriber and product label.
Dosing details from the FDA-approved label
From the Prochlorperazine prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Severe nausea and vomiting (adults) - intramuscular
- Initially 5 mg to 10 mg (1 mL to 2 mL) injected deeply into the upper, outer quadrant of the buttock
- If necessary, repeat every 3 or 4 hours
- Maximum: Total intramuscular (IM) dosage should not exceed 40 mg per day.
- Begin with lowest recommended dosage; increase more gradually in debilitated, emaciated or elderly patients.
- Severe nausea and vomiting (adults) - intravenous
- 2.5 mg to 10 mg (0.5 mL to 2 mL) by slow intravenous (IV) injection or infusion at a rate not to exceed 5 mg per minute
- May be given undiluted or diluted in isotonic solution
- Do not use bolus injection
- Maximum: A single dose should not exceed 10 mg; total intravenous (IV) dosage should not exceed 40 mg per day.
- Hypotension is a possibility with IV injection or infusion.
- Adult surgery (severe nausea and vomiting) - intramuscular
- 5 mg to 10 mg (1 mL to 2 mL) 1 to 2 hours before induction of anesthesia (repeat once in 30 minutes, if necessary), or to control acute symptoms during and after surgery (repeat once if necessary)
- Maximum: Total parenteral dosage should not exceed 40 mg per day.
- Adult surgery (severe nausea and vomiting) - intravenous
- 5 mg to 10 mg (1 mL to 2 mL) as a slow intravenous (IV) injection or infusion 15 to 30 minutes before induction of anesthesia, or to control acute symptoms during or after surgery
- Repeat once if necessary
- Rate not to exceed 5 mg per minute
- No bolus injection
- Maximum: Single dose should not exceed 10 mg; total parenteral dosage should not exceed 40 mg per day.
- May be given undiluted or diluted in isotonic solution.
- Adult psychiatric disorders (severe schizophrenia) - intramuscular
- Initial dose of 10 mg to 20 mg (2 mL to 4 mL) deeply into the upper, outer quadrant of the buttock
- Repeat the initial dose every 2 to 4 hours (or, in resistant cases, every hour) if necessary
- If parenteral therapy is needed for a prolonged period, give 10 mg to 20 mg (2 mL to 4 mL) every 4 to 6 hours
- After control, switch to an oral form at the same dosag
- Maximum: More than 3 or 4 doses are seldom necessary.
- Begin with the lowest recommended dose; adjust to response and severity.
- Elderly patients
- In general, dosages in the lower range are sufficient for most elderly patients
- More susceptible to hypotension and neuromuscular reactions; observe closely; increase dosage more gradually.
- Severe nausea and vomiting in children - intramuscular
- Calculate each dose on the basis of 0.06 mg of the drug per lb of body weight
- Give by deep intramuscular (IM) injection
- Control is usually obtained with one dose
- Not for pediatric patients under 20 pounds in weight or two years of age; duration of activity after IM may last up to 12 hours.
- Children with schizophrenia (ages under 12) - intramuscular
- Calculate each dose on the basis of 0.06 mg of prochlorperazine per lb of body weight
- Give by deep intramuscular (IM) injection
- Control is usually obtained with one dose
- After control, switch to an oral form at the same dosage level or higher
- Use lowest effective dosage; children are more prone to extrapyramidal reactions.
Read the label’s full dosing text
DOSAGE & ADMINISTRATION - ADULTS (For children’s dosage and administration, see below.) Dosage should be increased more gradually in debilitated or emaciated patients. Elderly Patients: In general, dosages in the lower range are sufficient for most elderly patients. Since they appear to be more susceptible to hypotension and neuromuscular reactions, such patients should be observed closely. Dosage should be tailored to the individual, response carefully monitored and dosage adjusted accordingly. Dosage should be increased more gradually in elderly patients. 1.To Control Severe Nausea and Vomiting: Adjust dosage to the response of the individual. Begin with the lowest recommended dosage. Oral Dosage-Tablets: Usually one 5mg or 10mg tablet 3 or 4 times daily. Daily dosages above 40 mgs should be used only in resistant cases. 2.In Adult Psychiatric Disorders: Adjust dosage to the response of the individual and according to the severity of the condition. Begin with the lowest recommended dose. Although response ordinarily is seen within a day or 2, longer treatment is usually required before maximal improvement is seen. Oral Dosage: Non-Psychotic Anxiety--Usual dosage is 5 mg 3 or4 times daily. Do not administer in doses of more than 20mg per day or for longer than 12 weeks. Psychotic Disorders including Schizophrenia -- In relatively mild conditions , as seen in private psychiatric practice or in out patient clinics, dosage is 5 or 10 mg 3 or 4 times daily. In moderate to severe conditions, for hospitalized or adequately supervised patients, usual starting dosage is 10 mg 3 or 4 times daily. Increase dosage gradually until symptoms are controlled or side effects become bothersome. When dosage is increased by small increments every 2 or 3 days, side effects either do not occur or are easily controlled. Some patients respond satisfactorily on 50 to 75mg daily. In more severe disturbances, optimum dosage is usually 100 to 150mg daily. DOSAGE AND ADMINISTRATION--CHILDREN Do not use in pediatric surgery. Children seem more prone to develop extrapyramidal reactions, even on moderate doses. Therefore, use lowest effective dosage. Tell parents not to exceed prescribed dosage, since the possibility for adverse reactions increases as dosage rises.
Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →
Prochlorperazine side effects
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Common effects include:
Common side effects
- Drowsiness
- Dizziness
- Blurred vision
- Low blood pressure
- Skin reactions
- Missed or absent periods (amenorrhea)
- Dry mouth
- Constipation
- Dry mouth, stuffy nose and constipation
When to get medical help
- Get help right away for a high fever with stiff muscles, confusion, or irregular pulse or blood pressure. These can be signs of neuroleptic malignant syndrome, which can be fatal.
- Tell your doctor about rhythmic, involuntary movements of the tongue, face, mouth or jaw. These can be tardive dyskinesia and may be permanent.
- Get help for neck muscle spasms, throat tightness, trouble swallowing or breathing, or tongue protrusion (dystonia). It usually appears in the first few days.
- Report a sudden sore throat or other signs of infection. Low white blood cell counts can occur.
- Report yellowing of the skin or eyes, or fever with flu-like symptoms. Liver problems (cholestatic jaundice) have occurred.
- Report tremor, drooling, shuffling walk or severe restlessness, which can be side effects on movement.
- Seek help for seizures, fainting from very low blood pressure, or allergic reactions such as swelling or trouble breathing.
Call your doctor for muscle spasms, uncontrolled movements, fever with stiffness, yellow skin or eyes, or a sudden sore throat or infection signs.
Prochlorperazine warnings and precautions
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- Boxed warning: higher risk of death in older adults with dementia-related psychosis.
- Tardive dyskinesia: possibly permanent involuntary movements; risk rises with longer use and higher total dose.
- Neuroleptic malignant syndrome: rare, potentially fatal, with fever, muscle rigidity, confusion and unstable pulse or blood pressure.
- Can impair alertness, especially in the first few days.
- Can cause drowsiness and low blood pressure on standing, leading to falls.
- Blood count drops and liver problems have occurred.
Prochlorperazine interactions
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Prochlorperazine can add to the effects of other drugs.
- Alcohol, narcotics, barbiturates, anesthetics: stronger or longer sedation.
- Lithium: possible serious brain toxicity, so close monitoring is needed.
- Injection: should not be mixed with other agents in the syringe.
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Prochlorperazine
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- Do not use it with a phenothiazine allergy, in a coma, or with large amounts of central nervous system depressants.
- Do not use it in children under 2 years or under 20 lbs, or in pediatric surgery.
- Older adults need lower doses and close monitoring.
- Tell your doctor about bone marrow depression or past reactions to phenothiazines.
- Pregnancy: not recommended unless severe, intractable nausea and vomiting requires it.
- Breastfeeding: it passes into breast milk, so use caution.
Prochlorperazine overdose
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Overdose can cause muscle reactions such as dystonia, marked drowsiness or coma, agitation, seizures, heart rhythm changes, fever and low blood pressure. Treatment is supportive, with close observation and keeping the airway open. Do not induce vomiting.
What Prochlorperazine does in the body
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Prochlorperazine acts on the chemoreceptor trigger zone to reduce nausea and vomiting. It also has an antipsychotic effect.
How your body processes Prochlorperazine
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After an intramuscular injection of prochlorperazine edisylate, it starts working within 10 to 20 minutes. Its effect lasts about 3 to 4 hours.
How to store Prochlorperazine
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Store at 20 - 25 o C (68 - 77 o F) . Protect from light. Dispense in a tight, light-resistant container.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Prochlorperazine
96 supplements and herbal products have documented interactions with Prochlorperazine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 5
- Moderate · 67
- Minor · 24
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Prochlorperazine: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Prochlorperazine — the kind of thing our pharmacy team would talk through with you at the counter.
What is prochlorperazine for?
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How should I take it?
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What side effects should I expect?
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When should I call my doctor?
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Can I drink alcohol with it?
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Is it safe in pregnancy or for older adults?
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Is Prochlorperazine available over the counter?
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When was Prochlorperazine first available?
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Who makes Prochlorperazine?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Prochlorperazine on HelloPharmacist
Prochlorperazine forms and strengths (how it comes)
Prochlorperazine is available in 4 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- Prochlorperazine Maleate tablets are used for severe nausea and vomiting.
- Prochlorperazine Maleate tablets are used to treat schizophrenia.
- Prochlorperazine Maleate tablets are used for short-term generalized non-psychotic anxiety, but are not usually the first drug tried.
- Prochlorperazine Maleate tablets for nausea and vomiting are usually taken 3 or 4 times daily, starting at the lowest recommended dosage.
- Prochlorperazine Maleate tablets for anxiety should not be used longer than 12 weeks.
Injection
How this form is used
- Prochlorperazine Edisylate injection is used to control severe nausea and vomiting.
- Prochlorperazine Edisylate injection is used to treat schizophrenia.
- Prochlorperazine Edisylate injection given into a muscle goes deeply into the upper, outer buttock.
- Prochlorperazine Edisylate injection should not be given under the skin because of local irritation.
- Prochlorperazine Edisylate injection should be protected from light and discarded if markedly discolored.
- Prochlorperazine Edisylate injection should not be mixed with other agents in the syringe.
Rectal suppository
How this form is used
- Compro and Prochlorperazine suppositories are indicated to control severe nausea and vomiting in adults.
- Compro and Prochlorperazine suppositories are used rectally, usually twice daily, starting at the lowest recommended dosage.
Oral solution
Prochlorperazine on the U.S. market: products, makers and brands
How Prochlorperazine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
45 companies list 83 Prochlorperazine product records with the FDA, mostly as tablet, injection, rectal suppository; the earliest marketing or approval year on record is 1956. Brand names on the directory include Compro, Procomp, Compazine and 1 more; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (7) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Prochlorperazine is used (Medicaid data)
A general measure of how commonly Prochlorperazine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Prochlorperazine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Prochlorperazine prescribed? Of the 1,601 medications we measure, Prochlorperazine ranks #315 by Medicaid prescriptions — more than 80% of them.
Utilization by Prochlorperazine product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
prochlorperazine 10 MG Oral Tablet Most dispensed
Summed across the 12 of 112 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198365
prochlorperazine 5 MG/ML Injectable Solution
Summed across the 13 of 38 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2102949
prochlorperazine 5 MG Oral Tablet
Summed across the 11 of 72 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 312635
prochlorperazine 25 MG Rectal Suppository
Summed across the 2 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 198159
2 ML prochlorperazine 5 MG/ML Injection
Summed across the 4 of 12 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 314192
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Prochlorperazine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 42 of 245 listed Prochlorperazine NDCs with Medicaid activity.
Compare Prochlorperazine products
A representative set of FDA-listed product records for Prochlorperazine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Injection | ||||
| 5 mg/mL | Intramuscular, Intravenous | Amneal Pharmaceuticals LLC | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Avenacy Inc. | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Baxter Healthcare Corporation | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Caplin Steriles Limited | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Cardinal Health 107, LLC | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Civica, Inc. | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Cosette Pharmaceuticals, Inc. | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Eugia US LLC | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Fosun Pharma Usa Inc | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Gland Pharma Limited × 2 listings | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. × 2 listings | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | HF Acquisition Co LLC, DBA HealthFirst | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Hikma Pharmaceuticals USA Inc. | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Mylan Institutional LLC | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Sagent Pharmaceuticals | ANDA | View NDC → |
| 5 mg/mL | Intramuscular, Intravenous | Somerset Therapeutics, LLC | ANDA | View NDC → |
| 💊Rectal suppository | ||||
| 25 mg | Rectal | Cosette Pharmaceuticals, Inc. | ANDA | View NDC → |
| 25 mg | Rectal | Padagis US LLC | ANDA | View NDC → |
| 25 mg | Rectal | PD-Rx Pharmaceuticals, Inc. | ANDA | View NDC → |
| 💊Tablet | ||||
| 5 mg | Oral | A-S Medication Solutions × 2 listings | ANDA | View NDC → |
| 10 mg | Oral | A-S Medication Solutions | ANDA | View NDC → |
| 5 mg | Oral | Ajanta Pharma USA Inc. | ANDA | View NDC → |
| 10 mg | Oral | Ajanta Pharma USA Inc. | ANDA | View NDC → |
| 5 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 10 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 5 mg | Oral | Amneal Pharmaceuticals NY LLC | ANDA | View NDC → |
| 10 mg | Oral | Amneal Pharmaceuticals NY LLC | ANDA | View NDC → |
| 5 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 10 mg | Oral | ANI Pharmaceuticals, Inc. | ANDA | View NDC → |
| 5 mg | Oral | Aurobindo Pharma Limited | ANDA | View NDC → |
| 10 mg | Oral | Aurobindo Pharma Limited | ANDA | View NDC → |
| 5 mg | Oral | AvPAK | ANDA | View NDC → |
| 10 mg | Oral | AvPAK | ANDA | View NDC → |
| 5 mg | Oral | Bionpharma Inc. × 2 listings | ANDA | View NDC → |
| 10 mg | Oral | Bionpharma Inc. × 2 listings | ANDA | View NDC → |
| 5 mg | Oral | Bryant Ranch Prepack | ANDA | View NDC → |
| 10 mg | Oral | Bryant Ranch Prepack × 3 listings | ANDA | View NDC → |
| 10 mg | Oral | Cardinal Health 107, LLC | ANDA | View NDC → |
| 5 mg | Oral | Chartwell RX, LLC | ANDA | View NDC → |
| 10 mg | Oral | Chartwell RX, LLC | ANDA | View NDC → |
| 10 mg | Oral | Direct_Rx | ANDA | View NDC → |
| 5 mg | Oral | Glenmark Pharmaceuticals Inc., Usa | ANDA | View NDC → |
| 10 mg | Oral | Glenmark Pharmaceuticals Inc., Usa | ANDA | View NDC → |
| 5 mg | Oral | Jubilant Cadista Pharmaceuticals Inc. | ANDA | View NDC → |
| 10 mg | Oral | Jubilant Cadista Pharmaceuticals Inc. | ANDA | View NDC → |
| 5 mg | Oral | Leading Pharma, LLC | ANDA | View NDC → |
| 10 mg | Oral | Leading Pharma, LLC | ANDA | View NDC → |
| 5 mg | Oral | Major Pharmaceuticals | ANDA | View NDC → |
| 10 mg | Oral | Major Pharmaceuticals | ANDA | View NDC → |
| 10 mg | Oral | Northstar Rx LLC | ANDA | View NDC → |
| 5 mg | Oral | Northwind Health Company, LLC | ANDA | View NDC → |
| 10 mg | Oral | Northwind Health Company, LLC × 2 listings | ANDA | View NDC → |
| 5 mg | Oral | NuCare Pharmaceuticals, Inc. | ANDA | View NDC → |
| 5 mg | Oral | PD-Rx Pharmaceuticals, Inc. | ANDA | View NDC → |
| 10 mg | Oral | PD-Rx Pharmaceuticals, Inc. × 2 listings | ANDA | View NDC → |
| 5 mg | Oral | PharmPak, Inc. | ANDA | View NDC → |
| 10 mg | Oral | Preferred Pharmaceuticals Inc. | ANDA | View NDC → |
| 5 mg | Oral | Proficient Rx LP | ANDA | View NDC → |
| 10 mg | Oral | Proficient Rx LP | ANDA | View NDC → |
| 10 mg | Oral | QPharma, Inc. | ANDA | View NDC → |
| 5 mg | Oral | Redpharm Drug × 2 listings | ANDA | View NDC → |
| 10 mg | Oral | Redpharm Drug | ANDA | View NDC → |
| 5 mg | Oral | Remedyrepack Inc. × 2 listings | ANDA | View NDC → |
| 10 mg | Oral | Remedyrepack Inc. × 3 listings | ANDA | View NDC → |
| 5 mg | Oral | Sportpharm LLC | ANDA | View NDC → |
| 10 mg | Oral | Sportpharm LLC | ANDA | View NDC → |
| 5 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 10 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 5 mg | Oral | Zydus Pharmaceuticals (USA) Inc. | ANDA | View NDC → |
| 10 mg | Oral | Zydus Pharmaceuticals (USA) Inc. | ANDA | View NDC → |
Showing 83 of 83 products — FDA National Drug Code Directory. See every product, package size and price: browse all 83 Prochlorperazine NDCs →
Prochlorperazine side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Prochlorperazine — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Prochlorperazine in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Prochlorperazine FDA approval history
How Prochlorperazine went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Prochlorperazine recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list one Prochlorperazine recall since July 2021. It is no longer listed as ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.
- Prochlorperazine Maleate Tablets, USP 5mg, 100 tablets, RX Only, Jubilant Cadista Pharmaceuticals, Inc., Salisbury, Maryland 21801, NDC 59746-113-06 Lots: Lot#: 21P0336, Exp: 04/2023 FDA record D-0096-2023 →
Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 8704 6 dose forms · 11 strengths
-
Dose form (SCDF) Buccal Tablet RxCUI 373606No current FDA listingClinical drug / strength (SCD) 3 MGRxCUI 251521 -
Dose form (SCDF) Injectable Solution RxCUI 373605In current FDA listings -
Dose form (SCDF) Injection RxCUI 1795152In current FDA listingsClinical drug / strength (SCD) 2 ML prochlorperazine 5 MG/MLRxCUI 314192 -
Dose form (SCDF) Oral Solution RxCUI 373610In current FDA listingsClinical drug / strength (SCD) 1 MG/MLRxCUI 245963 -
Dose form (SCDF) Oral Tablet RxCUI 373609In current FDA listings -
Dose form (SCDF) Rectal Suppository RxCUI 373608In current FDA listings
Look up RxCUI 8704 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Prochlorperazine supply and shortage status
Whether Prochlorperazine is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Prochlorperazine costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Tablet · Oral | 10 mg | $0.162 per tablet | NDC details & price history |
| Tablet · Oral | 5 mg | $0.115 per tablet | NDC details & price history |
| Tablet, Film Coated · Oral | 5 mg | $0.115 per tablet | NDC details & price history |
| Tablet, Film Coated · Oral | 10 mg | $0.162 per tablet | NDC details & price history |
| Suppository · Rectal | 25 mg | $6.74 each | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Prochlorperazine brand names
Prochlorperazine is sold under 4 brand names in the FDA directory — Compro, Procomp, Compazine, Prochlorperazine Edisylate. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Prochlorperazine: manufacturers and labelers
45 companies list Prochlorperazine products with the FDA. By number of product records, the largest are Remedyrepack Inc., Bionpharma Inc., Bryant Ranch Prepack. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
…and 21 more on the FDA NDC directory.
Prochlorperazine drug class (RxNorm)
Prochlorperazine belongs to the Phenothiazine class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Prochlorperazine page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
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