Medication interaction hub

What Supplements Interact with Fluphenazine?

Fluphenazine brand names: Prolixin, Permitil, Fluphenazine. Every interaction below applies to the brands too.

148 Interactions 5 Major 109 Moderate 34 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Fluphenazine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Fluphenazine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Take real care with supplements while on fluphenazine (Prolixin), an antipsychotic used mainly for schizophrenia. Five of the 148 ingredients on file rate major: herbs like henbane that stack anticholinergic side effects (dry mouth, blurred vision, confusion) onto a drug already prone to them, two rauwolfia plants that can intensify its sedative action, and activated charcoal, which can soak up the medication so less reaches your blood.

Of the 109 moderate entries, the largest group involves the CYP2D6 enzyme that clears fluphenazine, and goldenseal is one of a few herbs that can inhibit it and push the drug's level higher than intended. Twenty others add sun sensitivity, a problem fluphenazine can cause on its own, and a small cluster of fibers and charcoals can blunt absorption of an oral dose, so keep those well separated from your pill. The remaining 34 rate minor, but the anticholinergic herbs are the ones I would rule out first.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 109 Minor 34 No known interaction 1,304

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Fluphenazine: Top Interactions at a Glance

The Fluphenazine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 148 interacting ingredients — plus 1,304 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Fluphenazine Combinations Today

The Fluphenazine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Kava + Fluphenazinei

It is unclear if kava inhibits CYP1A2; research is conflicting.

Read the full interaction Minor Likelihood Unlikely Valerian + Fluphenazinei

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.

Read the full interaction Moderate Likelihood Possible Wild Lettuce + Fluphenazinei

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.

Read the full interaction Major Likelihood Probable Scopolia + Fluphenazinei

The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of anticholinergic dru...

Read the full interaction Minor Likelihood Possible Coffee + Fluphenazinei

Theoretically, phenothiazines might increase the levels and adverse effects of caffeine.

Read the full interaction Minor Likelihood Possible Cola Nut + Fluphenazinei

Theoretically, phenothiazines might increase the levels and adverse effects of the caffeine in cola nut.

Read the full interaction
The complete list

Every Supplement Checked Against Fluphenazine

All 1,452 ingredients in our database, ranked by severity — 148 with a Fluphenazine interaction on file and 1,304 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Fluphenazine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Kava with Fluphenazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. It is unclear if kava inhibits CYP1A2; research is conflicting.

Full Kava + Fluphenazine answer

Can you take Valerian with Fluphenazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.

Full Valerian + Fluphenazine answer

Can you take Wild Lettuce with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.

Full Wild Lettuce + Fluphenazine answer

Can you take Scopolia with Fluphenazine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. The alkaloid constituents of scopolia, including hyoscyamine, scopolamine, and atropine, could potentiate the effects and adverse effects of...

Full Scopolia + Fluphenazine answer

Can you take Coffee with Fluphenazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, phenothiazines might increase the levels and adverse effects of caffeine.

Full Coffee + Fluphenazine answer

Can you take Slippery Elm with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Fluphenazine answer

Can you take St. John's Wort with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Fluphenazine answer

Can you take Teazle with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that teazle extract can inhibit acetylcholinesterase activity.

Full Teazle + Fluphenazine answer

Can you take Terminalia with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Full Terminalia + Fluphenazine answer

Can you take Thuja with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Fluphenazine answer

Can you take Thyme with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.

Full Thyme + Fluphenazine answer

Can you take Tinospora Cordifolia with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.

Full Tinospora Cordifolia + Fluphenazine answer

Can you take Toothed Clubmoss with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animal models, toothed clubmoss and huperzine A, an active constituent of toothed clubmoss, reversed cognitive deficits induced by scopol...

Full Toothed Clubmoss + Fluphenazine answer

Can you take Tragacanth with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Fluphenazine answer

Can you take Tree Turmeric with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric might increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Tree Turmeric + Fluphenazine answer

Can you take Vitamin C with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin C might decrease levels of fluphenazine.

Full Vitamin C + Fluphenazine answer

Can you take Vitex Agnus-castus with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.

Full Vitex Agnus-castus + Fluphenazine answer

Can you take White Pepper with Fluphenazine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that some constituents of white pepper inhibit cytochrome P450 2D6 (CYP2D6).

Full White Pepper + Fluphenazine answer

Can you take Thyroid Extract with Fluphenazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Fluphenazine answer

Can you take 1,3-dmba with Fluphenazine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, 1,3-DMBA might modestly increase the levels of CYP2D6 substrates.

Full 1,3-dmba + Fluphenazine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Fluphenazine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Fluphenazine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Fluphenazine sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Fluphenazine through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Fluphenazine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Fluphenazine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Fluphenazine through this category.

Phenothiazines 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Fluphenazine through this category.

Antipsychotic Drugs 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Fluphenazine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Fluphenazine through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Fluphenazine through this category.

Fluphenazine (Prolixin) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Fluphenazine through this category.

About Fluphenazine

Fluphenazine is an antipsychotic medication used to manage psychotic disorders, including schizophrenia, available in oral and injectable forms.

Generic name: Fluphenazine  ·  Brand names: Prolixin, Permitil, Fluphenazine.

See the full Fluphenazine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Fluphenazine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Fluphenazine.

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Pharmacist Counseling Corner

Fluphenazine & Supplements: Common Questions

What supplements interact with Fluphenazine?
In our interaction database, 148 supplement and herbal ingredients have an interaction with Fluphenazine on file — 5 rated major, 109 moderate, and 34 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Henbane, Indian Snakeroot.
Which Fluphenazine supplement interactions are the most serious?
The 5 major-rated combinations — led by Activated Charcoal, Henbane, Indian Snakeroot, Rauvolfia Vomitoria and Scopolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Fluphenazine?
That depends entirely on which supplement. The honest answer for Fluphenazine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Prolixin have the same supplement interactions as Fluphenazine?
Yes — Prolixin, Permitil, Fluphenazine all contain Fluphenazine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Fluphenazine and my other medications?
This page covers Fluphenazine against supplements and herbal ingredients. Checking Fluphenazine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Fluphenazine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.