Fluphenazine

32 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Fluphenazine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Fluphenazine Buprenorphine Belbuca Explained An increased risk of respiratory and CNS depression and an increased risk of paralytic ileus Details Fluphenazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Fluphenazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Fluphenazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Fluphenazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Fluphenazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Fluphenazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Fluphenazine Diazepam Rectal Diastat Increased risk of CNS depression Details Fluphenazine Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Fluphenazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Fluphenazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Fluphenazine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Fluphenazine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Fluphenazine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Fluphenazine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Fluphenazine Hydromorphone Injection Dilaudid Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Fluphenazine Hydromorphone Rectal available generically Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Fluphenazine Hydroxychloroquine Plaquenil An increased risk of seizures Details Fluphenazine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Fluphenazine Lacosamide Injection Motpoly An increased risk of CNS depression Details Fluphenazine Levodopa Oral Inhalation Inbrija Reduce efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delusi... Details Fluphenazine Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Fluphenazine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Fluphenazine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression; increased risk of paralytic ileus Details Fluphenazine Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Fluphenazine Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.