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Fluphenazine

Fluphenazine is an antipsychotic medication used to manage psychotic disorders, including schizophrenia, available in oral and injectable forms.

Brand names PermitilProlixinFluphenazine DecanoateFluphenazine Hydrochoride
Drug class Phenothiazine
Rx Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 34 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 6, 2026 🚨Recall on record · 2
Fluphenazine at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Fluphenazine is a potent, older antipsychotic for schizophrenia and other psychotic disorders. It has been on the market since about 1959, is available generically, and is best known today for its long-acting shot given every few weeks. It is less sedating than many of its relatives, but movement effects like stiffness, inner restlessness and tremor are what people notice most. It carries a boxed warning for a higher risk of death in older adults with dementia-related psychosis, a use it is not approved for. Report any repetitive face or tongue movements (tardive dyskinesia, which can become permanent) right away, and treat high fever with rigid muscles and confusion (neuroleptic malignant syndrome) as an emergency.

Clinical pearls

  • Make sure emergency staff know you take fluphenazine, because epinephrine (adrenaline) can backfire with it and drop blood pressure further.
  • Expect periodic blood counts, and report a sore throat, mouth sores or unusual bruising, which can signal dangerous blood cell changes.
  • Skip alcohol and be cautious with opioids, sleep aids and sedating antihistamines, since fluphenazine adds to their drowsiness.
  • The long-acting shot releases slowly over weeks, so its side effects can linger and are worth reporting early.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Important safety warning: Fluphenazine Decanoate Injection is not approved for elderly patients with dementia-related psychosis. Older adults with dementia who are treated with antipsychotic drugs — including fluphenazine — have a significantly higher risk of death compared to those taking a placebo. The deaths were most often related to heart problems (such as heart failure or sudden death) or infections like pneumonia. If you or a family member has dementia, talk to the prescriber about whether this medication is appropriate.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asTablet, Injection, Oral solution
Earliest FDA record1959
Companies listing it with the FDA35
FDA label last updatedFeb 1, 2023
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide A plain-language walkthrough of Fluphenazine, written from its FDA label.

What Fluphenazine is used for

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Fluphenazine is an antipsychotic used to manage psychotic disorders across several formulations. The approved uses vary by product:

  • Fluphenazine hydrochloride tablets and Fluphenazine Hydrochloride oral solution: management of psychotic disorders (oral route)
  • Fluphenazine Hydrochloride Injection: management of psychotic disorders (intramuscular route)
  • Fluphenazine Decanoate Injection: long-acting antipsychotic therapy for patients who need prolonged treatment — particularly chronic schizophrenia (intramuscular or subcutaneous route)
  • None of the fluphenazine products have been shown effective for behavioral complications in patients with intellectual disability
  • Fluphenazine Decanoate Injection is specifically not approved for dementia-related psychosis in elderly patients

How Fluphenazine works

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Fluphenazine works throughout the central nervous system, though its precise mechanism of action is not fully known. It belongs to the phenothiazine class of antipsychotics and is notably more potent milligram-for-milligram than many older drugs in its class. Compared to other phenothiazines, it tends to produce less sedation and is less likely to cause significant drops in blood pressure.

The decanoate form is chemically modified (esterified) so it releases slowly after injection, extending the drug's effect over weeks without reducing its therapeutic benefit. The hydrochloride form acts more quickly but requires more frequent dosing.

Fluphenazine dosage

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How fluphenazine is taken depends entirely on the formulation prescribed — do not assume they are interchangeable.

  • Fluphenazine hydrochloride tablets and oral solution: Taken by mouth, typically in divided doses every 6 to 8 hours. Therapy starts at a low dose and is adjusted to the smallest amount that controls symptoms.
  • Fluphenazine Hydrochloride Injection: Given intramuscularly, with doses divided every 6 to 8 hours. Once symptoms are controlled, the prescriber may transition to oral tablets.
  • Fluphenazine Decanoate Injection: Given intramuscularly or subcutaneously; a single injection can be effective for up to 4 weeks or longer. The timing of repeat injections is based on individual response.

Always follow your prescriber's instructions exactly. Never stop fluphenazine suddenly without medical guidance.

Dosing details from the FDA-approved label

From the Fluphenazine prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Most patients (fluphenazine decanoate injection, initiation of therapy)
    • 12.5 to 25 mg (0.5 to 1 mL) IM or SC may be given to initiate therapy
    • Subsequent injections and dosage interval are determined in accordance with the patient's response
    • Maximum: Dosage should not exceed 100 mg
    • If doses greater than 50 mg are deemed necessary, the next and succeeding doses should be increased cautiously in increments of 12.5 mg
  • Psychotic patients stabilized on a fixed daily dosage of oral fluphenazine hydrochloride (conversion to decanoate)
    • 20 mg fluphenazine hydrochloride daily was equivalent to 25 mg (1 mL) of decanoate every three weeks
    • Approximate conversion ratio of 12.5 mg (0.5 mL) of decanoate every three weeks for every 10 mg of fluphenazine hydrochloride daily
    • Maximum: Dosage should not exceed 100 mg
    • No precise formula can be given; adjust dosage at the time of each injection
  • Severely agitated patients (decanoate injection)
    • Treat initially with a rapid-acting phenothiazine such as fluphenazine hydrochloride injection
    • When acute symptoms have subsided, 25 mg (1 mL) of fluphenazine decanoate may be administered
    • Subsequent dosage is adjusted as necessary
    • Maximum: Dosage should not exceed 100 mg
  • "Poor risk" patients (known hypersensitivity to phenothiazines or disorders predisposing to undue reactions)
    • Initiate cautiously with oral or parenteral fluphenazine hydrochloride
    • When pharmacologic effects and appropriate dosage are apparent, an equivalent dose of fluphenazine decanoate may be administered
    • Maximum: Dosage should not exceed 100 mg
  • Patients with no history of taking phenothiazines
    • May be advisable to treat initially with a shorter-acting form of fluphenazine before administering the decanoate
  • Adult psychotic patients (oral fluphenazine hydrochloride, initial)
    • Total daily dosage may range initially from 2.5 to 10 mg, divided and given at six- to eight-hour intervals
    • May be increased if necessary until desired clinical effects are achieved
    • Maximum: Daily doses up to 40 mg may be necessary; safety of prolonged administration of such doses not demonstrated in controlled studies
    • Therapeutic effect is often achieved with doses under 20 mg daily
  • Oral maintenance (when symptoms are controlled)
    • Reduce gradually to daily maintenance doses of 1 to 5 mg, often given as a single daily dose
  • Geriatric patients (oral fluphenazine hydrochloride)
    • Suggested starting dose is 1 to 2.5 mg daily, adjusted according to the response of the patient
    • Age-related starting dose
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION Depending on severity and duration of symptoms, total daily dosage for adult psychotic patients may range initially from 2.5 mg to 10 mg and should be divided and given at 6 to 8 hour intervals. The smallest amount that will produce the desired results must be carefully determined for each individual, since optimal dosage levels of this potent drug vary from patient to patient. In general, the oral dose has been found to be approximately 2 to 3 times the parenteral dose of fluphenazine. Treatment is best instituted with a low initial dosage , which may be increased, if necessary, until the desired clinical effects are achieved. Therapeutic effect is often achieved with doses under 20 mg daily. Patients remaining severely disturbed or inadequately controlled may require upward titration of dosage. Daily doses up to 40 mg may be necessary; controlled clinical studies have not been performed to demonstrate safety of prolonged administration of such doses. When symptoms are controlled, dosage can generally be reduced gradually to daily maintenance doses of 1 mg to 5 mg, often given as a single daily dose. Continued treatment is needed to achieve maximum therapeutic benefits; further adjustments in dosage may be necessary during the course of therapy to meet the patient's requirements. For psychotic patients who have been stabilized on a fixed daily dosage of orally administered fluphenazine hydrochloride dosage forms, conversion to the long-acting fluphenazine decanoate may be indicated (see package insert for fluphenazine decanoate for conversion information). For geriatric patients, the suggested starting dose is 1 mg to 2.5 mg daily, adjusted according to the response of the patient.

Read the full Dosage and Administration section on DailyMed →

Fluphenazine side effects

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Fluphenazine can cause a range of side effects — some common and manageable, others serious enough to require immediate attention.

Common side effects

  • Movement problems such as muscle stiffness, restlessness, or tremor (extrapyramidal symptoms)
  • Drowsiness or low energy
  • Dry mouth
  • Nausea or loss of appetite
  • Headache
  • Constipation
  • Blurred vision
  • Weight changes
  • Movement-related effects: muscle stiffness, tremor, restlessness (akathisia), muscle spasms (dystonia), or Parkinson's-like symptoms — these are the most common side effects
  • Headache, excessive sweating, increased saliva
  • Blurred vision or nasal congestion
  • Weight changes, menstrual irregularities, or sexual side effects
  • Skin sensitivity to sunlight, rash, or itching

When to get medical help

  • Call your doctor immediately if you develop uncontrolled, repetitive movements of the face, tongue, or limbs — this could be tardive dyskinesia
  • Seek emergency care if you have high fever, severe muscle rigidity, confusion, or irregular heartbeat — these may be signs of neuroleptic malignant syndrome (NMS), a rare but life-threatening reaction
  • Tell your doctor right away if you feel dizzy, faint, or fall, especially when standing up
  • Contact your doctor if you notice unusual bruising, mouth sores, sore throat, or signs of infection — these could signal dangerous blood cell changes
  • Seek help if you develop yellowing of the skin or eyes (jaundice), which may indicate liver problems
  • Get immediate help for severe allergic reactions such as swelling, difficulty breathing, or widespread skin rash

Fluphenazine warnings and precautions

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Tardive dyskinesia (uncontrolled, often permanent involuntary movements of the face, tongue, and limbs) is one of the most serious risks — it is more likely with higher doses and longer treatment. There is no established cure, so your doctor will use the lowest effective dose for the shortest time possible and periodically reassess the need for continued treatment.

Neuroleptic malignant syndrome (NMS) — a potentially fatal reaction marked by high fever, severe muscle rigidity, altered mental state, and unstable pulse or blood pressure — has been reported with antipsychotics including fluphenazine. If this occurs, the drug must be stopped immediately and emergency treatment started. Additional important risks include: increased fall risk (due to dizziness and unsteadiness), dangerous drops in blood pressure in patients with heart or vascular conditions, serious blood cell abnormalities requiring routine monitoring, liver damage (especially early in treatment), and impaired ability to drive or operate machinery.

Fluphenazine interactions

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Fluphenazine can interact with several substances and medicines — tell your prescriber and pharmacist about everything you take.

  • Alcohol: fluphenazine can significantly amplify alcohol's effects — avoid or strictly limit alcohol
  • Opioid pain medicines, barbiturates, antihistamines, and other sedatives: combined use can increase drowsiness and other CNS depressant effects
  • Large doses of hypnotics (sleep aids): should not be combined with fluphenazine
  • Epinephrine (adrenaline): phenothiazines can reverse epinephrine's blood-pressure-raising effect, causing a dangerous further drop in blood pressure — emergency personnel must be told you take this drug
  • Anesthetics: fluphenazine may intensify their effects; inform any surgical or anesthesia team

Interactions listed in the FDA-approved label

From the Fluphenazine prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

Leukopenia, Neutropenia and Agranulocytosis: In clinical trial and postmarketing experience, events of leukopenia/neutropenia have been reported temporally related to antipsychotic agents, including fluphenazine hydrochloride. Agranulocytosis (including fatal cases) has also been reported.

Read the label’s full interactions text

Leukopenia, Neutropenia and Agranulocytosis: In clinical trial and postmarketing experience, events of leukopenia/neutropenia have been reported temporally related to antipsychotic agents, including fluphenazine hydrochloride. Agranulocytosis (including fatal cases) has also been reported. Possible risk factors for leukopenia/neutropenia include preexisting low white blood cell count (WBC) and history of drug induced leukopenia/neutropenia. Patients with a preexisting low WBC or a history of drug induced leukopenia/neutropenia should have their complete blood count (CBC) monitored frequently during the first few months of therapy and should discontinue fluphenazine hydrochloride at the first sign of a decline in WBC in the absence of other causative factors. Patients with neutropenia should be carefully monitored for fever or other symptoms or signs of infection and treated promptly if such symptoms or signs occur. Patients with severe neutropenia (absolute neutrophil count <1000/mm 3 ) should discontinue fluphenazine hydrochloride and have their WBC followed until recovery.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿148 supplements and herbs with documented Fluphenazine interactions, ranked by severity Check Fluphenazine against a supplement or herb →

Before taking Fluphenazine

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Certain people need to take extra care — or may not be able to take fluphenazine at all:

  • Anyone with liver disease or blood disorders (blood dyscrasias) — these are contraindications
  • Patients with suspected or established brain damage to the subcortical region of the brain
  • Anyone in a comatose or severely depressed state — Fluphenazine Decanoate Injection is specifically contraindicated
  • Elderly patients with dementia-related psychosis — significantly increased risk of death; Fluphenazine Decanoate Injection is not approved for this use
  • Pregnant individuals — safety has not been established; weigh potential risks carefully with your doctor
  • Children under 12 — Fluphenazine Decanoate Injection is not intended for this age group; safety and efficacy in children have not been established for any form
  • People with heart, blood vessel, or kidney problems — higher risk of dangerous drops in blood pressure
  • Anyone with a history of seizures — high doses should be avoided
  • People with known allergy to fluphenazine or other phenothiazine medications — cross-sensitivity can occur

What Fluphenazine does in the body

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Fluphenazine acts at multiple levels of the central nervous system and affects multiple organ systems. It is more potent on a milligram basis than many other phenothiazines, produces less sedation, has less effect on potentiating CNS depressants and anesthetics than some phenothiazines, and is less likely to cause significant drops in blood pressure — though low blood pressure can still occur and appropriate precautions remain important.

How to store Fluphenazine

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Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) . Avoid excessive heat. Protect from light.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

148

Supplements & herbs that interact with Fluphenazine

148 supplements and herbal products have documented interactions with Fluphenazine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 5
  • Moderate · 109
  • Minor · 34
ACTIVATED CHARCOAL Major HENBANE Major INDIAN SNAKEROOT Major RAUVOLFIA VOMITORIA Major SCOPOLIA Major 1,3-DMAA Moderate ACACIA RIGIDULA Moderate ACTIVE HEXOSE CORRELATED COMPOUND (AHCC) Moderate +140 more
Every supplement checked against Fluphenazine — ranked by severity The full interaction hub: 5 major · 109 moderate · 34 minor · every one linked to its full report. Check Fluphenazine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Fluphenazine: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Fluphenazine — the kind of thing our pharmacy team would talk through with you at the counter.

What is fluphenazine actually used for?

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Fluphenazine is an antipsychotic medication used to manage psychotic disorders — most commonly schizophrenia. It's available as tablets, an oral liquid, and injections. The long-acting injectable form, Fluphenazine Decanoate, is especially helpful for people who need steady, ongoing treatment without taking a pill every day. It's not approved for dementia-related behavioral problems or intellectual disability.

How is the long-acting injection different from the tablets or regular shot?

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Fluphenazine Decanoate Injection is chemically designed to release slowly after a single shot, so one injection can keep working for up to four weeks or even longer. The regular tablets and Fluphenazine Hydrochloride Injection work faster but need to be taken or given much more frequently — usually every day in divided doses. Your doctor will choose the right form based on your situation and what works best for you.

What side effects should I know about going in?

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The most common side effects involve movement — things like muscle stiffness, a restless, fidgety feeling, or tremors. These can often be managed by adjusting your dose or adding another medication. You might also notice drowsiness, dry mouth, constipation, or nausea. Two more serious reactions to know about: tardive dyskinesia (uncontrolled, repetitive movements especially of the face or tongue) and a rare but dangerous reaction called neuroleptic malignant syndrome (high fever, severe muscle stiffness, confusion). If you experience either of those, contact your doctor or go to the ER right away.

Can I drink alcohol while taking this medication?

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It's best to avoid alcohol. Fluphenazine can significantly amplify alcohol's sedating effects, and combining them can make you much more drowsy and impaired than either one alone would. The same goes for other sedating medications — always let your prescriber know everything you're taking.

Is it safe to take fluphenazine during pregnancy?

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The safety of fluphenazine during pregnancy hasn't been clearly established. That doesn't mean it can never be used, but it does mean you and your doctor need to carefully weigh the potential benefits against the possible risks. If you're pregnant, planning to become pregnant, or think you might be, have that conversation with your prescriber as soon as possible.

What should I watch for and when should I call my doctor?

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Call your doctor promptly if you notice any unusual or uncontrolled movements — especially of your face, tongue, or limbs. Also reach out if you get a high fever with stiff muscles and confusion, feel faint or fall, notice yellowing of your skin or eyes, develop mouth sores or signs of infection, or have any severe skin reaction. These aren't things to wait and see about — getting checked early makes a real difference.

Is Fluphenazine available over the counter?

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No. Fluphenazine is a prescription medicine: every Fluphenazine product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Fluphenazine first available?

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The earliest FDA record we hold for Fluphenazine is from 1959: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Fluphenazine was first used.

Who makes Fluphenazine?

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35 companies currently list Fluphenazine products in the FDA's NDC Directory, including Upsher-Smith Laboratories, LLC, Novadoz Pharmaceuticals LLC, ANI Pharmaceuticals, Inc.. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Fluphenazine on HelloPharmacist

📊Fluphenazine supplement interactions148 checked — ranked by severity 🌿Drug & Supplement CheckerFluphenazine vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Fluphenazine NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Fluphenazine Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Fluphenazine forms and strengths (how it comes)

Fluphenazine is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Fluphenazine inactive ingredients by manufacturer.

Tablet

By mouth
Brands Fluphenazine Hydrochoride
How this form is used
What it may be used for
  • Fluphenazine hydrochloride tablets are indicated for the management of psychotic disorders
  • Fluphenazine hydrochloride tablets have not been shown effective for behavioral complications in patients with intellectual disability
Important instructions
  • Fluphenazine hydrochloride tablets are taken by mouth, typically divided into doses every 6 to 8 hours as directed by your prescriber
  • Treatment usually starts at a low dose and is adjusted gradually until symptoms are controlled
  • When symptoms are well controlled, your doctor may consolidate to a single daily dose — follow their guidance
Available strengths 4 strengths
1 mg 2.5 mg 5 mg 10 mg
216 FDA-listed product records ⓘ

Injection

Into a muscle · Under the skin
Brands Fluphenazine Decanoate
How this form is used
What it may be used for
  • Fluphenazine Decanoate Injection is a long-acting antipsychotic for patients with chronic schizophrenia who need extended treatment
  • Fluphenazine Hydrochloride Injection is used for the management of psychotic disorders
  • Fluphenazine Decanoate Injection is not approved for dementia-related psychosis or behavioral complications in patients with intellectual disability
  • Fluphenazine Hydrochloride Injection has not been shown effective for behavioral complications in patients with intellectual disability
Important instructions
  • Fluphenazine Decanoate Injection may be given intramuscularly or subcutaneously; a single injection may control symptoms for up to four weeks or longer
  • Fluphenazine Decanoate Injection typically begins working within 24–72 hours of the shot, with meaningful effects on symptoms within 48–96 hours
  • Fluphenazine Hydrochloride Injection is given intramuscularly, with doses typically divided and given every 6 to 8 hours as directed
  • Fluphenazine Hydrochloride Injection: once symptoms are controlled, your doctor may transition you to oral maintenance therapy
Available strengths 3 strengths
2.5 mg/mL 25 mg/mL 125 mg/5 mL
25 FDA-listed product records ⓘ

Oral solution

By mouth
How this form is used
What it may be used for
  • Fluphenazine Hydrochloride oral solution is indicated for the management of psychotic disorders
  • Fluphenazine Hydrochloride oral solution has not been shown effective for behavioral complications in patients with intellectual disability
Important instructions
  • Fluphenazine Hydrochloride oral solution is taken by mouth, typically divided into doses given every 6 to 8 hours
  • The dose is carefully individualized — your prescriber will start low and adjust based on your response
  • Follow your prescriber's and pharmacist's instructions exactly for measuring and taking the solution
Available strengths 3 strengths
0.5 mg/mL 5 mg/mL 1 kg/kg
7 FDA-listed product records ⓘ

Fluphenazine on the U.S. market: products, makers and brands

How Fluphenazine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

35 companies list 116 Fluphenazine product records with the FDA, mostly as tablet, injection, oral solution; the earliest marketing or approval year on record is 1959. Brand names on the directory include Permitil, Prolixin, Fluphenazine Decanoate and 1 more; the rest are generics.

3
Dose forms ⓘ
35
Labelers (makers, repackagers, distributors)
3
Brand names
116
FDA-listed product records ⓘ
1959
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (10) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Upsher-Smith Laboratories, LLC7%
Novadoz Pharmaceuticals LLC4%
ANI Pharmaceuticals, Inc.3%
Ajanta Pharma USA Inc.3%
Alembic Pharmaceuticals Inc.3%
Alembic Pharmaceuticals Limited3%
Other makers75%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Fluphenazine is used (Medicaid data)

A general measure of how commonly Fluphenazine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Fluphenazine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

127,346
Medicaid prescriptions filled (Q1–Q4 2025)
$6.5M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Fluphenazine prescribed? Of the 1,601 medications we measure, Fluphenazine ranks #474 by Medicaid prescriptions — more than 70% of them.

Where Fluphenazine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #474 of 1,601
#469 Tranexamic Acid 131,595 Rx #470 Olanzapine / Samidorph... 130,976 Rx #471 Bisoprolol 130,591 Rx #472 Miconazole 130,151 Rx #473 Bisacodyl Rectal 127,528 Rx #474 Fluphenazine 127,346 Rx #475 Adapalene 126,305 Rx #476 Misoprostol 125,269 Rx #477 Glucagon Injection 123,688 Rx #478 Olanzapine and Samidor... 123,672 Rx #479 Mometasone Oral Inhala... 120,997 Rx

Utilization by Fluphenazine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 25 mg/mL injectable solution is the most-dispensed Fluphenazine product — about 33% of these Medicaid prescriptions.

fluphenazine decanoate 25 MG/ML Injectable Solution Most dispensed

42,316 Medicaid prescriptions (Q1–Q4 2025) 33% of Fluphenazine prescriptions shown $3M gross reimbursement (before rebates) ≈ $72 per prescription (gross)

Summed across the 8 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 859824

fluphenazine hydrochloride 5 MG Oral Tablet

36,922 Medicaid prescriptions (Q1–Q4 2025) 29% of Fluphenazine prescriptions shown $1.4M gross reimbursement (before rebates) ≈ $37 per prescription (gross)

Summed across the 13 of 73 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 860918

fluphenazine hydrochloride 10 MG Oral Tablet

35,010 Medicaid prescriptions (Q1–Q4 2025) 27% of Fluphenazine prescriptions shown $1.7M gross reimbursement (before rebates) ≈ $48 per prescription (gross)

Summed across the 14 of 64 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 859841

fluphenazine hydrochloride 2.5 MG Oral Tablet

9,057 Medicaid prescriptions (Q1–Q4 2025) 7% of Fluphenazine prescriptions shown $259,941 gross reimbursement (before rebates) ≈ $29 per prescription (gross)

Summed across the 12 of 55 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 865123

fluphenazine hydrochloride 1 MG Oral Tablet

3,927 Medicaid prescriptions (Q1–Q4 2025) 3% of Fluphenazine prescriptions shown $142,738 gross reimbursement (before rebates) ≈ $36 per prescription (gross)

Summed across the 10 of 58 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 865117

fluphenazine hydrochloride 2.5 MG/ML Injectable Solution

75 Medicaid prescriptions (Q1–Q4 2025) <1% of Fluphenazine prescriptions shown $9,089 gross reimbursement (before rebates) ≈ $121 per prescription (gross)

Summed across the 1 of 1 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 865129

fluphenazine hydrochloride 5 MG/ML Oral Solution

28 Medicaid prescriptions (Q1–Q4 2025) <1% of Fluphenazine prescriptions shown $4,522 gross reimbursement (before rebates) ≈ $162 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 861848

fluphenazine hydrochloride 0.5 MG/ML Oral Solution

11 Medicaid prescriptions (Q1–Q4 2025) <1% of Fluphenazine prescriptions shown $1,616 gross reimbursement (before rebates) ≈ $147 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 859835

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Fluphenazine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 60 of 265 listed Fluphenazine NDCs with Medicaid activity.

Compare Fluphenazine products

A representative set of FDA-listed product records for Fluphenazine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 116 of 116 products — FDA National Drug Code Directory. See every product, package size and price: browse all 116 Fluphenazine NDCs →

Fluphenazine recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 2 Fluphenazine recalls since July 2021, covering 3 product listings. Both are still ongoing or began in the last six months. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Ongoing Class III Aug 25, 2026 · Ajanta Pharma USA Inc
Failed impurities/degradation specifications: (OOS) for Organic Impurities by HPLC (Impurity-A) during testing at the 18 months long term stability. Result: 1.1 percent. Spec: 1.0 percent.
  • Fluphenazine Hydrochloride Tablets, USP, 1mg, 100-count bottles, Rx Only, Marketed by: Ajanta Pharma USA Inc., Bridgewater, NJ 08807, Made in India, NDC 27241-255-01. Lots: Lot #: DJ23254, Exp. Date 11/30/2026; DJ10205, Exp. Date 04/30/2027. FDA record D-0836-2026 →
Ongoing Class II Mar 13, 2025 · Glenmark Pharmaceuticals Inc., USA
CGMP Deviations
  • Fluphenazine Hydrochloride Tablets 2.5mg, 100-count bottle, Rx Only, Manufactured by: Glenmark Pharmaceuticals Limited, Pithampur, Madhya Pradesh 454775, India, Manufactured for: Glenmark Pharmaceuti… Lots: Lot # 17232214, exp. date Sep-25 FDA record D-0327-2025 →
  • Fluphenazine Hydrochloride Tablets, 10mg, 100-Count Bottle, Rx Only, Manufactured by: Glenmark Pharmaceuticals Limited, Pithampur, Madhya Pradesh 454775, India, Manufactured for: Glenmark Pharmaceuti… Lots: Lot # 17232206, exp. date Sep-25 FDA record D-0326-2025 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Fluphenazine RxCUI 4496 3 dose forms · 9 strengths
  1. Dose form (SCDF) Injectable Solution RxCUI 372237 In current FDA listings
    Clinical drug / strength (SCD) decanoate 100 MG/ML RxCUI 865148 decanoate 25 MG/ML RxCUI 859824 hydrochloride 2.5 MG/ML RxCUI 865129

Look up RxCUI 4496 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Fluphenazine costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Tablet, Film Coated · Oral 10 mg $0.431 per tablet NDC details & price history
Tablet, Film Coated · Oral 5 mg $0.148 per tablet NDC details & price history
Tablet, Film Coated · Oral 1 mg $0.213 per tablet NDC details & price history
Tablet, Film Coated · Oral 2.5 mg $0.224 per tablet NDC details & price history
Injection, Solution · Intramuscular, Subcutaneous 25 mg/mL $10.84 per mL NDC details & price history
Injection, Solution · Intramuscular, Subcutaneous 125 mg/5 mL $10.84 per mL NDC details & price history
Injection, Solution · Intramuscular; Subcutaneous 25 mg/mL $10.84 per mL NDC details & price history
Injection, Solution · Intramuscular; Subcutaneous 125 mg/5 mL $10.84 per mL NDC details & price history
Tablet 2.5 mg $0.224 per tablet NDC details & price history
Tablet 5 mg $0.148 per tablet NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Fluphenazine brand names

Fluphenazine is sold under 4 brand names in the FDA directory — Permitil, Prolixin, Fluphenazine Decanoate, Fluphenazine Hydrochoride. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Permitil Prolixin Fluphenazine Decanoate Fluphenazine Hydrochoride

Who makes Fluphenazine: manufacturers and labelers

35 companies list Fluphenazine products with the FDA. By number of product records, the largest are Upsher-Smith Laboratories, LLC, Novadoz Pharmaceuticals LLC, ANI Pharmaceuticals, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Upsher-Smith Laboratories, LLC 8 Novadoz Pharmaceuticals LLC 5 ANI Pharmaceuticals, Inc. 4 Ajanta Pharma USA Inc. 4 Alembic Pharmaceuticals Inc. 4 Alembic Pharmaceuticals Limited 4 Amneal Pharmaceuticals NY LLC 4 Aurobindo Pharma Limited 4 AvPAK 4 Camber Pharmaceuticals, Inc. 4 Chartwell RX, LLC 4 Dr. Reddys Laboratories Inc. 4 Glenmark Pharmaceuticals Inc., USA 4 Golden State Medical Supply, Inc. 4 Lannett Company, Inc. 4 Major Pharmaceuticals 4 Marlex Pharmaceuticals, Inc. 4 Proficient Rx LP 4 Rising Pharma Holdings, Inc. 4 Sun Pharmaceutical Industries, Inc. 4 Zameer Pharmaceuticals LLC 4 Zydus Lifesciences Limited 4 Zydus Pharmaceuticals (USA) Inc. 4 Coupler LLC 3

…and 11 more on the FDA NDC directory.

Fluphenazine drug class (RxNorm)

Fluphenazine belongs to the Phenothiazine class.

Pharmacologic class Phenothiazine
Drug family (ATC) Phenothiazines with piperazine structure

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Fluphenazine page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Feb 1, 2023
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Fluphenazine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Fluphenazine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
34
Finished products in the current FDA directory
116
Companies listing them (makers, repackagers, distributors)
35
FDA labeler codes behind them ⓘ
36
Linked representative label ⓘ
Proficient Rx LP
Linked label effective
Feb 1, 2023
Composite sections available
14
Linked SPL Set ID
bc22941e-d2e7-4165-91ea-7239c8b9882d
Linked SPL Document ID
bc22941e-d2e7-4165-91ea-7239c8b9882d
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 36
71205-0837-00 Fluphenazine Hydrochloride 1 mg/1 TABLET, FILM COATED Proficient 71205-0837-11 Fluphenazine Hydrochloride 1 mg/1 TABLET, FILM COATED Proficient 71205-0837-30 Fluphenazine Hydrochloride 1 mg/1 TABLET, FILM COATED Proficient 71205-0837-55 Fluphenazine Hydrochloride 1 mg/1 TABLET, FILM COATED Proficient 71205-0837-60 Fluphenazine Hydrochloride 1 mg/1 TABLET, FILM COATED Proficient 71205-0837-64 Fluphenazine Hydrochloride 1 mg/1 TABLET, FILM COATED Proficient 71205-0837-72 Fluphenazine Hydrochloride 1 mg/1 TABLET, FILM COATED Proficient 71205-0837-78 Fluphenazine Hydrochloride 1 mg/1 TABLET, FILM COATED Proficient 71205-0837-90 Fluphenazine Hydrochloride 1 mg/1 TABLET, FILM COATED Proficient 71205-0838-00 Fluphenazine Hydrochloride 2.5 mg/1 TABLET, FILM COATED Proficient 71205-0838-11 Fluphenazine Hydrochloride 2.5 mg/1 TABLET, FILM COATED Proficient 71205-0838-30 Fluphenazine Hydrochloride 2.5 mg/1 TABLET, FILM COATED Proficient 71205-0838-55 Fluphenazine Hydrochloride 2.5 mg/1 TABLET, FILM COATED Proficient 71205-0838-60 Fluphenazine Hydrochloride 2.5 mg/1 TABLET, FILM COATED Proficient 71205-0838-64 Fluphenazine Hydrochloride 2.5 mg/1 TABLET, FILM COATED Proficient 71205-0838-72 Fluphenazine Hydrochloride 2.5 mg/1 TABLET, FILM COATED Proficient 71205-0838-78 Fluphenazine Hydrochloride 2.5 mg/1 TABLET, FILM COATED Proficient 71205-0838-90 Fluphenazine Hydrochloride 2.5 mg/1 TABLET, FILM COATED Proficient 71205-0839-00 Fluphenazine Hydrochloride 5 mg/1 TABLET, FILM COATED Proficient 71205-0839-11 Fluphenazine Hydrochloride 5 mg/1 TABLET, FILM COATED Proficient

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Proficient Rx LP is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →